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Preceptive Navigation wins $3m NIH grant for Vu-Path ultrasound nav device
Medtech company Perceptive Navigation said yesterday it won a $3 million Phase IIB Small Business Innovation Research grant from the National Heart, Lung and Blood Institute to support its Vu-Path ultrasound system. The Baltimore-based company’s Vu-path system is designed to aid in minimally-invasive, point-of-care procedures. The system is a miniaturized, forward-viewing ultrasound probe combined with an interventional channel designed for needles, guidewires and other tools, the company said. “I am delighted that Vu-Path is progressing to commercialization and look forward to seeing Vu-Path in the hands of cl...
Source: Mass Device - May 30, 2018 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Ultrasound Vascular perceptivenavigation Source Type: news

Percutaneous Cryoablation of Solitary, Sporadic Renal Cell Carcinoma: Outcome Analysis Based on Clear-Cell versus Papillary Subtypes
Conclusions Percutaneous ablation is a viable treatment option for patients with clinical stage T1a pRCC and ccRCC. Percutaneous ablation may be a very favorable treatment strategy particularly for pRCC.
Source: Journal of Vascular and Interventional Radiology - June 8, 2018 Category: Radiology Source Type: research

Embolx wins FDA nod for next-gen Sniper balloon occlusion microcath
Embolx said today that it won FDA 510(k) clearance for its next-gen Sniper balloon occlusion microcatheters designed for pressure-directed arterial embolization therapy. The Sunnyvale, Calif.-based company said that improvements to its next-gen Sniper microcath are intended to enhance access and navigation through small complex vascular structures. The catheter is available in 110 cm, 130 cm and 150 cm lengths to allow for access in either femoral or radial artery sites. “The great thing about Sniper’s enhanced design and longer lengths is that it allows me to perform procedures using a transradial approach wi...
Source: Mass Device - June 28, 2018 Category: Medical Devices Authors: Fink Densford Tags: 510(k) Catheters Food & Drug Administration (FDA) Regulatory/Compliance Vascular embolx Source Type: news

Percutaneous Cryoablation of Solitary, Sporadic Renal Cell Carcinoma: Outcome Analysis Based on Clear-Cell versus Papillary Subtypes
ConclusionsPercutaneous ablation is a viable treatment option for patients with clinical stage T1a pRCC and ccRCC. Percutaneous ablation may be a very favorable treatment strategy particularly for pRCC.
Source: Journal of Vascular and Interventional Radiology - July 5, 2018 Category: Radiology Source Type: research

A Comparison of Bleeding Complications in Patients Undergoing Percutaneous Renal Cryoablation Using Cryoprobes with and without Heat-Based Track Ablation
ConclusionsThe use of cryoprobes with heat-based track ablation did not decrease the incidence of bleeding complications after renal cryoablation compared with procedures performed without track ablation.
Source: Journal of Vascular and Interventional Radiology - July 5, 2018 Category: Radiology Source Type: research

Percutaneous Cryoablation of Solitary, Sporadic Renal Cell Carcinoma: Outcome Analysis Based on Clear-Cell versus Papillary Subtypes
ConclusionsPercutaneous ablation is a viable treatment option for patients with clinical stage T1a pRCC and ccRCC. Percutaneous ablation may be a very favorable treatment strategy particularly for pRCC.
Source: Journal of Vascular and Interventional Radiology - July 10, 2018 Category: Radiology Source Type: research

A Comparison of Bleeding Complications in Patients Undergoing Percutaneous Renal Cryoablation Using Cryoprobes with and without Heat-Based Track Ablation
ConclusionsThe use of cryoprobes with heat-based track ablation did not decrease the incidence of bleeding complications after renal cryoablation compared with procedures performed without track ablation.
Source: Journal of Vascular and Interventional Radiology - July 10, 2018 Category: Radiology Source Type: research

Cardiothoracic and Vascular Surgeons Achieve High Rates of K Award Conversion Into R01 Funding
ConclusionsCTV surgeons have an equal 10-year conversion rate to the first R01 award compared with other clinicians. These data suggest that NIH achieves a good return on investment when funding CTV surgeon–scientists with K-level funding.
Source: The Annals of Thoracic Surgery - July 23, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research

Repair of Vascular Stretch Injury to Distal Femoral Artery after Femur Fracture.
PMID: 30185331 [PubMed - in process]
Source: The American Surgeon - August 1, 2018 Category: Surgery Authors: Grant AA, Ginzburg E, Lineen EB Tags: Am Surg Source Type: research

Astrocytes Integrate Behavioral State and Vascular Signals during Functional Hyperemia
We examined peri-arteriole and peri-capillary astrocytes in the barrel cortex of active mice in response to sensory stimulation or volitional behaviors. We observed an AMPA and NMDA receptor-dependent elevation in astrocyte endfoot Ca2+ that followed functional hyperemia onset. This delayed astrocyte Ca2+ signal was dependent on the animal’s action at the time of measurement as well as a neurovascular pathway that linked to endothelial-derived nitric oxide. A similar elevation in endfoot Ca2+ was evoked using vascular chemogenetics or optogenetics, and opto-stimulated dilation recruited the same nitric oxide pathway as ...
Source: Neuron - October 26, 2018 Category: Neuroscience Source Type: research

Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in CYP46A1-Mediated Cholesterol Removal
CYP46A1 is the cytochrome P450 enzyme that converts cholesterol to 24-hydroxycholesterol, a cholesterol elimination product and a potent liver X receptor (LXR) ligand. We conducted retinal characterizations of Cyp46a1-/- mice that had normal fasting blood glucose levels but up to 1.8-fold increase in retinal cholesterol. The retina of Cyp46a1-/- mice exhibited venous beading and tortuosity, microglia/macrophage activation, and increased vascular permeability, features commonly associated with diabetic retinopathy.
Source: American Journal of Pathology - November 15, 2018 Category: Pathology Authors: Aicha Saadane, Natalia Mast, George Trichonas, Dibyendu Chakraborty, Sandra Hammer, Julia V. Busik, Maria B. Grant, Irina A. Pikuleva Tags: Regular Article Source Type: research

Effectiveness and Safety of Percutaneous CT-Guided Rib Biopsy
ConclusionsPercutaneous CT-guided core rib biopsy resulted in high diagnostic yield and low complications. Diagnostic biopsy rates were higher with larger lesion size and lytic rib lesions.
Source: Journal of Vascular and Interventional Radiology - December 7, 2018 Category: Radiology Source Type: research

Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1 –Mediated Cholesterol Removal
CYP46A1 is the cytochrome P450 enzyme that converts cholesterol to 24-hydroxycholesterol, a cholesterol elimination product and a potent liver X receptor (LXR) ligand. We conducted retinal characterizations of Cyp46a1 −/− mice that had normal fasting blood glucose levels but up to a 1.8-fold increase in retinal cholesterol. The retina of Cyp46a1−/− mice exhibited venous beading and tortuosity, microglia/macrophage activation, and increased vascular permeability, features commonly associated with diabetic retinopathy.
Source: American Journal of Pathology - November 15, 2018 Category: Pathology Authors: Aicha Saadane, Natalia Mast, George Trichonas, Dibyendu Chakraborty, Sandra Hammer, Julia V. Busik, Maria B. Grant, Irina A. Pikuleva Tags: Regular article Source Type: research

Clinical Outcome of Drug-Eluting Balloon Angioplasty in Patients With Femoropopliteal Disease: Real-World Single Center Experience
Several multicenter industry sponsored clinical trials reported satisfactory results in the use of drug-eluting balloons for the treatment of femoropopliteal occlusive disease. However, few single-center studies were published to verify the outcome from real world experience.
Source: Journal of Vascular Surgery - December 19, 2018 Category: Surgery Authors: Ali F. AbuRahma, Zachary AbuRahma, Grant Scott, Elliot Adams, Matthew Beasley, Meghan Davis, L. Scott Dean, Elaine Davis Tags: Abstract from the 2019 Southern Association for Vascular Surgery Annual Meeting Source Type: research

Growth factor signaling pathways in vascular development and disease.
Authors: Grant ZL, Coultas L Abstract Angiogenic blood vessel growth is essential to ensure organs receive adequate blood supply to support normal organ function and homeostasis. Angiogenesis involves a complex series of cellular events through which new vessels grow out from existing vasculature. Growth factor signaling, layered over a range of other signaling inputs, orchestrates this process. The response of endothelial cells (ECs) to growth factor signals must be carefully controlled through feedback mechanisms to prevent excessive vessel growth, remodeling or destabilization. In this article, we summarize rece...
Source: Growth Factors - July 11, 2019 Category: Research Tags: Growth Factors Source Type: research