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Dietary ginger as a traditional therapy for blood sugar control in patients with type 2 diabetes mellitus: A systematic review and meta-analysis
Conclusion: This analysis involving patients with T2DM showed no significant difference in FBS with ginger consumption. However, dietary ginger significantly improved HbA1c from baseline to follow-up showing that this natural medicine might have an impact on glucose control over a longer period of time in patients with T2DM.
Source: Medicine - March 1, 2019 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Establishment of Mouse Models of Psoriasis with Blood Stasis Syndrome Complicated with Glucose and Lipid Metabolism Disorders.
Conclusions: The established mouse models of psoriasis blood stasis syndrome complicated with glucose and lipid metabolism disorders met the clinical and Chinese Medicine characteristics, and thus they could be used as animal models in future studies of psoriasis complicated with glucose and lipid metabolism disorders. PMID: 31781274 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - December 1, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Researchers identify unique glucose-sensing neurons that regulate blood sugar
(Baylor College of Medicine) At Baylor College of Medicine and other institutions, researchers have identified a group of unique glucose-sensing neurons in the brain and how they work together to prevent severe hypoglycemia in mice.
Source: EurekAlert! - Medicine and Health - May 1, 2020 Category: International Medicine & Public Health Source Type: news

Salvia miltiorrhiza improves type 2 diabetes: A protocol for systematic review and meta-analysis
Conclusion: This systematic review provides evidence as to whether Salvia miltiorrhiza is effective and safe for type 2 diabetes. Ethics: Ethical approval is not necessary as this protocol is only for systematic review and does not involve in privacy data or an animal experiment. Systematic review registration: INPLASY2020110046.
Source: Medicine - February 12, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Molecular alteration may be cause -- not consequence -- of heart failure
(Johns Hopkins Medicine) Clinicians and scientists have long observed that cells in overstressed hearts have high levels of the simple sugar O-GlcNAc modifying thousands of proteins within cells. Now, researchers at Johns Hopkins Medicine have found evidence in mouse experiments that these excess sugars could well be a cause, not merely a consequence or marker of heart failure.
Source: EurekAlert! - Medicine and Health - May 13, 2021 Category: International Medicine & Public Health Source Type: news

< em > Dendrobium < /em > mixture attenuates renal damage in rats with diabetic nephropathy by inhibiting the PI3K/Akt/mTOR pathway
Mol Med Rep. 2021 Aug;24(2):590. doi: 10.3892/mmr.2021.12229. Epub 2021 Jun 24.ABSTRACTDendrobium mixture (DMix) is a Traditional Chinese Medicine widely used for preventing and treating diabetic nephropathy (DN). Autophagy contributes to DN development and progression. The present study aimed to investigate the mechanism underlying the protective effects of DMix on the kidneys of rats with DN and to determine whether this involves autophagy. Herein, a high‑sugar and high‑fat diet, combined with the intra‑abdominal injection of low‑dose streptozocin, was used to induce DN in 40 Sprague‑Dawley male rats. In total,...
Source: Molecular Medicine - June 24, 2021 Category: Molecular Biology Authors: Yong Chen Yan Fang Zheng Xiao Hui Lin Jie Ping Zhang Fan Lin Hong Shi Source Type: research

Fluctuations in the chemical constituents of Panax ginseng subterranean tissues with cultivation duration
ConclusionCultivation years may influence the specific medicinal properties and other health benefits of ginseng preparations.
Source: Traditional and Kampo Medicine - February 13, 2022 Category: Complementary Medicine Authors: Yuto Nishidono, Hina Yahata, Kotaro Niwa, Aoi Kitajima, Yasuhiro Tezuka, Shiro Watanabe, Ken Tanaka Tags: ORIGINAL ARTICLE Source Type: research

Latrophilin-2 is a novel receptor of LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function
Experimental & Molecular Medicine, Published online: 13 May 2022; doi:10.1038/s12276-022-00773-5A protein that initiates multiple tissue repair processes could offer effective treatment for erectile dysfunction arising from diabetes mellitus. High blood sugar levels can lead to serious damage to nerves and blood vessels, with impaired male sexual function one potential consequence. Guo Nan Yinof the Inha University School of Medicine, Incheon, South Korea, and colleagues have identified a molecular pathway that can be targeted to reverse such damage. They determined that a protein called LRG1 acts on a receptor called ...
Source: Experimental and Molecular Medicine - May 13, 2022 Category: Molecular Biology Authors: Guo Nan Yin Do-Kyun Kim Ji In Kang Yebin Im Dong Sun Lee Ah-reum Han Jiyeon Ock Min-Ji Choi Mi-Hye Kwon Anita Limanjaya Saet-Byel Jung Jimin Yang Kwang Wook Min Jeongwon Yun Yongjun Koh Jong-Eun Park Daehee Hwang Jun-Kyu Suh Ji-Kan Ryu Ho Min Kim Source Type: research

< em > Sigesbeckia orientalis < /em > Extract Ameliorates the Experimental Diabetic Nephropathy by Downregulating the Inflammatory and Oxidative Stress Signaling Pathways
Evid Based Complement Alternat Med. 2022 Aug 5;2022:3323745. doi: 10.1155/2022/3323745. eCollection 2022.ABSTRACTDiabetes in children and its complications are on the rise globally, which is accompanied by increasing in diabetes-related complications. Oxidative stress and inflammation induced by elevated blood sugar in diabetic patients are considered risk factors associated with the development of diabetes complications, including chronic kidney disease and its later development to end-stage renal disease. Microvascular changes within the kidneys of DM patients often lead to chronic kidney disease, which aggravates the il...
Source: Evidence-based Complementary and Alternative Medicine - August 15, 2022 Category: Complementary Medicine Authors: Chung-Ming Chen Jer-Yiing Houng Tsui-Ling Ko Shu-Hui Juan Hsiu-Chu Chou Source Type: research

Berberine Reduces Renal Cell Pyroptosis in Golden Hamsters with Diabetic Nephropathy through the Nrf2-NLRP3-Caspase-1-GSDMD Pathway
CONCLUSION: DN golden hamster kidney NLRP3-Caspase-1-GSDMD signalling was enhanced. BBR can reduce oxidative stress damage by regulating antioxidative Nrf2 and then regulating NLRP3-Caspase-1-GSDMD signalling to inhibit pyroptosis, antagonizing DN inflammation-induced damage.PMID:35971382 | PMC:PMC9375700 | DOI:10.1155/2021/5545193
Source: Evidence-based Complementary and Alternative Medicine - August 16, 2022 Category: Complementary Medicine Authors: Baozhu Ding Songyan Geng Xiaojie Hou Xuelian Ma Huazhou Xu Fan Yang Kun Liu Wenjie Liang Guoping Ma Source Type: research