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Source: Molecules
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Total 1353 results found since Jan 2013.
Molecules, Vol. 28, Pages 1844: Effects of Long-Term Intervention with Losartan, Aspirin and Atorvastatin on Vascular Remodeling in Juvenile Spontaneously Hypertensive Rats
This study aimed to evaluate the effects of long-term administration of losartan, aspirin, and atorvastatin on vascular remodeling in juvenile spontaneously hypertensive rats (SHRs). Losartan, aspirin, and atorvastatin were administered via gavage at doses of 20, 10, and 10 mg/kg/day, respectively, on SHRs aged 6–22 weeks. Paraffin sections of the blood vessels were stained with hematoxylin-eosin (H&E) and Sirius Red to evaluate the changes in the vascular structure and the accumulation of different types of collagen. The plasma levels of renin, angiotensin II (Ang II), aldosterone (ALD), endothel...
Source: Molecules - February 15, 2023 Category: Chemistry Authors: Qi Liu Shuai Dong Xue Zhou Yubo Zhao Bin Dong Jing Shen Kang Yang Linsen Li Dan Zhu Tags: Article Source Type: research
Molecules, Vol. 21, Pages 886: Gingerol Synergizes the Cytotoxic Effects of Doxorubicin against Liver Cancer Cells and Protects from Its Vascular Toxicity
In conclusion, despite its relatively weak antioxidant properties, gingerol protected from DOX-induced vascular damage, apparently not through a ROS scavenging mechanism. Besides, gingerol synergized the cytotoxic effects of DOX against liver cancer cells without influencing the cellular pharmacokinetics.
Source: Molecules - July 7, 2016 Category: Chemistry Authors: Fahad Al-AbbasiEman AlghamdiMohammed BaghdadiAbdulmohsin AlamoudiAli El-HalawanyHany El-BassossyAli AseeriAhmed Al-Abd Tags: Article Source Type: research
Molecules, Vol. 24, Pages 1150: Investigating the Formation of Structural Elements in Proteins Using Local Sequence-Dependent Information and a Heuristic Search Algorithm
tés
Structural elements inserted in proteins are essential to define folding/unfolding mechanisms and partner recognition events governing signaling processes in living organisms. Here, we present an original approach to model the folding mechanism of these structural elements. Our approach is based on the exploitation of local, sequence-dependent structural information encoded in a database of three-residue fragments extracted from a large set of high-resolution experimentally determined protein structures. The computation of conformational transitions leading to the formation of the structural elements is formulated...
Source: Molecules - March 21, 2019 Category: Chemistry Authors: Alejandro Esta ña Malik Ghallab Pau Bernad ó Juan Cort és Tags: Article Source Type: research
Molecules, Vol. 24, Pages 2233: Accelerating Drug Discovery by Early Protein Drug Target Prediction Based on a Multi-Fingerprint Similarity Search
This study demonstrates that the use of highly curated chemical and biological experimental data on one side, and a powerful multi-fingerprint search algorithm on the other, can be of the utmost importance in addressing the fate of newly conceived small molecules, by strongly reducing the attrition of early phases of drug discovery programs.
Source: Molecules - June 13, 2019 Category: Chemistry Authors: Montaruli Alberga Ciriaco Trisciuzzi Tondo Mangiatordi Nicolotti Tags: Article Source Type: research
Molecules, Vol. 26, Pages 640: Kahweol, a Diterpenoid Molecule, Inhibits CTGF-Dependent Synthetic Phenotype Switching and Migration in Vascular Smooth Muscle Cells
Kang
Vascular smooth muscle cell (VSMC) phenotype switching from contractile to synthetic is essential for proliferation and migration in vascular pathophysiology. Connective tissue growth factor (CTGF) is a matricellular protein involved in cell adhesion, migration, and proliferation. Kahweol, a diterpene molecule in arabica coffee beans, has been reported to have anti-inflammatory, antiproliferative, and apoptotic effects in many cells. However, in VSMCs, the effects of kahweol on CTGF activities have not been investigated. Thus, in this study, the effects and associated mechanisms of kahweol in CTGF-dependent phen...
Source: Molecules - January 26, 2021 Category: Chemistry Authors: Lee Choi Kang Tags: Article Source Type: research
Molecules, Vol. 26, Pages 1259: Combined Effects of Methyldopa and Flavonoids on the Expression of Selected Factors Related to Inflammatory Processes and Vascular Diseases in Human Placenta Cells —An In Vitro Study
Molecules, Vol. 26, Pages 1259: Combined Effects of Methyldopa and Flavonoids on the Expression of Selected Factors Related to Inflammatory Processes and Vascular Diseases in Human Placenta Cells—An In Vitro Study
Molecules doi: 10.3390/molecules26051259
Authors:
Anna Bogacz
Przemysław Ł. Mikołajczak
Marlena Wolek
Aleksandra Górska
Michał Szulc
Marcin Ożarowski
Radosław Kujawski
Bogusław Czerny
Hubert Wolski
Tomasz M. Karpiński
Agnieszka Seremak-Mrozikiewicz
The aim of the study was to investigate combined effects of flavonoids (apigenin, baicalein, chrysin, quercetin, and scutellarin...
Source: Molecules - February 26, 2021 Category: Chemistry Authors: Anna Bogacz Przemys ław Ł. Mikołajczak Marlena Wolek Aleksandra G órska Micha ł Szulc Marcin O żarowski Rados ław Kujawski Bogus ław Czerny Hubert Wolski Tomasz M. Karpi ński Agnieszka Seremak-Mrozikiewicz Tags: Article Source Type: research
Molecules, Vol. 26, Pages 3557: Potential Benefits of Flavonoids on the Progression of Atherosclerosis by Their Effect on Vascular Smooth Muscle Excitability
dez
Flavonoids are a group of secondary metabolites derived from plant-based foods, and they offer many health benefits in different stages of several diseases. This review will focus on their effects on ion channels expressed in vascular smooth muscle during atherosclerosis. Since ion channels can be regulated by redox potential, it is expected that during the onset of oxidative stress-related diseases, ion channels present changes in their conductive activity, impacting the progression of the disease. A typical oxidative stress-related condition is atherosclerosis, which involves the dysfunction of vascular smooth mu...
Source: Molecules - June 10, 2021 Category: Chemistry Authors: Rosa Edith Grijalva-Guiza Aura Matilde Jim énez-Garduño Luis Ricardo Hern ández Tags: Review Source Type: research
Molecules, Vol. 26, Pages 5593: Rapid Identification of Potential Drug Candidates from Multi-Million Compounds ’ Repositories. Combination of 2D Similarity Search with 3D Ligand/Structure Based Methods and In Vitro Screening
Molecules, Vol. 26, Pages 5593: Rapid Identification of Potential Drug Candidates from Multi-Million Compounds’ Repositories. Combination of 2D Similarity Search with 3D Ligand/Structure Based Methods and In Vitro Screening
Molecules doi: 10.3390/molecules26185593
Authors:
Katalin Szilágyi
Beáta Flachner
István Hajdú
Mária Szaszkó
Krisztina Dobi
Zsolt Lőrincz
Sándor Cseh
György Dormán
Rapid in silico selection of target focused libraries from commercial repositories is an attractive and cost-effective approach in early drug discovery. If structures of active compounds are available, rapid ...
Source: Molecules - September 15, 2021 Category: Chemistry Authors: Katalin Szil ágyi Be áta Flachner Istv án Hajdú M ária Szaszkó Krisztina Dobi Zsolt L őrincz S ándor Cseh Gy örgy Dormán Tags: Article Source Type: research
Molecules, Vol. 26, Pages 7201: Greedy 3-Point Search (G3PS) & mdash;A Novel Algorithm for Pharmacophore Alignment
Molecules, Vol. 26, Pages 7201: Greedy 3-Point Search (G3PS)—A Novel Algorithm for Pharmacophore Alignment
Molecules doi: 10.3390/molecules26237201
Authors:
Christian Permann
Thomas Seidel
Thierry Langer
Chemical features of small molecules can be abstracted to 3D pharmacophore models, which are easy to generate, interpret, and adapt by medicinal chemists. Three-dimensional pharmacophores can be used to efficiently match and align molecules according to their chemical feature pattern, which facilitates the virtual screening of even large compound databases. Existing alignment methods, used in computat...
Source: Molecules - November 27, 2021 Category: Chemistry Authors: Christian Permann Thomas Seidel Thierry Langer Tags: Article Source Type: research
Molecules, Vol. 27, Pages 2884: 5,2 & prime;-Dibromo-2,4 & prime;,5 & prime;-trihydroxydiphenylmethanone Inhibits LPS-Induced Vascular Inflammation by Targeting the Cav1 Protein
In conclusion, our results showed that TDD inhibited LPS-induced vascular inflammation and the NF-κB signaling pathway by specifically targeting the Cav1 protein. TDD may be a novel anti-inflammatory compound, especially for the treatment of atherosclerosis.
Source: Molecules - April 30, 2022 Category: Chemistry Authors: Hongxia Yuan Qianyi Hou Xiue Feng Yuanlin Zhang Fan Yang Rui Ge Qingshan Li Tags: Article Source Type: research
Molecules, Vol. 27, Pages 3333: Novel Oxime Synthesized from a Natural Product of Senecio nutans SCh. Bip. (Asteraceae) Enhances Vascular Relaxation in Rats by an Endothelium-Independent Mechanism
fuentes
Senecio nutans Sch. Bip. and its constituents are reported to have antihypertensive effects. We isolated metabolite–1, a natural compound from S. nutans (4-hydroxy-3-(isopenten-2-yl)-acetophenone), and synthesized novel oxime – 1 (4-hydroxy-3-(isopenten-2-yl)-acetophenoxime) to evaluate their effect on vascular reactivity. Compounds were purified (metabolite–1) or synthetized (oxime–1) and characterized using IR and NMR spectroscopy and Heteronuclear Multiple Quantum Coherence (HMQC). Using pharmacological agents such as phenylephrine (PE) and KCl (enhanci...
Source: Molecules - May 22, 2022 Category: Chemistry Authors: Javier Palacios Adri án Paredes Marcelo A. Catal án Chukwuemeka R. Nwokocha Fredi Cifuentes Tags: Article Source Type: research
Molecules, Vol. 27, Pages 4293: The Attenuating Effect of Beta-Carotene on Streptozotocin Induced Diabetic Vascular Dementia Symptoms in Rats
This study investigated the ameliorative effects of beta-carotene (BC) on diabetes-associated vascular dementia and its action against biomolecule oxidation. The diabetic vascular dementia (VaD) was induced by administration of nicotinamide (NA; 50 mg/kg; i.p.) and streptozotocin (STZ; 50 mg/kg; i.p.). The test compound, BC (50 and 100 mg/kg; p.o.), and the reference compound, donepezil (DP) (1 mg/kg; p.o.), were administered for 15 consecutive days. Changes in learning and memory were assessed by escape latency time (ELT) and times spent in target quadrant (TSTQ) in the Morris water maze (MWM) test. The changes in neurotr...
Source: Molecules - July 4, 2022 Category: Chemistry Authors: Khian Giap Lim Rajavel Varatharajan Arunachalam Muthuraman Tags: Article Source Type: research
Molecules, Vol. 28, Pages 6717: Hispidulin Inhibits the Vascular Inflammation Triggered by Porphyromonas & nbsp;gingivalis Lipopolysaccharide
Molecules, Vol. 28, Pages 6717: Hispidulin Inhibits the Vascular Inflammation Triggered by Porphyromonas gingivalis Lipopolysaccharide
Molecules doi: 10.3390/molecules28186717
Authors:
Yeon Kim
Hoyong Lee
Hyun-Joo Park
Mi-Kyoung Kim
Yong-Il Kim
Hyung Joon Kim
Soo-Kyung Bae
Yung-Jin Kim
Moon-Kyoung Bae
Hispidulin is a natural bioactive flavonoid that has been studied for its potential therapeutic properties, including its anti-inflammatory, antioxidant, and neuroprotective effects. The aim of this study was to explore whether hispidulin could inhibit the endothelial inflammation triggered by...
Source: Molecules - September 20, 2023 Category: Chemistry Authors: Yeon Kim Hoyong Lee Hyun-Joo Park Mi-Kyoung Kim Yong-Il Kim Hyung Joon Kim Soo-Kyung Bae Yung-Jin Kim Moon-Kyoung Bae Tags: Article Source Type: research
Molecules, Vol. 20, Pages 8198-8212: Antiproliferative Activity of Hinokitiol, a Tropolone Derivative, Is Mediated via the Inductions of p-JNK and p-PLCγ1 Signaling in PDGF-BB-Stimulated Vascular Smooth Muscle Cells
Abnormal proliferation of vascular smooth muscle cells (VSMCs) is important in the pathogenesis of vascular disorders such as atherosclerosis and restenosis. Hinokitiol, a tropolone derivative found in Chamacyparis taiwanensis, has been found to exhibit anticancer activity in a variety of cancers through inhibition of cell proliferation. In the present study, the possible anti-proliferative effect of hinokitiol was investigated on VSMCs. Our results showed that hinokitiol significantly attenuated the PDGF-BB-stimulated proliferation of VSMCs without cytotoxicity. Hinokitiol suppressed the expression of proliferating cell n...
Source: Molecules - May 7, 2015 Category: Chemistry Authors: Po-Sheng YangMeng-Jiy WangThanasekaran JayakumarDuen-Suey ChouChing-Ya KoMing-Jen HsuCheng-Ying Hsieh Tags: Article Source Type: research
Molecules, Vol. 21, Pages 956: Qingxuan Jiangya Decoction Reverses Vascular Remodeling by Inducing Vascular Smooth Muscle Cell Apoptosis in Spontaneously Hypertensive Rats
In this study, we examined the therapeutic efficacy of QXJYD against elevated systolic blood pressure in the spontaneously hypertensive rat (SHR) model, and investigated the underlying molecular mechanisms. We found that oral administration of QXJYD significantly reduced the elevation of systolic blood pressure in SHR but had no effect on body weight change. Additionally, QXJYD treatment significantly decreased the media thickness and ratio of media thickness/lumen diameter in the carotid arteries of SHR. Moreover, QXJYD remarkably promoted apoptosis of vascular smooth muscle cells and reduced the expression of anti-apopto...
Source: Molecules - July 21, 2016 Category: Chemistry Authors: Fei Xiao Fei He Hongwei Chen Shan Lin Aling Shen Youqin Chen Jianfeng Chu Jun Peng Tags: Article Source Type: research
