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In vitro antibacterial and antibiotic-potentiation activities of the methanol extracts from Beilschmiedia acuta, Clausena anisata, Newbouldia laevis and Polyscias fulva against multidrug-resistant Gram-negative bacteria
Conclusion: The overall results of the present study provide information for the possible use of the studied plants and mostly Beilschmedia acuta in the control of bacterial infections including MDR phenotypes.
Source: BMC Complementary and Alternative Medicine - November 22, 2015 Category: Complementary Medicine Authors: Simplice TankeoPierre TaneVictor Kuete Source Type: research

Let's Give Thanks and Hope We Haven't Lost the War Against Superbugs
Our holiday season has begun with an ominous report: In China, bacteria with a dangerous new antibiotic-resistance gene have spread from livestock to people. This gene bestows resistance against colistin -- an antibiotic that has become our last hope for treating people infected with some of the worst superbugs. The scariest part is that the gene can make copies of itself and then jump between bacteria. History shows us that these mobile resistance genes can spread around the world quickly, silently hitchhiking in the guts of people and animals or on the surface of food. Consequently, this could be our last Thanksgiving wh...
Source: Science - The Huffington Post - November 24, 2015 Category: Science Source Type: news

In vitro synergism of magnolol and honokiol in combination with antibacterial agents against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA)
Conclusion: ML and HL showed synergistic potentiation of antibacterial agents against clinical isolates of MRSA and warrant further pharmacological investigation.
Source: BMC Complementary and Alternative Medicine - December 1, 2015 Category: Complementary Medicine Authors: Guo-Ying ZuoXin-Juan ZhangJun HanYu-Qing LiGen-Chun Wang Source Type: research

Molecular epidemiology of beta-lactamases in ceftazidime-resistant Pseudomonas aeruginosa isolates.
In conclusion, it was considered that the detection of beta-lactamase genes in bacteria and the identification of beta-lactamase types may provide facilities in selection of antibiotics, monitorization of therapy, prevention of resistance development of infection control programs. PMID: 26167816 [PubMed - indexed for MEDLINE]
Source: Mikrobiyoloji Bulteni - December 2, 2015 Category: Microbiology Tags: Mikrobiyol Bul Source Type: research

Detection of the first QnrS gene positivity in aquatic Aeromonas spp. isolates in Turkey.
In conclusion, various resistance genes of aquatic bacteria may constitute a potential risk for the transmission of those genes to other bacteria as well as clinical isolates. PMID: 25706737 [PubMed - indexed for MEDLINE]
Source: Mikrobiyoloji Bulteni - December 2, 2015 Category: Microbiology Tags: Mikrobiyol Bul Source Type: research

Investigation of beta-lactamase genes and clonal relationship among the extended-spectrum beta-lactamase producing nosocomial Escherichia coli isolates.
In conclusion, it was considered that further studies are needed to explain the relationship between epidemic clones and plasmids with the use of plasmid analysis and multilocus sequence typing methods. PMID: 25706727 [PubMed - indexed for MEDLINE]
Source: Mikrobiyoloji Bulteni - December 2, 2015 Category: Microbiology Tags: Mikrobiyol Bul Source Type: research

Risk factors and antibiotic use in methicillin-resistant Staphylococcus aureus bacteremia in hospitalized patients at Hacettepe University Adult and Oncology Hospitals (2004-2011) and antimicrobial susceptibilities of the isolates: a nested case-control study.
Authors: Atmaca O, Zarakolu P, Karahan C, Cakır B, Unal S Abstract The aim of this study was to evaluate methicillin-resistant Staphylococcus aureus (MRSA) bacteremia cases who were followed at the Infectious Diseases Unit of Internal Medicine Department, at Hacettepe University Adult and Oncology Hospitals between January 2004-December 2011. A total of 198 patients, of them 99 had positive MRSA blood cultures (case group), and 99 without MRSA bacteremia (control group) who were selected randomly among patients at the same wards during the same time period, were included in the study. Demographic data, risk factor...
Source: Mikrobiyoloji Bulteni - December 2, 2015 Category: Microbiology Tags: Mikrobiyol Bul Source Type: research

Molecular characterization of beta-lactamase-associated resistance in Acinetobacter baumannii strains isolated from clinical samples.
In conclusion, multidrug resistant A.baumannii strains were common in our hospital and our epidemiologic data would be helpful for further investigations and in therapeutical approaches. PMID: 25052103 [PubMed - indexed for MEDLINE]
Source: Mikrobiyoloji Bulteni - December 2, 2015 Category: Microbiology Tags: Mikrobiyol Bul Source Type: research

Regional specifics of microbial landscape in outpatients with lower respiratory tract infections.
CONCLUSIONS: The results of the research carried out in the recent years in comparison with the data of the previous years, call for reviewing of the standard approaches to the choice of antimicrobial agents in respiratory tract infections. In order to improve the standard of care, the choice of medicines should be based on a number of factors, namely the age, the severity of the respective pathological condition, previous antimicrobial use, and the level of care. PMID: 26639714 [PubMed - in process]
Source: International Journal of Risk and Safety in Medicine - December 9, 2015 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Antibiotics for skin and soft tissues infections in type 2 diabetes mellitus.
CONCLUSIONS: There is a vicious circle in patients with type 2 diabetes: the infectious process leads to decompensation of carbohydrate metabolism parameters; in turn, hyperglycemia leads to increase of severity of SSTIs. Normalization of glucose levels promotes prompt relief of symptoms of infection and bacterial eradication, rational treatment of infection contributes to rapid correction of glucose level. Therefore, an essential element of comprehensive treatment of this group of patients should be rational antibiotic therapy; the choice of medication should be based on the severity of the disease and potential etiologic...
Source: International Journal of Risk and Safety in Medicine - December 9, 2015 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Pharmacists' knowledge of the safety of antibiotics for systemic use.
CONCLUSIONS: The study identified gaps in the knowledge of pharmacists about the safety of antimicrobial agents. Views of professionals about antibiotics are mostly consistent with current data about the properties of drugs. However, detailed analysis shows that such views are not supported by clear knowledge of the properties of each drug and are mostly intuitive. In terms of the prevalence of self-medication with antibiotics and OTC dispensing of antimicrobial drugs it is necessary to improve the professional knowledge of pharmaceutical workers on antibiotics for systemic use. PMID: 26639686 [PubMed - in process]
Source: International Journal of Risk and Safety in Medicine - December 9, 2015 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Effect of Sucralfate on the Relative Bioavailability of Enrofloxacin and Ciprofloxacin in Healthy Fed Dogs
Conclusions and Clinical ImportanceA possible clinically relevant drug interaction for the relative bioavailability of ciprofloxacin with sucralfate was found. No significant difference in bioavailability was documented for enrofloxacin with sucralfate. Further research is warranted in fasted dogs and clinical cases requiring enrofloxacin or other approved fluoroquinolones in combination with sucralfate.
Source: Journal of Veterinary Internal Medicine - November 1, 2015 Category: Veterinary Research Authors: K. KuKanich, B. KuKanich, S. Guess, E. Heinrich Tags: Standard Article Source Type: research

Molecular Characterization of Extended-Spectrum β-Lactamase-Producer Klebsiella pneumoniae Isolates Causing Neonatal Sepsis in Peru.
Abstract Klebsiella pneumoniae (KP) is the most common cause of neonatal sepsis in the low- and middle-income countries. Our objective was to describe the phenotypic and molecular characteristics of extended-spectrum β-lactamase (ESBL)-producer KP in neonatal care centers from Peru. We collected 176 non-duplicate consecutive KP isolates from blood isolates of neonates from eight general public hospitals of Lima, Peru. The overall rate of ESBL production was 73.3% (N = 129). The resistance rates were higher among ESBL-producer isolates when compared with the nonproducers: 85.3% versus 12.8% for gentamicin (P < ...
Source: The American Journal of Tropical Medicine and Hygiene - December 7, 2015 Category: Tropical Medicine Authors: García C, Astocondor L, Rojo-Bezares B, Jacobs J, Sáenz Y Tags: Am J Trop Med Hyg Source Type: research

Antimicrobial susceptibility of Salmonella enterica isolated during the pre-harvest period in swine in Colombia.
Conclusion The results show that it is essential to reinforce containment measures to prevent the development of antimicrobial resistances and improve training of the operators, workers, and veterinarians in Colombia involved in the primary production, product processing, distribution, and sale to the consumer, thereby guaranteeing a safe food product and the effectiveness of antimicrobial agents in human and veterinary medicine. PMID: 26437705 [PubMed - in process]
Source: Revista de Salud Publica - December 11, 2015 Category: Global & Universal Tags: Rev Salud Publica (Bogota) Source Type: research

Liver Transplantation in Antituberculosis Drugs-Induced Fulminant Hepatic Failure: A Case Report and Review of the Literature
This report presents a case of liver transplantation in antituberculosis drugs-induced FHF and reviews the relevant literature. A 39-year-old woman with pelvic and salpinx tuberculosis experienced complex pelvic exenteration. After the operation, she was administrated INH, RMP, PZA, and EMB to prevent tuberculosis. Two months later, examination revealed severe FHF and the antituberculosis therapy regimen was changed to ciprofloxacin and streptomycin. Subsequently, urgent orthotopic liver transplantation was performed. Posttransplantation, her serum transaminases improved gradually, but her total bilirubin level and direct ...
Source: Medicine - December 1, 2015 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research