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A Research Agenda for Precision Medicine in Sepsis and Acute Respiratory Distress Syndrome: An Official American Thoracic Society Research Statement
Conclusions: Precision medicine approaches that incorporate variability in genomic, biologic, and environmental factors may provide a path forward for better individualizing the delivery of therapies and improving care for patients with sepsis and ARDS.PMID:34652268 | DOI:10.1164/rccm.202108-1908ST
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2021 Category: Respiratory Medicine Authors: Faraaz Ali Shah Nuala J Meyer Derek C Angus Rana Awdish Élie Azoulay Carolyn S Calfee Gilles Clermont Anthony C Gordon Arthur Kwizera Aleksandra Leligdowicz John C Marshall Carmen Mikacenic Pratik Sinha Balasubramanian Venkatesh Hector R Wong Fernando G Source Type: research

A questionnaire to measure medical students' attitudes towards occupational medicine
Conclusions This questionnaire can be used to measure attitude towards occupational medicine; however, this questionnaire needs to be developed further.
Source: Occupational Medicine - July 17, 2015 Category: Respiratory Medicine Authors: Smits, P. B. A., Verbeek, J. H. A. M. Tags: Health information and reporting Original Paper Source Type: research

An official american thoracic society/american association of critical-care nurses/american college of chest physicians/society of critical care medicine policy statement: the choosing wisely® top 5 list in critical care medicine.
CONCLUSIONS: These five recommendations provide a starting point for clinicians and patients to make decisions leading to higher-quality, lower-cost care. Future work is needed to promote adherence to these recommendations and to develop additional ways for intensive care clinicians to take leadership in reining in health-care costs. PMID: 25271745 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - October 1, 2014 Category: Respiratory Medicine Authors: Halpern SD, Becker D, Curtis JR, Fowler R, Hyzy R, Kaplan LJ, Rawat N, Sessler CN, Wunsch H, Kahn JM, Choosing Wisely Taskforce Tags: Am J Respir Crit Care Med Source Type: research

Personalized Respiratory Medicine: Exploring the Horizon, Addressing the Issues.
EK, Sterk PJ, Sznajder JI Abstract This Pulmonary Perspective summarizes the content and main conclusions of an international workshop on personalized respiratory medicine co-organized by the Barcelona Respiratory Network (www.brn.cat) and the AJRCCM in June 2014. It discusses: (1) its definition, historical, social, legal and ethical aspects; (2) the view from different disciplines, including basic science, epidemiology, bioinformatics and network/systems medicine.; (3) the bottlenecks and opportunities identified by some currently ongoing projects; and, (4) the implications for the individual, the health-care s...
Source: American Journal of Respiratory and Critical Care Medicine - December 22, 2014 Category: Respiratory Medicine Authors: Agusti A, Antó JM, Auffray C, Barbé F, Barreiro E, Dorca J, Escarrabill J, Faner R, Furlong LI, Garcia-Aymerich J, Gea J, Lindmark B, Monsó E, Plaza V, Puhan MA, Roca J, Ruiz-Manzano J, Sampietro-Colom L, Sanz F, Serrano L, Sharpe J, Sibila O, Silverma Tags: Am J Respir Crit Care Med Source Type: research

CF Bowel Obstruction Study
This study focuses on cystic fibrosis patients who have complaints of bowel obstruction and constipation. The goal of this study is to see if and how osteopathic manipulative medicine will affect these patients’ bowel functions. The study is being performed through Touro University. Treatments will take place in Vallejo, CA and in Portola Valley, CA. What is osteopathic manipulative medicine? Osteopathic manipulative medicine (OMM) is a hands-on technique of moving and mobilizing tissues of the body to be able to function optimally. In this project, the techniques that will be utilized are gentle and will be ...
Source: Cystic Fibrosis Alternative Medicine Forum - September 25, 2015 Category: Respiratory Medicine Authors: Sara Modlin Tags: Alternative Medicine Source Type: forums

Precision respiratory medicine and the microbiome
Publication date: Available online 12 December 2015 Source:The Lancet Respiratory Medicine Author(s): Geraint B Rogers, Steve Wesselingh A decade of rapid technological advances has provided an exciting opportunity to incorporate information relating to a range of potentially important disease determinants in the clinical decision-making process. Access to highly detailed data will enable respiratory medicine to evolve from one-size-fits-all models of care, which are associated with variable clinical effectiveness and high rates of side-effects, to precision approaches, where treatment is tailored to individual patient...
Source: The Lancet Respiratory Medicine - December 12, 2015 Category: Respiratory Medicine Source Type: research

Precision Medicine: The New Frontier in Idiopathic Pulmonary Fibrosis.
Abstract Precision medicine is defined by the NIH's Precision Medicine Initiative Working Group as an approach to disease treatment that takes into account individual variability in genes, environment, and lifestyle. There has been increased interest in applying the concept of precision medicine to idiopathic pulmonary fibrosis (IPF), in particular to search for genetic and molecular biomarker-based profiles (so called endotypes) that identify mechanistically-distinct disease subgroups. The relevance of precision medicine to IPF is yet to be established, but we believe that it holds great promise to provide target...
Source: American Journal of Respiratory and Critical Care Medicine - March 18, 2016 Category: Respiratory Medicine Authors: Brownell R, Kaminski N, Woodruff PG, Bradford WZ, Richeldi L, Martinez FJ, Collard HR Tags: Am J Respir Crit Care Med Source Type: research

Enhancing Insights into Pulmonary Vascular Disease (PVD) Through a Precision Medicine Approach. A Joint NHLBI-CMREF Workshop Report.
Discussion of priorities in line with NHLBI Strategic Vision Goals included: 1. A national effort to coordinate bio-samples and bio-data from all funded programs to a web based repository so that information can be shared and correlated with other research projects. Example NHLBI programs include PVDOMICS, Pulmonary Hypertension Breakthrough Initiative (PHBI), the National Biological Sample and Data Repository for PAH, and the National Precision Medicine Initiative. 2. A taskforce to develop a master clinical trials protocol for PVD to apply precision medicine principles to future clinical trials. Specific features include...
Source: American Journal of Respiratory and Critical Care Medicine - April 21, 2017 Category: Respiratory Medicine Authors: Newman JH, Rich S, Abman SH, Alexander JH, Barnard J, Beck GJ, Benza RL, Bull TM, Chan SY, Chun HJ, Doogan D, Dupuis J, Erzurum SC, Frantz RP, Geraci M, Gillies H, Gladwin M, Gray MP, Hemnes AR, Herbst RS, Hernandez AF, Hill NS, Horn EM, Hunter K, Jing ZC Tags: Am J Respir Crit Care Med Source Type: research

An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome.
CONCLUSIONS: The panel formulated and provided the rationale for recommendations on selected ventilatory interventions for adult patients with ARDS. Clinicians managing patients with ARDS should personalize decisions for their patients, particularly regarding the conditional recommendations in this guideline. PMID: 28459336 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - May 1, 2017 Category: Respiratory Medicine Authors: Fan E, Del Sorbo L, Goligher EC, Hodgson CL, Munshi L, Walkey AJ, Adhikari NKJ, Amato MBP, Branson R, Brower RG, Ferguson ND, Gajic O, Gattinoni L, Hess D, Mancebo J, Meade MO, McAuley DF, Pesenti A, Ranieri VM, Rubenfeld GD, Rubin E, Seckel M, Slutsky AS Tags: Am J Respir Crit Care Med Source Type: research

In This Issue of Occupational Medicine
This issue showcases the unique preventive role of occupational medicine. Heralding the Society of Occupational Medicine Annual Scientific Meeting in Leeds in June, Mathie [1] applauds the legacy of Charles Turner Thackrah, anatomist, experimental physiologist, clinician, teacher, founder of the Leeds Medical School, preventive medicine pioneer and humanitarian. Thackrah packed so much into his short life before dying of pulmonary tuberculosis the day after his 38th birthday in 1833. He was a shrewd observer, an assiduous recorder, who married benevolence with imagination and vision. He published his famous tract in 1831 w...
Source: Occupational Medicine - May 29, 2017 Category: Respiratory Medicine Source Type: research

Personalised medicine in asthma: time for action: Number 1 in the Series "Personalised medicine in respiratory diseases" Edited by Renaud Louis and Nicolas Roche
Asthma is a heterogeneous disease comprising several phenotypes driven by different pathways. To define these phenotypes or endotypes (phenotypes defined by mechanisms), an unbiased approach to clustering of various omics platforms will yield molecular phenotypes from which composite biomarkers can be obtained. Biomarkers can help differentiate between these phenotypes and pinpoint patients suitable for specific targeted therapies – the basis for personalised medicine. Biomarkers need to be linked to point-of-care biomarkers that may be measured readily in exhaled breath, blood or urine. The potential for using mobil...
Source: European Respiratory Review - September 27, 2017 Category: Respiratory Medicine Authors: Chung, K. F. Tags: Asthma and allergy Personalised Medicine in Respiratory Diseases Source Type: research

Precision medicine in asthma: linking phenotypes to targeted treatments
Purpose of review Asthma is a heterogeneous disease consisting of different phenotypes that are driven by different mechanistic pathways. The purpose of this review is to emphasize the important role of precision medicine in asthma management. Recent findings Despite asthma heterogeneity, the approach to management has been on the basis of disease severity, with the most severe patients reserved for the maximum treatments with corticosteroids and bronchodilators. At the severe end, the recent availability of biologic therapies in the form of anti-IgE (omalizumab) and anti-IL5 therapies (mepolizumab and reslizumab) has...
Source: Current Opinion in Pulmonary Medicine - November 29, 2017 Category: Respiratory Medicine Tags: ASTHMA: Edited by Nicola A. Hanania and Zuzana Diamant Source Type: research

Bringing together occupational and environmental medicine specialists Development of the International Occupational Medicine Society Collaborative (IOMSC)
Occupational and environmental medicine (OEM) is aunique preventive medicine specialty that positively impacts the health and productivity of workforces and therefore, the health of national economies. OEM specialists work to ensure that the highest standards of health and safety can be achieved and maintained in the workplace. OEM involves a variety of disciplines —however, its primary focus is preventive medicine and the management of illness and injuries related to the workplace [1,2]. The traditional role of OEM physicians has been identifying hazards, assessing exposures, protecting the workforce and educating worke...
Source: Occupational Medicine - December 2, 2017 Category: Respiratory Medicine Source Type: research

Bringing together occupational and environmental medicine specialistsDevelopment of the International Occupational Medicine Society Collaborative (IOMSC)
Occupational and environmental medicine (OEM) is aunique preventive medicine specialty that positively impacts the health and productivity of workforces and therefore, the health of national economies. OEM specialists work to ensure that the highest standards of health and safety can be achieved and maintained in the workplace. OEM involves a variety of disciplines —however, its primary focus is preventive medicine and the management of illness and injuries related to the workplace [1,2]. The traditional role of OEM physicians has been identifying hazards, assessing exposures, protecting the workforce and educating worke...
Source: Occupational Medicine - December 2, 2017 Category: Respiratory Medicine Source Type: research

Precision medicine in asthma: linking phenotypes to targeted treatments
Purpose of review Asthma is a heterogeneous disease consisting of different phenotypes that are driven by different mechanistic pathways. The purpose of this review is to emphasize the important role of precision medicine in asthma management. Recent findings Despite asthma heterogeneity, the approach to management has been on the basis of disease severity, with the most severe patients reserved for the maximum treatments with corticosteroids and bronchodilators. At the severe end, the recent availability of biologic therapies in the form of anti-IgE (omalizumab) and anti-IL5 therapies (mepolizumab and reslizumab) has...
Source: Current Opinion in Pulmonary Medicine - January 1, 2018 Category: Respiratory Medicine Tags: ASTHMA: Edited by Nicola A. Hanania and Zuzana Diamant Source Type: research