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Total 139 results found since Jan 2013.

Pregabalin for pain in fibromyalgia in adults.
CONCLUSIONS: Pregabalin 300 to 600 mg produces a major reduction in pain intensity over 12 to 26 weeks with tolerable adverse events for a small proportion of people (about 10% more than placebo) with moderate or severe pain due to fibromyalgia. The degree of pain relief is known to be accompanied by improvements in other symptoms, quality of life, and function. These results are similar to other effective medicines in fibromyalgia (milnacipran, duloxetine). PMID: 27684492 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - September 28, 2016 Category: Journals (General) Authors: Derry S, Cording M, Wiffen PJ, Law S, Phillips T, Moore RA Tags: Cochrane Database Syst Rev Source Type: research

Evaluation of the analgesic effects of ammoxetine, a novel potent serotonin and norepinephrine reuptake inhibitor
ou-zhi Zhang
Source: Acta Pharmacologica Sinica - August 31, 2016 Category: Drugs & Pharmacology Authors: Ting-ting Zhang Rui Xue Lei Zhu Juan Li Qiong-yin Fan Bo-hua Zhong Yun-feng Li Cai-ying Ye You-zhi Zhang Tags: ammoxetine duloxetine SNRIs analgesia neuropathic pain fibromyalgia 5-HT descending inhibitory system Source Type: research

Medication Treatment Efficacy and Chronic Orofacial Pain
Publication date: August 2016 Source:Oral and Maxillofacial Surgery Clinics of North America, Volume 28, Issue 3 Author(s): Glenn T. Clark, Mariela Padilla, Raymond DionneTeaser Chronic pain in the orofacial region has always been a vexing problem for dentists to diagnose and treat effectively. For trigeminal neuropathic pain, there are 3 medications (gabapentinoids, tricyclic antidepressants, and serotonin-norepinephrine reuptake inhibitors) to use plus topical anesthetics that have therapeutic efficacy. For chronic daily headaches (often migraine in origin), 3 prophylactic medications have reasonable therapeutic efficac...
Source: Oral and Maxillofacial Surgery Clinics of North America - August 1, 2016 Category: ENT & OMF Source Type: research

Medication Treatment Efficacy and Chronic Orofacial Pain.
Abstract Chronic pain in the orofacial region has always been a vexing problem for dentists to diagnose and treat effectively. For trigeminal neuropathic pain, there are 3 medications (gabapentinoids, tricyclic antidepressants, and serotonin-norepinephrine reuptake inhibitors) to use plus topical anesthetics that have therapeutic efficacy. For chronic daily headaches (often migraine in origin), 3 prophylactic medications have reasonable therapeutic efficacy (β-blockers, tricyclic antidepressants, and antiepileptic drugs). The 3 Food and Drug Administration-approved drugs for fibromyalgia (pregabalin, duloxetine, ...
Source: The Surgical Clinics of North America - July 31, 2016 Category: Surgery Authors: Clark GT, Padilla M, Dionne R Tags: Oral Maxillofac Surg Clin North Am Source Type: research

Medication Treatment Efficacy and Chronic Orofacial Pain
Chronic pain in the orofacial region has always been a vexing problem for dentists to diagnose and treat effectively. For trigeminal neuropathic pain, there are 3 medications (gabapentinoids, tricyclic antidepressants, and serotonin-norepinephrine reuptake inhibitors) to use plus topical anesthetics that have therapeutic efficacy. For chronic daily headaches (often migraine in origin), 3 prophylactic medications have reasonable therapeutic efficacy ( β-blockers, tricyclic antidepressants, and antiepileptic drugs). The 3 Food and Drug Administration–approved drugs for fibromyalgia (pregabalin, duloxetine, and milnacipran...
Source: Oral and Maxillofacial Surgery Clinics - July 28, 2016 Category: ENT & OMF Authors: Glenn T. Clark, Mariela Padilla, Raymond Dionne Source Type: research

Evaluation of the analgesic effects of ammoxetine, a novel potent serotonin and norepinephrine reuptake inhibitor.
CONCLUSION: Ammoxetine effectively alleviates inflammatory, continuous, neuropathic and fibromyalgia-related pain in animal models, which can be attributed to enhanced neurotransmission of 5-HT and NE in the descending inhibitory systems. PMID: 27424654 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - July 17, 2016 Category: Drugs & Pharmacology Authors: Zhang TT, Xue R, Zhu L, Li J, Fan QY, Zhong BH, Li YF, Ye CY, Zhang YZ Tags: Acta Pharmacol Sin Source Type: research

Duloxetine-Induced Hypertension: A Case Report.
Abstract Duloxetine, a serotonin-norepinephrine reuptake inhibitor, is used for diabetic neuropathic pain and fibromyalgia as well as major depressive disorder. Serotonin-norepinephrine reuptake inhibitors may lead to increased blood pressure via their noradrenergic effects in addition to their cardiovascular side effects. In this paper, we report a case with increased blood pressure after the initiation of duloxetine that recovered by discontinuation of the medication. PMID: 27369688 [PubMed - in process]
Source: Turkish Journal of Psychiatry - July 4, 2016 Category: Psychiatry Authors: Mermi O, Atmaca M Tags: Turk Psikiyatri Derg Source Type: research

Combination of pregabalin with duloxetine for fibromyalgia: a randomized controlled trial
Abstract: Fibromyalgia is a syndrome characterized by chronic widespread pain and associated with sleep disturbance, depression, fatigue, and cognitive dysfunction. Polypharmacy is commonly used, but supportive evidence is limited. Most fibromyalgia trials focus primarily on pain reduction with monotherapy. This trial compares a pregabalin–duloxetine combination to each monotherapy. Using a randomized, double-blind, 4-period crossover design, participants received maximally tolerated doses of placebo, pregabalin, duloxetine, and pregabalin–duloxetine combination—for 6 weeks. Primary outcome was daily pain (0-10); sec...
Source: Pain - July 1, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Treatment Initiation Timing and Healthcare Costs in Newly Diagnosed Patients with Fibromyalgia (P6.276)
Conclusions:Total healthcare costs were significantly lower among early initiation patients, suggesting early use as a potential cost-saving strategy. FM patients had substantial comorbidity and most did not receive ACR recommended medications. Study Supported by: Daiichi Sankyo, Inc.Disclosure: Dr. Frech-Tamas has nothing to disclose. Dr. Qian has nothing to disclose. Dr. Gore has nothing to disclose. Dr. Zhang has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Frech, F., Qian, C., Gore, M., Zhang, Q. Tags: Pain and Palliative Care Source Type: research

Comparative efficacy and tolerability of duloxetine, pregabalin, and milnacipran for the treatment of fibromyalgia: a Bayesian network meta-analysis of randomized controlled trials
Abstract The aim of this study was to assess the relative efficacy and tolerability of duloxetine, pregabalin, and milnacipran at the recommended doses in patients with fibromyalgia. Randomized controlled trials (RCTs) examining the efficacy and safety of duloxetine 60 mg, pregabalin 300 mg, pregabalin 150 mg, milnacipran 200 mg, and milnacipran 100 mg compared to placebo in patients with fibromyalgia were included in this Bayesian network meta-analysis. Nine RCTs including 5140 patients met the inclusion criteria. The proportion of patients with >30 % improvement from baseline in pain was significantly h...
Source: Rheumatology International - March 20, 2016 Category: Rheumatology Source Type: research

R-Duloxetine and N-Methyl Duloxetine as Novel Analgesics Against Experimental Postincisional Pain.
CONCLUSIONS: R-Duloxetine and N-methyl duloxetine are highly effective against postoperative pain using the skin incision model, and they elicit both tonic and use-dependent block of neuronal Na channels. Our results suggest that R-duloxetine and N-methyl duloxetine are applicable as novel analgesics. PMID: 26646348 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - December 7, 2015 Category: Anesthesiology Authors: Wang CF, Russell G, Wang SY, Strichartz GR, Wang GK Tags: Anesth Analg Source Type: research

Palmitoylethanolamide in Fibromyalgia: Results from Prospective and Retrospective Observational Studies
Conclusion Our study confirms the efficacy of DLX + PGB and demonstrates as well the added benefit and safety of PEA in the treatment of pain in patients affected by FM.
Source: Pain and Therapy - September 3, 2015 Category: Anesthesiology Source Type: research

A randomized, double-blind, placebo-controlled phase III trial of duloxetine in Japanese fibromyalgia patients
Conclusions: Although the MMRM analysis did not demonstrate superiority of duloxetine over placebo, duloxetine treatment was associated with improved outcomes in secondary and post hoc analyses of the mean change in the BPI average pain score and most of the secondary outcomes, including analgesia and QoL. Duloxetine treatment was safe and well tolerated. These results suggest that duloxetine treatment could be associated with improvements in pain relief and QoL in Japanese patients with fibromyalgia.Trial registrationClinicalTrials.gov Identifier: NCT01552057. Registered 9 March 2012.
Source: Arthritis Research and Therapy - August 22, 2015 Category: Rheumatology Authors: Masato MurakamiKenichi OsadaHiromichi MizunoToshimitsu OchiaiLevent AlevKusuki Nishioka Source Type: research

The Local and Systemic Actions of Duloxetine in Allodynia and Hyperalgesia Using a Rat Skin Incision Pain Model.
CONCLUSIONS: Our results demonstrate that duloxetine can act as a local anesthetic and an analgesic drug via both local and systemic applications. Because duloxetine inhibits neuronal Na currents with high potency, it may exert its antihyperalgesic effects through inhibition of the spontaneous nerve impulses that result from peripheral injury, encompassing its actions on multiple central nervous system and peripheral targets. PMID: 26049779 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - June 3, 2015 Category: Anesthesiology Authors: Wang CF, Russell G, Strichartz GR, Wang GK Tags: Anesth Analg Source Type: research

Objective Assessment of the Rheological Muscle Property in the Treatment of Fibromyalgia.
In conclusion, our study demonstrate combined treatment duloxetine- physiotherapy effectively reduces a symptom often disabling and particularly troublesome in patients with FM as the exaggerated muscle contraction. PMID: 25809192 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 27, 2015 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research