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Tropical Travel Trouble 010 Fever, Arthralgia and Rash
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
aka Tropical Travel Trouble 010
Peer Reviewer: Dr Jennifer Ho, ID physician QLD, Australia
You are an ED doc working in Perth over schoolies week. An 18 yo man comes into ED complaining of fever, rash a “cracking headache” and body aches. He has just hopped off the plane from Bali where he spent the last 2 weeks partying, boozing and running amok. He got bitten by “loads” of mosquitoes because he forgot to take insect repellent.
On examination he looks miserable,...
Source: Life in the Fast Lane - July 16, 2018 Category: Emergency Medicine Authors: Amanda McConnell Tags: Clinical Cases Tropical Medicine arthralgia dengue fever rash Source Type: blogs
Hepatitis B virus infection in the Democratic Republic of Congo: a systematic review of prevalence studies (2000 –2016)
ConclusionThis review suggests that DRC is a country characterized by an intermediate level of HBV infection endemicity rate. It remains however an important public health problem and efforts should continue in prevention and in policy to control this viral disease.
Source: Journal of Public Health - October 1, 2018 Category: Health Management Source Type: research
Association between methylmercury environmental exposure and neurological disorders: a systematic review
Publication date: Available online 6 December 2018Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Bruna Puty, Luana Ketlen Reis Leão, Maria Elena Crespo Lopez, Anna Paula Costa Ponte Sousa Carvalho Almeida, Nathália Carolina Fernandes Fagundes, Lucianne Cople Maia, Rafael Rodrigues LimaAbstractThe mercury-related central nervous system disorders have been extensively studied on animal models and human beings. However, clinical evidences of which neurological changes are in fact associated with mercury exposure remains controversial. This systematic review (Prospero registration under the number CRD420...
Source: Journal of Trace Elements in Medicine and Biology - December 7, 2018 Category: Biochemistry Source Type: research
IJERPH, Vol. 16, Pages 11: Effectiveness of Screening and Treatment Approaches for Schistosomiasis and Strongyloidiasis in Newly-Arrived Migrants from Endemic Countries in the EU/EEA: A Systematic Review
Pottie
Ana Requena-Méndez
We aimed to evaluate the evidence on screening and treatment for two parasitic infections—schistosomiasis and strongyloidiasis—among migrants from endemic countries arriving in the European Union and European Economic Area (EU/EEA). We conducted a systematic search of multiple databases to identify systematic reviews and meta-analyses published between 1 January 1993 and 30 May 2016 presenting evidence on diagnostic and treatment efficacy and cost-effectiveness. We conducted additional systematic search for individual studies published between 2010 and 2017. We assessed the methodologic...
Source: International Journal of Environmental Research and Public Health - December 20, 2018 Category: Environmental Health Authors: Eric N. Agbata Rachael L. Morton Zeno Bisoffi Emmanuel Bottieau Christina Greenaway Beverley-A Biggs Nadia Montero Anh Tran Nick Rowbotham Ingrid Arevalo-Rodriguez Daniel T. Myran Teymur Noori Pablo Alonso-Coello Kevin Pottie Ana Requena-M éndez Tags: Review Source Type: research
Parasitic infections of the spine: case series and review of the literature.
CONCLUSIONSKey findings on imaging modalities, laboratory studies suggestive of parasitic infection, and most importantly a thorough patient history are required to correctly diagnose parasitic spinal infections.
PMID: 30611161 [PubMed - in process]
Source: Neurosurgical Focus - January 1, 2019 Category: Neurosurgery Authors: Majmundar N, Patel PD, Dodson V, Tran A, Goldstein I, Assina R Tags: Neurosurg Focus Source Type: research
Diagnostic accuracy of urinary latex agglutination test (KAtex) for the diagnosis of visceral leishmaniasis: A meta-analysis
Latex agglutination test (KAtex) has been used in the last two decades for the diagnosis of visceral leishmaniasis (VL) in different VL-endemic areas. Here, we present a meta-analysis of studies which evaluated the KAtex for the diagnosis of VL to find out its overall diagnostic performance. A database search was performed on PubMed, Scopus, ISI Web of Science, Iranmedex and Google Scholar. The search of databases found 57 papers, of which 17 articles fulfilled our eligibility criteria. Meta-analysis of diagnostic accuracy (MADA) and Hierarchical Summary Receiver Operating Curve (HSROC) packages were used to do the meta-an...
Source: The Journal of Infection in Developing Countries - January 10, 2019 Category: Infectious Diseases Source Type: research
Nucleoside Hydrolase NH 36: A Vital Enzyme for the Leishmania Genus in the Development of T-Cell Epitope Cross-Protective Vaccines
Conclusions
Nucleoside hydrolases are vital enzymes for the replication of Leishmania, conserved phylogenetic marker of the genus and strong-specific immunogens. We demonstrated that NH36 is an excellent target for chemotherapy of visceral leishmaniasis. Searching for the most immunogenic fraction of promastigotes of Leishmania we described the FML antigen of L. (L.) donovani, that has as its main component, the NH36 Nucleoside hydrolase. We developed second–generation vaccines with the FML and the NH36 native antigens, and with the NH36 recombinant protein. In addition, we obtained a third generation vaccine base...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research
TWiV 546: Delta blues and chitlins
The un-encapsidated TWiV Humans discuss finding hepatitis D virus-related sequences in birds and snakes, and fatal swine acute diarrhoea syndrome caused by a coronavirus of bat origin. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode European Virus Archive ASV early bird registrationends 15 May FDA approves Dengvaxia Divergent hepatitis D-like agentin birds(Viruses) Novel deltavirus in snakes(mBio) SADS-coronavirusin piglets (Nature) Hosts and sources of endemic human corona...
Source: This Week in Virology - MP3 Edition - May 5, 2019 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Cryptococcosis in the Amazon: A current overview and future perspectives.
This article aims to provide a comprehensive review of the literature on cryptococcosis in the Amazon region and its future prospects. Thus, the present study searched the Scientific Electronic Library Online, Latin American and Caribbean Health Sciences Literature, Medical Literature Analysis and Retrieval System, Virtual Health Library, PubMed, and CAPES Periodical Portal for studies on cryptococcosis in the Amazon region, with an established search period of 1999 to 2018, using the search terms "Cryptococcus," "cryptococcosis," and "Amazon" with the Boolean operator AND. Out of 275 articles found, 29 were selected accor...
Source: Acta Tropica - June 6, 2019 Category: Infectious Diseases Authors: Corrêa Pinheiro M, Dos Reis DST, de Brito MTFM, Simões Quaresma JA Tags: Acta Trop Source Type: research
Molecules, Vol. 24, Pages 2700: Potent Vasodilator and Cellular Antioxidant Activity of Endemic Patagonian Calafate Berries (Berberis microphylla) with Nutraceutical Potential
ro
Hydroalcoholic extracts of Patagonian Calafate berry (Berberis microphylla) contain mono or disaccharide conjugated anthocyanins and flavonols. The Liquid Chromatography-Mass Spectrometry (LC-MS) chemical extract profile identified glycosylated anthocyanidins such as delphinidin-, petunidin- and malvidin-3-glucoside as the major constituents. The predominant flavonols were 3-O substituents quercetin-rutinoside or -rhamnoside. Anthocyanins doubled flavonols in mass (13.1 vs. 6 mg/g extract). Polyphenols vascular actions were examined in the rat arterial mesenteric bed bioassay; extract perfusion elicited concentratio...
Source: Molecules - July 24, 2019 Category: Chemistry Authors: Camila Calf ío Juan Pablo Huidobro-Toro Tags: Article Source Type: research
Inside the Race to Build the World ’s First Commercial Octopus Farm
For decades, my father taught biology at Middlebury College in Vermont. One of his signature courses focused on invertebrates and, as a kid, I’d often tag along on class field trips to the Maine coast. Students would fan out across the rocky shore at low tide and count as many spineless creatures as they could—which, as it turns out, was pretty easy. There were dozens of invertebrate species to be found, including snails, crabs, starfish and, of course, lobster.
I didn’t lay eyes on an octopus, however, until I was about 8. My dad sporadically hosted a lunch for his class, to which he brought an assortmen...
Source: TIME: Science - August 22, 2019 Category: Science Authors: Tik Root Tags: Uncategorized Source Type: news
Molecules, Vol. 25, Pages 520: Fast Isolation of Flavonoids from the Endemic Species Nolana ramosissima I.M. Johnst and its Endothelium-Independent Relaxation Effect in Rat Aorta
Simirgiotis
The infusion of the desertic plant Nolana ramosissima I.M. Johnst showed vascular smooth muscle relaxation in rat aorta and the presence of several phenolic compounds, which were detected by high resolution UHPLC-Orbitrap-HESI-MS. In addition, five flavonoids were rapidly isolated from a methanolic extract using high-performance counter-current chromatography (HPCCC). The N. ramosissima extract showed endothelium-independent relaxation effect in rat aorta. Sixty-one compounds were detected in the infusion, mainly glycosylated flavonoids, flavanones and several oxylipins, suggesting that a synergistic effe...
Source: Molecules - January 23, 2020 Category: Chemistry Authors: Cifuentes Palacios B órquez Paredes Parra Bravo Simirgiotis Tags: Article Source Type: research
Vasorelaxing Activity of R-( −)-3′-Hydroxy-2,4,5-trimethoxydalbergiquinol from Dalbergia tonkinensis: Involvement of Smooth Muscle CaV1.2 Channels
In conclusion, D. tonkinensis species may represent a source of agents potentially useful for the development of novel antihypertensive drugs. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Planta Medica - January 27, 2020 Category: Drugs & Pharmacology Authors: Cuong, Nguyen Manh Son, Ninh The Nhan, Ngu Truong Khanh, Pham Ngoc Huong, Tran Thu Tram, Nguyen Thi Thu Sgaragli, Giampietro Ahmed, Amer Trezza, Alfonso Spiga, Ottavia Fusi, Fabio Tags: Original Papers Source Type: research
Epidemiology of Carbapenemase-producing Enterobacterales in the Middle East: a systematic review.
In conclusion, the health care system actors should take in a count the endemicity of CPE in these countries and develop local surveillance programs to limit the spread of these MDR bacteria.
PMID: 32043905 [PubMed - as supplied by publisher]
Source: Expert Review of Anti-Infective Therapy - February 12, 2020 Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Natural Phenolic Compounds and Derivatives as Potential Antimalarial Agents
Planta Med DOI: 10.1055/a-1148-9000Malaria is a parasitic disease endemic to tropical and subtropical regions responsible for hundreds of millions of clinical cases and hundreds of thousands of deaths yearly. Its agent, the Plasmodium sp., has a highly variable antigenicity, which accounts for the emergence and spread of resistance to all available treatments. In light of this rising problem, scientists have turned to naturally occurring compounds obtained from plants recurrently used in traditional medicine in endemic areas. Ethnopharmacological approaches seem to be helpful in selecting the most interesting plants for th...
Source: Planta Medica - April 22, 2020 Category: Drugs & Pharmacology Authors: Mamede, Lucia Ledoux, Allison Jansen, Olivia Fr édérich, Michel Tags: Reviews Source Type: research
