Filtered By:
Drug: Neurontin

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 3219 results found since Jan 2013.

All about pain pharmacology: what pain physicians should know.
Authors: Kim KH, Seo HJ, Abdi S, Huh B Abstract From the perspective of the definition of pain, pain can be divided into emotional and sensory components, which originate from potential and actual tissue damage, respectively. The pharmacologic treatment of the emotional pain component includes antianxiety drugs, antidepressants, and antipsychotics. The anti-anxiety drugs have anti-anxious, sedative, and somnolent effects. The antipsychotics are effective in patients with positive symptoms of psychosis. On the other hand, the sensory pain component can be divided into nociceptive and neuropathic pain. Non-steroidal ...
Source: Korean Journal of Pain - April 4, 2020 Category: Anesthesiology Tags: Korean J Pain Source Type: research

Myofascial Pain: An Open Study on the Pharmacotherapeutic Response to Stepped Treatment with Tricyclic Antidepressants and Gabapentin.
CONCLUSION: This study has demonstrated the good pharmacotherapeutic response of persistent myofascial pain, even in more severe cases. Not being a randomized controlled trial, the results may be biased and should be interpreted with caution. Patients who do not respond to TCAs may be a distinct subgroup and this needs further investigation. The results also suggest that gabapentin, at a lower dose than previously reported, is a good alternative in TCA-resistant patients. PMID: 25905532 [PubMed - as supplied by publisher]
Source: Journal of Orofacial Pain - April 24, 2015 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Skin/Muscle Incision and Retraction Induces Evoked and Spontaneous Pain in Mice.
Conclusion: These data suggested that the mice model of SMIR demonstrated a persistent pain syndrome, including evoked pain and spontaneous pain. Clonidine and gabapentin could relieve mechanical hypersensitivity dose-dependently simultaneously. However, clonidine but not gabapentin could alleviate the spontaneous pain of SMIR in the mice model. PMID: 31467625 [PubMed - in process]
Source: Pain Research and Management - August 31, 2019 Category: Anesthesiology Authors: Yang J, Yuan F, Ye G, Wang YJ, Wu C, Wang J, Li XY, Feng Z Tags: Pain Res Manag Source Type: research

Defining an Opioid Sparing Treatment Pathway for Chronic Abdominal Pain of Somatic and Visceral Origin: A Case Series.
We present a treatment algorithm for chronic abdominal pain using a combination of interventional therapy using transversus abdominis plane (TAP) blocks along with post injection medical management for treatment of somatic and visceral pain. This is a case series of 4 patients presenting with diverse causes of chronic abdominal pain were treated with the treatment algorithm defined below. Patients received either bilateral or unilateral TAP blocks based on pain location using a combination of 0.25% bupivicaine 10ml, 40mg triamcinolone, and clonidine 50 mcg by a single physician upon admission to our acute care hospital. Fo...
Source: Journal of Pain and Palliative Care Pharmacotherapy - October 25, 2020 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Gabapentin versus Transdermal Fentanyl Matrix for the Alleviation of Chronic Neuropathic Pain of Radicular Origin: A Randomized Blind Multicentered Parallel-Group Noninferiority Trial.
This study demonstrated that the analgesic effect of fentanyl matrix is noninferior in comparison with gabapentin and supports the use of fentanyl matrix as an effective and safe treatment for moderate-to-severe chronic neuropathic pain. This trial is registered with NCT01127100. PMID: 30863474 [PubMed - in process]
Source: Pain Research and Management - March 15, 2019 Category: Anesthesiology Authors: Hwang CJ, Lee JH, Kim JH, Min SH, Park KW, Seo HY, Song KS Tags: Pain Res Manag Source Type: research

Pregabalin and gabapentin in neuropathic pain management after spinal cord injury: a systematic review and meta-analysis.
The objective of this systematic review is to examine the safety and efficacy of pregabalin (PGB) and gabapentin (GBP) in the treatment of neuropathic pain due to SCI. PubMed, the Cochrane Library, Embase, Scopus, and the Web of Science were searched up to December 2018. The reference lists of key and review studies were reviewed for additional citations. The quality of the studies was evaluated using the Cochrane Collaboration's tools for assessing the risk of bias. A meta-analysis was performed for primary and secondary outcomes. Eight studies were eligible for inclusion. Meta-analysis of PGB vs. placebo showed that PGB ...
Source: Korean Journal of Pain - January 2, 2020 Category: Anesthesiology Tags: Korean J Pain Source Type: research

Effects of gabapentin on pain and opioid consumption after abdominal hysterectomy.
CONCLUSION: <⁄span> 1200 mg gabapentin reduced postoperative pain and the need for opioids, and enabled earlier ambulation of the patient. Significant side effects were not observed. PMID: 23662292 [PubMed - in process]
Source: Pain Research and Management - March 1, 2013 Category: Anesthesiology Authors: Frouzanfard F, Fazel MR, Abolhasani A, Fakharian E, Mousavi G, Moravveji A Tags: Pain Res Manag Source Type: research

Pharmacological management of chronic neuropathic pain: Revised consensus statement from the Canadian Pain Society.
CONCLUSIONS: These guidelines provide an updated, stepwise approach to the pharmacological management of NeP. Treatment should be individualized for each patient based on efficacy, side-effect profile and drug accessibility, including cost. Additional studies are required to examine head-to-head comparisons among analgesics, combinations of analgesics, long-term outcomes and treatment of pediatric, geriatric and central NeP. PMID: 25479151 [PubMed - as supplied by publisher]
Source: Pain Research and Management - November 1, 2014 Category: Anesthesiology Authors: Moulin D, Boulanger A, Clark AJ, Clarke H, Dao T, Finley GA, Furlan A, Gilron I, Gordon A, Morley-Forster PK, Sessle BJ, Squire P, Stinson J, Taenzer P, Velly A, Ware MA, Weinberg EL, Williamson OD Tags: Pain Res Manag Source Type: research

Donepezil, an Acetylcholinesterase Inhibitor, Can Attenuate Gabapentinoid-Induced Somnolence in Patients with Neuropathic Pain: A Retrospective Chart Review.
Authors: Kogure T, Sumitani M, Ikegami K, Abe H, Hozumi J, Inoue R, Kawahara K, Yamada Y Abstract Donepezil, an oral acetylcholinesterase inhibitor, is used to treat Alzheimer's disease and reportedly attenuates opioid-induced sedation in patients with cancer pain. Neuropathic pain is often treated with gabapentinoids (pregabalin, gabapentin), but gabapentinoid-induced somnolence sometimes prevents patients from using these agents. We conducted a retrospective chart review of patients with neuropathic pain to examine whether donepezil is useful for gabapentinoid-induced somnolence. We investigated pain severity in ...
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 15, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Gabapentin Does Not Appear to Improve Postoperative Pain and Sleep Patterns in Patients Who Concomitantly Receive Regional Anesthesia for Lower Extremity Orthopedic Surgery: A Randomized Control Trial.
Abstract In recent years, gabapentin has gained popularity as an adjuvant therapy for the treatment of postoperative pain. Numerous studies have shown a decrease in pain score, even with immediate postoperative activity, which is significant for early post-op ambulation and regaining functionality sooner. However, studies have been in conclusive in patients undergoing lower extremity orthopedic surgery. For this reason, we hoped to study the effect of gabapentin on postoperative pain in patients undergoing total knee arthroplasty, total hip arthroplasty, or a hip fracture repair. This was done in the setting of en...
Source: Pain Research and Management - March 31, 2017 Category: Anesthesiology Authors: Eloy JD, Anthony C, Amin S, Caparó M, Reilly MC, Shulman S Tags: Pain Res Manag Source Type: research

Effects of Gabapentinoids Premedication on Shoulder Pain and Rehabilitation Quality after Laparoscopic Cholecystectomy: Pregabalin versus Gabapentin.
Conclusion: Preemptive premedication with gabapentinoids can enhance postoperative rehabilitation quality after laparoscopic cholecystectomy by reducing postoperative shoulder pain, decreasing PONV incidence, and improving sleep quality during the first postoperative night. This trial is registered with ClinicalTrial.gov (NCT03241875). PMID: 30123399 [PubMed - in process]
Source: Pain Research and Management - August 21, 2018 Category: Anesthesiology Authors: Nakhli MS, Kahloul M, Jebali C, Frigui W, Naija W Tags: Pain Res Manag Source Type: research

Comparing Effectiveness of Gabapentin and Pregabalin in Treatment of Neuropathic Pain: A Retrospective Cohort of Palliative Care Outpatients.
This study demonstrates that pregabalin may afford better tolerability and lower pill burden compared to gabapentin. PMID: 32924715 [PubMed - as supplied by publisher]
Source: Journal of Pain and Palliative Care Pharmacotherapy - September 16, 2020 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Effect of a Novel, Orally Active Matrix Metalloproteinase-2 and -9 Inhibitor in Spinal and Trigeminal Rat Models of Neuropathic Pain.
CONCLUSION: The results demonstrated that oral AQU-118 attenuates mechanical allodynia in both neuropathic pain models and with efficacies that mirror gabapentin at the 40 mg/kg dose used in the CCI-IoN model but without effect on basal sensitivity to mechanical stimulation/locomotive activity. These findings support a possible role for MMP-2/-9 in the etiology of neuropathic pain and also suggest that inhibition strategies represent a viable treatment option. PMID: 26244437 [PubMed - in process]
Source: Journal of Orofacial Pain - August 7, 2015 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Low doses of amitriptyline, pregabalin, and gabapentin are preferred for management of neuropathic pain in India: is there a need for revisiting dosing recommendations?
CONCLUSIONS: Commonly prescribed drugs for management of neuropathic pain, such as amitriptyline, pregabalin, and gabapentin are preferred at lower doses in Indian clinical settings. Acceptable efficacy and low tolerance to the standard dosage is believed to be the reason behind the prescribed dose. PMID: 28757918 [PubMed]
Source: Korean Journal of Pain - August 1, 2017 Category: Anesthesiology Tags: Korean J Pain Source Type: research

The Role and Treatment Implications of Peripheral and Central Processing of Pain, Pruritus, and Nausea in Heightened Somatic Awareness: A Review
This article reviews the acute neural transmission of pain, pruritus, and nausea symptoms, which can begin in the periphery and/or viscera. The subsequent multiple pathways in the central nervous system that become involved in the processing of these symptoms are also discussed. The authors describe human brain imaging studies that have revealed consistent cortical and subcortical networks  activated by these symptoms, including sensory, limbic, and associative regions. In particular, the authors discuss information revealed by the studies regarding the primary somatosensory cortex, secondary somatosensory cortex, anterio...
Source: Innovations in Clinical Neuroscience - June 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Neurologic Systems and Symptoms Neurology Pain Review central processing nausea pruritus Source Type: research