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Infectious Disease: Outbreaks

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Is it right to cut corners in the search for a coronavirus cure? | Julian Savulescu
Vaccine and drug trials are slow, to account for safety. But in a pandemic time isn ’t just money – it’s lives• Coronavirus latest updates• See all our coronavirus coverageThe race is on to find a treatment for coronavirus. This race is split between two approaches: the trialling of pre-existing drugs used for similar diseases, and thehunt for a vaccine. In both instances, important ethical decisions must be made. Is it OK to reassign a treatment that comes with side-effects? And with thousands dying from coronavirus every day, is it acceptable to cut corners in the search for a vaccine?Related:Coronavirus vaccin...
Source: Guardian Unlimited Science - March 25, 2020 Category: Science Authors: Julian Savulescu Tags: Coronavirus outbreak Infectious diseases Medical research Science World news Ethics Source Type: news

COVID-19 Financial Resources for Physicians
The appropriate focus in dealing with the COVID-19 pandemic in the United States has been addressing access and delivery of care to the population impacted by the outbreak. All sectors of the U.S economy have been significantly impacted including physicians. Physician groups of all specialties and sizes have experienced the financial impact of the pandemic. Hospitals have received billions of dollars to support and enable them to handle emergencies and cover the cost of the disruption. However, many Vascular Surgeons are under great financial pressure because of postponement of all non-emergency procedures.
Source: Journal of Vascular Surgery - April 28, 2020 Category: Surgery Authors: Bhagwan Satiani, Todd A. Zigrang, Jessica L. Bailey –Wheaton Source Type: research

Pattern of Vascular Disease in Lombardia (Italy) during the first month of the COVID-19 outbreak
The first confirmed case of COVID-19 infection in Italy was reported in Lombardia region on February 20, 2020, following the outbreak in Hubei Province in China, where in just 30 days it spread from the city of Wuhan to the entire country (1). Aggressive policies allowed containment of the epidemic in China, however by that time the WHO had declared a global pandemic.
Source: Journal of Vascular Surgery - April 28, 2020 Category: Surgery Authors: Germano Melissano, Daniele Mascia, Domenico Baccellieri, Andrea Kahlberg, Luca Bertoglio, Enrico Rinaldi, Roberto Chiesa Source Type: research

Thinking beyond the box: preparing for the end of COVID-19 outbreak in a vascular surgery department
On 11 February 2020 the World Health Organisation declared the COVID-19 outbreak a pandemic and since then there has been a race against the clock to readjust healthcare systems, to limit the spread, to find a treatment or to develop a vaccine.
Source: Annals of Vascular Surgery - May 9, 2020 Category: Surgery Authors: Calin Gheorghe Precup, Marine Bordet, Patrick Lermusiaux, Antoine Millon, Nellie Della Schiava Source Type: research

Managing Endovascular Workload During COVID-19 Outbreak – the Singapore Experience
As the COVID-19 pandemic intensifies globally, challenges in timely delivery of non-COVID-19 related healthcare service such as endovascular service arise due to infection control matters, resource conservation/diversion, and patient/physician movement restrictions. To this end, guidelines on triage of vascular surgery patients was recently published by both the American College of Surgeons (ACS) with the endovascular component adapted by the Society of Interventional Radiology (SIR).1-2
Source: Annals of Vascular Surgery - May 9, 2020 Category: Surgery Authors: Lawrence Han Hwee Quek, Glenn Wei Leong Tan, Uei Pua Source Type: research

Pattern of vascular disease in Lombardy, Italy, during the first month of the COVID-19 outbreak
The first confirmed case of COVID-19 infection in Italy was reported in the Lombardy region on February 20, 2020, after the outbreak in Hubei Province, China, where, in just 30  days, it had spread from the city of Wuhan to the entire country.1 Aggressive policies allowed for containment of the epidemic in China; however, by that time, the World Health Organization had declared a global pandemic.
Source: Journal of Vascular Surgery - April 27, 2020 Category: Surgery Authors: Germano Melissano, Daniele Mascia, Domenico Baccellieri, Andrea Kahlberg, Luca Bertoglio, Enrico Rinaldi, Roberto Chiesa Source Type: research

Problems related with anticoagulant usage during Covid-19 outbreak
Publication date: Available online 12 May 2020Source: Journal of Vascular Surgery: Venous and Lymphatic DisordersAuthor(s): Suat Doganci, Alperen Kutay Yildirim
Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders - May 12, 2020 Category: Surgery Source Type: research

Managing Endovascular Workload during COVID-19 Outbreak —The Singapore Experience
At the outset and during the throes of the COVID-19 pandemic, as valuable resources are channeled to combat the pandemic, challenges in timely delivery of non –COVID-19-related health care services such as endovascular service arise. As such, this article looks at a tertiary institution's experience in managing its endovascular workload—referenced to the American College of Surgeons' triage of vascular surgery patient acuity-based case classification.
Source: Annals of Vascular Surgery - May 9, 2020 Category: Surgery Authors: Lawrence Han Hwee Quek, Glenn Wei Leong Tan, Uei Pua Tags: Clinical Research Source Type: research

Can an Algorithm Predict the Pandemic ’s Next Moves?
Researchers have developed a model that uses social-media and search data to forecast outbreaks of Covid-19 well before they occur.
Source: NYT Health - July 3, 2020 Category: Consumer Health News Authors: Benedict Carey Tags: your-feed-science Data-Mining and Database Marketing Computers and the Internet Search Engines Coronavirus (2019-nCoV) Social Media Medicine and Health Research Smartphones your-feed-health Google Inc Source Type: news

Management of vascular surgical urgencies during COVID-19 pandemic
COVID-19 pandemic characterized for a very quick outbreak and Italy was one of the first European countries to be heavily affected [1,2]. This condition required a fast re-organization of hospital departments and activities, in order to give priority to patients affected by COVID-19 and, at the same time, give assistance to other people suffering from urgent conditions [3, 4].
Source: Annals of Vascular Surgery - August 26, 2020 Category: Surgery Authors: Montanari Francesca, Tinelli Giovanni, Tshomba Yamume Tags: Correspondence Source Type: research

Screening the CALIBR ReFRAME Library in Search for Inhibitors of Candida auris Biofilm Formation
Candida auris is an emerging yeast which, since its first isolation about a decade ago, has spread rapidly and triggered major infectious outbreaks in health care facilities around the world. C. auris strains often display resistance to clinically-used antifungal agents, contributing to high mortality rates. Thus, there is an urgent need for new antifungals to contain the spread of this emerging multi-drug resistant pathogen and to improve patient outcomes. However, the timeline for the development of a new antifungal agent typically exceeds 10‑15 years. Thus, repurposing of current drugs could significantly accelerate t...
Source: Frontiers in cellular and infection microbiology - November 25, 2020 Category: Microbiology Source Type: research

A review on viral data sources and search systems for perspective mitigation of COVID-19.
Abstract With the outbreak of the COVID-19 disease, the research community is producing unprecedented efforts dedicated to better understand and mitigate the effects of the pandemic. In this context, we review the data integration efforts required for accessing and searching genome sequences and metadata of SARS-CoV2, the virus responsible for the COVID-19 disease, which have been deposited into the most important repositories of viral sequences. Organizations that were already present in the virus domain are now dedicating special interest to the emergence of COVID-19 pandemics, by emphasizing specific SARS-CoV2 ...
Source: Briefings in Bioinformatics - December 22, 2020 Category: Bioinformatics Authors: Bernasconi A, Canakoglu A, Masseroli M, Pinoli P, Ceri S Tags: Brief Bioinform Source Type: research

Viruses, Vol. 13, Pages 106: Systematic Search for SARS-CoV-2 Main Protease Inhibitors for Drug Repurposing: Ethacrynic Acid as a Potential Drug
In this study we present systematic and integrative antiviral drug repurposing effort aimed at identifying, among the drugs already authorized for clinical use, some active inhibitors of the SARS-CoV-2 main protease. The most important result of this analysis is the demonstration that ethacrynic acid, a powerful diuretic, is revealed to be an effective inhibitor of SARS-CoV-2 main protease. Even with all the necessary cautions, given the particular nature of this drug, these data can be the starting point for the development of an effective therapeutic strategy against SARS-CoV-2.
Source: Viruses - January 13, 2021 Category: Virology Authors: Camilla Isgr ò Anna Maria Sardanelli Luigi Leonardo Palese Tags: Article Source Type: research

EACTA/SCA Recommendations for the Cardiac Anesthesia Management of Patients with Suspected or Confirmed COVID-19 Infection: An Expert Consensus from the European Association of Cardiothoracic Anesthesiology and Society of Cardiovascular Anesthesiologists with the endorsement from the Chinese Society of Cardiothoracic and Vascular Anesthesiology
The European Association of Cardiothoracic Anaesthesiology (EACTA) and the Society of Cardiovascular Anesthesia (SCA) aimed to create joint recommendations for the perioperative management of patients with suspected or proven SARS-CoV-2 infection undergoing cardiac surgery or invasive cardiac procedures.To produce appropriate recommendations, we combined the evidence from the literature review, re-evaluating the clinical experience of routine cardiac surgery in similar cases during the Middle East Respiratory Syndrome (MERS-CoV) outbreak and the current pandemic with suspected COVID-19 patients, and the expert opinions thr...
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 17, 2021 Category: Anesthesiology Authors: Fabio Guarracino, Stanton K. Shernan, Mohamed El Tahan, Pietro Bertini, Marc E. Stone, Bessie Kachulis, Gianluca Paternoster, Chirojit Mukherjee, Patrick Wouters, Steffen Rex Source Type: research

Ebolavirus: Comparison of Survivor Immunology and Animal Models in the Search for a Correlate of Protection
Ebola viruses are enveloped, single-stranded RNA viruses belonging to the Filoviridae family and can cause Ebola virus disease (EVD), a serious haemorrhagic illness with up to 90% mortality. The disease was first detected in Zaire (currently the Democratic Republic of Congo) in 1976. Since its discovery, Ebola virus has caused sporadic outbreaks in Africa and was responsible for the largest 2013–2016 EVD epidemic in West Africa, which resulted in more than 28,600 cases and over 11,300 deaths. This epidemic strengthened international scientific efforts to contain the virus and develop therapeutics and vaccines. Immunology...
Source: Frontiers in Immunology - February 19, 2021 Category: Allergy & Immunology Source Type: research