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Total 139 results found since Jan 2013.

Suicidality and other severe psychiatric events with duloxetine: Re-analysis of safety data from a placebo-controlled trial for juvenile fibromyalgia
CONCLUSIONS: Antidepressants may put adolescents at risk of suicidality and other severe psychiatric disorders even when the treatment indication is not depression or anxiety.PMID:34397423 | DOI:10.3233/JRS-200033
Source: International Journal of Risk and Safety in Medicine - August 16, 2021 Category: Drugs & Pharmacology Authors: Michael P Hengartner Martin Pl öderl Source Type: research

Substituting Cannabidiol for Opioids and Pain Medications Among Individuals with Fibromyalgia: a Large Online Survey
Fibromyalgia (FM) is a common chronic pain condition that affects 2-4% of the population.15 People with FM typically experience widespread pain and co-occurring symptoms, including fatigue, sleep disturbances, and cognitive dysfunction.15 FM symptom management is difficult: non-pharmacological FM interventions (such as acupuncture, massage, and nutrition) are typically not covered by insurance and it can be difficult to find qualified practitioners for these non-pharmacological modalities.3, 7 Further, while there are three approved medications for FM (duloxetine, pregabalin, and milnacipran), these medications typically o...
Source: The Journal of Pain - May 12, 2021 Category: Materials Science Authors: Kevin F. Boehnke, Joel J. Gagnier, Lynne Matallana, David A. Williams Source Type: research

Treatment of Fibromyalgia in the 21st Century
To the Editor The thorough, systematic review of therapies for fibromyalgia written by Mascarenhas et al concludes that antidepressants and central nervous system depressants are effective treatments for this condition, but the effect sizes are small and fail to reach the threshold for clinical importance. While their findings are congruent with clinical trials, their discussion assumes that most patients with fibromyalgia are treated with a single modality at a time (pharmacologic or otherwise); however, the current standard of care for fibromyalgia and other chronic pain conditions is to use a stepped care model where mu...
Source: JAMA Internal Medicine - March 8, 2021 Category: Internal Medicine Source Type: research

Duloxetine suppresses BMP-4-induced release of osteoprotegerin via inhibition of the SMAD signaling pathway in osteoblasts
Biochem Cell Biol. 2021 Mar 1. doi: 10.1139/bcb-2020-0347. Online ahead of print.ABSTRACTDuloxetine, a selective serotonin-norepinephrine reuptake inhibitor, is currently recommended to use in the treatment of chronic painful disorders such as fibromyalgia, chronic musculoskeletal pain and diabetic peripheral neuropathy. We previously demonstrated that bone morphogenetic protein-4 (BMP-4) stimulates osteoprotegerin (OPG) production in osteoblast-like MC3T3-E1 cells, and that p70 S6 kinase positively regulates the OPG synthesis. The present study is aimed to investigate the effect of duloxetine on BMP-4-stimulated OPG synth...
Source: Biochemistry and Cell Biology - March 1, 2021 Category: Biochemistry Authors: Junko Tachi Takashi Onuma Shinobu Yamaguchi Woo Kim Tomoyuki Hioki Rie Matsushima-Nishiwaki Kumiko Tanabe Haruhiko Tokuda Osamu Kozawa Hiroki Iida Source Type: research

Endometriosis and chronic overlapping pain conditions
DISCUSSION: Pain physicians can play a role in the management of patients with endometriosis and COPCs. A multimodal therapy should include physiotherapy and pain-related psychological treatment and possibly centrally acting pain modulation medication.PMID:33576864 | DOI:10.1007/s00482-021-00535-8
Source: Schmerz - February 12, 2021 Category: Anesthesiology Authors: Winfried H äuser Source Type: research

Endometriosis and chronic overlapping pain conditions.
DISCUSSION: Pain physicians can play a role in the management of patients with endometriosis and COPCs. A multimodal therapy should include physiotherapy and pain-related psychological treatment and possibly centrally acting pain modulation medication. PMID: 33576864 [PubMed - as supplied by publisher]
Source: Schmerz - February 11, 2021 Category: Anesthesiology Authors: Häuser W Tags: Schmerz Source Type: research

A Systematic Review of Efficacy, Safety, and Tolerability of Duloxetine
Duloxetine is a serotonin-norepinephrine reuptake inhibitor approved for the treatment of patients affected by major depressive disorder (MDD), generalized anxiety disorder (GAD), neuropathic pain (NP), fibromyalgia (FMS), and stress incontinence urinary (SUI). These conditions share parallel pathophysiological pathways, and duloxetine treatment might be an effective and safe alternative. Thus, a systematic review was conducted following the 2009 Preferred Reporting Items (PRISMA) recommendations and Joanna Briggs Institute Critical (JBI) Appraisals guidelines. Eighty-five studies focused on efficacy, safety, and tolerabil...
Source: Frontiers in Psychiatry - October 23, 2020 Category: Psychiatry Source Type: research

Influence of anti-osteoporosis treatments on the incidence of COVID-19 in patients with non-inflammatory rheumatic conditions.
Abstract Coronavirus disease 19 (COVID-19) is currently a global pandemic that affects patients with other pathologies. Here, we investigated the influence of treatments for osteoporosis and other non-inflammatory rheumatic conditions, such as osteoarthritis and fibromyalgia, on COVID-19 incidence. To this end, we conducted a cross-sectional study of 2,102 patients being treated at the Rheumatology Service of Hospital del Mar (Barcelona, Spain). In our cohort, COVID-19 cumulative incidence from March 1 to May 3, 2020 was compared to population estimates for the same city. We used Poisson regression models to deter...
Source: Aging - October 20, 2020 Category: Biomedical Science Authors: Blanch-Rubió J, Soldevila-Domenech N, Tío L, Llorente-Onaindia J, Ciria-Recasens M, Polino L, Gurt A, de la Torre R, Maldonado R, Monfort J, Group TCS Tags: Aging (Albany NY) Source Type: research

Achiral and chiral analysis of duloxetine by chromatographic and electrophoretic methods, a review on the separation methodologies.
Abstract Duloxetine (DLX) is a widely used antidepressant drug belonging to the class of selective serotonin and norepinephrine reuptake inhibitors (SNRIs); its efficacy has been demonstrated in the treatment of not only major depressive disorders but also diabetic neuropathic pain, generalized anxiety disorder, fibromyalgia or stress urinary incontinence. It is a chiral substance and is used in therapy in the form of the enantiopure S-DLX which is twice as active as R-DLX. Several methods have been published for the achiral and chiral determination of DLX in pharmaceuticals, biological materials and environmental...
Source: Biomedical Chromatography : BMC - May 11, 2020 Category: Biomedical Science Authors: Lupu D, Hancu G Tags: Biomed Chromatogr Source Type: research

Patterns of pharmacologic and non-pharmacologic treatment, treatment satisfaction and perceived tolerability in patients with fibromyalgia: a patients' survey.
CONCLUSIONS: Patients with FM in Spain are overtreated with a combination of non-pharmacologic and pharmacologic therapies. Several of these therapies lack adequate support from randomised clinical trials and/or clinical practice guidelines. This overtreatment is not associated with relevant clinical benefits or patient satisfaction and, in the case of pharmacologic treatments, poses tolerability and safety issues. PMID: 32116211 [PubMed - in process]
Source: Clinical and Experimental Rheumatology - March 3, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research