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Total 4168 results found since Jan 2013.

Complementary and alternative medicine use in patients before and after a cancer diagnosis.
Conclusions: Use of cam, particularly biologic products, increased significantly after a cancer diagnosis. Further studies are required to examine the effect of cam use on the efficacy and safety of cancer therapies. PMID: 30111972 [PubMed - in process]
Source: Current Oncology - August 17, 2018 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Value of Supportive Care Pharmacogenomics in Oncology Practice
AbstractGenomic medicine provides opportunities to personalize cancer therapy for an individual patient. Although novel targeted therapies prolong survival, most patients with cancer continue to suffer from burdensome symptoms including pain, depression, neuropathy, nausea and vomiting, and infections, which significantly impair quality of life. Suboptimal management of these symptoms can negatively affect response to cancer treatment and overall prognosis. The effect of genetic variation on drug response—otherwise known as pharmacogenomics—is well documented and directly influences an individual patient's response to ...
Source: The Oncologist - August 17, 2018 Category: Cancer & Oncology Authors: Jai N. Patel, Lauren A. Wiebe, Henry M. Dunnenberger, Howard L. McLeod Tags: Symptom Management and Supportive Care, Precision Medicine Source Type: research

Promotion of Cell-Based Therapy: Special Focus on the Cooperation of Mesenchymal Stem Cell Therapy and Gene Therapy for Clinical Trial Studies.
In this study has been focused on genetically modified MSCs for use in RM with an emphasis on CTSs. We highlight the basic concept of genetic modifications and also discuss recent clinical studies aspects. Recently reviewed studies show that MSC therapy with assistant gene therapy can be used in cancer therapy, heart diseases, Fanconi anemia and several other diseases. PMID: 30155859 [PubMed - as supplied by publisher]
Source: Advances in Experimental Medicine and Biology - August 31, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

Using clinical genomic sequencing to guide personalized cancer therapy in China
Personalized Medicine, Ahead of Print.
Source: Future Medicine: Personalized Medicine - March 20, 2019 Category: Genetics & Stem Cells Authors: Yuxian Bai Guan Wang Jinwang Wei Chun Dai Xiaoman Xu Xin Cai Bing Wu Wending Sun Qiang Xu Shunchang Jiao Source Type: research

Precision Cardio-Oncology
Modern oncologic therapies and care have resulted in a growing population of cancer survivors with comorbid, chronic health conditions. As an example, many survivors have an increased risk of cardiovascular complications secondary to cardiotoxic systemic and radiation therapies. In response, the field of cardio-oncology has emerged as an integral component of oncologic patient care, committed to the early diagnosis and treatment of adverse cardiac events. However, as current clinical management of cancer therapy–related cardiovascular disease remains limited by a lack of phenotypic data, implementation of precision m...
Source: Journal of Nuclear Medicine - March 31, 2019 Category: Nuclear Medicine Authors: Dreyfuss, A. D., Bravo, P. E., Koumenis, C., Ky, B. Tags: The State of the Art Source Type: research

ARTIFICIAL CELL evolves into nanomedicine, biotherapeutics, blood substitutes, drug delivery, enzyme/gene therapy, cancer therapy, cell/stem cell therapy, nanoparticles, liposomes, bioencapsulation, replicating synthetic cells, cell encapsulation/scaffold, biosorbent/immunosorbent haemoperfusion/plasmapheresis, regenerative medicine, encapsulated microbe, nanobiotechnology, nanotechnology.
Authors: Chang TMS Abstract It is only in the last 20 years that many of the original ideas on artificial cells are being increasingly applied and extended by researchers around the world. Artificial cell has now evolved into nanomedicine, biotherapeutics, blood substitutes, drug delivery, enzyme/gene therapy, cancer therapy, cell/stem cell therapy, nanoparticles, liposomes, bioencapsulation, replicating synthetic cells, cell encapsulation/scaffold, biosorbent/immunosorbent haemoperfusion/plasmapheresis, regenerative medicine, encapsulated microbe, nanobiotechnology, nanotechnology and other areas. More futuristi...
Source: Artificial Cells, Nanomedicine and Biotechnology - April 5, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Molecular targets of β-elemene, a herbal extract used in traditional Chinese medicine, and its potential role in cancer therapy: A review
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Bingtao Zhai, Nana Zhang, Xuemeng Han, Qiujie Li, Mingming Zhang, Xiaying Chen, Guohua Li, Ruonan Zhang, Peng Chen, Wengang Wang, Chenxi Li, Yu Xiang, Shuiping Liu, Ting Duan, Jianshu Lou, Tian Xie, Xinbing SuiAbstractβ-Elemene is a sesquiterpene compound extracted from the herb Curcuma Rhizoma and is used in traditional Chinese medicine (TCM) to treat several types of cancer, with no reported severe adverse effects. Recent studies, using in vitro and in vivo studies combined with molecular methods, have shown that β-elemene can inhibi...
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

Reynoutria japonica from Traditional Chinese Medicine: A source of Competitive Adenosine Deaminase Inhibitors for Anticancer.
CONCLUSION: Emodin may represent a good candidate anti-cancer therapy and adenosine protective agent. PMID: 30987561 [PubMed - as supplied by publisher]
Source: Combinatorial Chemistry and High Throughput Screening - April 13, 2019 Category: Chemistry Authors: Zhang XG, Ma GY, Kou F, Liu WJ, Sun QY, Guo GJ, Ma XD, Guo SJ, Jian-Ning Z Tags: Comb Chem High Throughput Screen Source Type: research

Signaling Complexity Measured by Shannon Entropy and Its Application in Personalized Medicine
In this report, we explored data from human RNA-seq and protein–protein interaction (PPI) networks using bioinformatics to investigate the relationship between tumor entropy and aggressiveness. To compare PPI subnetworks of different sizes, we calculated the Shannon entropy associated with vertex connections of differentially expressed genes comparing tumor samples with their paired control tissues. We found that the inhibition of up-regulated connectivity hubs led to a higher reduction of subnetwork entropy compared to that obtained with the inhibition of targets selected at random. Furthermore, these hubs were describe...
Source: Frontiers in Genetics - October 20, 2019 Category: Genetics & Stem Cells Source Type: research

Molecular profiling for precision cancer therapies
We describe novel molecular characterization strategies beyond tumor DNA sequencing, such as transcriptomics, immunophenotyping, epigenetic profiling, and single-cell analyses. We also review current and potential applications of liquid biopsies to evaluate blood-based biomarkers, such as circulating tumor cells and circulating nucleic acids. Last, lessons learned from the existing limitations of genotype-derived therapies provide insights into ways to expand precision medicine beyond genomics.
Source: Genome Medicine - January 13, 2020 Category: Genetics & Stem Cells Source Type: research

Anticancer Effects of Herbal Medicine Compounds and Novel Formulations: a Literature Review
ConclusionConsidering side effects, toxicity, and higher costs of common cancer therapy approaches, application of novel herbal medicine-based therapies will confer promising insights for health outcomes.
Source: Journal of Gastrointestinal Cancer - March 4, 2020 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 12, Pages 1016: Epigenetic Research in Stem Cell Bioengineering —Anti-Cancer Therapy, Regenerative and Reconstructive Medicine in Human Clinical Trials
Cancers, Vol. 12, Pages 1016: Epigenetic Research in Stem Cell Bioengineering—Anti-Cancer Therapy, Regenerative and Reconstructive Medicine in Human Clinical Trials Cancers doi: 10.3390/cancers12041016 Authors: Claudia Dompe Krzysztof Janowicz Greg Hutchings Lisa Moncrieff Maurycy Jankowski Mariusz J. Nawrocki Małgorzata Józkowiak Paul Mozdziak Jim Petitte Jamil A. Shibli Marta Dyszkiewicz-Konwińska Małgorzata Bruska Hanna Piotrowska-Kempisty Bartosz Kempisty Michał Nowicki The epigenome denotes all the information related to gene expression that is not contained in the DNA sequen...
Source: Cancers - April 20, 2020 Category: Cancer & Oncology Authors: Claudia Dompe Krzysztof Janowicz Greg Hutchings Lisa Moncrieff Maurycy Jankowski Mariusz J. Nawrocki Ma łgorzata Józkowiak Paul Mozdziak Jim Petitte Jamil A. Shibli Marta Dyszkiewicz-Konwi ńska Ma łgorzata Bruska Hanna Piotrowska-Kempisty Bartosz Kemp Tags: Review Source Type: research

Guideline-recommended incorporation of biomarker testing results in metastatic colorectal cancer therapy
Personalized Medicine, Ahead of Print.
Source: Future Medicine: Personalized Medicine - April 23, 2020 Category: Genetics & Stem Cells Authors: Jared Freml Thomas Delate Jesus Hermosillo-Rodriguez Source Type: research

Molecules, Vol. 25, Pages 4632: Mitotic Poisons in Research and Medicine
ová Cancer is one of the greatest challenges of the modern medicine. Although much effort has been made in the development of novel cancer therapeutics, it still remains one of the most common causes of human death in the world, mainly in low and middle-income countries. According to the World Health Organization (WHO), cancer treatment services are not available in more then 70% of low-income countries (90% of high-income countries have them available), and also approximately 70% of cancer deaths are reported in low-income countries. Various approaches on how to combat cancer diseases have since been described, targe...
Source: Molecules - October 12, 2020 Category: Chemistry Authors: Jan Škubník Michal Jur ášek Tom áš Ruml Silvie Rimpelov á Tags: Review Source Type: research

Unlocking the Mystery of the Therapeutic Effects of Chinese Medicine on Cancer
Over the past decade, the rise of cancer immunotherapy has coincided with a remarkable breakthrough in cancer therapy, which attracted increased interests in public. The scientific community clearly showed that the emergence of immunotherapy is an inevitable outcome of a holistic approach for cancer treatment. It is well established that traditional Chinese medicine (TCM) utilizes the principle of homeostasis and balance to adjust the healthy status of body. TCM treatment toward cancer has a long history, and the diagnosis and treatment of tumors were discussed in the ancient and classical literatures of Chinese medicine, ...
Source: Frontiers in Pharmacology - January 15, 2021 Category: Drugs & Pharmacology Source Type: research