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Fibromyalgia and Its Clinical Relevance in Renal Transplant Recipients
Recent evidence suggests that fibromyalgia syndrome (FS) is associated with inflammation and endothelial dysfunction. Our aim was to determine the prevalence of FS in renal transplant recipients and to identify possible links between FS and clinical and laboratory parameters.
Source: Transplantation Proceedings - May 1, 2015 Category: Transplant Surgery Authors: M. Erkmen Uyar, S. Sezer, Z. Bal, O. Guliyev, E. Tutal, G. Genctoy, E. Kulah, N. Ozdemir Acar, M. Haberal Tags: 14th Congress of the Middle East Society for Organ Transplantation and the 5th Middle East Transplant Games Source Type: research

Evaluation for renal auto-transplantation for multiple renal calculi or loin pain hematuria syndrome
There were 24 patients that underwent evaluation for auto-transplantation of the kidney due to intractable pain. Multiple renal calculi was the etiology for 16 patients, and loin pain hematuria syndrome for 8 patients. The two groups were given the PHQ-9, GAD -7, EQ-5D and the Somatoform Disorders Symptom checklist. The multiple stone group was 68.75% female, 31.25% male, versus the LPHS group which was 100% female. Ages of the two groups were similar, 34.1years old for the MS group, 32.5years old for the LPHS group. The scores on the PHQ-9 were nearly identical, 10.43 for the MS group and 10.38 for the LPHS group. Similar...
Source: Journal of Psychosomatic Research - May 20, 2014 Category: Psychiatry & Psychology Authors: K. Coffman Tags: Abstracts of the Second Annual Conference of the European Association of Psychosomatic Medicine (EAPM) Source Type: research

Abstract 5579: Medication exposures and subsequent development of Ewing sarcoma: a review of FDA adverse event reports
CONCLUSIONS: This study provides a closer look at medication use and underlying disorders in patients who later developed ESFT. While we found no clear causative association between ESFT and prior use of a single product or drug class, many associated drugs were used to treat immune-related disease, and growth or hormonal disturbances. Further studies are needed to better understand possible immune or neuroendocrine abnormalities that may predispose to the later development of ESFT.canres;75/15_Supplement/5579/table1T1Table: Summary of FAERS reports of medication use prior to Ewing Sarcoma Family of Tumor (ESFT) diagnosis,...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Cope, J. U., Reaman, G. H., Tonning, J. M. Tags: Epidemiology Source Type: research

Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives.
This article reviews the efficacy and safety of FMT used in treating a variety of diseases, methodology, criteria for donor selection and screening, and various concerns regarding FMT. PMID: 26956193 [PubMed - as supplied by publisher]
Source: Clinical Endoscopy - March 11, 2016 Category: Gastroenterology Tags: Clin Endosc Source Type: research

We are not alone: a case for the human microbiome in extra intestinal diseases
ConclusionsEvaluating diseases remote from the gut would unfold the mysteries of the microbiome.
Source: Gut Pathogens - March 6, 2017 Category: Microbiology Source Type: research

Juvenile- and adult-onset systemic lupus erythematosus: a comparative study in a large cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER).
CONCLUSIONS: jSLE shares many clinical and serological features with aSLE. However, jSLE patients typically manifested more activity, severity, cumulative damage in certain areas, than their aSLE counterparts. PMID: 28628467 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - June 21, 2017 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Thrombolysis: A Useful Tool in the Primary PCI Cupboard.
Authors: Schwarz K, Goyal D, Routledge H Abstract A 44-year-old woman presented to the emergency department with central crushing chest pain and dynamic anterior ST elevation on a background of a known left bundle-branch block on her electrocardiogram. Past medical history included insulin-dependent diabetes, asthma, fibromyalgia, and a gradually failing kidney transplant. This case demonstrates the rarely utilized niche role for intracoronary thrombolysis in STEMI treatment in the modern angioplasty era. PMID: 28756427 [PubMed - in process]
Source: The Journal of Invasive Cardiology - August 1, 2017 Category: Cardiology Tags: J Invasive Cardiol Source Type: research

Trazodone for Insomnia: A Systematic Review
Conclusion. A review of the literature suggests that there are adequate data supporting the efficacy and general safety of the low-dose use of trazodone for the treatment of insomnia. keywords: insomnia, hypnotics, treatment, trazodone, sedative Keywords: insomnia, hypnotics, treatment, trazodone, sedative Innov Clin Neurosci. 2017;14(9–10):24–34 Introduction Insomnia is characterized by difficulty falling asleep, difficulty staying asleep, or waking too early1 and is associated with significant impairments in daytime activities, which might occur despite adequate opportunities for sleep.2–6 Primary insomnia is an or...
Source: Innovations in Clinical Neuroscience - July 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review hypnotics insomnia sedative trazodone treatment Source Type: research

The Case | An unusual cause of proteinuria in a kidney transplant recipient
A 49-year-old Black woman with hypertension and kidney failure of unknown etiology underwent deceased-donor kidney transplantation. The donor was a 27-year-old Black man with fibromyalgia and depression who died of lymphocytic myocarditis, per the autopsy report. The donor had terminal creatinine of 0.6 mg/dl, unremarkable urinalysis, a Kidney Donor Profile Index of 23%, positive IgG for Epstein-Barr virus, and otherwise negative routine screening for infectious diseases. The recipient, who had no family history of kidney disease, was maintained on prednisone, tacrolimus, and mycophenolate mofetil.
Source: Kidney International - August 18, 2022 Category: Urology & Nephrology Authors: Raphael J. Rosen, Sindhuri Prakash-Polet, Patty Liu, Ibrahim Batal, Satoru Kudose Tags: Make Your Diagnosis Source Type: research

Sj ögren’s syndrome
AbstractSj ögren’s syndrome (SS) is characterised as keratoconjunctivitis sicca (dry eyes), xerostomia (dry mouth) commonly associated with salivary gland enlargement, and is referred to as Primary Sjögren’s syndrome. It is known as Secondary Sjögren’s syndrome when it occurs in patients, with connect ive tissue disease, such as rheumatoid arthritis, systemic lupus erythematosus, polyarthritis nodosa, polymyositis, and systemic sclerosis. SS has also been associated with chronic graft-versus-host disease after allogeneic bone marrow transplantation, human immunodeficiency syndrome (AIDS), hepatit is C infection (H...
Source: Inflammopharmacology - May 17, 2023 Category: Drugs & Pharmacology Source Type: research

Gut microbiota in chronic pain: Novel insights into mechanisms and promising therapeutic strategies
Int Immunopharmacol. 2023 Feb;115:109685. doi: 10.1016/j.intimp.2023.109685. Epub 2023 Jan 24.ABSTRACTChronic pain remains one of the world's most persistent and unsolved clinical challenges that severely affect patients' quality of life. Presently, considering that the mechanisms underlying chronic pain are not fully understood, there is a lack of effective drugs and interventions to treat chronic pain in clinical practice. Therefore, exploring the pathogenic mechanism of chronic pain and establishing potential targets are the keys to treating chronic pain. Substantial evidence has indicated that gut microbiota plays a cr...
Source: International Immunopharmacology - June 6, 2023 Category: Allergy & Immunology Authors: Liping Liu Qin Wu Yuping Chen Huiling Ren Qi Zhang Hengyue Yang Wenying Zhang Tingyu Ding Shujie Wang Yan Zhang Yun Liu Jihu Sun Source Type: research