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Salubrious effects of ulinastatin and quercetin alone or in combination in endothelial dysfunction and vascular dementia
CONCLUSION: 2K1C renovascular hypertension-induced impairment in behavioural, biochemical, and endothelial parameters were attenuated by the treatment with UTI and quercetin alone as well as in combination. Therefore, the utility of these agents might be studied further to understand their full potential in hypertension-induced VaD.PMID:35396697 | DOI:10.1007/s43440-022-00364-1
Source: Pharmacological Reports - April 9, 2022 Category: Drugs & Pharmacology Authors: Poonam Sharma Nikita Gaur Shalini Jayant B M Sharma Bhagwat Singh Harsha Kharkwal Bhupesh Sharma Source Type: research
Vasculopathy and Increased Vascular Congestion in Fatal COVID-19 and ARDS
Conclusions Severe COVID-19 pneumonia is characterized by significant vasculopathy and aberrant alveolar-septal-congestion. Our findings also highlight the role that vascular alterations may play in Vd and clinical outcomes in ARDS in general.PMID:35671465 | DOI:10.1164/rccm.202109-2150OC
Source: American Journal of Respiratory and Critical Care Medicine - June 7, 2022 Category: Respiratory Medicine Authors: Julian A Villalba Caroline F Hilburn Michelle A Garlin Grant A Elliott Yijia Li Keiko Kunitoki Sergio Poli George A Alba Emilio Madrigal Manuel Taso Melissa C Price Alexis J Aviles Milagros Araujo-Medina Liana Bonanno Baris Boyraz Samantha N Champion Cynt Source Type: research
Predicting CT-Based Coronary Artery Disease Using Vascular Biomarkers Derived from Fundus Photographs with a Graph Convolutional Neural Network
This study first examined the association between retinal vascular changes and the Coronary Artery Disease Reporting and Data System (CAD-RADS) as assessed on CCTA. Then, we developed a graph neural network (GNN) model for predicting the CAD-RADS as a proxy for coronary artery disease. The CCTA scans were stratified by CAD-RADS scores by expert readers, and the vascular biomarkers were extracted from their fundus images. Association analyses of CAD-RADS scores were performed with patient characteristics, retinal diseases, and quantitative vascular biomarkers. Finally, a GNN model was constructed for the task of predicting ...
Source: Atherosclerosis - June 24, 2022 Category: Cardiology Authors: Fan Huang Jie Lian Kei-Shing Ng Kendrick Shih Varut Vardhanabhuti Source Type: research
Vascular adhesion protein-1 (VAP-1) in vascular inflammatory diseases
Vasa. 2022 Oct 6. doi: 10.1024/0301-1526/a001031. Online ahead of print.ABSTRACT Vascular adhesion protein-1 (VAP-1) also known as amino oxidase copper containing 3 (AOC3) is a pro-inflammatory and versatile molecule with adhesive and enzymatic properties. VAP-1 is a primary amine oxidase belonging to the semicarbazide-sensitive amine oxidase (SSAO) family, which catalyzes the oxidation of primary amines leading to the production of ammonium, formaldehyde, methylglyoxal, and hydrogen peroxide. VAP-1 is mainly expressed by endothelial cells, smooth muscle cells, adipocytes and pericytes. It is involved in a repertoire of bi...
Source: Atherosclerosis - October 6, 2022 Category: Cardiology Authors: Marianna Danielli Roisin Clare Thomas Lauren Marie Quinn Bee Kang Tan Source Type: research
Elevated vascular transformation blood biomarkers in Long-COVID indicate angiogenesis as a key pathophysiological mechanism
CONCLUSIONS: Long-COVID patients suffer prolonged, diffuse symptoms and poorer health. Vascular transformation blood biomarkers were significantly elevated in Long-COVID, with angiogenesis markers (ANG-1/P-SEL) providing classification accuracy of 96%. Vascular transformation blood biomarkers hold potential for diagnostics, and modulators of angiogenesis may have therapeutic efficacy.PMID:36217108 | DOI:10.1186/s10020-022-00548-8
Source: Molecular Medicine - October 10, 2022 Category: Molecular Biology Authors: Maitray A Patel Michael J Knauer Michael Nicholson Mark Daley Logan R Van Nynatten Claudio Martin Eric K Patterson Gediminas Cepinskas Shannon L Seney Verena Dobretzberger Markus Miholits Brian Webb Douglas D Fraser Source Type: research
