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Vasculogenic Conditioning of Peripheral Blood Mononuclear Cells Promotes Endothelial Progenitor Cell Expansion and Phenotype Transition of Anti-Inflammatory Macrophage and T Lymphocyte to Cells With Regenerative Potential Vascular Medicine
Conclusions QQ culture potentiates the ability of PBMNCs to promote regeneration of injured tissue; considering the feasible cell preparation, QQ culture-treated PBMNCs may provide a promising therapeutic option for ischemic diseases. Clinical Trial Registration URL: irb.med.u-tokai.ac.jp/d/2/monthly/2010.html; IRB No.: 10R-020. URL: irb.med.u-tokai.ac.jp/d/2/monthly/201312.html; IRB No.: 13R228.
Source: JAHA:Journal of the American Heart Association - June 25, 2014 Category: Cardiology Authors: Masuda, H., Tanaka, R., Fujimura, S., Ishikawa, M., Akimaru, H., Shizuno, T., Sato, A., Okada, Y., Iida, Y., Itoh, J., Itoh, Y., Kamiguchi, H., Kawamoto, A., Asahara, T. Tags: Vascular Medicine Source Type: research

D-Dimer Concentrations in Dogs with Pulmonary Embolism
The incidence of pulmonary embolism in dogs is unknown. Clinical signs are not specific for pulmonary embolism and mimic signs of other cardiopulmonary diseases. However, it has been reported in dogs and associated with immune-mediated hemolytic anemia, sepsis, neoplasia, protein-losing nephropathies, hyperadrenocorticism, and cardiac diseases. Pulmonary embolism is suspected in patients that develop respiratory difficulty in which no primary cardiac or respiratory disease can be confirmed and with concurrent diseases predisposing to thromboembolic complications. Antemortem confirmation of pulmonary embolism is rarely done...
Source: Advances in Small Animal Medicine and Surgery - July 1, 2014 Category: Veterinary Research Tags: Respiratory Medicine Source Type: research

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis or Fn14 Deficiency Reduce Elastase Perfusion-Induced Aortic Abdominal Aneurysm in Mice Vascular Medicine
Conclusions TWEAK/Fn14 axis participates in AAA formation by promoting lesion inflammatory cell accumulation, angiogenesis, matrix-degrading protease expression, and vascular remodeling. Blocking TWEAK/Fn14 interaction could be a new target for the treatment of AAA.
Source: JAHA:Journal of the American Heart Association - August 4, 2014 Category: Cardiology Authors: Tarin, C., Fernandez-Laso, V., Sastre, C., Madrigal-Matute, J., Gomez, M., Zaragoza, C., Egido, J., Burkly, L. C., Martin-Ventura, J. L., Blanco-Colio, L. M. Tags: Vascular Medicine Source Type: research

Variations in energy metabolism along the pericardium meridian and its relationship with visceral function adjustments during electroacupuncture
Background: Electroacupuncture (EA) is a traditional Chinese medicine treatment guided by meridian theory. As it gradually gains more worldwide acceptance, a clarification of its mechanisms is extremely urgent. We observed variations in transcutaneous oxygen pressure/carbon dioxide pressure (tcpO2/tcpCO2) and microcirculation blood perfusion units (BPU) along the pericardium meridian, and cardiac function during EA at Neiguan (PC6) to explore variations in energy metabolism and its relationship with visceral function adjustments during EA. Methods: Twenty-two healthy volunteers participated in this study. Three channel las...
Source: BMC Complementary and Alternative Medicine - August 30, 2014 Category: Complementary Medicine Authors: Shu-Xia ZhengXiao-Hua PanJin-Sen XuChun-Ying XiuYa-Qin DongXiaoxiang Zhu Source Type: research

Improved rat liver decellularization by arterial perfusion under oscillating pressure conditions
Abstract One approach of regenerative medicine to generate functional hepatic tissue in vitro is decellularization and recellularization, and several protocols for the decellularization of livers of different species have been published. This appears to be the first report on rat liver decellularization by perfusion under oscillating pressure conditions, intending to optimize microperfusion and minimize damage to the ECM. Four decellularization protocols were compared: perfusion via the portal vein (PV) or the hepatic artery (HA), with (+P) or without (–P) oscillating pressure conditions. All rat livers (n = 24) were...
Source: Journal of Tissue Engineering and Regenerative Medicine - September 1, 2014 Category: Molecular Biology Authors: Benjamin Struecker, Antje Butter, Karl Hillebrandt, Dietrich Polenz, Anja Reutzel‐Selke, Peter Tang, Steffen Lippert, Anne Leder, Susanne Rohn, Dominik Geisel, Timm Denecke, Khalid Aliyev, Korinna Jöhrens, Nathanael Raschzok, Peter Neuhaus, Johann Prat Tags: Research Article Source Type: research

Adrenocortical hormones
Publication date: October 2014 Source:Anaesthesia & Intensive Care Medicine, Volume 15, Issue 10 Author(s): Iain Campbell The adrenal glands lie on top of the kidneys. The adrenal medulla produces catecholamines and the adrenal cortex produces three types of steroid hormone (mineralocorticoids (aldosterone), glucocorticoids (cortisol) and androgens (dehydroepiandrosterone, DHEA)). All are synthesized from cholesterol. Cortisol secretion is controlled by adrenocorticotrophic hormone from the pituitary. It rises in response to stress and is essential for life. It stimulates gluconeogenesis, breaking down lean tissu...
Source: Anaesthesia and intensive care medicine - October 12, 2014 Category: Anesthesiology Source Type: research

Management of shock in trauma
Publication date: September 2014 Source:Anaesthesia & Intensive Care Medicine, Volume 15, Issue 9 Author(s): Jonathan D. Pearson , Jonathan A. Round , Michael Ingram Shock is failure of the circulatory system to provide the organ perfusion and tissue oxygenation required to meet cellular metabolic demands. Traumatic shock is most commonly associated with haemorrhage, although it is recognized the trauma patient may present with non-haemorrhagic shock. The ‘lethal triad’ of metabolic acidosis, hypothermia, and acute coagulopathy seen in trauma patients has been fundamental to the development of the current app...
Source: Anaesthesia and intensive care medicine - October 12, 2014 Category: Anesthesiology Source Type: research

Hypertonic saline (HTS) versus standard (isotonic) fluid therapy for traumatic brain injuries: a systematic review
Publication date: Available online 9 June 2014 Source:African Journal of Emergency Medicine Author(s): Andrit Lourens , Johanna Catharina Botha Traumatic Brain Injury (TBI) is one of the foremost causes of mortality secondary to trauma. Poorer outcomes are associated with secondary insults, after the initial brain injury occurred. The management goal of TBI is to prevent or minimise the effects of secondary brain injuries. The primary objective of this systematic review/meta-analysis was to assess the effects of Hypertonic Saline (HTS) compared to Standard Fluid Therapy (SFT) in the treatment and resuscitation of TBI pat...
Source: African Journal of Emergency Medicine - October 12, 2014 Category: Emergency Medicine Source Type: research

Inhaled nitric oxide as a salvage therapy in patients with severe ARDS
Conclusion iNO may be used as a salvage therapy for refractory hypoxemia and right heart failure in severe ARDS.
Source: Current Medicine Research and Practice - November 2, 2014 Category: Journals (General) Source Type: research

Endoleak after endovascular aneurysm repair: Current status
Publication date: June 2014 Source:Reviews in Vascular Medicine, Volume 2, Issue 2 Author(s): N. Green , D.A. Sidloff , P.W. Stather , M.J. Bown , R.D. Sayers , E. Choke Since the introduction in 1991 of endovascular aortic aneurysm repair (EVAR), through its evolution from a straight graft system to modular component systems with supported prostheses, endoleak has been its Achilles heel. Defined as continued perfusion of the aneurysm sac in spite of endograft deployment and associated with sac expansion, re-intervention and the risk of rupture, here in this review we discuss the different types of endoleak and current e...
Source: Reviews in Vascular Medicine - November 6, 2014 Category: Cardiology Source Type: research

Evaluation of the patient with diabetes mellitus and suspected coronary artery disease
In conclusion, MPI provides clinicians with an important diagnostic tool, because it offers perfusion as well as functional information for diagnosis and risk stratification in patients with diabetes. These capabilities facilitate decision making regarding the appropriateness of medical therapy or surgical intervention in these individuals.
Source: The American Journal of Medicine Supplements - November 6, 2014 Category: Drugs & Pharmacology Source Type: research

Prognostic value of T peak-to-end interval for risk stratification after acute myocardial infarction
Conclusion TpTe was significantly and independently associated with increased odds of SCD and is linked to deterioration of Lv functions and myocardial aneurysms. It's highly correlated to presence of LAS and associate with severity of coronary lesions. Patients with prolonged TpTe intervals and dispersions were likely to develop fatal arrhythmias.
Source: The Egyptian Journal of Critical Care Medicine - November 6, 2014 Category: Intensive Care Source Type: research

Assessment of hypotension during dialysis as a manifestation of myocardial ischemia in patients with chronic renal failure
Conclusions Patients with CKD and regular hemodialysis who experience moderate or severe intradialytic hypotension have significantly higher prevalence of myocardial ischemia and stress induced myocardial dysfunction, than those who experience no or mild intradialytic hypotension.
Source: The Egyptian Journal of Critical Care Medicine - November 6, 2014 Category: Intensive Care Source Type: research

The added value of advanced neuro-imaging (MR diffusion, perfusion and proton spectroscopy) in diagnosis of primary CNS lymphoma
Conclusions Restricted diffusion, relative hypo perfusion, increased Cho/Cr, Cho/NAA, decreased NAA/Cho, NAA/Cr and presence of lactate or lipid peaks are consistent imaging finding in CNS lymphoma.
Source: Alexandria Journal of Medicine - November 15, 2014 Category: Journals (General) Source Type: research

Chronic perfusion changes and reduction in preeclampsia incidence in pregnant smokers: an ophthalmic artery Doppler study
Journal of Maternal-Fetal and Neonatal Medicine, Ahead of Print.
Source: Journal of Maternal-Fetal and Neonatal Medicine - November 11, 2014 Category: Perinatology & Neonatology Tags: article Source Type: research