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Drug: Cipro

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Total 2344 results found since Jan 2013.

Synergistic antibacterial action of β-sitosterol-D-glucopyranoside isolated from Desmostachya bipinnata leaves with antibiotics against common human pathogens
Desmostachya bipinnata (L.) Stapf, Poaceae, or Kusha in Sanskrit, is a sacred grass used extensively in Indian Vedic practices. It is well known for its medicinal value and is used in traditional Indian medicine to treat microbial infection in combination with other herbs. An effort has been made to isolate and characterize the bioactive compounds from the hydroalcoholic extract of D. bipinnata through bioassay guided fractionation, column chromatography. Their individual or combined antimicrobial properties were determined by the Resazurin Microtitre Assay, the checkerboard assay in combination with antibiotics, and by ti...
Source: Revista Brasileira de Farmacognosia - May 20, 2014 Category: Drugs & Pharmacology Source Type: research

Population pharmacokinetic analysis of ciprofloxacin in the elderly patients with lower respiratory tract infections.
Abstract The aims of the study were to develop a population pharmacokinetic model of ciprofloxacin (CPX) in the elderly patients and to examine the impact of patient-dependent variables, such as: age, body weight, serum creatinine, creatinine clearance, co-existing diseases and concurrent use of other drugs on pharmacokinetic parameter values of this drug. The study was conducted in a group of 44 patients at the age of 44-96years, hospitalized in the Department of Internal Medicine and Gerontology, Jagiellonian University/University Hospital, Cracow, Poland due to pneumonia lobaris or bronchopneumonia. Patients re...
Source: Experimental Gerontology - May 23, 2014 Category: Geriatrics Authors: Cios A, Wyska E, Szymura-Oleksiak J, Grodzicki T Tags: Exp Gerontol Source Type: research

Multiresistant extended-spectrum beta-lactamase-producing Enterobacteriaceae from humans, companion animals and horses in central Hesse, Germany
Conclusions: Isolates from human, companion animals and horses shared several characteristics regarding presence of ESBL, PMQR and combination of different resistance genes. The results indicate active transmission and dissemination of multi-resistant Enterobacteriaceae among human and animal populations.
Source: Epidemiologic Perspectives and Innovations - July 12, 2014 Category: Epidemiology Authors: Judith SchmiedelLinda FalgenhauerEugen DomannRolf BauerfeindEllen Prenger-BerninghoffCan ImirzaliogluTrinad Chakraborty Source Type: research

Antibiotic consumption and its influence on the resistance in Enterobacteriaceae
This study aimed at analyzing the development of resistance of Enterobacteriaceae to selected beta-lactam, fluoroquinolone and aminoglycoside antibiotics in the University Hospital Olomouc and assessing the effect of selection pressure of these antibiotics. Methods: For the period between 1 January 2000 and 31 December 2011, resistance of Klebsiella pneumoniae, Escherichia coli, Enterobacter cloacae and Proteus mirabilis to third- and fourth-generation cephalosporins, meropenem, piperacillin/tazobactam, fluoroquinolones and aminoglycosides was retrospectively studied. For the assessment of selection pressure of antibiotics...
Source: BMC Research Notes - July 16, 2014 Category: Research Authors: Miroslava SedlákováKarel UrbánekVladimíra VojtováHana SuchánkováPeter ImwensiMilan Kolá¿ Source Type: research

Multiresistant extended-spectrum ß-lactamase-producing Enterobacteriaceae from humans, companion animals and horses in central Hesse, Germany
Conclusions: Isolates from human, companion animals and horses shared several characteristics regarding presence of ESBL, PMQR and combination of different resistance genes. The results indicate active transmission and dissemination of multi-resistant Enterobacteriaceae among human and animal populations.
Source: BMC Microbiology - Latest articles - July 12, 2014 Category: Microbiology Authors: Judith SchmiedelLinda FalgenhauerEugen DomannRolf BauerfeindEllen Prenger-BerninghoffCan ImirzaliogluTrinad Chakraborty Source Type: research

Typhoid fever in Fiji: a reversible plague?
Abstract The country of Fiji, with a population of approximately 870 000 people, faces a growing burden of several communicable diseases including the bacterial infection typhoid fever. Surveillance data suggest that typhoid has become increasingly common in rural areas of Fiji and is more frequent amongst young adults. Transmission of the organisms that cause typhoid is facilitated by faecal contamination of food or water and may be influenced by local behavioural practices in Fiji. The Fijian Ministry of Health, with support from Australian Aid, hosted a meeting in August 2012 to develop comprehensive control and preven...
Source: Tropical Medicine and International Health - July 25, 2014 Category: Tropical Medicine Authors: Corinne N. Thompson, Mike Kama, Shrish Acharya, Una Bera, John Clemens, John A. Crump, Aggie Dawainavesi, Gordon Dougan, W. John Edmunds, Kimberley Fox, Kylie Jenkins, M. Imran Khan, Josefa Koroivueta, Myron M. Levine, Laura B. Martin, Eric Nilles, Virgin Tags: Original Article Source Type: research

Evidence Linking Some Fluoroquinolones to Uveitis GrowsEvidence Linking Some Fluoroquinolones to Uveitis Grows
Moxifloxacin or ciprofloxacin appear to increase the risk for uveitis; levofloxacin less so. Medscape Medical News
Source: Medscape Infectious Diseases Headlines - October 7, 2014 Category: Infectious Diseases Tags: Internal Medicine News Source Type: news

Analysis of Mechanisms of Interaction between Ciprofloxacin-Based Radiopharmaceutical Labeled with Technetium-99m and Cultured Staphylococcus aureus
Mechanisms of interaction between ciprofloxacin-based radiopharmaceutical labeled with technetium-99m and cultured Staphylococcus aureus were studied. The substance, reagent for radiopharmaceutical, and the radiopharmaceutical demonstrated similar bactericidal activity against the test bacterial cultures, which confi rmed specifi c antibacterial activity of technetium-99m-labeled ciprofloxacin. The technetium-99m-labeled antibiotic reversibly interacts with inactivated Staphylococcus aureus culture, which indicates the existence of an additional non-specific pathway for radiopharmaceutical accumulation in the bacterial inf...
Source: Bulletin of Experimental Biology and Medicine - October 24, 2014 Category: Biology Source Type: research

Non-Invasive Management of Madura Foot with Oral Posaconazole and Ciprofloxacin.
We report a case of Madura foot in a Somali refugee successfully managed with oral posaconazole and ciprofloxacin. PMID: 25349373 [PubMed - as supplied by publisher]
Source: The American Journal of Tropical Medicine and Hygiene - October 27, 2014 Category: Tropical Medicine Authors: Sharma AM, Sharma N, Nat A, Rane M, Endy TP Tags: Am J Trop Med Hyg Source Type: research

Antibiotic therapy for diabetic foot infections in a tertiary care hospital in Jakarta, Indonesia
Conclusion Diabetic foot infections (62.8%) were polymicrobial. S. aureus was most commonly found in the foot infection. Most of the microorganisms isolated from diabetic foot infection were resistant to many types of antibiotics.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - October 12, 2014 Category: Endocrinology Source Type: research

Lactococcus garvieae carries a chromosomally encoded pentapeptide repeat protein that confers reduced susceptibility to quinolones in Escherichia coli producing a cytotoxic effect
This study characterises a chromosomal gene of Lactococcus garvieae encoding a pentapeptide repeat protein designated as LgaQnr. This gene has been implicated in reduced susceptibility to quinolones in this bacterium, which is of relevance to both veterinary and human medicine. All of the L. garvieae isolates analysed were positive for the lgaqnr gene. The expression of lgaqnr in Escherichia coli reduced the susceptibility to quinolones, producing an adverse effect. The reduced susceptibility to ciprofloxacin was 16-fold in E. coli ATCC 25922 and 32-fold in E. coli DH10B, compared to the control strains. The minimum inhibi...
Source: Research in Microbiology - October 12, 2014 Category: Microbiology Source Type: research

Phenotypic and genotypic characteristics of Vibrio cholerae O1 isolated from the Sierra Leone cholera outbreak in 2012
Conclusions This study demonstrates that altered variants of V. cholerae O1 of four clonal types were responsible for the 2012 outbreak of cholera in Sierra Leone.
Source: Transactions of the Royal Society of Tropical Medicine and Hygiene - October 9, 2014 Category: Tropical Medicine Authors: Mahmud, Z. H., Islam, S., Zaman, R. U., Akter, M., Talukder, K. A., Bardhan, P. K., Khan, A. I., Rhodes, F. C., Kamara, A., Wurie, I. M., Alemu, W., Jambai, A., Faruque, S. M., Clemens, J. D., Islam, M. S. Tags: ORIGINAL ARTICLES Source Type: research

Detection of bacteria and analyses of Chlamydia trachomatis viability in patients with postvenereal reactive arthritis
Abstract Postvenereal reactive arthritis is an inflammatory form of arthritis that commonly develops after urogenital infection, predominantly in human leucocyte antigen‐B27‐positive men in the third decade of life. In our hospital, patients underwent synovectomy before a 4‐month course of antibiotics (ciprofloxacin, tetracycline and roxithromicin). The clinical remission was achieved in approximately 70% patients. At molecular level, the remission was associated with the negative polymerase chain reaction findings of bacteria.
Source: Internal Medicine Journal - December 1, 2014 Category: Internal Medicine Authors: N. Strelić, J. Bojović, L. Pavlica, B. Cikota‐Aleksić, B. Miličić, Z. Magić Tags: Brief Communications Source Type: research

Comparative Effectiveness of Different Oral Antibiotics Regimens for Treatment of Urinary Tract Infection in Outpatients: An Analysis of National Representative Claims Database
Abstract: There are very limited data on the postmarketing outcome comparison of different guideline antibiotic regimens for patients with urinary tract infections (UTIs). We carried out a population-based comparative effectiveness study from year 2000 through 2009, using the administrative data of 2 million patients from the National Health Informatics Project of Taiwan. Treatment failure was defined as either hospitalization or emergency department visits for UTI. Odd ratios were computed using conditional logistic regression models matched on propensity score. We identified 73,675 individuals with UTI, of whom 54,796 (7...
Source: Medicine - December 1, 2014 Category: Internal Medicine Tags: Article: Observational Study Source Type: research

Relative Frequency, Characteristics, and Antimicrobial Susceptibility Patterns of Vibrio spp., Aeromonas spp., Chromobacterium violaceum, and Shewanella spp. in the Northern Territory of Australia, 2000-2013.
Abstract Vibrio, Aeromonas, Chromobacterium violaceum, and Shewanella (VACS) are water-associated Gram-negative organisms that can cause a variety of infections. The frequency, patient characteristics, and antimicrobial susceptibilities for 468 isolates from 442 patients from the Northern Territory were reviewed. Aeromonas spp. (312 of 468; 67%) were most commonly isolated followed by Vibrio spp. (71 of 468; 15%), Shewanella spp. (61 of 468; 13%), and C. violaceum (24 of 468; 5%). A strong male predominance was found (male to female ratio of 2.3:1). Skin and soft tissue isolations (373 of 468; 79%) from lower limb...
Source: The American Journal of Tropical Medicine and Hygiene - December 29, 2014 Category: Tropical Medicine Authors: McAuliffe GN, Hennessy J, Baird RW Tags: Am J Trop Med Hyg Source Type: research