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< em > Salmonella < /em > infection after anterior cruciate ligament reconstruction: A case report
CONCLUSION: Infection after ACLR is rare and requires an early diagnosis and management in order to treat the infection and prevent arthritis-related joint cartilage destruction and damage to the graft.PMID:33959488 | PMC:PMC8082509 | DOI:10.5312/wjo.v12.i4.246
Source: World Journal of Orthopaedics - May 7, 2021 Category: Orthopaedics Authors: Thomas Neri Margaux Dehon Elisabeth Botelho-Nevers Celine Cazorla Sven Putnis Remi Philippot Frederic Farizon Bertrand Boyer Source Type: research

Polymorphisms of Gene Cassette Promoters of the Class 1 Integron in Clinical Proteus Isolates
Conclusion: To the best of our knowledge, this study provides the first evidence for polymorphisms of the class 1 integron variable promoter in clinical Proteus isolates, which generally contain relatively strong promoters. Resistance genotypes showed a higher coincidence rate with the drug-resistant phenotype in strong-promoter-containing strains, resulting in an ability to confer strong resistance to antibiotics among host bacteria and a relatively limited ability to capture gene cassettes. Moreover, strains with relatively weak integron promoters can “afford” a heavier “extra-integron antibiotic res...
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research

What are Common Pitfalls in Measuring the QTc in Hospitalized Adult Patients?
Case Ms. S. is a 60-year-old woman admitted with gastroenteritis and hypovolemia in the setting of three days of nausea and diarrhea. She was also found to have atrial fibrillation with rapid ventricular response. Her tachycardia improved after intravenous fluids. The following morning, nausea prompted her nurse to request antiemetic medications. You inspect the admission electrocardiogram (ECG) (Figure 1). Are QT-prolonging antiemetics safe to administer? In this review, we provide background and practical guidance regarding QT interval (QTc) interpretation for the internist caring for hospitalized adults.  Accurate meas...
Source: The Hospitalist - August 1, 2023 Category: Hospital Management Authors: Ronda Whitaker Tags: Clinical Guidelines Key Clinical Questions Source Type: research

Identification of a nth-Like Gene Encoding an Endonuclease III in Campylobacter jejuni
In this study, a BER homolog encoded by cj0595c (named nth) in C. jejuni was analyzed for endonuclease III activity and for its role in maintaining genomic stability. It was found that inactivation of nth resulted in elevated frequencies of spontaneous fluoroquinolone-resistant (FQR) and oxidative stress resistant (OXR) mutants, compared with the wild-type strain in C. jejuni. Sequencing analysis of the FQR and OXR mutants revealed that the elevated mutation rates were associated with C → T or G → A transition in gyrA (FQR mutants) or perR (for OXR mutants). In an in vitro assay, a purified recombinant C. jej...
Source: Frontiers in Microbiology - April 9, 2019 Category: Microbiology Source Type: research

Isolation of Antimicrobial Compounds From Cnestis ferruginea Vahl ex. DC (Connaraceae) Leaves Through Bioassay-Guided Fractionation
Conclusion In conclusion, aqueous extracts of C. ferruginea leaves showed antimicrobial activity due to the presence of hydroquinone and caffeic acid methyl ester. This supports its traditional use for infections and confirmed that the active molecules are water-soluble. Author Contributions KK, SP, LVP, and WL conceived and designed the experiments. SP, KK, M-RY, and J-GL performed the experiments. SP, LVP, WL, M-RY, J-GL, and Z-HJ analyzed the data. WL and Z-HJ contributed reagents, materials, and analysis tools. KK, SP, WL, M-RY, Z-HJ, and LVP contributed to the writing of the manuscript. All authors contributed to m...
Source: Frontiers in Microbiology - April 10, 2019 Category: Microbiology Source Type: research

Characterizing the Personalized Microbiota Dynamics for Disease Classification by Individual-Specific Edge-Network Analysis
Conclusion There is growing interest in bolstering resistance to infections or diseases by altering the microbiota (Jia et al., 2008; Holmes, 2016; Waterman et al., 2016; Delzenne and Bindels, 2018). Here, we have presented a computational framework, i.e., iENA, to identify the key OTU features to distinguish normal and disease states, by extracting higher-order statistics and dynamic information from 16S rRNA (ribosomal RNA) gene sequencing data in a one-sample manner. As a proof-of-concept study, we carried out iENA on the temporal development data of twelve subjects (healthy adults) undergoing a challenge with intestin...
Source: Frontiers in Genetics - April 10, 2019 Category: Genetics & Stem Cells Source Type: research

Shared Multidrug Resistance Patterns in Chicken-Associated Escherichia coli Identified by Association Rule Mining
In conclusion, association rule mining is an effective tool for identifying patterns of multidrug resistance within antimicrobial susceptibility testing data and evaluating the statistical and biological significance of the patterns. Rule quality measures used to sort and differentiate rules should be tested using resampling procedures to minimize the false discovery rate. Rule mining identified consistent multidrug resistance patterns involving beta-lactams, sulfisoxazole, tetracycline, gentamicin, and streptomycin in E. coli isolated from chicken carcasses and meat between 2004 and 2012. The generally low rule overlap su...
Source: Frontiers in Microbiology - April 11, 2019 Category: Microbiology Source Type: research

In vitro Antimicrobial Activity of Robenidine, Ethylenediaminetetraacetic Acid and Polymyxin B Nonapeptide Against Important Human and Veterinary Pathogens
Conclusion The results of our study demonstrate that robenidine is not suitable as a sole antimicrobial agent for the treatment of Gram-negative pathogen infections due to the lack of activity against the majority of Gram-negative isolates except for A. baumannii and A. calcoaceticus. However, we demonstrated in vitro efficacy against all selected Gram-negative organisms when robenidine was tested in combination with EDTA or PMBN, including against multidrug-resistant strains. Therefore, robenidine may be an appropriate candidate as a component of a combination preparation for the treatment of otitis externa in dogs. This...
Source: Frontiers in Microbiology - April 24, 2019 Category: Microbiology Source Type: research

Application of Antimicrobial Peptides of the Innate Immune System in Combination With Conventional Antibiotics —A Novel Way to Combat Antibiotic Resistance?
In this study erythrocytes, mononuclear cells and neutrophils, used for evaluation of cytotoxic activity of the peptides and antibiotics, were obtained from blood of healthy donors. Since authors of this article served as such the donors, ethical approval was not required by the Ethics Committee of the Institute of Experimental Medicine. All subjects/authors gave their written consent. Results Effects on Bacterial Cells Combined Antibacterial Action At the first stage of the study we explored the combined action of AMPs and lysozyme with antibiotics against drug-susceptible bacteria. MIC values for individual substance...
Source: Frontiers in cellular and infection microbiology - April 29, 2019 Category: Microbiology Source Type: research

Diagnostic pitfalls in a young Romanian ranger with an acute psychotic episode
We present the case of a 35-year-old ranger who had no history of acute or chronic infectious disease or any previous neuropsychiatric symptoms. He arrived at the Psychiatry Clinic and was admitted as an emergency case, displaying bizarre behavior, hallucinations, paranoid ideation, and delusional faults. These symptoms had first appeared 7 days earlier. An objective examination revealed abnormalities of behavior, anxiety, visual hallucinations, choreiform, and tic-like facial movements. After the administration of neuroleptic and antidepressant treatment, he showed an initial improvement, but on day 10 entered i...
Source: Neuropsychiatric Disease and Treatment - May 2, 2016 Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research

The Prevalence of Extended-Spectrum Beta-Lactamase-Producing Multidrug-Resistant Escherichia Coli in Poultry Chickens and Variation According to Farming Practices in Punjab, India
Conclusions: Our findings suggest that unregulated use of clinically relevant antimicrobials in Indian broiler and layer farms may contribute to the emergence of resistance and support the need to curb the nontherapeutic use of medically important antimicrobials in food animal production. https://doi.org/10.1289/EHP292 Received: 31 March 2016 Revised: 16 December 2016 Accepted: 17 December 2016 Published: 20 July 2017 Address correspondence to R. Laxminarayan and C. Brower, Center for Disease Dynamics, Economics & Policy, 1400 Eye St. NW, #500, Washington, DC 20005 USA. Telephone: 202-939-3300. Email: raman...
Source: EHP Research - July 20, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Source Type: research