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Source: BMJ Open

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Total 1635 results found since Jan 2013.

Validity of breast, lung and colorectal cancer diagnoses in administrative databases: a systematic review protocol
Introduction Breast, lung and colorectal cancers constitute the most common cancers worldwide and their epidemiology, related health outcomes and quality indicators can be studied using administrative healthcare databases. To constitute a reliable source for research, administrative healthcare databases need to be validated. The aim of this protocol is to perform the first systematic review of studies reporting the validation of International Classification of Diseases 9th and 10th revision codes to identify breast, lung and colorectal cancer diagnoses in administrative healthcare databases. Methods and analysis This revi...
Source: BMJ Open - March 18, 2016 Category: Journals (General) Authors: Abraha, I., Giovannini, G., Serraino, D., Fusco, M., Montedori, A. Tags: Open access, Health services research, Oncology Protocol Source Type: research

Clinical impact of neoadjuvant treatment in resectable pancreatic cancer: a systematic review and meta-analysis protocol
Introduction Although the only curative strategy for pancreatic cancer is surgical resection, up to 85% of patients relapse after surgery. The efficacy of neoadjuvant treatment in resectable pancreatic cancer (RPC) remains unclear and there is no systematic review focusing fully on this issue. Recently, two prospective trials of neoadjuvant treatment in RPC were terminated early because of slow recruiting and existing randomised controlled trials (RCTs) have too small sample sizes. Therefore, to overcome probable biases, it would be more reasonable to include both RCTs and non-randomised studies (NRSs) with selected criter...
Source: BMJ Open - March 24, 2016 Category: Journals (General) Authors: Lee, J.-c., Ahn, S., Paik, K.-h., Kim, H. W., Kang, J., Kim, J., Hwang, J.-H. Tags: Open access, Gastroenterology and hepatology, Oncology Protocol Source Type: research

Use of heparins in patients with cancer: individual participant data meta-analysis of randomised trials study protocol
Introduction Parenteral anticoagulants may improve outcomes in patients with cancer by reducing risk of venous thromboembolic disease and through a direct antitumour effect. Study-level systematic reviews indicate a reduction in venous thromboembolism and provide moderate confidence that a small survival benefit exists. It remains unclear if any patient subgroups experience potential benefits. Methods and analysis First, we will perform a comprehensive systematic search of MEDLINE, EMBASE and The Cochrane Library, hand search scientific conference abstracts and check clinical trials registries for randomised control trial...
Source: BMJ Open - April 28, 2016 Category: Journals (General) Authors: Schünemann, H. J., Ventresca, M., Crowther, M., Briel, M., Zhou, Q., Garcia, D., Lyman, G., Noble, S., Macbeth, F., Griffiths, G., DiNisio, M., Iorio, A., Beyene, J., Mbuagbaw, L., Neumann, I., Van Es, N., Brouwers, M., Brozek, J., Guyatt, G., Lev Tags: Open access, Cardiovascular medicine, Haematology (incl blood transfusion), Oncology, Research methods Protocol Source Type: research

Impact of e-alert for detection of acute kidney injury on processes of care and outcomes: protocol for a systematic review and meta-analysis
Introduction Acute kidney injury (AKI) is a common complication in hospitalised patients. It imposes significant risk for major morbidity and mortality. Moreover, patients suffering an episode of AKI consume considerable health resources. Recently, a number of studies have evaluated the implementation of automated electronic alerts (e-alerts) configured from electronic medical records (EMR) and clinical information systems (CIS) to warn healthcare providers of early or impending AKI in hospitalised patients. The impact of e-alerts on care processes, patient outcomes and health resource use, however, remains uncertain. Met...
Source: BMJ Open - May 4, 2016 Category: Journals (General) Authors: Lachance, P., Villeneuve, P.-M., Wilson, F. P., Selby, N. M., Featherstone, R., Rewa, O., Bagshaw, S. M. Tags: Open access, Intensive care, Renal medicine Protocol Source Type: research

Nipple sparing versus skin sparing mastectomy: a systematic review protocol
The objective of this systematic review will be to determine the safety and efficacy of NSM as compared with skin sparing mastectomy (SSM). Methods and analysis All original comparative studies including; randomised controlled trials, cohort studies and case–control studies involving women undergoing either NSM or SSM for breast cancer will be included. Outcomes are primary—relating to oncological outcomes and secondary—relating to clinical, aesthetic, patient reported and quality of life outcomes. A comprehensive electronic literature search, designed by a search specialist, will be undertaken. Grey lit...
Source: BMJ Open - May 19, 2016 Category: Journals (General) Authors: Agha, R. A., Wellstead, G., Sagoo, H., Al Omran, Y., Barai, I., Rajmohan, S., Fowler, A. J., Orgill, D. P., Rusby, J. E. Tags: Open access, Oncology, Surgery Protocol Source Type: research

Epidemiology, health systems and stakeholders in rheumatic heart disease in Africa: a systematic review protocol
Introduction Rheumatic heart disease (RHD) is a chronic disease affecting the heart valves, secondary to group A streptococcal infection (GAS) and subsequent acute rheumatic fever (ARF). However, RHD cure and preventative measures are inextricably linked with socioeconomic development, as the disease mainly affects children and young adults living in poverty. In order to address RHD, public health officials and health policymakers require up-to-date knowledge on the epidemiology of GAS, ARF and RHD, as well as the existing enablers and gaps in delivery of evidence-based care for these conditions. We propose to conduct a sy...
Source: BMJ Open - May 19, 2016 Category: Journals (General) Authors: Moloi, A. H., Watkins, D., Engel, M. E., Mall, S., Zühlke, L. Tags: Open access, Cardiovascular medicine, Epidemiology, Evidence based practice, Global health, Patient-centred medicine Protocol Source Type: research

Treatment goal setting for complex patients: protocol for a scoping review
This study aims to examine the extent and nature of the literature on treatment goal setting in complex patients, identify gaps in evidence and areas for further inquiry and guide a research programme to develop definitions, measures and recommendations for treatment goal setting. Methods and analysis This study protocol outlines a scoping review of the peer reviewed and the grey literature, using established scoping review methodology. Literature will be identified using a multidatabase and grey literature search strategy developed by two librarians. Papers and reports on the topic of goal setting that address complexity...
Source: BMJ Open - May 24, 2016 Category: Journals (General) Authors: Grudniewicz, A., Nelson, M., Kuluski, K., Lui, V., Cunningham, H. V., X Nie, J., Colquhoun, H., Wodchis, W. P., Taylor, S., Loganathan, M., Upshur, R. E. Tags: Open access, Geriatric medicine, Health services research, Palliative care, Research methods Protocol Source Type: research

Efficacy and safety of acupuncture for chemotherapy-induced leucopoenia: protocol for a systematic review
The objective of this review is to assess the efficacy and safety of acupuncture for treating CIL. Methods and analysis This systematic review will electronically search the following databases: the Cochrane Central Register of Controlled Trials (CENTRAL), the Cochrane Library, Medline, EMBASE, the China National Knowledge Infrastructure Database (CNKI), the Chinese Biomedical Literature Database (CBM), the Chinese Scientific Journal Database (VIP Database) and the Wanfang database from their inception to 1 January 2016. Other sources will also be searched including potential grey literature, conference proceedings and th...
Source: BMJ Open - May 25, 2016 Category: Journals (General) Authors: Nian, J., Sun, X., Guo, J., Yan, C., Wang, X., Yang, G., Yang, L., Yu, M., Zhang, G. Tags: Open access, Complementary medicine, Health economics, Oncology Protocol Source Type: research

Reporting of planned statistical methods in published surgical randomised trial protocols: a protocol for a methodological systematic review
In this report, we present a protocol for a systematic review of published surgical randomised controlled trial (RCT) protocols, with the purpose of assessing the reporting quality and completeness of the statistical aspects. Methods We will include all published protocols of randomised trials that investigate surgical interventions. We will search MEDLINE, EMBASE, and CENTRAL for relevant studies. Author pairs will independently review all titles, abstracts, and full texts identified by the literature search, and extract data using a structured data extraction form. We will extract the following: year of publication, cou...
Source: BMJ Open - June 2, 2016 Category: Journals (General) Authors: Madden, K., Arseneau, E., Evaniew, N., Smith, C. S., Thabane, L. Tags: Open access, Epidemiology, Surgery Protocol Source Type: research

Systematic review of the cost-effectiveness of implementing guidelines on low back pain management in primary care: is transferability to other countries possible?
Conclusions Despite the resemblance of the implementation strategies, the 3 studies report conflicting results on cost-effectiveness. This review showed that transferring the results from the identified studies is not straightforward and underlines the importance of transparent reporting. Future research should focus on transferability of effects, for example, development of a supplement to Welte's model.
Source: BMJ Open - June 6, 2016 Category: Journals (General) Authors: Jensen, C. E., Jensen, M. B., Riis, A., Petersen, K. D. Tags: Open access, Health economics, Health services research Source Type: research

Systematic review of the literature on the effectiveness of product reformulation measures to reduce the sugar content of food and drink on the population's sugar consumption and health: a study protocol
Introduction Obesity, type 2 diabetes and dental caries are all major public health problems in the UK, with significant costs to the healthcare service. We aim to conduct a systematic review to summarise the evidence on the effectiveness of product reformulation measures to reduce the sugar content of food and drink on the population's sugar consumption and health. Methods and analysis Electronic database will be systematically searched using a combination of terms, tailored to optimise sensitivity, specificity, and the syntax and functionality of each database. The databases searched will include the Cochrane Library, E...
Source: BMJ Open - June 8, 2016 Category: Journals (General) Authors: Hashem, K. M., He, F. J., MacGregor, G. A. Tags: Open access, Global health, Health policy, Public health Protocol Source Type: research

Interventions for Meniere's disease: protocol for an umbrella systematic review and a network meta-analysis
Introduction The large number of treatment modalities for patients diagnosed with Menière's disease (MD) complicates the selection of the best available treatment as the comparative efficacy of these interventions is not clear. We aim to identify the treatment or treatments with the highest efficacy of current pharmacological and non-pharmacological treatments for MD. Methods and analysis We will identify all available systematic reviews on the treatment of MD. An online database search will be conducted in association with the UK Cochrane Centre, particularly the Ear, Nose and Throat Group. We will screen the syst...
Source: BMJ Open - June 8, 2016 Category: Journals (General) Authors: van Esch, B. F., van der Zaag-Loonen, H. J., Bruintjes, T. D., van Benthem, P. P. G. Tags: Open access, Ear, nose and throat/otolaryngology, Evidence based practice, Medical management, Patient-centred medicine, Qualitative research Protocol Source Type: research

Making patient values visible in healthcare: a systematic review of tools to assess patient treatment priorities and preferences in the context of multimorbidity
Conclusions Given the importance of eliciting patient priorities and preferences in providing patient-centred care in the context of multimorbidity and polypharmacy, we found surprisingly few relevant tools. Some aspects of the tools used for single-disease contexts may also be useful in the context of multimorbidity. There is an urgent need to develop ways to make patient priorities explicitly visible in the clinical record and medical decision-making and to test the effect on patient-relevant outcomes.
Source: BMJ Open - June 9, 2016 Category: Journals (General) Authors: Mangin, D., Stephen, G., Bismah, V., Risdon, C. Tags: Open access, General practice / Family practice, Patient-centred medicine Research Source Type: research

Gender-based violence and absent fathers: a scoping review protocol
Discussion We anticipate finding a large number of studies on GBV diagnostic interventions in sub-Saharan Africa which, once summarised, will be useful to guide future research. The protocol for the scoping review has been registered in PROSPERO. Dissemination The study will be disseminated electronically and in print. It will also be presented to conferences related to GBV, Father Connections and Children's Health. PROSPERO registration number CRD42015022094.
Source: BMJ Open - June 12, 2016 Category: Journals (General) Authors: Sikweyiya, Y., Nduna, M., Khuzwayo, N., Mthombeni, A., Mashamba-Thompson, T. P. Tags: Open access, Public health, Research methods Protocol Source Type: research

Diagnostic utility of CSF {alpha}-synuclein species in Parkinson's disease: protocol for a systematic review and meta-analysis
Introduction The diagnostic criteria currently used for Parkinson's disease (PD) are mainly based on clinical motor symptoms. For these reasons many biomarkers are under investigation to support the diagnosis at the early stage. The neuropathological hallmark of PD is represented by Lewy bodies (LBs), which are intracytoplasmic inclusions in substantia nigra neurons. The major component of LBs, α-synuclein (α-syn), has been implicated in the pathogenesis of PD and in other ‘synucleinopathies’ such as multisystem atrophy (MSA) and dementia with LBs (DLBs). Several studies have investigated this presy...
Source: BMJ Open - June 12, 2016 Category: Journals (General) Authors: Eusebi, P., Giannandrea, D., Biscetti, L., Abraha, I., Chiasserini, D., Orso, M., Calabresi, P., Parnetti, L. Tags: Open access, Diagnostics, Neurology Protocol Source Type: research