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Total 4168 results found since Jan 2013.
Head and Neck, Oral and Oropharyngeal Cancer: A Review of Medicolegal Cases
Conclusions In addition to diagnosis of malignant disease, our review identified failure to properly prevent and manage oral complications as potential causes of medicolegal actions. Evidence-based care with a multi-disciplinary team may promote diagnosis of disease and prevention and management of complications.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - November 6, 2014 Category: ENT & OMF Source Type: research
Nanobody–photosensitizer conjugates for targeted photodynamic therapy
This study investigates the role of EGFR targeting nanobodies to deliver traceable photosensitizers to cancer molecules for therapeutic exploitation and concomitant imaging. Altogether, EGFR-targeted NB–PS conjugates combine molecular imaging with cancer therapy, the method is specific and potent, paving the way to clinical application of this technology. Graphical abstract
Source: Nanomedicine: Nanotechnology, Biology and Medicine - November 10, 2014 Category: Nanotechnology Source Type: research
Cancer modeling and network biology: Accelerating toward personalized medicine
Publication date: Available online 23 June 2014 Source:Seminars in Cancer Biology Author(s): Ali Masoudi-Nejad , Edwin Wang The complexity of cancer progression can manifests itself on at least three scales that can be described using mathematical models, namely microscopic, mesoscopic and macroscopic scales. Multiscale cancer models have proven to be advantageous in this context because they can simultaneously incorporate the many different characteristics and scales of complex diseases such as cancer. This has driven the expansion of more predictive data-driven models, coupled to experimental and clinical data. These m...
Source: Seminars in Cancer Biology - November 12, 2014 Category: Cancer & Oncology Source Type: research
Implementation of biomarker-driven cancer therapy: existing tools and remaining gaps.
Authors: Bailey AM, Mao Y, Zeng J, Holla V, Johnson A, Brusco L, Chen K, Mendelsohn J, Routbort MJ, Mills GB, Meric-Bernstam F
Abstract
There has been growing interest in biomarker-driven personalized cancer therapy, also known as precision medicine. Recently, dozens of molecular tests, including next generation sequencing, have been developed to detect biomarkers that have the potential to predict response of cancers to particular targeted therapies. However, detection of cancer-related biomarkers is only the first step in the battle. Deciding what therapy options to pursue can also be daunting, especially when tu...
Source: Discovery Medicine - November 14, 2014 Category: Research Tags: Discov Med Source Type: research
Integration of genomics into medical practice.
Authors: Korf BR
Abstract
Although some have wondered whether the sequencing of the human genome has led to major advances in medicine, in fact there are multiple examples where genomics has been integrated into medical practice. In the area of prevention, genomic approaches are now used for non-invasive prenatal testing of fetal DNA in the maternal circulation, for expanded preconceptional screening for carrier status, for autosomal recessive disorders, and for assessment of risk of common disease. In the area of diagnosis, major advances have been made in cytogenomics and in use of whole exome or whole genome seq...
Source: Discovery Medicine - November 14, 2014 Category: Research Tags: Discov Med Source Type: research
New imaging technique identifies receptors for targeted cancer therapy
(The Geisel School of Medicine at Dartmouth) Dartmouth researchers have developed a fluorescence imaging technique that can more accurately identify receptors for targeted cancer therapies without a tissue biopsy. They report on their findings in 'Quantitative in vivo immunohistochemistry of epidermal growth factor receptor using a receptor concentration imaging approach,' which was recently published in Cancer Research.
Source: EurekAlert! - Medicine and Health - November 14, 2014 Category: Global & Universal Source Type: news
A signature for success
(Ludwig Institute for Cancer Research) A team led by Ludwig and Memorial Sloan Kettering researchers has published a landmark study on the genetic basis of response to a powerful cancer therapy known as immune checkpoint blockade. Their paper, in the current issue of the New England Journal of Medicine, describes the precise genetic signatures in melanoma tumors that determine whether a patient will respond to one such therapy.
Source: EurekAlert! - Medicine and Health - November 19, 2014 Category: Global & Universal Source Type: news
Natural molecules as tumour inhibitors: Promises and prospects
Publication date: Available online 19 October 2014 Source:Journal of Herbal Medicine Author(s): Swaroop Makam N , Kotamballi N. Chidambara Murthy , Chandrashekhar M. Sultanpur , Raghavendra M. Rao Numerous natural substances derived from plants have demonstrated promising roles in providing substantial benefit in the prevention, treatment and management of various forms of cancer. Of the myriad of natural constituents found in plants, only a limited number have been screened for their potential role in cancer prevention or their cancer inhibition efficiency using in vitro or in silico models. Of those constituents that h...
Source: Journal of Herbal Medicine - November 20, 2014 Category: Complementary Medicine Source Type: research
Targeted delivery of anticancer drugs by aptamer AS1411 mediated Pluronic F127/cyclodextrin-linked polymer composite micelles
In conclusion, aptamer-conjugated multifunctional composite micelles could be a potential delivery vehicle for cancer therapy. Graphical abstract
Source: Nanomedicine: Nanotechnology, Biology and Medicine - November 29, 2014 Category: Nanotechnology Source Type: research
Evaluation of thermo-triggered drug release in intramuscular-transplanted tumors using thermosensitive polymer-modified liposomes and MRI
In conclusion, MTPLs with MRI are useful for low-invasive cancer theranostics. Graphical abstract
Source: Nanomedicine: Nanotechnology, Biology and Medicine - November 29, 2014 Category: Nanotechnology Source Type: research
Trends of Gold Nanoparticle-Based Drug Delivery System in Cancer Therapy
Publication date: Available online 29 November 2014 Source:Journal of Experimental & Clinical Medicine Author(s): Giimel Ajnai , Amy Chiu , Tzuchun Kan , Chun-Chia Cheng , Teh-Hua Tsai , Jungshan Chang Following surgical removal of malignant tumors, chemotherapeutic intervention usually is subsequently applied in patients with advanced stages of cancer. Most chemotherapeutic drugs are intravenously injected into patients, leading to systemic cytotoxicity in organs and tissues, including healthy tissue and tumors. Currently, it has been demonstrated that gold nanoparticles can easily penetrate blood vessels and ti...
Source: Journal of Experimental and Clinical Medicine - November 30, 2014 Category: Journals (General) Source Type: research
The DNA Damage Response: Implications for Tumor Responses to Radiation and Chemotherapy.
Abstract
Cellular responses to DNA damage are important determinants of both cancer development and cancer outcome following radiation therapy and chemotherapy. Identification of molecular pathways governing DNA damage signaling and DNA repair in response to different types of DNA lesions allows for a better understanding of the effects of radiation and chemotherapy on normal and tumor cells. Although dysregulation of the DNA damage response (DDR) is associated with predisposition to cancer development, it can also result in hypersensitivity or resistance of tumors to therapy and can be exploited for improvement o...
Source: Annual Review of Medicine - November 24, 2014 Category: Journals (General) Authors: Goldstein M, Kastan MB Tags: Annu Rev Med Source Type: research
Cancer therapy shows promise for nuclear medicine treatment
Cancer therapy can be much more effective using a new way to customize nuclear medicine treatment, researchers say. The process could also be useful for other diseases that could benefit from targeted radiation.
Source: ScienceDaily Headlines - December 9, 2014 Category: Science Source Type: news
Self-focusing therapeutic gene delivery with intelligent gene vector swarms: Intra-swarm signalling through receptor transgene expression in targeted cells
Conclusions It is hoped that proposed self-focusing cell-targeted gene vector swarms with receptor-mediated intra-swarm signalling could be particularly effective in ‘top-up’ gene delivery scenarios, achieving high-level and sustained expression of therapeutic transgenes that are prone to shut-down through degradation and silencing. Crucially, in contrast to low-precision ‘general location’ vector guidance by diffusible chemo-attractants, ear-marking non-diffusible receptors can provide high-accuracy targeting of therapeutic vector particles to the specific cell, which has undergone a ‘successful cell-specific hi...
Source: Artificial Intelligence in Medicine - December 18, 2014 Category: Bioinformatics Source Type: research
Altered gene products involved in the malignant reprogramming of cancer stem/progenitor cells and multitargeted therapies
Publication date: October 2014 Source:Molecular Aspects of Medicine, Volume 39 Author(s): Murielle Mimeault , Surinder K. Batra Recent studies in the field of cancer stem cells have revealed that the alterations in key gene products involved in the epithelial–mesenchymal transition (EMT) program, altered metabolic pathways such as enhanced glycolysis, lipogenesis and/or autophagy and treatment resistance may occur in cancer stem/progenitor cells and their progenies during cancer progression. Particularly, the sustained activation of diverse developmental cascades such as hedgehog, epidermal growth factor receptor (EGFR...
Source: Molecular Aspects of Medicine - December 25, 2014 Category: Molecular Biology Source Type: research
