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Total 6886 results found since Jan 2013.

60 Years of Achievements by KSNM in Neuroimaging Research
Nucl Med Mol Imaging. 2022 Feb;56(1):3-16. doi: 10.1007/s13139-021-00727-1. Epub 2022 Jan 15.ABSTRACTNuclear medicine neuroimaging is able to show functional and molecular biologic abnormalities in various neuropsychiatric diseases. Therefore, it has played important roles in the clinical diagnosis and in research on the normal and pathological states of the brain. More than 400 outstanding studies have been conducted by Korean researchers over the past 60 years. In the 1990s, when multiheaded single-photon emission computed tomography (SPECT) scanners were first introduced in South Korea, stroke research using brain perfu...
Source: Molecular Medicine - February 21, 2022 Category: Molecular Biology Authors: Jae Seung Kim Hye Joo Son Minyoung Oh Dong Yun Lee Hae Won Kim Jungsu Oh Source Type: research

Deep learning –based denoising of low-dose SPECT myocardial perfusion images: quantitative assessment and clinical performance
ConclusionThe noise was effectively suppressed by the proposed network, and the predicted standard-dose images were comparable to reference standard-dose images at half- and quarter-dose levels. However, recovery of the underlying signals/information in low-dose images beyond a quarter of the standard dose would not be feasible (due to very poor signal-to-noise ratio) which will adversely affect the clinical interpretation of the resulting images.
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 23, 2022 Category: Nuclear Medicine Source Type: research

Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging
The development of new radiotracers for PET and SPECT is central to addressing unmet diagnostic needs related to systemwide trends toward molecular characterization and personalized therapies in cardiovascular medicine. In the following 2-part review, we discuss select emerging radiotracers that may help address important unmet diagnostic needs in central areas of cardiovascular medicine, such as heart failure, arrhythmias, valvular disease, atherosclerosis, and thrombosis. Part 1 examines key technical considerations pertaining to cardiovascular radiotracer development and reviews emerging radiotracers for perfusion and n...
Source: Journal of Nuclear Medicine - April 28, 2022 Category: Nuclear Medicine Authors: Stendahl, J. C., Kwan, J. M., Pucar, D., Sadeghi, M. M. Tags: Continuing Education Source Type: research

Current status of nuclear cardiology practice in Latin America and the Caribbean, in the era of multimodality cardiac imaging approach: 2022 update
Cardiovascular diseases (CVDs) are the leading cause of mortality in Latin America and the Caribbean (LAC), with the risk in men being slightly higher than in women. The coronavirus disease 2019 (COVID-19) pandemic caused a significant reduction in the number of cardiac diagnostic procedures globally and in particular in LAC. Nuclear cardiology is available in the region, but there is variability in terms of existing technology, radiopharmaceuticals, and human resources. In the region, there are 2385 single photon emission computed tomography (SPECT) and 315 PET scanners, Argentina and Brazil have the largest number. There...
Source: Nuclear Medicine Communications - November 10, 2022 Category: Nuclear Medicine Tags: Review article Source Type: research

Perfusion in vivo bioreactor promotes regeneration of vascularized tissue-engineered bone
Regenerative Medicine, Ahead of Print.
Source: Future Medicine: Regenerative Medicine - August 17, 2023 Category: Genetics & Stem Cells Authors: Peng Liu Jian Wang Yun Xue Lei Zou Yongzheng Tian Ruilong Sun Wenhua Zhang Yunfei Li Lijun Lv Qiuming Gao Bo Fan Source Type: research

Hyperlactatemia caused by intra-venous administration of glycerol: A case study
Shinshu Katayama, Shin Nunomiya, Masahiko Wada, Kazuhide Misawa, Shinichiro Tanaka, Kansuke Koyama, Toshitaka KoinumaIndian Journal of Critical Care Medicine 2012 16(4):241-244Glyceol® is an intracranial pressure reducing agent composed of 5% fructose and concentrated glycerol. Although rapid administration of fructose is known to cause lactic acidosis, little is known about hyperlactatemia caused by Glyceol® administration itself in adults. We observed an adult case of hyperlactatemia occurred after administration of 200 mL of Glyceol® over a period of 30 minutes. Since there was...
Source: Indian Journal of Critical Care Medicine - January 25, 2013 Category: Intensive Care Authors: Shinshu KatayamaShin NunomiyaMasahiko WadaKazuhide MisawaShinichiro TanakaKansuke KoyamaToshitaka Koinuma Source Type: research

Multimodal Optical, X-ray CT, and SPECT Imaging of a Mouse Model of Breast Cancer Lung Metastasis.
Abstract Tumor heterogeneity is recognized as a major issue within clinical oncology, and the concept of personalized molecular medicine is emerging as a means to mitigate this problem. Given the vast number of cancer types and subtypes, robust pre-clinical models of cancer must be studied to interrogate the molecular mechanisms involved in each scenario. In particular, mouse models of tumor metastasis are of critical importance for pre-clinical cancer research at the cancer cell molecular level. In many of these experimental systems, tumor cells are injected intravenously, and the distribution and proliferation o...
Source: Current Molecular Medicine - January 15, 2013 Category: Molecular Biology Authors: Davison CA, Chapman SE, Sasser TA, Wathen C, Diener J, Schafer ZT, Leevy WM Tags: Curr Mol Med Source Type: research

Novel applications of contrast-enhanced ultrasound imaging in vascular medicine.
Abstract The use of contrast-enhanced ultrasound (CEUS) for vascular imaging indications has increased dramatically during the last decade. Ultrasound contrast agents are gas-filled microbubbles that are injected into the bloodstream and serve as strict intravascular reflectors of ultrasound waves. Numerous studies have addressed the potential clinical use of CEUS in different vascular fields including the carotid arteries, the abdominal aorta, renal arteries and the kidneys. In this review article we discuss the clinical value of contrast agents in vascular ultrasound by enhancing the vascular lumen, and more imp...
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - January 1, 2013 Category: Surgery Authors: Staub D, Partovi S, Imfeld S, Uthoff H, Baldi T, Aschwanden M, Jaeger K Tags: Vasa Source Type: research

Letter from the Editors: Radionuclide Imaging in Acute Care
It has been a decade since we last devoted an issue of Seminars to the subject of the role of Nuclear Medicine in acute care. Many of the clinical areas discussed then remain relatively similar but they have benefited from enhanced knowledge and experience. It is important to keep in mind that several of these areas of acute care radionuclide procedures represent a considerable portion of our daily routine practice and have evolved into standard of care studies. These include hepatobiliary scintigraphy for acute cholecystitis, gastrointestinal bleeding studies, ventilation-perfusion lung imaging for pulmonary embolism and ...
Source: Seminars in Nuclear Medicine - February 18, 2013 Category: Radiology Authors: Leonard M. Freeman, M. Donald Blaufox Source Type: research

Pediatric Nuclear Medicine in Acute Care
This article focuses on the common applications used on a pediatric patient in acute care. To confirm the clinical diagnosis of brain death, brain scintigraphy is considered accurate and has been favorably compared with other methods of detecting the presence or absence of cerebral blood flow. Ventilation-perfusion lung scans are easy and safe to perform with less radiation exposure than computed tomography pulmonary angiography and remain an appropriate procedure to perform on children with suspected pulmonary embolism as a first imaging test in a hemodynamically stable patient with no history of lung disease and normal c...
Source: Seminars in Nuclear Medicine - February 18, 2013 Category: Radiology Authors: Amer Shammas, Reza Vali, Martin Charron Source Type: research

Critical Role for the Advanced Glycation End-Products Receptor in Pulmonary Arterial Hypertension Etiology Vascular Medicine
Conclusion We have demonstrated the implications of RAGE in PAH etiology. Thus, RAGE constitutes a new attractive therapeutic target for PAH.
Source: JAHA:Journal of the American Heart Association - January 16, 2013 Category: Cardiology Authors: Meloche, J., Courchesne, A., Barrier, M., Carter, S., Bisserier, M., Paulin, R., Lauzon-Joset, J.-F., Breuils-Bonnet, S., Tremblay, E., Biardel, S., Racine, C., Courture, C., Bonnet, P., Majka, S. M., Deshaies, Y., Picard, F., Provencher, S., Bonnet, S. Tags: Vascular Medicine Source Type: research

Nuclear Medicine Enables Earlier COPD Diagnosis
In vivo ventilation/perfusion (V/Q) imaging can detect early changes to the lung caused by cigarette smoke exposure and provides a noninvasive method for studying lung dysfunction in preclinical models, according to research published in the April issue of The Journal of Nuclear Medicine. These measures have the potential to be applied clinically to study and diagnose the early stages of chronic obstructive pulmonary disease (COPD). COPD is a slow-progressing, debilitating lung disease which is commonly caused by cigarette smoking...
Source: Health News from Medical News Today - April 3, 2013 Category: Consumer Health News Tags: COPD Source Type: news

The role of hemorheological factors in cardiovascular medicine.
Abstract Cardiovascular diseases (CVD) are the most frequent cause of death throughout the world. The coronary vessel system is a special part of the circulation since there is a continuous change in blood flow, perfusion pressure and shear rate during each cardiac cycle. It is also the place of the narrowest capillaries in the human body, therefore the role of rheological alterations may be of greater importance than in the other parts of the circulatory system. During the past decades, our group has investigated hemorheological parameters (HP) in over 1,000 patients diagnosed with various forms of ischemic heart...
Source: Clinical Hemorheology and Microcirculation - February 27, 2013 Category: Hematology Authors: Toth A, Papp J, Rabai M, Kenyeres P, Marton Z, Kesmarky G, Juricskay I, Meiselman HJ, Toth K Tags: Clin Hemorheol Microcirc Source Type: research

Terlipressin with Limited Fluid Resuscitation in a Swine Model of Hemorrhage
Conclusion: Subjects receiving 7.5 μg/kg of TP demonstrated improved MAP within 10 min of administration. When combined with minimal IVF resuscitation, TP doses between 3.75 and 15 μg/kg do not elevate lactate levels in hemorrhaged swine.
Source: The Journal of Emergency Medicine - April 22, 2013 Category: Emergency Medicine Authors: John J. Devlin, Sara S. DeVito, Lanny F. Littlejohn, Miguel A. Gutierrez, Gosia Nowak, José Henao, Anthony Bielawski, Joseph Kotora, Andrew S. Johnson Tags: Pharmacology in Emergency Medicine Source Type: research