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Drug: Dexamethasone
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Total 7130 results found since Jan 2013.
TNF-α induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways.
Conclusion:TNF-α stimulates CXCL1 release from human ECs through JNK-mediated CXCL1 mRNA expression and p38 MAPK- and PI-3K-mediated CXCL1 secretory processes.
PMID: 24487964 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - February 3, 2014 Category: Drugs & Pharmacology Authors: Lo HM, Lai TH, Li CH, Wu WB Tags: Acta Pharmacol Sin Source Type: research
A case of primary (AL) amyloidosis with predominantly vascular amyloid deposition in the kidney
We report a 70-year-old man with primary (AL) amyloidosis with predominantly vascular deposition of amyloid diagnosed by renal biopsy, who was successfully treated using two chemotherapy regimens. There was rapid elevation of the serum creatinine level without remarkable proteinuria or hematuria. Renal histological examination showed some thickened arterial walls with amyloid fibril accumulation, and only a small amount of amyloid deposition in the glomeruli. Immunohistochemical examination was positive for anti-kappa staining. Serum immunoelectrophoresis and immunofixation testing did not show monoclonal proteins, and uri...
Source: CEN Case Reports - December 2, 2014 Category: Urology & Nephrology Source Type: research
miR-29c Induction Contributes to Down-Regulation of Vascular Extracellular Matrix Proteins by Glucocorticoids.
Abstract
Maternal undernutrition (MUN) increases maternal glucocorticoids (GC) and alters offspring miRNA expression. Given that the mechanisms of GC action on vascular development are not clear, this study examined the influence of GC on miR-29c and its predicted targets in primary rat aorta smooth muscle cells (RAOSMC). Dexamethasone (DEX) and corticosterone (COR) time-dependently increased miR-29c expression, and reduced Col3A1, Col4A5, ELN, and MMP2 protein in RAOSMC. These effects were blocked by mifepristone. These genes were also targeted by miR-29c as confirmed by a significant decrease in luciferase repor...
Source: Am J Physiol Cell Ph... - May 27, 2015 Category: Cytology Authors: Chuang T, Pearce WJ, Khorram O Tags: Am J Physiol Cell Physiol Source Type: research
Vascular endothelial growth factor antagonism restores epithelial barrier dysfunction via affecting zonula occludens proteins.
Authors: Yuksel H, Yilmaz O, Karaman M, Firinci F, Turkeli A, Kanik ET, Inan S
Abstract
Epithelial barrier dysfunction is important in the pathogenesis of asthma and allergic responses, and is therefore a therapeutic target. The aim of the present study was to investigate the effects of dexamethasone, a classic therapeutic agent, an anti-tumor necrosis factor agent (etanercept), which is used to treat difficult cases of asthma, and an anti-vascular endothelial growth factor (VEGF) agent (bevacizumab), which is an angiogenesis inhibitor, on zonula occludens (ZO) proteins in an experimental asthma model. The experime...
Source: Experimental and Therapeutic Medicine - November 18, 2015 Category: Journals (General) Tags: Exp Ther Med Source Type: research
Pituicyte Cues Regulate the Development of Permeable Neuro-Vascular Interfaces.
Abstract
The hypothalamo-neurohypophyseal system (HNS) regulates homeostasis through the passage of neurohormones and blood-borne proteins via permeable blood capillaries that lack the blood-brain barrier (BBB). Why neurohypophyseal capillaries become permeable while the neighboring vasculature of the brain forms BBB remains unclear. We show that pituicytes, the resident astroglial cells of the neurohypophysis, express genes that are associated with BBB breakdown during neuroinflammation. Pituicyte-enriched factors provide a local microenvironment that instructs a permeable neurovascular conduit. Thus, genetic and...
Source: Developmental Cell - November 14, 2018 Category: Cytology Authors: Anbalagan S, Gordon L, Blechman J, Matsuoka RL, Rajamannar P, Wircer E, Biran J, Reuveny A, Leshkowitz D, Stainier DYR, Levkowitz G Tags: Dev Cell Source Type: research
The effect of single dose adjunctive dexamethasone implant on diabetic macular edema in patients on anti-vascular endothelial growth factor treatment: 1 year follow-up from a real-life practice.
CONCLUSION: A single-dose Dx implant after three consecutive IVR injections for poorly responsive diabetic macular edema has limited effect on either VA or CMT. The need for IVR injections did not decrease with a Dx implant.
PMID: 31196662 [PubMed - as supplied by publisher]
Source: Journal Francais d Ophtalmologie - June 16, 2019 Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Human intracerebroventricular (ICV) injection of autologous, non-engineered, adipose-derived stromal vascular fraction (ADSVF) for neurodegenerative disorders: results of a 3-year phase 1 study of 113 injections in 31 patients.
Abstract
We have chosen to test the safety of human intracerebroventricular (ICV) brain injections of autologous non-genetically-modified adipose-derived stromal vascular fraction (ADSVF). In this IRB-approved trial, 24 patients received ICV ADSVF via an implanted reservoir between 5/22/14 and 5/22/17. Seven others were injected via their ventriculo-peritoneal shunts. Ten patients had Alzheimer's disease (AD), 6 had amyotrophic lateral sclerosis (ALS), 6 had progressive multiple sclerosis (MS-P), 6 had Parkinson's "Plus" (PD+), 1 had spinal cord injury, 1 had traumatic brain injury, and 1 had stroke. Median age wa...
Source: Molecular Biology Reports - July 19, 2019 Category: Molecular Biology Authors: Duma C, Kopyov O, Kopyov A, Berman M, Lander E, Elam M, Arata M, Weiland D, Cannell R, Caraway C, Berman S, Scord K, Stemler L, Chung K, Khoudari S, McRory R, Duma C, Farmer S, Bravo A, Yassa C, Sanathara A, Singh E, Rapaport B Tags: Mol Biol Rep Source Type: research
Effect of low-dose dexamethasone on extra vascular lung water in patients following on-pump elective primary coronary artery bypass graft surgery.
Conclusions: There were no beneficial effects of low-dose dexamethasone on EVLWI or other volumetric parameters in patients subjected to on-pump primary coronary bypass surgery. Hemodynamic parameters were also not affected. Probably, the advanced hemodynamic monitoring aided in optimal fluid management in the nonsteroidal group impacting EVLW accumulation.
PMID: 31621671 [PubMed - in process]
Source: Annals of Cardiac Anaesthesia - September 30, 2019 Category: Anesthesiology Authors: Maddali MM, Waje ND, Arora NR, Panchatcharam SM Tags: Ann Card Anaesth Source Type: research
Multicentre study of 4626 patients assesses the effectiveness, safety and burden of two categories of treatments for central retinal vein occlusion: intravitreal anti-vascular endothelial growth factor injections and intravitreal Ozurdex injections.
CONCLUSIONS: VA improvements were greater and more sustained with anti-VEGF treatment. Lower starting acuity resulted in bigger gains in both groups, while higher starting acuity resulted in higher VA at 36 months. Although treatment burden was greater with anti-VEGF, Ozurdex was associated with higher rates of endophthalmitis.
PMID: 32962992 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - September 21, 2020 Category: Opthalmology Authors: Gale R, Gill C, Pikoula M, Lee AY, Hanson RLW, Denaxas S, Egan C, Tufail A, Taylor P, UK EMR Database Users Group Tags: Br J Ophthalmol Source Type: research
Seabuckthorn Berries Extract Attenuates Pulmonary Vascular Hyperpermeability in Lipopolysaccharide-Induced Acute Lung Injury in Mice
ConclusionSBE maintained alveolar-capillary barrier integrity under endotoxin challenge in mice by suppressing the key factors in the pathogenesis of ALI.
Source: Chinese Journal of Integrative Medicine - December 7, 2021 Category: Internal Medicine Source Type: research
The Intervention of Nano-targeted Drugs & amp; Angioplastryin Treatment and Prevention of Vascular Restenosis and its Influence on Monocyte Chemotactic Protein-1 in Lower Extremity Angiopathy
In conclusion, MCP-1 is one of the major causes of lower extremity angiopathy. The nano-targeted drugs and angioplastry can raise the expression level of MCP-1 in patients with lower extremity angiopathy. The experimental results had a high application value and the nano-targeted drugs & angioplastry can be promoted clinically.PMID:35988189 | DOI:10.14715/cmb/2022.68.3.38
Source: Cellular and Molecular Biology - August 21, 2022 Category: Molecular Biology Authors: Kun Ji Yaming Zhang Daojing Huang Source Type: research
Dexamethasone induces caveolin-1 in vascular endothelial cells: implications for attenuated responses to VEGF
We examined if steroids modulate abundance of caveolin-1, a regulatory protein of cell-surface receptor pathways that regulates the magnitudes of endothelial response to vascular endothelial growth factor (VEGF). Dexamethasone, a synthetic glucocorticoid, induces caveolin-1 at both levels of protein and mRNA in a time- and dose-dependent manner in pharmacologically relevant concentrations in cultured bovine aortic endothelial cells. Aldosterone, a mineralocorticoid, but not the sex steroids 17β-estradiol, testosterone, or progesterone, elicits similar caveolin-1 induction. Caveolin-1 induction by dexamethasone and tha...
Source: AJP: Cell Physiology - April 15, 2013 Category: Cytology Authors: Igarashi, J., Hashimoto, T., Shoji, K., Yoneda, K., Tsukamoto, I., Moriue, T., Kubota, Y., Kosaka, H. Tags: ARTICLES Source Type: research
