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Total 4168 results found since Jan 2013.
Research Status and Molecular Mechanism of the Traditional Chinese Medicine and Antitumor Therapy Combined Strategy Based on Tumor Microenvironment
This article summarizes the existing research on the molecular mechanism of TCM regulation of the TME and provides a theoretical basis for further screening of the predominant population. Moreover, it predicts the effects of the combination of TCM and antitumor therapy and proposes further developments in clinical practice to optimize the combined strategy.
Source: Frontiers in Immunology - January 21, 2021 Category: Allergy & Immunology Source Type: research
Genetically-Modified Stem Cell in Regenerative Medicine and Cancer Therapy; A New Era
Curr Gene Ther. 2021 Jul 7. doi: 10.2174/1566523221666210707125342. Online ahead of print.ABSTRACTRecently, genetic engineering by various strategies to stimulate gene expression in a specific and controllable mode is a speedily growing therapeutic approach. Genetic modification of human stem or progenitor cells, such as embryonic stem cells (ESCs), neural progenitor cells (NPCs), mesenchymal stem/stromal cells (MSCs), and hematopoietic stem cells (HSCs) for direct delivery of specific therapeutic molecules or genes has been evidenced as an opportune plan in the context of regenerative medicine due to their supported viabi...
Source: Current Gene Therapy - July 9, 2021 Category: Genetics & Stem Cells Authors: Ali Hassanzadeh Somayeh Shamlou Niloufar Yousefi Marzieh Nikoo Javad Verdi Source Type: research
Intuitive repositioning of an anti-depressant drug in combination with tivozanib: precision medicine for breast cancer therapy
Mol Cell Biochem. 2021 Jul 29. doi: 10.1007/s11010-021-04230-1. Online ahead of print.ABSTRACTDespite the existing therapies and lack of receptors such as HER-2, estrogen receptor and progesterone receptor, triple-negative breast cancer is one of the most aggressive subtypes of breast cancer. TNBCs are known for their highly aggressive metastatic behavior and typically migrate to brain and bone for secondary site propagation. Many diseases share similar molecular pathology exposing new avenues in molecular signaling for engendering innovative therapies. Generation of newer therapies and novel drugs are time consuming assoc...
Source: Molecular and Cellular Biochemistry - July 29, 2021 Category: Biochemistry Authors: Naveen Kumar Masoom Raza Seema Sehrawat Source Type: research
The emerging roles of NGS in clinical oncology and personalized medicine
Pathol Res Pract. 2022 Jan 10;230:153760. doi: 10.1016/j.prp.2022.153760. Online ahead of print.ABSTRACTNext-generation sequencing (NGS) has been increasingly popular in genomics studies over the last decade, as new sequencing technology has been created and improved. Recently, NGS started to be used in clinical oncology to improve cancer therapy through diverse modalities ranging from finding novel and rare cancer mutations, discovering cancer mutation carriers to reaching specific therapeutic approaches known as personalized medicine (PM). PM has the potential to minimize medical expenses by shifting the current traditio...
Source: Pathology, Research and Practice - January 16, 2022 Category: Pathology Authors: Bashdar Mahmud Hussen Sara Tharwat Abdullah Abbas Salihi Dana Khdr Sabir Karzan R Sidiq Mohammed Fatih Rasul Hazha Jamal Hidayat Soudeh Ghafouri-Fard Mohammad Taheri Elena Jamali Source Type: research
Chinese Herbal Medicine for Primary Liver Cancer Therapy: Perspectives and Challenges
Conclusion: This review provides a deeper the understanding of CHMs as PLC treatments and provides ideas for the development of new natural drugs against PLC.
Source: Frontiers in Pharmacology - May 5, 2022 Category: Drugs & Pharmacology Source Type: research
Current Status of PSMA-Targeted Radioligand Therapy in the Era of Radiopharmaceutical Therapy Acquiring Marketing Authorization
AbstractProstate-specific membrane antigen (PSMA) is highly expressed in PCa, which gradually increases in high-grade tumors, metastatic tumors, and tumors nonresponsive to androgen deprivation therapy. PSMA has been a topic of interest during the past decade for both diagnostic and therapeutic targets. Radioligand therapy (RLT) utilizes the delivery of radioactive nuclides to tumors and tumor-associated targets, and it has shown better efficacy with minimal toxicity compared to other systemic cancer therapies. Nuclear medicine has faced a new turning point claiming theranosis as the core of academic identity, since new RL...
Source: Nuclear Medicine and Molecular Imaging - August 20, 2022 Category: Nuclear Medicine Source Type: research
Correction to: Nuclear medicine in the assessment and prevention of cancer therapy ‑related cardiotoxicity: prospects and proposal of use by the European Association of Nuclear Medicine (EANM)
Eur J Nucl Med Mol Imaging. 2022 Nov 21. doi: 10.1007/s00259-022-06039-6. Online ahead of print.NO ABSTRACTPMID:36409318 | DOI:10.1007/s00259-022-06039-6
Source: Molecular Medicine - November 21, 2022 Category: Molecular Biology Authors: Matthias Totzeck Nicolas Aide Johann Bauersachs Jan Bucerius Panagiotis Georgoulias Ken Herrmann Fabien Hyafil Jolanta Kunikowska Mark Lubberink Carmela Nappi Tienush Rassaf Antti Saraste Roberto Sciagra Riemer H J A Slart Hein Verberne Christoph Rischple Source Type: research
