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Total 4168 results found since Jan 2013.
Head and neck, oral, and oropharyngeal cancer: a review of medicolegal cases
Conclusions In addition to failure in the diagnosis of malignant disease, our review identified failure to properly prevent and manage oral complications as potential causes of medicolegal actions. Evidence-based care with a multidisciplinary team may promote diagnosis of disease and prevention and management of complications.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - January 9, 2015 Category: ENT & OMF Source Type: research
Multifunctional nanoparticle–EpCAM aptamer bioconjugates: A paradigm for targeted drug delivery and imaging in cancer therapy
Publication date: February 2015 Source:Nanomedicine: Nanotechnology, Biology and Medicine, Volume 11, Issue 2 Author(s): Manasi Das , Wei Duan , Sanjeeb K. Sahoo The promising proposition of multifunctional nanoparticles for cancer diagnostics and therapeutics has inspired the development of theranostic approach for improved cancer therapy. Moreover, active targeting of drug carrier to specific target site is crucial for providing efficient delivery of therapeutics and imaging agents. In this regard, the present study investigates the theranostic capabilities of nutlin-3a loaded poly (lactide-co-glycolide) nanoparticles,...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - February 3, 2015 Category: Nanotechnology Source Type: research
In vitro and in vivo toxicity studies of copper sulfide nanoplates for potential photothermal applications
Publication date: Available online 31 January 2015 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Wei Feng , Wei Nie , Yanhua Cheng , Xiaojun Zhou , Liang Chen , Kexin Qiu , Zhigang Chen , Meifang Zhu , Chuanglong He Copper sulfide (CuS) has recently emerged as a promising photothermal agent. However, the potential toxic effects of CuS still remained poorly understood. Herein, CuS nanoplates were synthesized for toxicity assessment. The in vitro study indicated that the cell viability decreased when CuS nanoplates concentration was higher than 100μg/mL. CuS nanoplates caused apparent toxicity to HU...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - February 3, 2015 Category: Nanotechnology Source Type: research
Approval may embolden industry to combine cancer therapies
Nature Medicine 21, 105 (2015).
doi:10.1038/nm0215-105
Author: Boer Deng
Source: Nature Medicine - February 5, 2015 Category: Journals (General) Authors: Boer Deng Tags: News Source Type: research
TCR gene therapy of leukemia
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Shao-An Xue Conventional cancer therapies are limited by their toxicity and lack of specificity. To achieve targeted immunotherapy of cancer, we have chosen Wilm's Tumour antigen (WT1) as a target as it is over-expressed in most leukemia and many solid cancers. Using sophisticated WT1-TCR retroviral constructs, we have performed in vivo engraftment studies with CD34+ leukemic progenitor cells. In our model, treatment with WT1-TCR engineered patiens' T cells had cleared patients own leukemic cells. As the analysis of...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research
Anti-tumor effects of the human monoclonal anti-nuclear antibody on the HEp-2 cells
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Fengmin Zhang , Yujun Li , Yong Fang , Wenping Kao , Wuqi Song Function of autoantibodies from patients with autoimmune diseases in malignancies development is not clear yet. It has been reported that a cell-penetrating lupus autoantibody, 3E10, which was isolated from a mouse model of systemic lupus erythematosus (SLE), has been a potential targeted therapy for DNA-repair deficient malignancies. We have got four human monoclonal antinuclear antibodies from patients with autoimmune disease, 3B5, 3C1, 3E8 and 4F3. Ou...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research
Antibody-based targeting of TNF-ligands for cancer therapy
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Edwin Bremer The tumor necrosis factor (TNF) ligand and cognate TNF receptor superfamily constitute an important immunoregulatory axis pivotal for the correct execution of immune responses. TNF ligand and receptor family members among others are involved in induction of cell death in malignant cells as well as in providing co-stimulatory signals that help mount effective anti-cancer immune responses. This diverse and important regulatory role in immunity has sparked great interest in the development of TNFL/TNFR-tar...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research
Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy
Review Articles Silvia Pandolfi, Barbara Stecca, Expert Reviews in Molecular Medicine, Volume 17, pp e5Abstract
Source: Expert Reviews in Molecular Medicine - February 9, 2015 Category: Molecular Biology Source Type: research
Rational design of cancer-targeted selenium nanoparticles to antagonize multidrug resistance in cancer cells
This study provides an effective strategy for the design of cancer-targeted nanodrugs against multidrug resistant cancers. Graphical abstract
Source: Nanomedicine: Nanotechnology, Biology and Medicine - February 13, 2015 Category: Nanotechnology Source Type: research
Protamine-carboxymethyl cellulose magnetic nanocapsules for enhanced delivery of anticancer drugs against drug resistant cancers
Publication date: Available online 7 February 2015 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Rajasegaran Elumalai , Shilpa Patil , Naseer Maliyakkal , Annapoorni Rangarajan , Paturu Kondaiah , Ashok M. Raichur Multidrug resistance is a major therapeutic challenge faced in the conventional chemotherapy. Nanocarriers are beneficial in the transport of chemotherapeutics by their ability to bypass the P-gp efflux in cancers. Most of the P-gp inhibitors under Phase II clinical trial are facing failures and hence there is a need to develop a suitable carrier to address P-gp efflux in cancer therapy. ...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - February 13, 2015 Category: Nanotechnology Source Type: research
Complementary and Alternative Medicine Use by Breast Cancer Patients at Time of Surgery Which Increases the Potential for Excessive Bleeding
Conclusion. Further research is needed to better understand the risks associated with use of a variety of herbs and supplements among women approaching surgery.
Source: Integrative Cancer Therapies - February 12, 2015 Category: Cancer & Oncology Authors: Andersen, M. R., Sweet, E., Zhou, M., Standish, L. J. Tags: Research Articles Source Type: research
Conformation-dependent binding and tumor-targeted delivery of siRNA by a designed TRBP2: Affibody fusion protein
Publication date: Available online 23 February 2015 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Ghulam Hassan Dar , Vijaya Gopal , Madhusudhana Rao Efficiency of systemically delivered siRNA in gene silencing is compromised due to lack of target-specific delivery and rapid clearance of siRNA by in vivo elimination pathways. We designed a fusion protein consisting of a dsRNA binding domain of Transactivation Response RNA Binding Protein (TRBP2) fused to ErbB2 binding affibody (AF) for target specific delivery of siRNA. Designated as TRAF, the fusion protein is stable and binds efficiently and spec...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - February 24, 2015 Category: Nanotechnology Source Type: research
Cutting-edge technology optimizes cancer therapy with nanomedicine drug combinations
(University of California - Los Angeles) Designing optimized combination therapies for cancer is remarkably difficult due to the infinite possible drug dose ratios and variable patient-specific response to treatment. In a landmark advance for personalized medicine, University of California Los Angeles bioengineers have developed a novel technology that, for the first time, overcomes these challenges. By assessing phenotype, or physical biological traits as they respond to chemotherapy to drive a powerful analytics platform, the most effective and safe drug combinations possible can be systematically designed.
Source: EurekAlert! - Medicine and Health - February 24, 2015 Category: Global & Universal Source Type: news
High tolerated paclitaxel nano-formulation delivered by poly (lactic-co-glycolic acid) -g-dextran micelles to efficient cancer therapy
Publication date: Available online 25 February 2015 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Ping Liu , Jun-Qing Situ , Wei-Shuo Li , Chun-Lei Shan , Jian You , Hong Yuan , Fu-Qiang Hu , Yong-Zhong Du The amphiphilic graft copolymer poly (lactic-co-glycolic acid)-g-dextran (Dex-PLGA) was successfully synthesized to fabricate micelles for the delivery of paclitaxel with low critical micelle concentration (CMC). The sizes of paclitaxel-loaded Dex-PLGA (Dex-PLGA/PTX) micelles were kept below 100nm with a relatively narrow size distribution. This novel PTX nano-formulation was found to exhibit sli...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - February 25, 2015 Category: Nanotechnology Source Type: research
High tolerated paclitaxel nano-formulation delivered by poly (lactic-co-glycolic acid)-g-dextran micelles to efficient cancer therapy
Publication date: Available online 25 February 2015 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Ping Liu , Jun-Qing Situ , Wei-Shuo Li , Chun-Lei Shan , Jian You , Hong Yuan , Fu-Qiang Hu , Yong-Zhong Du The amphiphilic graft copolymer poly (lactic-co-glycolic acid)-g-dextran (Dex-PLGA) was successfully synthesized to fabricate micelles for the delivery of paclitaxel with low critical micelle concentration (CMC). The sizes of paclitaxel-loaded Dex-PLGA (Dex-PLGA/PTX) micelles were kept below 100nm with a relatively narrow size distribution. This novel PTX nano-formulation was found to exhibit sli...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 2, 2015 Category: Nanotechnology Source Type: research
