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Effects of teneligliptin on PDMPs and PAI-1 in patients with diabetes on hemodialysis
Conclusion: By modulating PDMPs or PAI-1, teneligliptin shows an antiatherothrombotic effect that may be beneficial in the primary prevention of CVD in patients with T2DM on HD.Keywords: type 2 diabetes mellitus, teneligliptin, hemodialysis, PDMP, PAI-1 
Source: International Journal of General Medicine - April 12, 2016 Category: Journals (General) Tags: International Journal of General Medicine Source Type: research

Differences in genotype frequencies of salt-sensitive genes between fishing and nonfishing communities in Japan
Conclusion: The incidence of the salt-sensitive genotypes AGT and AT1 in residents of FCs were significantly lower than in NFCs.Keywords: salt-sensitive, hypertension, single-nucleotide polymorphisms, regional difference, lifestyle, behavior 
Source: International Journal of General Medicine - April 12, 2016 Category: Journals (General) Tags: International Journal of General Medicine Source Type: research

June blogs digest: irritable bowel syndrome, regenerative medicine, single cell omics, and more
Overcoming irritable bowel syndrome The various mysteries about the nature and causes of irritable bowel syndrome are particularly frustrating for patients who experience it, as well as for those who try to treat it. Following the Digestive Disease Week conference which took place in San Diego from 21-24 May, Shanti Eswaran explained more about the work she presented on a diet found to improve symptoms of irritable bowel syndrome. Regenerative medicine in China: when myth meets reality Burns & Trauma has recently started a thematic series titled ‘Trauma regeneration’ introducing the latest developments of rege...
Source: BioMed Central Blog - July 6, 2016 Category: Journals (General) Authors: Sophie Marchant Tags: Biology Health Medicine blogs digest Source Type: blogs

Precision Medicine in Myelodysplastic Syndromes and Leukemias: Lessons from Sequential Mutations.
Abstract Precision medicine can be simply defined as the identification of personalized treatment that matches patient-specific clinical and genomic characteristics. Since the completion of the Human Genome Project in 2003, significant advances have been made in our understanding of the genetic makeup of diseases, especially cancers. The identification of somatic mutations that can drive cancer has led to the development of therapies that specifically target the abnormal proteins derived from these mutations. This has led to a paradigm shift in our treatment methodology. Although some success has been achieved in ...
Source: Annual Review of Medicine - September 6, 2016 Category: Journals (General) Authors: Nazha A, Sekeres MA Tags: Annu Rev Med Source Type: research

Ensuring a Secure Environment for Participatory Medicine
Keith Mattox Keith Mattox is Security and Privacy Program Manager at Citrix. Prior to joining Citrix, Keith was Senior Compliance Officer at Hewlett Packard Enterprise. He has 14+ years in compliance and information security. Previous positions include Senior Security Consultant at CTG and Information Security Manager at RBC Bank. Keith joined the Society for Participatory Medicine in 2016.     Unlike many members of Society for Participatory Medicine (S4PM) who have championed collaborative technology to improve patient outcomes and treatment for years, I am a relatively new proponent. Indeed, my experience in h...
Source: Society for Participatory Medicine - October 11, 2016 Category: Journals (General) Authors: Nanette Mattox Tags: Newsletter compliance EHRs Health Information Technology Himss Hipaa patients records privacy security Source Type: news

Noninvasive Prenatal DNA Testing: The Vanguard of Genomic Medicine.
Abstract Noninvasive prenatal DNA testing is the vanguard of genomic medicine. In only four years, this screening test has revolutionized prenatal care globally and opened up new prospects for personalized medicine for the fetus. There are widespread implications for increasing the scope of human genetic variation that can be detected before birth, and for discovering more about materno-fetal and placental biology. These include an urgent need to develop pretest education for all pregnant women and consistent posttest management recommendations for those with discordant test results. The reduction in invasive test...
Source: Annual Review of Medicine - October 9, 2016 Category: Journals (General) Authors: Hui L, Bianchi DW Tags: Annu Rev Med Source Type: research

Patient, Doctor, and the Data: Emergence of the Third Player
Amith Vikramr The conventional model of medicine had only two players. The doctor alone had access to all medical information and his encounter with the patient was the only way to obtain health-related information. The dawn of the information age led to a change in the dynamics in this relationship. A consumerist model of healthcare has emerged where doctors partner with patients in managing the patient’s illness. The advances in systems biology, big data and consumer health care electronics will add patient data as a new element to the patient-physician interface. In the next decade, individual patients will generate ...
Source: Society for Participatory Medicine - December 6, 2016 Category: Journals (General) Authors: Nanette Mattox Tags: Newsletter e-patient movement empowered patient Moral Injury participatory medicine Patient Participation Source Type: news

Physical medicine modalities most frequently applied in the lower limbs chronic wounds treatment in Poland
Conclusions Variable magnetic fields, low-level laser therapy and hyperbaric oxygen therapy are modalities revealing various working mechanisms. The significance of their administration in chronic wounds treatment can be attributed to a variety of their biological effects.
Source: Polish Annals of Medicine - January 12, 2017 Category: Journals (General) Source Type: research

Difficult Doctors, Difficult Patients: a Comic for Empathy-Building
People usually don’t have courses in school on empathy: how to be compassionate towards each other. There are some professions, however, where empathy is part of the formal learning process — with health care professionals leading the way, learning how to listen and how to consider the patient’s perspective. This is critical for any context in which doctors and patients need to communicate, but even more so when they seek to collaborate. But don’t doctors and nurses deserve empathy, too? At the University of Michigan, this was the question we faced: How could we help patients and clinicians find a way towards e...
Source: Society for Participatory Medicine - February 14, 2017 Category: Journals (General) Authors: Nanette Mattox Tags: Newsletter bibliotherapy clinician education comics in education consumer health information doctor-patient relations communication Graphic medicine informed consent Patient Communication pictorial work Source Type: news

Screening for psychological distress among High School Graduates Accepted for Enrollment at Alexandria Faculty of Medicine: Academic year 2016/2017
Conclusion Nearly half of the prospective medical students might have some sort of psychological distress before starting their study in the Faculty of Medicine. They should be investigated to verify diagnosis and start intervention to minimize its adverse effects on academic performance and advancement at the faculty. Stress management courses should be considered for all medical students.
Source: Alexandria Journal of Medicine - June 4, 2017 Category: General Medicine Source Type: research

Patient, Doctor, and the Data: Emergence of the Third Player
The conventional model of medicine had only two players. The doctor alone had access to all medical information and his encounter with the patient was the only way to obtain health-related information. The dawn of the information age led to a change in the dynamics in this relationship. A consumerist model of healthcare has emerged where doctors partner with patients in managing the patient’s illness. The advances in systems biology, big data and consumer health care electronics will add patient data as a new element to the patient-physician interface. In the next decade, individual patients will generate billions of da...
Source: Society for Participatory Medicine - December 6, 2016 Category: General Medicine Authors: Nanette Mattox Tags: Newsletter e-patient movement empowered patient Moral Injury participatory medicine Patient Participation Source Type: news

From Evidence Based Medicine to Medicine Based Evidence
• Medicine based evidence starts with a longitudinal profile of the biological, clinical, psychological, and social environmental history of a single index patient.• Profiles that approximately match the index patient provide the comparative empirical base for management of the index case.• Th e evidential core of medicine based evidence, the approximate matches to an index case, is focused on the needs of clinical practice and sharply at odds with evidence based medicine.
Source: The American Journal of Medicine - July 12, 2017 Category: General Medicine Authors: Ralph I. Horwitz, Allison Hayes-Conroy, Roberto Caricchio, Burton H. Singer Tags: Review Source Type: research

Precision Medicine: Functional Advancements.
Abstract Precision medicine was conceptualized on the strength of genomic sequence analysis. High-throughput functional metrics have enhanced sequence interpretation and clinical precision. These technologies include metabolomics, magnetic resonance imaging, and I rhythm (cardiac monitoring), among others. These technologies are discussed and placed in clinical context for the medical specialties of internal medicine, pediatrics, obstetrics, and gynecology. Publications in these fields support the concept of a higher level of precision in identifying disease risk. Precise disease risk identification has the potent...
Source: Annual Review of Medicine - December 20, 2017 Category: General Medicine Authors: Caskey T Tags: Annu Rev Med Source Type: research

Therapeutic effects of acupuncture with MOK, a polyherbal medicine, on PTU-induced hypothyroidism in rats.
Authors: Hwang JH, Jung HW, Kang SY, Kang AN, Ma JN, Meng XL, Hwang MS, Park YK Abstract Acupuncture with MOK, a polyherbal medicine (MOK pharmacopuncture), has been used for the treatment of thyroid syndromes including hypothyroidism and hyperthyroidism in traditional Korean medicine. The present study investigated the effect of MOK pharmacopuncture on hypothyroidism and the mechanism underlying its antioxidation and immune regulation effects. Hypothyroidism was induced in Sprague-Dawley rats by subcutaneous injection of Propylthiouracil (PTU; 10 mg/kg) once daily for 4 weeks. MOK was administered by acupuncture o...
Source: Experimental and Therapeutic Medicine - June 15, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Screening for psychological distress among High School Graduates Accepted for Enrollment at Alexandria Faculty of Medicine: Academic year 2016/2017
ConclusionNearly half of the prospective medical students might have some sort of psychological distress before starting their study in the Faculty of Medicine. They should be investigated to verify diagnosis and start intervention to minimize its adverse effects on academic performance and advancement at the faculty. Stress management courses should be considered for all medical students.
Source: Alexandria Journal of Medicine - July 5, 2018 Category: General Medicine Source Type: research