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Infectious Disease: Parasitic Diseases

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Total 6720 results found since Jan 2013.

Ferula species: A rich source of antimicrobial compounds
Publication date: Available online 1 November 2018Source: Journal of Herbal MedicineAuthor(s): Zahra Boghrati, Mehrdad IranshahiAbstractFerula species, particularly F. assa-foetida and F. gummosa, have a long history of use in traditional medicine. They have extensively been used for the treatment of infectious diseases including diarrhea, skin infection, intestinal parasites and influenza.This review is an attempt to explore secondary metabolites from Ferula species as a rich source of molecules with antimicrobial property and highlights the gaps in our knowledge deserving future research. In this review, the authors expl...
Source: Journal of Herbal Medicine - November 2, 2018 Category: Complementary Medicine Source Type: research

Once thought to be asexual, single-celled parasites caught in the act
(Washington University School of Medicine) The single-celled parasite Leishmania can reproduce sexually, according to a study from Washington University School of Medicine in St. Louis and the National Institutes of Health (NIH). The finding could pave the way towards finding genes that help the parasite cause disease.
Source: EurekAlert! - Medicine and Health - June 13, 2019 Category: International Medicine & Public Health Source Type: news

Sepsis in the era of data-driven medicine: personalizing risks, diagnoses, treatments and prognoses.
Abstract Sepsis is a series of clinical syndromes caused by the immunological response to infection. The clinical evidence for sepsis could typically attribute to bacterial infection or bacterial endotoxins, but infections due to viruses, fungi or parasites could also lead to sepsis. Regardless of the etiology, rapid clinical deterioration, prolonged stay in intensive care units and high risk for mortality correlate with the incidence of sepsis. Despite its prevalence and morbidity, improvement in sepsis outcomes has remained limited. In this comprehensive review, we summarize the current landscape of risk estimat...
Source: Briefings in Bioinformatics - June 10, 2019 Category: Bioinformatics Authors: Liu AC, Patel K, Vunikili RD, Johnson KW, Abdu F, Belman SK, Glicksberg BS, Tandale P, Fontanez R, Mathew OK, Kasarskis A, Mukherjee P, Subramanian L, Dudley JT, Shameer K Tags: Brief Bioinform Source Type: research

David Geffen School of Medicine names 2019 winner of Switzer Prize
Dr. Zhijian (James) Chen of the UT Southwestern Medical Center in Dallas will be the 2019 recipient of the Switzer Prize, awarded by the  David Geffen School of Medicine at UCLA. Chen has performed groundbreaking work on the mechanisms underlying the cellular response to infection.Chen ’s group has been instrumental in the identification of immune response pathways that have significantly added to scientists’ understanding of how these pathways work in microbial infections and autoimmune diseases.Most significantly, his team at UT Southwestern discovered the DNA-sensing enzyme cGAS, which helps launch the immune defen...
Source: UCLA Newsroom: Health Sciences - June 17, 2019 Category: Universities & Medical Training Source Type: news

Medical students learn about practicing medicine with limited resources in Peru
Five UCLA medical students flew to Peru shortly before graduation to complete a clinical rotation at a hospital in Iquitos. Surrounded by the Amazon jungle, it ’s the world’s largest city that’s unreachable by road.After four years of working with the latest technology and state-of-the-art treatments, the students found their interaction with patients, who sometimes traveled weeks on the Amazon River by boat from remote villages,  a life-changing experience.Organized by theglobal health program in theDavid Geffen School of Medicine at UCLA, the three-week training, which was captured byNBC News, immersed the budding...
Source: UCLA Newsroom: Health Sciences - July 8, 2019 Category: Universities & Medical Training Source Type: news

N-myristoylation: from cell biology to translational medicine.
Abstract Various lipids and lipid metabolites are bound to and modify the proteins in eukaryotic cells, which are known as 'protein lipidation'. There are four major types of the protein lipidation, i.e. myristoylation, palmitoylation, prenylation, and glycosylphosphatidylinositol anchor. N-myristoylation refers to the attachment of 14-carbon fatty acid myristates to the N-terminal glycine of proteins by N-myristoyltransferases (NMT) and affects their physiology such as plasma targeting, subcellular tracking and localization, thereby influencing the function of proteins. With more novel pathogenic N-myristoylated ...
Source: Acta Pharmacologica Sinica - March 17, 2020 Category: Drugs & Pharmacology Authors: Yuan M, Song ZH, Ying MD, Zhu H, He QJ, Yang B, Cao J Tags: Acta Pharmacol Sin Source Type: research

Study: Dangerous parasite controls host cell to spread around body
(Indiana University School of Medicine) Researchers at Indiana University School of Medicine have discovered new information about how a dangerous parasite takes control of a patient's cells as it spreads throughout their body, an important finding that could help in the development of new drugs to treat this infection.
Source: EurekAlert! - Medicine and Health - July 16, 2020 Category: International Medicine & Public Health Source Type: news

“Tobacco Is the Chief Medicinal Plant in My Work”: Therapeutic Uses of Tobacco in Peruvian Amazonian Medicine Exemplified by the Work of a Maestro Tabaquero
ConclusionsTo our knowledge, this is the first study employing a transdisciplinary clinical approach to examine therapeutic applications of tobacco by an Amazonian tabaquero. Our findings significantly contribute to the growing research literature on Amazonian medicine and emergent psychedelic-assisted therapies and could, in the long-term, open new treatment avenues in several domains. Forthcoming studies should assess toxicity/safety and clinical outcomes of patients receiving Amazonian tobacco-based treatment.
Source: Frontiers in Pharmacology - October 6, 2020 Category: Drugs & Pharmacology Source Type: research

Hypereosinophilia with Hepatic Nodule Formation Caused by Ganoderma lucidum
Intern Med. 2021;60(24):3897-3903. doi: 10.2169/internalmedicine.7431-21. Epub 2021 Dec 15.ABSTRACTA 61-year-old man who underwent surgery for rectal adenocarcinoma developed multiple hepatic nodules. The nodules were 1-3 cm without a capsular structure or contrast enhancement on computed tomography/magnetic resonance imaging, findings that were atypical for adenocarcinoma metastases. A biopsy showed the aggregation of eosinophils without larval bodies, ova, or granulomas. Laboratory tests showed a marked increase in eosinophils and a slight liver enzyme elevation. He had been taking the commercial herbal medicine Ganoderm...
Source: Internal Medicine - December 16, 2021 Category: Internal Medicine Authors: Takayuki Kogure Akinobu Koiwai Daisuke Fukushi Mari Satoh Keigo Murakami Morihisa Hirota Katsuya Endo Kazuhiro Murakami Kennichi Satoh Source Type: research

Discovery and repurposing of artemisinin
AbstractMalaria is an ancient infectious disease that threatens millions of lives globally even today. The discovery of artemisinin, inspired by traditional Chinese medicine (TCM), has brought in a paradigm shift and been recognized as the “best hope for the treatment of malaria” by World Health Organization. With its high potency and low toxicity, the wide use of artemisinin effectively treats the otherwise drug-resistant parasites and helps many countries, including China, to eventually eradicate malaria. Here, we will first rev iew the initial discovery of artemisinin, an extraordinary journey that was in stark cont...
Source: Frontiers of Medicine - March 15, 2022 Category: General Medicine Source Type: research

A Strategic Partnership for Medicine Creation and Access to Medicine for Neglected Tropical Diseases
Yakugaku Zasshi. 2022;142(7):703-708. doi: 10.1248/yakushi.21-00210-4.ABSTRACTNeglected tropical diseases (NTDs) are communicable diseases that are uncommon in developed countries but epidemic in developing countries of the tropical and subtropical regions around the world. One of the important contributions expected of pharmaceutical companies is the development and provision of drugs effective against NTDs. Firstly, Eisai has distributed at price zero to endemic countries worldwide diethylcarbamazine (DEC) tablets for patients suffering with lymphatic filariasis (LF). Eisai's efforts toward improving global health have r...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2022 Category: Drugs & Pharmacology Authors: Katsura Hata Source Type: research