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TriVascular loses appeal in patent spat with vascular stent inventor
TriVascular Technologies (NSDQ:TRIV) last Friday lost an appeal in a vascular stent patent spat after a Federal Circuit court upheld a Patent Trial and Appeal Board ruling that found the stent’s patent, held by a separate inventor, was not invalid due to obviousness. The court upheld the ruling on the grounds that TriVascular didn’t demonstrate that the patent, held by Shaun Samuels, was invalid because of obviousness, nor did they find that the board was in error in its claims construction process, according to court documents. “…We find no error in the board’s claim construction or its judgme...
Source: Mass Device - February 8, 2016 Category: Medical Equipment Authors: Fink Densford Tags: Business/Financial News Legal News Stents TriVascular Source Type: news

Small Vessel Vascular Contributions to Cognitive Impairment and Dementia (VCID) Biomarkers Development Projects (UH2/UH3)
Funding Opportunity RFA-NS-16-020 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to support research that evaluates and further develops candidate predictive, diagnostic, target engagement and progression candidate biomarkers of small vessel cerebrovascular disease in human vascular contributions to cognitive impairment and dementia (VCID) and vascular/Alzheimer's mixed dementias. Biomarkers development projects funded under this FOA, with support from the Coordinating Center (RFA-NS-16-019), will: study biomarkers as individual projects and concurrently establ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 26, 2016 Category: Research Source Type: funding

Elucidation of Mechanisms of Radiation-Induced Endovascular Injury and Development of Treatments / Mitigators for Radiation-Induced Endothelial Cell and Vascular Dysfunction (U01)
Funding Opportunity ID: 286871 Opportunity Number: RFA-AI-16-053 Opportunity Title: Elucidation of Mechanisms of Radiation-Induced Endovascular Injury and Development of Treatments / Mitigators for Radiation-Induced Endothelial Cell and Vascular Dysfunction (U01)Opportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: Cooperative AgreementCategory of Funding Activity: HealthCategory Explanation: CFDA Number(s): 93.85593.856Eligible Applicants: State governmentsCounty governmentsCity or township governmentsSpecial district governmentsIndependent school districtsPublic and State c...
Source: Grants.gov - August 2, 2016 Category: Research Tags: Health Source Type: funding

Radial Artery Compression with Threatened Transection: Catfish Injury in a Pediatric Patient
We report a 7-year old boy with penetrating trauma and retained foreign body in the forearm from a catfish injury. Initial imaging suggested transection of the radial artery, but on exposure in a controlled setting the foreign body was found to compress the artery without any vascular injury.
Source: Annals of Vascular Surgery - September 22, 2016 Category: Surgery Authors: Lara Reichert, Jennifer Worsham, Grant Fankhauser Source Type: research

Role of survivin in experimental models of pulmonary arterial hypertension
Conclusions: Survivin expression is increased in two different experimental models of PAH, suggesting that it might be involved in the pathogenesis of the disease. Funded by Grants from FIS (PI14/00782), SEPAR, SOCAP and FCHP.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Blanco, I., Ferrer, E., Maqueda, S., Paul, T., Luque, N., Tura-Ceide, O., Peinado, V. I., Barbera, J. A. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases Source Type: research

Metactive Medical raises $1m in Series A, brings total to $10m
Vascular medical device developer Metactive Medical said yesterday it closed an additional $1.2 million in its Series A financing round, bringing the total raised up to $10 million. The Fairway, Kan.-based company also said it received a $1.5 million Phase 2 SBIR grant to commercialize its over-the-wire Blockstent Microcatheter embolic device designed for occluding peripheral arteries and veins. “This new investment capital and grant funding will be used to continue the development of our novel platform of embolic products, which we believe will provide physicians with devices that are exceptionally deliverable, can ...
Source: Mass Device - March 9, 2018 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Vascular metactivemedical Source Type: news

Cardiothoracic and Vascular Surgeons Achieve High Rates of K-Award Conversion Into R01 Funding.
CONCLUSIONS: CTV surgeons have an equal 10-year conversion rate to first R01 award compared to other clinicians. These data suggest that NIH achieves a good return on investment when funding CTV surgeon-scientists with K-level funding. PMID: 29550206 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - March 14, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Narahari AK, Mehaffey JH, Hawkins RB, Baderdinni PK, Chandrabhatla AS, Tribble CG, Kron IL, Roeser ME, Walters DM, Ailawadi G Tags: Ann Thorac Surg Source Type: research

Selected Abstracts from the September Issues of the Journal of Vascular Surgery and the Journal of Vascular Surgery: Venous and Lymphatic Disorders
Guy Martin, MRCS, Nandesh Patel, Yasmin Grant, MRCS, Michael Jenkins, FRCS, Richard Gibbs, FRCS, and Colin Bicknell, FRCS
Source: European Journal of Vascular and Endovascular Surgery - September 1, 2018 Category: Surgery Tags: Abstracts Source Type: research

Characterizing the Impact of Women in Academic IR: A 12-Year Analysis
ConclusionsWomen are equally as productive as men as determined by metrics such as number of publications, citations, and grants and are proportionally represented in the literature. No data indicating collaborative or citation/grant discrimination were observed, suggesting that the academic IR community is inclusive of its female constituents and equally respects their research contributions. Based on the statistically significant increases in female authorship observed in this 12-year study, this article reports encouraging trends for the future of women in interventional radiology.
Source: Journal of Vascular and Interventional Radiology - October 6, 2018 Category: Radiology Source Type: research

Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in CYP46A1-Mediated Cholesterol Removal.
Abstract CYP46A1 is the cytochrome P450 enzyme that converts cholesterol to 24-hydroxycholesterol, a cholesterol elimination product and a potent liver X receptor (LXR) ligand. We conducted retinal characterizations of Cyp46a1-/- mice that had normal fasting blood glucose levels but up to 1.8-fold increase in retinal cholesterol. The retina of Cyp46a1-/- mice exhibited venous beading and tortuosity, microglia/macrophage activation, and increased vascular permeability, features commonly associated with diabetic retinopathy. The expression of Lxrα and Lxrβ was increased in both the whole Cyp46a1-/- retina and reti...
Source: The American Journal of Pathology - November 15, 2018 Category: Pathology Authors: Saadane A, Mast N, Trichonas G, Chakraborty D, Hammer S, Busik JV, Grant MB, Pikuleva IA Tags: Am J Pathol Source Type: research

Mechanistic Basis of Diffuse White Matter Disease in Vascular Contributions to Cognitive Impairment and Dementia (VCID)(R01 Clinical Trial Not Allowed)
Funding Opportunity RFA-NS-19-039 from the NIH Guide for Grants and Contracts. (Reissue of RFA-NS-16-021, PAR-18-413) Diffuse brain white matter disease is highly prevalent in the elderly, and has been clinically associated with vascular contributions to cognitive impairment and dementia (VCID) in both men and women. Diffuse white matter disease is thought to include a variety of pathologies including demyelination and/or fiber loss due to multifocal infarction and local ischemia. It is often accompanied by arteriosclerosis in deep penetrating arteries, multiple infarcts in the basal ganglia, brainstem or cerebellum. Thou...
Source: NIH Funding Opportunities (Notices, PA, RFA) - June 14, 2019 Category: Research Source Type: funding

Clinical Trials Planning for Symptomatic Vascular Contributions to Cognitive Impairment and Dementia (VCID) (R34 Clinical Trial Not Allowed)
Funding Opportunity RFA-NS-20-012 from the NIH Guide for Grants and Contracts. This initiative will provide two years of support for planning activities necessary for initiating a Phase III clinical trial designed to validate VCID biomarkers and/or treat patients with VCID. The full spectrum of VCID is in scope, and the one or more VCID disorders(s) to be targeted in the trial must be clearly specified in the application, for example (but not limited to): vascular insults including clinical stroke, silent infarcts and microinfarcts, leukoaraiosis, cerebral amyloid angiopathy (CAA), transient ischemic attack (TIA), micro-b...
Source: NIH Funding Opportunities (Notices, PA, RFA) - November 20, 2019 Category: Research Source Type: funding

The influence of frozen-thawed and fresh embryo transfer on utero-placental (vascular) development: the Rotterdam Periconception cohort
AbstractSTUDY QUESTIONDoes frozen-thawed or fresh embryo transfer (ET) influence utero-placental (vascular) development, when studied using three-dimensional (3D) ultrasound and virtual reality imaging techniques?SUMMARY ANSWERIn the first trimester, placental developmental parameters, that is, placental volume (PV) and utero-placental vascular volume (uPVV), were comparable between pregnancies resulting from frozen-thawed ET, fresh ET and natural conception; and in the second and the third trimester, uterine artery Doppler indices were lower in pregnancies after frozen-thawed ET compared to pregnancies after fresh ET and ...
Source: Human Reproduction - May 11, 2021 Category: Reproduction Medicine Source Type: research

Everybody wins
If everybody wins, then does nobody win? The study by Nguyen and Li, “Analysis of “spin” in vascular surgery randomized controlled trials with nonsignificant outcomes,”1 is an interesting and provocative evaluation of phase 3 randomized trials in vascular surgery with “nonsignificant” outcomes that impacted clinical practice, clinical guidelines, health p olicy, coverage determinations, and industry funding of additional research, and calls for grant proposals. Words matter. Words can be influential and possibly alter approaches to a disease process, a patient, or a procedure.
Source: Journal of Vascular Surgery - February 18, 2022 Category: Surgery Authors: Ruth L. Bush Tags: Invited commentary Source Type: research