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Novel object recognition test as an alternative approach to assessing the pharmacological profile of sigma-1 receptor ligands
CONCLUSIONS: The nonlinear dose-response effect of PRE-084 in this assay does not justify its use for routine assessment of the functional activity of σ1R ligands.PMID:37572216 | DOI:10.1007/s43440-023-00516-x
Source: Pharmacological Reports - August 12, 2023 Category: Drugs & Pharmacology Authors: Katarzyna Szczepa ńska Andrzej J Bojarski Piotr Popik Natalia Malikowska-Racia Source Type: research

Key Device Attributes for Injectable Somatostatin Receptor Ligand Therapy in Acromegaly and Neuroendocrine Tumours
ConclusionThe results identified key features of injection devices for SRL therapy which merit consideration for optimal management and underscore the importance of patient partnership in treatment decisions.
Source: Advances in Therapy - August 12, 2023 Category: Drugs & Pharmacology Source Type: research

Immersive virtual reality in orthopaedics —a narrative review
ConclusionImmersive virtual reality holds significant promise in orthopaedics, demonstrating potential for improved surgical training, patient functional recovery, and pain management but further research is needed to fully exploit the benefits of VR technology in these areas.
Source: International Orthopaedics - August 11, 2023 Category: Orthopaedics Source Type: research

COVID-19 ’ s Impact on Heart Health Still Confounds Doctors
(ST. LOUIS) — Firefighter and paramedic Mike Camilleri once had no trouble hauling heavy gear up ladders. Now battling long COVID, he gingerly steps onto a treadmill to learn how his heart handles a simple walk. “This is, like, not a tough-guy test so don’t fake it,” warned Beth Hughes, a physical therapist at Washington University in St. Louis. [time-brightcove not-tgx=”true”] Somehow, a mild case of COVID-19 set off a chain reaction that eventually left Camilleri with dangerous blood pressure spikes, a heartbeat that raced with slight exertion, and episodes of intense chest pain...
Source: TIME: Health - August 10, 2023 Category: Consumer Health News Authors: Lauran Needgaard/ Associated Press Tags: Uncategorized COVID-19 healthscienceclimate wire Source Type: news

Machine Learning for Decision-Support in Acute Abdominal Pain - Proof of Concept and Central Considerations
Zentralbl Chir. 2023 Aug;148(4):376-383. doi: 10.1055/a-2125-1559. Epub 2023 Aug 10.ABSTRACTAcute abdominal pain is a common presenting symptom in the emergency department and represents heterogeneous causes and diagnoses. There is often a decision to be made regarding emergency surgical care. Machine learning (ML) could be used here as a decision-support and relieve the time and personnel resource shortage.Patients with acute abdominal pain presenting to the Department of Surgery at Bonn University Hospital in 2020 and 2021 were retrospectively analyzed. Clinical parameters as well as laboratory values were used as predic...
Source: Zentralblatt fur Chirurgie - August 10, 2023 Category: Surgery Authors: Jonas Henn Simon Hatterscheidt Anshupa Sahu Andreas Buness Jonas Dohmen Jan Arensmeyer Philipp Feodorovici Nils Sommer Joachim Schmidt J örg C Kalff Hanno Matthaei Source Type: research

Effect of WiFi signal exposure in utero and early life on neurodevelopment and behaviors of rats
Environ Sci Pollut Res Int. 2023 Aug 10. doi: 10.1007/s11356-023-29159-4. Online ahead of print.ABSTRACTThe aim of this study is to examine the long-term effects of prenatal and early-life WIFI signal exposure on neurodevelopment and behaviors as well as biochemical alterations of Wistar rats. On the first day of pregnancy (E0), expectant rats were allocated into two groups: the control group (n = 12) and the WiFi-exposed group (WiFi group, n = 12). WiFi group was exposed to turn on WiFi for 24 h/day from E0 to postnatal day (PND) 42. The control group was exposed to turn-off WiFi at the same time. On PND7-42, we evaluated...
Source: Environmental Science and Pollution Research International - August 10, 2023 Category: Environmental Health Authors: Hongmei Wu Dongyu Min Buxun Sun Yifan Ma Hongpeng Chen Jing Wu Ping Ren Jiabi Wu Yonggang Cao Baoshan Zhao Peng Wang Source Type: research

Machine Learning for Decision-Support in Acute Abdominal Pain - Proof of Concept and Central Considerations
Zentralbl Chir. 2023 Aug;148(4):376-383. doi: 10.1055/a-2125-1559. Epub 2023 Aug 10.ABSTRACTAcute abdominal pain is a common presenting symptom in the emergency department and represents heterogeneous causes and diagnoses. There is often a decision to be made regarding emergency surgical care. Machine learning (ML) could be used here as a decision-support and relieve the time and personnel resource shortage.Patients with acute abdominal pain presenting to the Department of Surgery at Bonn University Hospital in 2020 and 2021 were retrospectively analyzed. Clinical parameters as well as laboratory values were used as predic...
Source: Zentralblatt fur Chirurgie - August 10, 2023 Category: Surgery Authors: Jonas Henn Simon Hatterscheidt Anshupa Sahu Andreas Buness Jonas Dohmen Jan Arensmeyer Philipp Feodorovici Nils Sommer Joachim Schmidt J örg C Kalff Hanno Matthaei Source Type: research

Effect of WiFi signal exposure in utero and early life on neurodevelopment and behaviors of rats
Environ Sci Pollut Res Int. 2023 Aug 10. doi: 10.1007/s11356-023-29159-4. Online ahead of print.ABSTRACTThe aim of this study is to examine the long-term effects of prenatal and early-life WIFI signal exposure on neurodevelopment and behaviors as well as biochemical alterations of Wistar rats. On the first day of pregnancy (E0), expectant rats were allocated into two groups: the control group (n = 12) and the WiFi-exposed group (WiFi group, n = 12). WiFi group was exposed to turn on WiFi for 24 h/day from E0 to postnatal day (PND) 42. The control group was exposed to turn-off WiFi at the same time. On PND7-42, we evaluated...
Source: Cell Research - August 10, 2023 Category: Cytology Authors: Hongmei Wu Dongyu Min Buxun Sun Yifan Ma Hongpeng Chen Jing Wu Ping Ren Jiabi Wu Yonggang Cao Baoshan Zhao Peng Wang Source Type: research

Machine Learning for Decision-Support in Acute Abdominal Pain - Proof of Concept and Central Considerations
Zentralbl Chir. 2023 Aug;148(4):376-383. doi: 10.1055/a-2125-1559. Epub 2023 Aug 10.ABSTRACTAcute abdominal pain is a common presenting symptom in the emergency department and represents heterogeneous causes and diagnoses. There is often a decision to be made regarding emergency surgical care. Machine learning (ML) could be used here as a decision-support and relieve the time and personnel resource shortage.Patients with acute abdominal pain presenting to the Department of Surgery at Bonn University Hospital in 2020 and 2021 were retrospectively analyzed. Clinical parameters as well as laboratory values were used as predic...
Source: Zentralblatt fur Chirurgie - August 10, 2023 Category: Surgery Authors: Jonas Henn Simon Hatterscheidt Anshupa Sahu Andreas Buness Jonas Dohmen Jan Arensmeyer Philipp Feodorovici Nils Sommer Joachim Schmidt J örg C Kalff Hanno Matthaei Source Type: research

Effect of WiFi signal exposure in utero and early life on neurodevelopment and behaviors of rats
Environ Sci Pollut Res Int. 2023 Aug 10. doi: 10.1007/s11356-023-29159-4. Online ahead of print.ABSTRACTThe aim of this study is to examine the long-term effects of prenatal and early-life WIFI signal exposure on neurodevelopment and behaviors as well as biochemical alterations of Wistar rats. On the first day of pregnancy (E0), expectant rats were allocated into two groups: the control group (n = 12) and the WiFi-exposed group (WiFi group, n = 12). WiFi group was exposed to turn on WiFi for 24 h/day from E0 to postnatal day (PND) 42. The control group was exposed to turn-off WiFi at the same time. On PND7-42, we evaluated...
Source: Environmental Science and Pollution Research International - August 10, 2023 Category: Environmental Health Authors: Hongmei Wu Dongyu Min Buxun Sun Yifan Ma Hongpeng Chen Jing Wu Ping Ren Jiabi Wu Yonggang Cao Baoshan Zhao Peng Wang Source Type: research

Machine Learning for Decision-Support in Acute Abdominal Pain - Proof of Concept and Central Considerations
Zentralbl Chir. 2023 Aug;148(4):376-383. doi: 10.1055/a-2125-1559. Epub 2023 Aug 10.ABSTRACTAcute abdominal pain is a common presenting symptom in the emergency department and represents heterogeneous causes and diagnoses. There is often a decision to be made regarding emergency surgical care. Machine learning (ML) could be used here as a decision-support and relieve the time and personnel resource shortage.Patients with acute abdominal pain presenting to the Department of Surgery at Bonn University Hospital in 2020 and 2021 were retrospectively analyzed. Clinical parameters as well as laboratory values were used as predic...
Source: Zentralblatt fur Chirurgie - August 10, 2023 Category: Surgery Authors: Jonas Henn Simon Hatterscheidt Anshupa Sahu Andreas Buness Jonas Dohmen Jan Arensmeyer Philipp Feodorovici Nils Sommer Joachim Schmidt J örg C Kalff Hanno Matthaei Source Type: research