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Infectious Disease: Malaria

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Total 6951 results found since Jan 2013.

Burkina Faso: Herbal Tea to Treat Malaria Heads for Clinical Trial
[SciDev.Net] Saye was licensed as a herbal medicine in Burkina Faso ten years ago It will be trialled against the conventional malaria drug artemisinin But promising early drug tests are often less encouraging in later human trials
Source: AllAfrica News: Health and Medicine - April 28, 2015 Category: African Health Source Type: news

Antibacterial and antifungal activities of various solvent extracts from the leaves and stem bark of Anisophyllea laurina R. Br ex Sabine used as traditional medicine in Guinea
Conclusions The current study confirmed that the leaves and stem bark extracts of A. laurina R. Br ex Sabine proved to be most effective as antibacterial and antifungal activities. Graphical abstract
Source: Journal of Ethnopharmacology - April 29, 2015 Category: Drugs & Pharmacology Source Type: research

Eye disorders reported with the use of mefloquine (Lariam®) chemoprophylaxis – a drug safety database analysis
Between 80 and 90 million travellers visit malaria endemic areas annually and many require malaria chemoprophylaxis. The characterization of the risk and nature of eye disorders occurring during the use of malaria chemoprophylaxis is relevant for travel medicine advisors.
Source: Travel Medicine and Infectious Disease - April 30, 2015 Category: Infectious Diseases Authors: Miriam Adamcova, Martin T. Schaerer, Isabella Bercaru, Iain Cockburn, Hans-Georg Rhein, Patricia Schlagenhauf Source Type: research

Eye disorders reported with the use of mefloquine (Lariam) chemoprophylaxis – A drug safety database analysis
Between 80 and 90 million travellers visit malaria endemic areas annually and many require malaria chemoprophylaxis. The characterization of the risk and nature of eye disorders occurring during the use of malaria chemoprophylaxis is relevant for travel medicine advisors.
Source: Travel Medicine and Infectious Disease - April 30, 2015 Category: Infectious Diseases Authors: Miriam Adamcova, Martin T. Schaerer, Isabella Bercaru, Iain Cockburn, Hans-Georg Rhein, Patricia Schlagenhauf Source Type: research

A brief review on biomarkers and proteomic approach for malaria research
Publication date: April 2015 Source:Asian Pacific Journal of Tropical Medicine, Volume 8, Issue 4 Author(s): Vivek Bhakta Mathema , Kesara Na-Bangchang Malaria remains as one of the significant health threat to people living in countries throughout tropical and subtropical zones. Proteomic studies of Plasmodium, the protozoan causing malaria, is essential for understanding its cellular structure, growth stage-specific expression of protein metabolites and complex interaction with host. In-depth knowledge of the pathogen is required for identification of novel biomarkers that can be utilized to develop diagnostic tests an...
Source: Asian Pacific Journal of Tropical Medicine - May 11, 2015 Category: Tropical Medicine Source Type: research

Antiprotozoal assessment and phenolic acid profiling of five Fumaria (fumitory) species
Conclusions According to our results, Fumaria densiflora deserve further study for its promising antiprotozoal activity.
Source: Asian Pacific Journal of Tropical Medicine - May 11, 2015 Category: Tropical Medicine Source Type: research

Differential Diagnosis of Illness in Travelers Arriving From Sierra Leone, Liberia, or Guinea: A Cross-sectional Study From the GeoSentinel Surveillance Network.
Conclusion: Although EVD may currently drive clinical evaluation of ill travelers arriving from Sierra Leone, Liberia, and Guinea, clinicians must be aware of other more common, potentially fatal diseases. Malaria remains a common diagnosis among travelers seen at GeoSentinel sites. Prompt exclusion of malaria and other life-threatening conditions is critical to limiting morbidity and mortality. Primary Funding Source: Centers for Disease Control and Prevention. PMID: 25961811 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - May 12, 2015 Category: Internal Medicine Authors: Boggild AK, Esposito DH, Kozarsky PE, Ansdell V, Beeching NJ, Campion D, Castelli F, Caumes E, Chappuis F, Cramer JP, Gkrania-Klotsas E, Grobusch MP, F Hagmann SH, Hynes NA, Lim PL, López-Vélez R, M Malvy DJ, Mendelson M, Parola P, Sotir MJ, Wu HM, Hame Tags: Ann Intern Med Source Type: research

Historical review: does stress provoke Plasmodium falciparum recrudescence?
Plasmodium falciparum, unlike P. vivax, must maintain infection in the blood/bone marrow over many months/years in order to bridge periods between transmission periods. Asymptomatic parasitemia at very low concentrations is now known to be quite common due to molecular detection methods. Old tropical medicine texts commonly list many stressful events stated to provoke recrudescent falciparum parasitemia such as fatigue, heat/chill, trauma/surgery, famine/war, transit between areas and other febrile illness. The older literature is reviewed to discover the factual basis of such varied reports since they have not been recent...
Source: Transactions of the Royal Society of Tropical Medicine and Hygiene - May 20, 2015 Category: Tropical Medicine Authors: Shanks, G. D. Tags: REVIEW Source Type: research

Optimizing the design of protein nanoparticles as carriers for vaccine applications
Publication date: Available online 4 June 2015 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Tais A.P.F. Doll , Tobias Neef , Nha Duong , David E. Lanar , Philippe Ringler , Shirley A. Müller , Peter Burkhard Successful vaccine development remains a huge challenge for infectious diseases such as malaria, HIV and influenza. As a novel way to present antigenic epitopes to the immune system, we have developed icosahedral self-assembling protein nanoparticles (SAPNs) to serve as a prototypical vaccine platform for infectious diseases. Here we examine some biophysical factors that affect the self-assem...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - June 5, 2015 Category: Nanotechnology Source Type: research

Striding Toward Malaria Elimination in China.
Abstract In this month's American Journal of Tropical Medicine and Hygiene, China's remarkable progress in malaria control and elimination over the last decade is showcased in two articles. Feng and others reported annual national trends from 38,972 reported cases in 2004, to a peak of 60,193 (or 0.40/10,000) in 2006, to just 4,128 in 2013.(1) Chen and others reported similar data from Zhejiang province, whereby reported malaria cases peaked in 2007 at 598 (0.12/10,000)(2) and then declined to 215 in 2014.(3) As the populations in many of China's provinces exceed those of most other countries-the population of Zhe...
Source: The American Journal of Tropical Medicine and Hygiene - June 15, 2015 Category: Tropical Medicine Authors: Hsiang MS, Gosling RD Tags: Am J Trop Med Hyg Source Type: research

Oral zinc and common childhood infections—An update
Publication date: July 2015 Source:Journal of Trace Elements in Medicine and Biology, Volume 31 Author(s): Sudha Basnet , Maria Mathisen , Tor A. Strand Zinc is an essential micronutrient important for growth and for normal function of the immune system. Many children in developing countries have inadequate zinc nutrition. Routine zinc supplementation reduces the risk of respiratory infections and diarrhea, the two leading causes of morbidity and mortality in young children worldwide. In childhood diarrhea oral zinc also reduces illness duration and risk of persistent episodes. Oral zinc is therefore recommended for the ...
Source: Journal of Trace Elements in Medicine and Biology - June 23, 2015 Category: Biochemistry Source Type: research

Andrographolide effect on both Plasmodium falciparum infected and non infected RBCs membranes
Conclusions In spite of its success to inhibit plasmodium induced permeation pathway and the potential of merozoites to invade new RBCs, its anti-plasmodium effect can't be attributed to these functions as they were attained at concentrations higher than what is required to eradicate the parasite. Consequently, other mechanisms may be associated with its claimed actions.
Source: Asian Pacific Journal of Tropical Medicine - July 11, 2015 Category: Tropical Medicine Source Type: research

Neurological disorders in the emergency centre of the Douala General Hospital, Cameroon: A cross-sectional study
Conclusion Neurological disorders are common in the emergency centre of the DGH. Aetiologies are diverse and in-hospital mortality is high. This highlights the need to organize neurologist calls at the EC and/or to improve the human resources capacity through regular training and evaluation.
Source: African Journal of Emergency Medicine - July 11, 2015 Category: Emergency Medicine Source Type: research

Crime-scene compound may be newest tool in fight against malaria
(Washington University School of Medicine) The compound that detectives spray at crime scenes to find trace amounts of blood may be used one day to kill the malaria parasite.
Source: EurekAlert! - Medicine and Health - August 7, 2015 Category: Global & Universal Source Type: news

In vitro anti-cancer effects of artemisone nano-vesicular formulations on melanoma cells
Publication date: Available online 15 August 2015 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Anupma Dwivedi, Anisha Mazumder, Lissinda du Plessis, Jan L. du Preez, Richard K. Haynes, Jeanetta du Plessis Artemisone is a 10-amino-artemisinin derivative that is markedly superior in vitro and in vivo to current artemisinins against malaria and also possesses antitumor activity. In seeking to capitalize on the last property, we have examined the encapsulation of artemisone in nano- vesicular niosomes and solid lipid nano-particles (SLNs), and have evaluated efficacies of the free and encapsulat...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - August 16, 2015 Category: Nanotechnology Source Type: research