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Infectious Disease: Malaria

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Total 6951 results found since Jan 2013.

Capacity Building in Pediatric Critical Care-Global Health Research and Education: The Blantyre Experience
Am J Trop Med Hyg. 2023 Jun 12:tpmd220445. doi: 10.4269/ajtmh.22-0445. Online ahead of print.ABSTRACTPediatric critical care medicine (PCCM), as it is practiced in high-income countries, is focused on specialized medical care for the most vulnerable pediatric patient populations. However, best practices for provision of that care globally are lacking. Thus, PCCM research and education programming can potentially fill significant knowledge gaps by facilitating the development of evidence-based clinical guidelines that reduce child mortality on a global scale. Malaria remains a leading cause of pediatric mortality worldwide....
Source: The American Journal of Tropical Medicine and Hygiene - June 12, 2023 Category: Tropical Medicine Authors: Madiha Q Raees Yamikani Chimalizeni Alice W Muiruri Liomba Paul Pensulo Montfort Benard Gushu Andrew Tebulo Albert Malenga Michael J Sikorski Adrian J Holloway Adnan T Bhutta Allan Doctor Kenneth E Remy Nicole F O'Brien Douglas G Postels Terrie E Taylor Source Type: research

A Case of Imported Severe Plasmodium falciparum Malaria in the Emergency Department and the Current Role of Exchange Transfusion Treatment
Conclusions: The high level of parasitemia presenting with acute kidney injury, hyperbilirubinemia, and thrombocytopenia supported the use of exchange transfusion as adjunct therapy. Exchange transfusion was a reasonable consideration in this case and was well tolerated by our patient. Institutions that are equipped with apheresis units should evaluate each case individually in concert with Centers for Disease Control experts and local consultants and weigh the risks and benefits of the use of exchange transfusion as an adjunct in the treatment of severe P. falciparum malaria.
Source: The Journal of Emergency Medicine - May 21, 2012 Category: Emergency Medicine Authors: Hania Habeeb, Jill R. Ripper, Alice Cohen, Patrick B. Hinfey Tags: Clinical Communications: Adults Source Type: research

Public health challenges and prospects for malaria control and elimination
Nature Medicine 19, 150 (2013). doi:10.1038/nm.3077 Authors: Pedro L Alonso & Marcel Tanner
Source: Nature Medicine - February 6, 2013 Category: Journals (General) Authors: Pedro L AlonsoMarcel Tanner Tags: Perspective Source Type: research

Malaria biology and disease pathogenesis: insights for new treatments
Nature Medicine 19, 156 (2013). doi:10.1038/nm.3073 Authors: Louis H Miller, Hans C Ackerman, Xin-zhuan Su & Thomas E Wellems
Source: Nature Medicine - February 6, 2013 Category: Journals (General) Authors: Louis H MillerHans C AckermanXin-zhuan SuThomas E Wellems Tags: Review Source Type: research

Immune mechanisms in malaria: new insights in vaccine development
Nature Medicine 19, 168 (2013). doi:10.1038/nm.3083 Authors: Eleanor M Riley & V Ann Stewart
Source: Nature Medicine - February 6, 2013 Category: Journals (General) Authors: Eleanor M RileyV Ann Stewart Tags: Review Source Type: research

ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase
l Schimmel Febrifugine is the active component of the Chinese herb Chang Shan (Dichroa febrifuga Lour.), which has been used for treating malaria-induced fever for about 2,000 years. Halofuginone (HF), the halogenated derivative of febrifugine, has been tested in clinical trials for potential therapeutic applications in cancer and fibrotic disease. Recently, HF was reported to inhibit TH17 cell differentiation by activating the amino acid response pathway, through inhibiting human prolyl-transfer RNA synthetase (ProRS) to cause intracellular accumulation of uncharged tRNA. Curiously, inhibition requires the pres...
Source: Nature - December 23, 2012 Category: Research Authors: Huihao ZhouLitao SunXiang-Lei YangPaul Schimmel Tags: Letter Source Type: research

Study suggests infant deaths can be prevented
(University Health Network) An international team of tropical medicine researchers have discovered a potential method for preventing low birth weight in babies born to pregnant women who are exposed to malaria. Low birth weight is the leading cause of infant death globally.
Source: EurekAlert! - Medicine and Health - February 13, 2013 Category: Global & Universal Source Type: news

Young malaria parasites refuse to take their medicine, may explain emerging drug resistance
(University of Melbourne) New research has revealed that immature malaria parasites are more resistant to treatment with key antimalarial drugs than older parasites, a finding that could lead to more effective treatments for a disease that kills one person every minute and is developing resistance to drugs at an alarming rate.
Source: EurekAlert! - Medicine and Health - February 18, 2013 Category: Global & Universal Source Type: news

Artemisinin based combination therapy in travel medicine
Summary: A steadily increasing number of Western travellers are exposed to malaria. Also, numbers of migrants from malarious areas are increasing. Fast and effective treatment options are needed to ensure effective malaria treatment in these groups in the future. Artemisinin combinations are well tolerated and have shown high efficacy in malaria endemic areas. Since 2001, 42 malaria endemic countries, 23 of them in Africa, have adopted artemisinin based combination therapies recommended by WHO. An additional 14 countries are in the process of changing their malaria treatment policy. Studies in non-immune travellers confirm...
Source: Travel Medicine and Infectious Disease - February 27, 2013 Category: Infectious Diseases Authors: Tomas Jelinek Tags: Reviews Source Type: research

Suppressive chemoprophylaxis invites avoidable risk of serious illness caused by Plasmodium vivax malaria
Summary: Despite inadequacy in preventing vivax malaria after travel, suppressive chemoprophylaxis has dominated travel medicine strategy since the advent of chloroquine in 1946. The lethal threat of falciparum malaria versus the perceived benign consequence of vivax malaria underpins this strategic posture. Recent evidence demonstrating vivax malaria as often pernicious should prompt reconsideration of that posture. Causal prophylaxis kills early developing forms of plasmodia in the liver, thus preventing attacks of falciparum and vivax malaria during travel and delayed onset vivax malaria following travel. Primaquine is ...
Source: Travel Medicine and Infectious Disease - March 4, 2013 Category: Infectious Diseases Authors: J. Kevin Baird Tags: Controversial Commentary Source Type: research