Filtered By:
Therapy: Cancer Therapy
This page shows you your search results in order of relevance. This is page number 11.
Order by Relevance | Date
Total 4168 results found since Jan 2013.
Predictors of Use of Complementary and Alternative Medicine by Non-Hodgkin Lymphoma Survivors and Relationship to Quality of Life
Conclusions. CAM use may be related to more positive mental health–related quality of life by increasing patients’ perception of perceived control over their health; however, cause and effect cannot be determined. Physicians should be aware that cancer survivors have a need to take an active role in improving their health.
Source: Integrative Cancer Therapies - April 18, 2013 Category: Cancer & Oncology Authors: Hamilton, A. S., Miller, M. F., Arora, N. K., Bellizzi, K. M., Rowland, J. H. Tags: Articles Source Type: research
Building a Personalized Medicine Infrastructure at a Major Cancer Center REVIEW ARTICLES
This article will focus on the challenges and opportunities that accompany the building of infrastructure for personalized cancer therapy.
Source: Journal of Clinical Oncology - May 17, 2013 Category: Cancer & Oncology Authors: Meric-Bernstam, Farhangfar, Mendelsohn, Mills Tags: REVIEW ARTICLES Source Type: research
A Systematic Review of Complementary and Alternative Medicine Interventions for the Management of Cancer-Related Fatigue
Fatigue, experienced by patients during and following cancer treatment, is a significant clinical problem. It is a prevalent and distressing symptom yet pharmacological interventions are used little and confer limited benefit for patients. However, many cancer patients use some form of complementary and alternative medicine (CAM), and some evidence suggests it may relieve fatigue. A systematic review was conducted to appraise the effectiveness of CAM interventions in ameliorating cancer-related fatigue. Systematic searches of biomedical, nursing, and specialist CAM databases were conducted, including Medline, Embase, and A...
Source: Integrative Cancer Therapies - June 13, 2013 Category: Cancer & Oncology Authors: Finnegan-John, J., Molassiotis, A., Richardson, A., Ream, E. Tags: Articles Source Type: research
Roadblocks to translational advances on metastasis research
Nature Medicine 19, 1104 (2013).
doi:10.1038/nm.3327
Authors: Thomas Brabletz, David Lyden, Patricia S Steeg & Zena Werb
Promising advances in cancer therapy stemming from an increasing understanding of the molecular and genetic underpinnings of the tumorigenic process have been fueled by a strong, determined scientific community, influential patient advocacy groups and committed funding bodies. Despite these efforts, the development of effective drugs to prevent systemic dissemination of cancer cells or to eliminate overt metastasis in secondary organs remains a challenge to both researchers and physicians. In...
Source: Nature Medicine - September 6, 2013 Category: Journals (General) Authors: Thomas BrabletzDavid LydenPatricia S SteegZena Werb Tags: Commentary Source Type: research
Radiolabelled probes targeting tumor hypoxia for personalized medicine.
Abstract
Hypoxia is a characteristic feature of many solid tumors which has been described in a wide range of tumor types. Its presence impairs the effectiveness of common anti-cancer therapies and accordingly, invasive measurement of tumor hypoxia has been associated with an aggressive tumor phenotype, poor response to radio- and chemotherapy, and worse prognosis. In order to predict outcome and identify patients with a worse prognosis and/or patients that would benefit from appropriate treatments, in vivo measurement of tumor hypoxia is required. Given the difficulties associated with invasive methods, a non-inv...
Source: Current Pharmaceutical Design - September 11, 2013 Category: Drugs & Pharmacology Authors: Mees G, Sathekge M, Maes A, Yves D'Asseler EY, Wiele CV Tags: Curr Pharm Des Source Type: research
Systems medicine paves the way for improved treatment for leukemia patients
A multi-disciplinary team of researchers at the Institute for Molecular Medicine Finland, FIMM, and the Helsinki University Central Hospital has developed a novel individualized systems medicine (ISM) strategy which enables selection of potentially effective cancer therapies for individual patients. Furthermore, this strategy helps in understanding and predicting drug resistance and may pave a path for individualized optimization of patient therapies in the clinic for various types of cancers.
Source: Health News from Medical News Today - December 16, 2013 Category: Consumer Health News Tags: Lymphoma / Leukemia / Myeloma Source Type: news
Avatars of personalized cancer therapy can lead to a reduction in head and neck cancer survival disparities
Personalized Medicine May 2014, Vol. 11, No. 3, Pages 243-246.
Source: Future Medicine: Personalized Medicine - June 17, 2014 Category: Genetics & Stem Cells Tags: article Source Type: research
Personalized cancer therapy for stage IV non-small cell lung cancer: Combined use of active hexose correlated compound and genistein concentrated polysaccharide
Conclusions AHCC and GCP resulted in increased patient survival time, better QOL, and reduced adverse effects related to cancer chemotherapy.
Source: Personalized Medicine Universe - November 6, 2014 Category: Drugs & Pharmacology Source Type: research
Abstract 3565: Ultra-sensitive multiplex analysis of somatic mutations in plasma DNA by InsightTM Onco mutant enrichment parallel sequencing for cancer personalized medicine
In conclusion, the InsightTM Onco Panel provides a reliable direction for non-invasive validation of acquired resistance to cancer therapy as well as mutant characterization for drug discovery and development.
Citation Format: Deokhwe Hur, Minsik Song, Jinwook Jung, Heekyung Park. Ultra-sensitive multiplex analysis of somatic mutations in plasma DNA by InsightTM Onco mutant enrichment parallel sequencing for cancer personalized medicine. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Hur, D., Song, M., Jung, J., Park, H. Tags: Molecular and Cellular Biology Source Type: research
Plasma-activated medium induced A549 cell injury by a spiral apoptotic cascade involving the mitochondrial-nuclear network.
The objective of this study was to demonstrate the inhibitory effects of PAM on A549 cell survival and elucidate the signaling mechanisms responsible for cell death. PAM maintained its ability to suppress cell viability for at least 1 week when stored at -80°C. The severity of PAM-triggered cell injury depended on the kind of culture medium used to prepare PAM, especially that with or without pyruvate. Hydrogen peroxide (H2O2) and/or its derived or cooperating reactive oxygen species reduced the mitochondrial membrane potential, down-regulated the expression of the anti-apoptotic protein Bcl2, activated poly(ADP-ribose) p...
Source: Free Radical Biology and Medicine - November 26, 2014 Category: Biology Authors: Adachi T, Tanaka H, Nonomura S, Hara H, Kondo SI, Hori M Tags: Free Radic Biol Med Source Type: research
A Chinese Medicine Formula Gegen Qinlian Decoction Suppresses Expansion of Human Renal Carcinoma With Inhibition of Matrix Metalloproteinase-2
Conclusion. The findings of this study provide experimental evidence of the inhibition of expansion and neoangiogenesis of renal carcinoma by Chinese medicine formula GQLD with involvement of MMP-2 suppression.
Source: Integrative Cancer Therapies - December 10, 2014 Category: Cancer & Oncology Authors: Wang, N., Feng, Y., Cheung, F., Wang, X., Zhang, Z., Feng, Y. Tags: Articles Source Type: research
Keeping the Kraken asleep
(University of Veterinary Medicine -- Vienna) Despite enormous progress in cancer therapy, many patients still relapse because their treatment addresses the symptoms of the disease rather than the cause, the so-called stem cells. Work in the group of Veronika Sexl at the University of Veterinary Medicine, Vienna has given a tantalizing clue to a solution. In the current issue of Blood, the scientists report that the cell-cycle kinase CDK6 is required for activation of the stem cells responsible for causing leukemia.
Source: EurekAlert! - Medicine and Health - January 27, 2015 Category: Global & Universal Source Type: news
Traditional Herbal Medicine as Adjunctive Therapy for Nasopharyngeal Cancer: A Systematic Review and Meta-Analysis
The effectiveness of traditional herbal medicine (THM) as treatment for nasopharyngeal cancer (NPC) has not been clearly demonstrated. The aim of this study is to assess the effectiveness of THM as adjunctive therapies for NPC using the results of randomized controlled trials (RCTs). Five electronic databases, including English and Chinese databases, were systematically searched up to February 2014. All RCTs involving traditional herbal medicine in combination with conventional cancer therapy for NPC were included. Twenty-two RCTs involving 2,298 NPC patients were systematically reviewed. Of these 22 studies, 15 on 1482 pa...
Source: Integrative Cancer Therapies - April 13, 2015 Category: Cancer & Oncology Authors: Kim, W., Lee, W.-B., Lee, J., Min, B.-I., Lee, H., Cho, S.-H. Tags: Articles Source Type: research
ZEB1‐associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat
Abstract
Therapy resistance is a major clinical problem in cancer medicine and crucial for disease relapse and progression. Therefore, the clinical need to overcome it, particularly for aggressive tumors such as pancreatic cancer, is very high. Aberrant activation of an epithelial–mesenchymal transition (EMT) and an associated cancer stem cell phenotype are considered a major cause of therapy resistance. Particularly, the EMT‐activator ZEB1 was shown to confer stemness and resistance. We applied a systematic, stepwise strategy to interfere with ZEB1 function, aiming to overcome drug resistance. This led to the identifi...
Source: EMBO Molecular Medicine - April 1, 2015 Category: Molecular Biology Authors: Simone Meidhof, Simone Brabletz, Waltraut Lehmann, Bogdan‐Tiberius Preca, Kerstin Mock, Manuel Ruh, Julia Schüler, Maria Berthold, Anika Weber, Ulrike Burk, Michael Lübbert, Martin Puhr, Zoran Culig, Ulrich Wellner, Tobias Keck, Peter Bronsert, Simon Tags: Research Article Source Type: research
Precision Medicine for Advanced Pancreas Cancer: The Individualized Molecular Pancreatic Cancer Therapy (IMPaCT) Trial.
CONCLUSIONS: Documenting the feasibility of acquiring and screening biospecimens for actionable molecular targets in real time will aid other groups embarking on similar trials. Key elements include the need to better prescreen patients, screen more patients, and offer more attractive clinical trial options. Clin Cancer Res; 21(9); 1-9. ©2015 AACR.
PMID: 25896973 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - April 20, 2015 Category: Cancer & Oncology Authors: Chantrill LA, Nagrial AM, Watson C, Johns AL, Martyn-Smith M, Simpson S, Mead S, Jones MD, Samra JS, Gill AJ, Watson N, Chin VT, Humphris JL, Chou A, Brown B, Morey A, Pajic M, Grimmond SM, Chang DK, Thomas D, Sebastian L, Sjoquist K, Yip S, Pavlakis N, A Tags: Clin Cancer Res Source Type: research
