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The Role and Treatment Implications of Peripheral and Central Processing of Pain, Pruritus, and Nausea in Heightened Somatic Awareness: A Review
This article reviews the acute neural transmission of pain, pruritus, and nausea symptoms, which can begin in the periphery and/or viscera. The subsequent multiple pathways in the central nervous system that become involved in the processing of these symptoms are also discussed. The authors describe human brain imaging studies that have revealed consistent cortical and subcortical networks  activated by these symptoms, including sensory, limbic, and associative regions. In particular, the authors discuss information revealed by the studies regarding the primary somatosensory cortex, secondary somatosensory cortex, anterio...
Source: Innovations in Clinical Neuroscience - June 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Neurologic Systems and Symptoms Neurology Pain Review central processing nausea pruritus Source Type: research

Comorbidities in patients with all‐positive symptoms on sinonasal outcomes test quality‐of‐life instrument
ConclusionThe SNOT‐20 questionnaire assists clinicians to monitor outcomes in patients treated for CRS. However, clinicians should suspect other underlying chronic conditions in SNOT‐20 pan‐positive patients. Level of Evidence3B. Laryngoscope, 2015
Source: The Laryngoscope - July 7, 2015 Category: ENT & OMF Authors: Alexander Caten, Christopher Johnson, David Jang, Jose Gurrola, Stilianos Kountakis Tags: Allergy/Rhinology Source Type: research

The impact of comorbid migraine on quality of life outcomes after endoscopic sinus surgery
Conclusion: Patients with comorbid migraine and CRS are more likely to have less severe evidence of disease and worse preoperative baseline QOL scores. This may imply that comorbid migraine disorder, in the setting of CRS, compels these patients to seek surgical management earlier in the disease process. Regardless, ESS provides comparable improvement for both patients with and without comorbid migraine.
Source: The Laryngoscope - January 15, 2014 Category: ENT & OMF Authors: Adam S. DeConde, Jess C. Mace, Timothy L. Smith Tags: Original Report Source Type: research

The impact of comorbid migraine on quality‐of‐life outcomes after endoscopic sinus surgery
ConclusionPatients with comorbid migraine and CRS are more likely to have less severe evidence of disease and worse preoperative baseline QOL scores. This may imply that comorbid migraine disorder, in the setting of CRS, compels these patients to seek surgical management earlier in the disease process. Regardless, ESS provides comparable improvement for both patients with and without comorbid migraine. Level of Evidence2c. Laryngoscope, 2014
Source: The Laryngoscope - February 20, 2014 Category: ENT & OMF Authors: Adam S. DeConde, Jess C. Mace, Timothy L. Smith Tags: Allergy/Rhinology Source Type: research

Identification of chronic rhinosinusitis phenotypes using cluster analysis
ConclusionA simplified algorithm based upon hierarchical clustering is able to classify CRS patients and predict medication usage. Further studies are warranted to determine if such clustering predicts treatment outcomes.
Source: International Forum of Allergy and Rhinology - February 17, 2015 Category: Allergy & Immunology Authors: Zachary M. Soler, J. Madison Hyer, Viswanathan Ramakrishnan, Timothy L. Smith, Jess Mace, Luke Rudmik, Rodney J. Schlosser Tags: ORIGINAL ARTICLE Source Type: research

Irritable bowel syndrome subtypes: Clinical and psychological features, body mass index and comorbidities.
CONCLUSION: IBS-M is characterized by symptoms frequently reported by both IBS-C (straining) and IBS-D (urgency), higher levels of anxiety, and high prevalence of comorbidities. These features should be considered in the clinical management of this subgroup. PMID: 26616258 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - December 3, 2015 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives.
This article reviews the efficacy and safety of FMT used in treating a variety of diseases, methodology, criteria for donor selection and screening, and various concerns regarding FMT. PMID: 26956193 [PubMed - as supplied by publisher]
Source: Clinical Endoscopy - March 11, 2016 Category: Gastroenterology Tags: Clin Endosc Source Type: research

Effects of vonoprazan on intractable NSAID ‐induced ulcers that cannot be controlled with conventional proton pump inhibitors: a case report
This article is protected by copyright. All rights reserved.
Source: Digestive Endoscopy - November 16, 2016 Category: Gastroenterology Authors: Kazuhiro Mizukami, Kazunari Murakami Tags: Letters, techniques and images Source Type: research

Examination of high ‐antibiotic users in a multi‐institutional cohort of chronic rhinosinusitis patients
ConclusionVariability in antibiotic use in CRS appears to be driven by symptom burden, independent of objective measures of disease severity, patient demographics, and presence of comorbid disease. Clear guidelines are essential to define appropriate antibiotic use in CRS.
Source: International Forum of Allergy and Rhinology - December 31, 2016 Category: Allergy & Immunology Authors: Vijay R. Ramakrishnan, Jess C. Mace, Zachary M. Soler, Timothy L. Smith Tags: ORIGINAL ARTICLE Source Type: research

Associations between Unconventional Natural Gas Development and Nasal and Sinus, Migraine Headache, and Fatigue Symptoms in Pennsylvania
Conclusions: This study provides evidence that UNGD is associated with nasal and sinus, migraine headache, and fatigue symptoms in a general population representative sample. Citation: Tustin AW, Hirsch AG, Rasmussen SG, Casey JA, Bandeen-Roche K, Schwartz BS. 2017. Associations between unconventional natural gas development and nasal and sinus, migraine headache, and fatigue symptoms in Pennsylvania. Environ Health Perspect 125:189–197; http://dx.doi.org/10.1289/EHP281 Address correspondence to B.S. Schwartz, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Room W7041, Baltimore, MD 21205 USA. Teleph...
Source: EHP Research - February 1, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles February 2017 Source Type: research