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Specialty: Respiratory Medicine

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Total 38250 results found since Jan 2013.

Negative trials in critical care medicine and the hurdles
Publication date: October 2018Source: The Lancet Respiratory Medicine, Volume 6, Issue 10Author(s): Matthieu Legrand
Source: The Lancet Respiratory Medicine - October 5, 2018 Category: Respiratory Medicine Source Type: research

Precision Medicine in Acute Kidney Injury - A Promising Future?
PMID: 30398896 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - November 6, 2018 Category: Respiratory Medicine Authors: Schaub JA, Heung M Tags: Am J Respir Crit Care Med Source Type: research

Recommended Reading from University of Colorado Anesthesia Critical Care Medicine Fellows.
PMID: 30423258 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - November 13, 2018 Category: Respiratory Medicine Authors: Hansen C, Scupp T, Nelson J, Brainard J Tags: Am J Respir Crit Care Med Source Type: research

Recommended Reading from the University of Toronto Sleep Medicine Fellows.
PMID: 30433816 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - November 15, 2018 Category: Respiratory Medicine Authors: Perger E, Gonzaga-Carvalho C, Inami T, Ryan CM, Lyons OD Tags: Am J Respir Crit Care Med Source Type: research

Immunotherapy strategies for mesothelioma - the role of tumor specific neoantigens in a new era of precision medicine.
Authors: Ye L, Ma S, Robinson BW, Creaney J Abstract INTRODUCTION: Immunotherapy has long been considered a potential therapy for malignant mesothelioma and is currently being pursued as such. Some of the early phase clinical trials involving immunomodulators have demonstrated encouraging results and numerous clinical trials are underway to further investigate this treatment approach in various treatment settings and larger patient cohorts. Areas covered: This review summarizes the current and emerging clinical evidence for checkpoint blockade and other immunotherapeutic strategies in mesothelioma. The mesothelioma...
Source: Expert Review of Respiratory Medicine - January 1, 2019 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Towards Personalized Medicine in Bronchiolitis.
PMID: 30657699 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 18, 2019 Category: Respiratory Medicine Authors: Alvarez Paggi D, Polack FP Tags: Am J Respir Crit Care Med Source Type: research

Unmet Needs in Severe Asthma Subtyping and Precision Medicine Trials: Bridging Clinical and Patient Perspectives.
Abstract Severe asthma affects a small proportion of asthma patients (~ 3-5%) and reflects a failure of conventional asthma medications to provide adequate control. Severe asthma is a disease of significant clinical heterogeneity, likely caused by different pathobiological mechanisms, frequently referred to as endotypes. In the last decade, multiple monoclonal therapies have been developed to target airway type-2 eosinophilic and/or allergic severe asthma. However, the underlying mechanisms of both type 2 immunity and eosinophilia (blood and airway) remain incompletely understood and offer a potential for novel th...
Source: American Journal of Respiratory and Critical Care Medicine - February 6, 2019 Category: Respiratory Medicine Authors: Siddiqui S, Denlinger LC, Fowler SJ, Akuthota P, Shaw DE, Heaney LG, Brown L, Castro M, Winders TA, Kraft M, Wagers S, Peters MC, Pavord ID, Walker S, Jarjour NN Tags: Am J Respir Crit Care Med Source Type: research

Recommended Reading from Yale University Pulmonary and Critical Care Medicine Fellows.
PMID: 30822095 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - February 28, 2019 Category: Respiratory Medicine Authors: Manning EP, Losier A, Emeagwali N, Ryu C, Honiden S Tags: Am J Respir Crit Care Med Source Type: research

Recommended Reading from the University College London Hospitals Pulmonary Medicine Fellows.
PMID: 30860861 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - March 11, 2019 Category: Respiratory Medicine Authors: Allinson JP, Brown J, Gibb K, Navani N Tags: Am J Respir Crit Care Med Source Type: research

Precision medicine for cell therapy in acute respiratory distress syndrome – Authors' reply
Publication date: April 2019Source: The Lancet Respiratory Medicine, Volume 7, Issue 4Author(s): Michael A Matthay, Hanjing Zhuo, Jeffrey E Gotts, Kathleen D Liu, Carolyn S Calfee
Source: The Lancet Respiratory Medicine - March 27, 2019 Category: Respiratory Medicine Source Type: research

Precision medicine for cell therapy in acute respiratory distress syndrome
Publication date: April 2019Source: The Lancet Respiratory Medicine, Volume 7, Issue 4Author(s): Haibo Zhang, Yimin Li, Arthur S S.sky
Source: The Lancet Respiratory Medicine - March 27, 2019 Category: Respiratory Medicine Source Type: research

Precision medicine: integration of genetics and functional genomics in prediction of bronchiolitis obliterans after lung transplantation
Purpose of review Lung transplantation (LTx) can be a life saving treatment in end-stage pulmonary diseases, but survival after transplantation is still limited. Posttransplant development of chronic lung allograft dysfunction with bronchiolits obliterans syndrome (BOS) as the major subphenotype, is the main cause of morbidity and mortality. Early identification of high-risk patients for BOS is a large unmet clinical need. In this review, we discuss gene polymorphisms and gene expression related to the development of BOS. Recent findings Candidate gene studies showed that donor and recipient gene polymorphisms affect ...
Source: Current Opinion in Pulmonary Medicine - March 29, 2019 Category: Respiratory Medicine Tags: GENETICS: Edited by Coline H.M. van Moorsel Source Type: research

Sleep Apnea Heterogeneity, Phenotypes, and Cardiovascular Risk: Implications for Trial Design and Precision Sleep Medicine.
PMID: 30916985 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - March 26, 2019 Category: Respiratory Medicine Authors: Zinchuk A, Yaggi HK Tags: Am J Respir Crit Care Med Source Type: research

Recommended Reading from the Massachusetts General Hospital/ Beth Israel Deaconess Medical Center/ Harvard Pulmonary and Critical Care Medicine Fellows.
PMID: 31014082 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - April 22, 2019 Category: Respiratory Medicine Authors: Sclafani A, Worsham CM, McNeill J, Anandaiah A Tags: Am J Respir Crit Care Med Source Type: research

More than the Sum of the Respiratory Events: Personalized Medicine Approaches for Obstructive Sleep Apnea.
Abstract Traditionally, the presence and severity of obstructive sleep apnea (OSA) has been defined by the apnea-hypopnea index (AHI). Continuous positive airway pressure (CPAP) is generally first line therapy despite low adherence as it reliably reduces the AHI when used, and the response to other therapies is variable. However, there is growing appreciation that the underlying etiologies (i.e. endotype) and clinical manifestations (i.e. phenotype) of OSA in an individual are not well described by the AHI. We define and review the important progress made on understanding and measuring physiological mechanisms (or...
Source: American Journal of Respiratory and Critical Care Medicine - April 24, 2019 Category: Respiratory Medicine Authors: Edwards BA, Redline S, Sands SA, Owens RL Tags: Am J Respir Crit Care Med Source Type: research