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Infectious Disease: Epidemics
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Total 4946 results found since Jan 2013.
97. Gene expression changes with short- and long-term cannabinoid treatments in a spinal fusion model
The rising opioid epidemic is a public health crisis at the crossroads of orthopedic care and pain management. Medical marijuana is a potential non-opioid analgesic yet to be studied in the surgical setting and its effects on fracture repair are not fully understood. In addition to the analgesic effects of cannabinoids, studies have demonstrated potentially osteo-inductive properties, albeit controversial at the molecular level. Osteoblasts, osteoclasts and bone peripheral nerve terminals have been shown to have endocannabinoid receptors (CB1, CB2), comparably expressed to that of brain tissue.
Source: The Spine Journal - August 22, 2023 Category: Orthopaedics Authors: Harold Fogel, Caleb Yeung, Diana Yeritsyan, Kaveh Momenzadeh, Nadim Kheir, Mohammadreza Abbasian, Ara Nazarian Source Type: research
An answered call for aid? Cannabinoid clinical framework for the opioid epidemic
The opioid crisis continues in full force, as physicians and caregivers are desperate for resources to help patients with opioid use and chronic pain disorders find safer and more accessible non-opioid tools.
Source: Harm Reduction Journal - August 16, 2023 Category: Drugs & Pharmacology Authors: Krista Hammaker, Nathaniel Weathington, Joseph Maroon, Lawton W. Tang, Brian Donohue, Rachel Yehuda, Kenneth M. Ford, Myro Figura, Ben Kelmendi, Belinda Tan, Matthew W. Cook, Steven D. Factor, Laura Lagano, Henry Patrick Driscoll, Adam S. Howe, EunBit G. Tags: Perspective Source Type: research
We Can Prevent Overdose Deaths If We Change How We Think About Them
I’ve been living in recovery from opioid use disorder for eight and a half years, and this might be a weird thing to say about addiction, but I feel lucky—like I dodged a bullet. I was addicted to opioids in Florida throughout the early 2000s, during the heyday of pill mills that flooded the streets with powerful pharmaceuticals like OxyContin. I say I’m lucky because this was just before the drug supply turned into a toxic sludge of potent fentanyl analogues, mysterious tranquilizers, and deadly counterfeit pills. Sometimes I wonder what it would be like if I were using today. The chances of my survival ...
Source: TIME: Health - August 15, 2023 Category: Consumer Health News Authors: Ryan Hampton Tags: Uncategorized freelance Source Type: news
Opioid Use, Disposition, and Parent Satisfaction Following Common Pediatric Surgical Procedures
CONCLUSIONS: Despite heightened awareness of the opioid epidemic, there is still a poor understanding of appropriate pain control regimens in the pediatric surgical population. We demonstrate that most patients are discharged home with excess opioids and that many families save the leftover pills/liquid. Further research and education are encouraged to limit the use of opioids in standard pediatric surgical procedures.PMID:37555374 | DOI:10.1177/00031348231191239
Source: The American Surgeon - August 9, 2023 Category: Surgery Authors: Raphael H Parrado Kunal J Patel Daniel P Allen Ariana Feuvrier Julie H Mansfield Robert A Cina Source Type: research
The Emerging Role of Peripheral Nerve Stimulation in Postoperative Analgesia
AbstractPurpose of ReviewThough peripheral nerve stimulation has long been utilized in the field of chronic pain management, its use in acute pain management in the postoperative period is relatively novel and warrants further consideration.Recent FindingsIn the postsurgical period, peripheral nerve stimulation may offer an additional low-risk, opioid-sparing analgesic option, which is particularly pertinent in the setting of the ongoing opioid epidemic, as inadequate postsurgical analgesia has been shown to increase the risk of developing persistent or chronic postsurgical pain.SummaryIn this review, we discuss the curren...
Source: Current Pain and Headache Reports - August 9, 2023 Category: Neurology Source Type: research
Laparoscopic injection of bupivacaine at the uterosacral ligaments during benign laparoscopic and robotic hysterectomy: A randomized controlled trial
Post-operative pain continues to be an undermanaged part of the surgical experience. Multimodal analgesia has been adopted in response to the opioid epidemic, but opioid prescribing practices remain high following minimally invasive hysterectomy. Novel adjuvant opioid-sparing analgesia to optimize acute post-operative pain control is critical in preventing chronic pain and minimizing opioid usage.
Source: American Journal of Obstetrics and Gynecology - July 30, 2023 Category: OBGYN Authors: Anja S. Frost, Jaden R. Kohn, Margot Le Neveu, Tara Brah, Obianuju Okonkwo, Mostafa A. Borahay, Harold Wu, Khara Simpson, Kristin E. Patzkowsky, Karen C. Wang Tags: Original Research: Gynecology Source Type: research
Laparoscopic administration of bupivacaine at the uterosacral ligaments during benign laparoscopic and robotic hysterectomy: a randomized controlled trial
Postoperative pain continues to be an undermanaged part of the surgical experience. Multimodal analgesia has been adopted in response to the opioid epidemic, but opioid prescribing practices remain high after minimally invasive hysterectomy. Novel adjuvant opioid-sparing analgesia to optimize acute postoperative pain control is crucial in preventing chronic pain and minimizing opioid usage.
Source: American Journal of Obstetrics and Gynecology - July 30, 2023 Category: OBGYN Authors: Anja S. Frost, Jaden R. Kohn, Margot Le Neveu, Tara Brah, Obianuju Okonkwo, Mostafa A. Borahay, Harold Wu, Khara Simpson, Kristin E. Patzkowsky, Karen C. Wang Tags: Original Research Source Type: research
Cultivating Agents of Change in Medical Students: Addressing the Overdose Epidemic in the United States Through Enhancing Knowledge of Multimodal Pain Medicine and Increasing Accessibility via Open-Access, Web-Based Medical Education and Technology
JMIR Med Educ. 2023 Jul 25;9:e46784. doi: 10.2196/46784.ABSTRACTMedical students of today will soon be physician leaders and teachers of tomorrow about important relevant topics including the overdose epidemic and its devastating impact on our society. In the United States, the overdose crisis, including drug opioid-related overdoses, the increasing prevalence of opioid use disorder along with the increasing number of patients with chronic pain are intensifying and call attention for nationwide action. A strong medical educational foundation of the understanding of the relationship between pain and substance use disorder, ...
Source: Pain Physician - July 25, 2023 Category: Anesthesiology Authors: Julia H Miao Source Type: research
Molecular mechanisms of morphine tolerance and dependence; novel insights and future perspectives
Mol Cell Biochem. 2023 Jul 20. doi: 10.1007/s11010-023-04810-3. Online ahead of print.ABSTRACTDrug addiction is a devastating condition that poses a serious burden on the society. The use of some drugs like morphine for their tremendous analgesic properties is also accompanied with developing tolerance, dependence and the withdrawal symptoms. These symptoms are frequently severe enough to reinforce the person in recovery to start over the use of drug again and hinder the clinical use of drugs like morphine for chronic pain. Research into opioid receptors and related molecular pathways has seen resurgence in the wake of the...
Source: Molecular and Cellular Biochemistry - July 20, 2023 Category: Biochemistry Authors: Ismail Badshah Maira Anwar Babar Murtaza Muhammad Imran Khan Source Type: research
What can traditional plant therapy do in the face of Covid-19? Examples from traditional Chinese medicine
Conclusion: TCM can obtain obvious curative effect in symptomatic treatment, has strong anti-inflammatory effect, and can effectively reduce symptoms and patients ' pain.Keywords: COVID-19; traditional plant therapy; Qingfei Paidu decoction.
Source: African Health Sciences - July 13, 2023 Category: African Health Authors: Dandan Song, Qian Deng, Hualiang Chen Source Type: research
Questioning the Right to Pain Relief and Its Role in the Opioid Epidemic
The new discipline of palliative care helped to establish the right to pain relief at the end of life and the necessity of using opioids to achieve that goal. Professional pain organizations followed the United Nations ’ model for universal human rights in their declaration of a universal right to pain management. Both palliative care and pain medicine specialties worked to establish pain as a legitimate focus of medical treatment separate from its association with disease. Pain intensity became the metric used to determine the need for treatment and the success of that treatment.
Source: Mayo Clinic Proceedings - July 7, 2023 Category: Internal Medicine Authors: Mark D. Sullivan, Jane C. Ballantyne Tags: Special Article Source Type: research
Defining text neck: a scoping review
ConclusionThis study showed that posture is the defining characteristic of text neck in the academic literature. For research purposes, it seems that text neck is a habit of texting on the smartphone in a flexed neck position. Since there is no scientific evidence linking text neck with neck pain regardless of the definition used, adjectives like inappropriate or incorrect should be avoided when intended to qualify posture.
Source: European Spine Journal - July 5, 2023 Category: Orthopaedics Source Type: research
