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Infectious Disease: Hepatitis
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In silico Identification and Mechanism Exploration of Hepatotoxic Ingredients in Traditional Chinese Medicine
Conclusion: Overall, this study provides a high accurate approach to predict HILI and an in silico perspective into understanding the hepatotoxicity mechanism of TCM, which might facilitate the discovery and development of new drugs.
Introduction
Liver injury induced by drug, novel foods or phytotherapy, also known as hepatotoxicity, is still a major clinical and pharmaceutical concern (Amadi and Orisakwe, 2018; Hammann et al., 2018; Kyawzaw et al., 2018; Real et al., 2018). According to the data from United States National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), hepatotoxicity accounts for...
Source: Frontiers in Pharmacology - May 2, 2019 Category: Drugs & Pharmacology Source Type: research
Vitamins: stop taking the pills
This article was corrected on 7 June 2013. During editing, a line in the fifth from last paragraph, beginning 'Another example is St John's wort…' was accidentally transposed, leading to the suggestion that serotonin was a medicine rather than a brain chemical.Alternative medicineHealth & wellbeingHealthCancerCancerMedical researchPharmaceuticals industryDepressionguardian.co.uk © 2013 Guardian News and Media Limited or its affiliated companies. All rights reserved. | Use of this content is subject to our Terms & Conditions | More Feeds
Source: Guardian Unlimited Science - June 7, 2013 Category: Science Tags: The Guardian Depression Pharmaceuticals industry Health Medical research & wellbeing Society Extracts Features Cancer Life and style Alternative medicine Science Source Type: news
Topics of internal medicine for undergraduate dental education: a qualitative study
ConclusionWe identified the internal medicine topics most relevant for dental education by surveying practising dentists and internists. The relevance of these topics should be confirmed by larger quantitative studies to develop guidelines how to design specific learning objectives for internal medicine in the dental curriculum.
Source: European Journal of Dental Education - August 1, 2014 Category: Dentistry Authors: A. Kunde, S. Harendza Tags: Original Article Source Type: research
Cautiously using natural medicine to treat liver problems.
This article highlights the current practice and recommended improvement of natural medicines in the treatment of liver diseases and gives some specific examples to emphasize the prevention and management of adverse reactions of the natural agents and suggests that natural medicine should be cautiously used to treat liver problems.
PMID: 28596675 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - May 21, 2017 Category: Gastroenterology Authors: Xiong F, Guan YS Tags: World J Gastroenterol Source Type: research
Doctors Tried Transplants Using Diseased Organs. One Year Later, the Recipients Are Still Disease-Free
More than 90,000 people in the U.S. are waiting for a kidney transplant, and new research suggests an unusual approach may help cut down the list: using diseased kidneys.
In a new study published in the journal Annals of Internal Medicine, researchers gave 10 willing people, who were in need of a kidney transplant, kidneys that were infected with hepatitis-C, followed by medication known to clear the infection. All 10 remained free of the disease one year after their landmark transplants.
The trial, which occurred at Johns Hopkins University School of Medicine, is one of a few happening nationwide. Currently, hepatitis-C i...
Source: TIME: Health - March 5, 2018 Category: Consumer Health News Authors: Alexandra Sifferlin Tags: Uncategorized healthytime hepatitis C hepatitis-C organ transplant Johns Hopkins kidney transplant medicine Source Type: news
Clinical trial with traditional Chinese medicine intervention ''tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'' for chronic hepatitis B-associated liver failure.
CONCLUSION: Treatment with "TTK" improved the survival rates of patients with liver failure due to chronic hepatitis B. Additionally, liver tissue was regenerated and liver function was restored.
PMID: 25561817 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 28, 2014 Category: Gastroenterology Authors: Li HM, Ye ZH, Zhang J, Gao X, Chen YM, Yao X, Gu JX, Zhan L, Ji Y, Xu JL, Zeng YH, Yang F, Xiao L, Sheng GG, Xin W, Long Q, Zhu QJ, Shi ZH, Ruan LG, Yang JY, Li CC, Wu HB, Chen SD, Luo XL Tags: World J Gastroenterol Source Type: research
Efficacy of traditional Chinese medicine for cooling blood and eliminating toxins and strengthening and purifying spleen in the treatment of refractory hepatitis C.
This study was designed to observe the comprehensive efficacy of traditional Chinese medicine (TCM) combined with interferon in the treatment of chronic hepatitis C (CHC), compare this combined therapy with interferon therapy alone and investigate its possible mechanism to provide a basis for the development of an integrated traditional Chinese and Western medicine for the treatment of CHC. According to patient contraindications for antiviral treatment, patients who were suitable for interferon therapy and willing to use TCM were enrolled as combined traditional Chinese and Western medicine group, and 21 CHC patients were ...
Source: Journal of Biological Regulators and Homeostatic Agents - April 8, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Viruses, Vol. 11, Pages 186: Chronic Hepatitis E in Rheumatology and Internal Medicine Patients: A Retrospective Multicenter European Cohort Study
Conclusion: Rheumatology and internal medicine patients, including patients treated with methotrexate without corticosteroids, are at risk of developing chronic HEV infection. Rheumatology and internal medicine patients with abnormal liver tests should be screened for HEV infection.
Source: Viruses - February 22, 2019 Category: Virology Authors: Sven Pischke Jean-Marie Peron Moritz von Wulffen Johann von Felden Christoph H öner zu Siederdissen Sophie Fournier Marc L ütgehetmann Christoph Iking-Konert Dominik Bettinger Gabriella Par Robert Thimme Alain Cantagrel Ansgar W. Lohse Heiner Wedemeyer Tags: Article Source Type: research
Viruses, Vol. 12, Pages 998: Advanced Therapeutics, Vaccinations, and Precision Medicine in the Treatment and Management of Chronic Hepatitis B Viral Infections; Where Are We and Where Are We Going?
w D. Miller
The management of chronic hepatitis B virus (CHB) infection is an area of massive unmet clinical need worldwide. In spite of the development of powerful nucleoside/nucleotide analogue (NUC) drugs, and the widespread use of immune stimulators such as interferon-alpha (IFNα) or PEGylated interferon-alpha (PEG-IFNα), substantial improvements in CHB standards of care are still required. We believe that the future for CHB treatment now rests with advanced therapeutics, vaccination, and precision medicine, if all are to bring under control this most resilient of virus infections. In sp...
Source: Viruses - September 6, 2020 Category: Virology Authors: Ganesh Selvaraj Duraisamy Dattatry Bhosale Ivana Lipensk á Ivana Huvarova Daniel R ůžek Marc Windisch Andrew D. Miller Tags: Review Source Type: research
3 Win Nobel Medicine Prize for Discovering Hepatitis C Virus
(STOCKHOLM) — Americans Harvey J. Alter and Charles M. Rice and British-born scientist Michael Houghton won the Nobel Prize for medicine on Monday for their discovery of the hepatitis C virus, a major source of liver disease that affects millions worldwide.
Announcing the prize in Stockholm, the Nobel Committee noted that the trio’s work identified a major source of blood-borne hepatitis that couldn’t be explained by the previously discovered hepatitis A and B viruses. Their work, dating back to the 1970s and 1980s, has helped saved millions of lives, the committee said.
“Thanks to their discovery, ...
Source: TIME: Science - October 5, 2020 Category: Science Authors: DAVID KEYTON and FRANK JORDANS / AP Tags: Uncategorized News News Desk wire Source Type: news
Egypt’s Poor Easy Victims of Quack Medicine
Many pharmacies and herbalists in Egypt prescribe their own 'wasfa' (secret drug or herbal elixir). Credit: Cam McGrath/IPSBy Cam McGrathCAIRO, Aug 10 2014 (IPS) Magda Ibrahim first learnt that she had endometrial cancer when she went to a clinic to diagnose recurring bladder pain and an abnormal menstrual discharge. Unable to afford the recommended hospital treatment, the uninsured 53-year-old widow turned to what she hoped would be a quicker and cheaper therapy.
A local Muslim sheikh claimed religious incantations, and a suitable donation to his pocket, could cure the cancer. But when her symptoms persisted, Ibrahim cons...
Source: IPS Inter Press Service - Health - August 10, 2014 Category: Global & Universal Authors: Cam McGrath Tags: Civil Society Education Featured Headlines Health Human Rights Middle East & North Africa Poverty & MDGs Projects Women's Health AIDS avian flu blood dialysis clinics Corruption Doctors Egypt Health care Hepatitis C h Source Type: news
Optimal control of anti-HBV treatment based on combination of Traditional Chinese Medicine and Western Medicine
Publication date: January 2015 Source:Biomedical Signal Processing and Control, Volume 15 Author(s): Yongmei Su , Deshun Sun In this paper, a Hepatitis B virus model with standard incidence rate and logistic proliferation of healthy and infected cells is presented. Based on this model, we study an optimal control problem about anti-HBV infection combination therapy of Traditional Chinese Medicine and Western Medicine, the optimal strategies of taking medicine are given by simulation. Two optimal strategies with or without the impact to the infection rate by treatment are compared, simulation shows the impact to the reduc...
Source: Biomedical Signal Processing and Control - November 1, 2014 Category: Biomedical Science Source Type: research
A Case of Lead Poisoning with Drug-induced Liver Injury after Ingestion of Herbal Medicine.
Abstract
A 61-year-old male patient was admitted because of unexplained abdominal pain and anemia. His past medical history was unremarkable except for having taken herbal medicine to treat facial palsy two months ago. The result of health examination performed about a month ago showed increased serum aspartate and alanine aminotransferase level, and he was diagnosed with toxic hepatitis by herbal medicine. When the patient presented to the outpatient department three weeks ago, follow-up liver function test results showed improvement but he complained of abdominal pain. Despite extensive blood chemistry tests and...
Source: Korean J Gastroenter... - June 20, 2015 Category: Gastroenterology Authors: Jeon GJ, Park JH, Kim MS, Yu JW, Park JH, Kim MS Tags: Korean J Gastroenterol Source Type: research
The influence of maternal exposure history to virus and medicine during pregnancy on congenital heart defects of fetus.
This study focuses on investigating the influence of virus infection and medicine history during pregnancy on the incidence rate of CHD of fetus. We conducted a retrospective birth cohort study of infant born in the maternal and child health hospital of Fanyu district in Guangzhou. Five thousand three hundred eighty one cases with complete medical records, including mothers, fathers, and infants, were enrolled. The exposure history of mothers to virus and medicine from 6 months before pregnancy to prenatal examination was investigated, including mflu, mumps, measles, rubella, chickenpox, and hepatitis and antibiotics, toc...
Source: Environmental Science and Pollution Research International - December 29, 2016 Category: Environmental Health Authors: Liang Q, Gong W, Zheng D, Zhong R, Wen Y, Wang X Tags: Environ Sci Pollut Res Int Source Type: research
Two recent scientific advances underscore an encouraging future for precision medicine at FDA
By: Janet Woodcock, M.D.
FDA helps bring precision medicine – in the form of targeted therapies — to people living with diseases that have specific genetic features.
Two recent FDA drug approvals point to an encouraging future for “precision medicine” — an approach for disease treatment that tailors medical therapies, including medications, to the needs of individual patients. These approvals involve diseases resulting from particular genetic characteristics identified by laboratory testing.
In mid-May, FDA announced that we expanded the approval of Kalydeco (ivacaftor), enabling a larger number of patients with...
Source: Mass Device - July 17, 2017 Category: Medical Devices Authors: Danielle Kirsh Tags: Blog FDA Voice Source Type: news
