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Drug: Dexamethasone

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Total 7130 results found since Jan 2013.

Cognitive impairment of MRL mice is related to NMDA receptor-mediated inflammatory response and production of adhesion molecules in MRL/lpr mice-derived micro-vascular endothelial cells
In conclusion, cognitive impairment of MRL mice might be associated with NMDA receptor-mediated inflammatory response and production of adhesion molecules in MRL/lpr mice-derived MVECs.PMID:37114958 | DOI:10.5114/fn.2023.125903
Source: Folia Neuropathologica - April 28, 2023 Category: Pathology Authors: Xiaoyan Guan Jingyuan Wang Source Type: research

Coadministration of 5% Glucose Solution and Dexamethasone and Oxaliplatin-Related Vascular Pain Grade: A Case Study.
Abstract Agents used in cancer treatment can cause many side effects in patients. Oxaliplatin is a platinum-based cytotoxic agent that is used in the treatment of colorectal cancers, and one of its potential side effects is vascular pain. The current article will discuss the coadministration of dexamethasone and its potential effect on oxaliplatin-related vascular pain. PMID: 24080056 [PubMed - as supplied by publisher]
Source: Clinical Colorectal Cancer - October 1, 2013 Category: Cancer & Oncology Authors: Okada Y, Kajiume S, Taniguchi T, Kimoto S, Ogawa Y, Kiba T Tags: Clin J Oncol Nurs Source Type: research

Dexamethasone effects on vascular flow and organ injury in septic mice
Conclusions: Low-dose dexamethasone has beneficial effects on mesenteric blood flow and organ injury in experimental sepsis models.
Source: Journal of Surgical Research - January 31, 2014 Category: Surgery Authors: Huseyin Ozgur Aytac, Alper B. Iskit, Iskender Sayek Tags: Shock/Sepsis/Trauma/Critical Care Source Type: research

Sildenafil Stimulates and Dexamethasone Inhibits Pulmonary Vascular Development in Congenital Diaphragmatic Hernia Rat Lungs.
Conclusions: PDE-5 inhibitors may improve pulmonary arteriolar development in fetuses with CDH. In contrast, prenatal corticosteroids could have deleterious effects on arteriolar and arterial development in CDH lungs. © 2014 S. Karger AG, Basel. PMID: 24819293 [PubMed - as supplied by publisher]
Source: Neonatology - May 10, 2014 Category: Perinatology & Neonatology Authors: Kattan J, Céspedes C, González A, Vio CP Tags: Neonatology Source Type: research

Exercise training attenuates dexamethasone-induced hypertension by improving autonomic balance to the heart, sympathetic vascular modulation and skeletal muscle microcirculation
Conclusion: These results demonstrate that exercise training improves cardiovascular autonomic balance to the heart associated with an improvement in sympathetic modulation of vascular tone and microcirculatory function in the skeletal muscle of DEX-induced hypertensive rats.
Source: Journal of Hypertension - September 2, 2016 Category: Cardiology Tags: ORIGINAL PAPERS: Exercise Source Type: research

Retinal vascular calibre changes after intravitreal bevacizumab or dexamethasone implant treatment for diabetic macular oedema
Conclusions DEX had a significant narrowing effect on venular diameter in eyes with DMO not seen with BVZ. The changes in retinal vascular calibre suggest that these agents have a differing actions effects retinal vasculature and thereby suggest a potentially different mechanism of action on reducing DMO. Trial registration number NCT01298076.
Source: British Journal of Ophthalmology - September 26, 2017 Category: Opthalmology Authors: Wickremasinghe, S. S., Fraser-Bell, S., Alessandrello, E., Mehta, H., Gillies, M. C., Lim, L. L. Tags: Original articles - Clinical science Source Type: research

Analysis of anatomical biomarkers in subtypes of diabetic macular edema refractory to anti-vascular endothelial growth factor treated with dexamethasone implant.
CONCLUSION:: Dexamethasone implant is effective for all persistent diabetic macular edema subtypes with sustained functional and morphologic gains in the first 6 months. PMID: 30832509 [PubMed - as supplied by publisher]
Source: European Journal of Ophthalmology - March 3, 2019 Category: Opthalmology Authors: Castro-Navarro V, Cervera-Taulet E, Navarro-Palop C, Hernández-Bel L, Monferrer-Adsuara C, Mata-Moret L, Montero-Hernández J Tags: Eur J Ophthalmol Source Type: research

Real world evidence on 5661 patients treated for macular oedema secondary to branch retinal vein occlusion with intravitreal anti-vascular endothelial growth factor, intravitreal dexamethasone or macular laser.
CONCLUSIONS: Visual acuity improvements were higher and more sustained with anti-VEGF. Higher treatment burden occurred with anti-VEGF but this reduced over 36 months. Patients with better vision at baseline than those in the clinical trials maintained high levels of vision with both anti-VEGF and dexamethasone. PMID: 32532760 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - June 11, 2020 Category: Opthalmology Authors: Gale R, Pikoula M, Lee AY, Denaxas S, Egan C, Tufail A, Taylor P, UK EMR Users Group Tags: Br J Ophthalmol Source Type: research

Dexamethasone Induces Caveolin-1 In Vascular Endothelial Cells: implications for attenuated responses to VEGF.
We examined if steroids modulate abundance of caveolin-1, a regulatory protein of cell-surface receptor pathways, that regulates the magnitudes of endothelial response to vascular endothelial growth factor (VEGF). Dexamethasone, a synthetic glucocorticoid, induces caveolin-1 at both levels of protein and mRNA in a time- and dose-dependent manner in pharmacologically relevant concentrations in cultured bovine aortic endothelial cells. Aldosterone, a mineralocorticoid, but not sex steroids 17beta-estradiol, testosterone, or progesterone, elicits similar caveolin-1 induction. Caveolin-1 induction by dexamethasone and that by ...
Source: Am J Physiol Cell Ph... - February 20, 2013 Category: Cytology Authors: Igarashi J, Hashimoto T, Shoji K, Yoneda K, Tsukamoto I, Moriue T, Kubota Y, Kosaka H Tags: Am J Physiol Cell Physiol Source Type: research

Role of vascular endothelial growth factor antagonism on airway remodeling in asthma.
CONCLUSION: VEGF blockage may provide adjunctive therapeutic options as steroid-sparing agents for more effective treatment of remodeling in asthma. PMID: 23548522 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - March 1, 2013 Category: Allergy & Immunology Authors: Yuksel H, Yilmaz O, Karaman M, Bagriyanik HA, Firinci F, Kiray M, Turkeli A, Karaman O Tags: Ann Allergy Asthma Immunol Source Type: research