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Total 265 results found since Jan 2013.
(208) Catastrophizing cognitions promote proinflammatory cytokine responses to acute pain in fibromyalgia
For patients that suffer from musculoskeletal pain conditions such as fibromyalgia and osteoarthritis, catastrophizing plays an important role in shaping the pain experience. The mechanisms that underlie catastrophizing’s effects are multifactorial, and some research has reported that high levels of catastrophizing are associated with enhanced physiological reactivity to painful stimulation. In the present study we investigated the association between catastrophizing and inflammatory pain responses (i.e., increases in IL-6 during experimental pain testing) in several groups.
Source: The Journal of Pain - March 27, 2015 Category: Materials Science Authors: O. Franceschelli, C. Cahalan, M. Martel, R. Edwards Tags: B04 Fibromyalgia Source Type: research
(210) Prevalence of migraine headaches in patients with Fibromyalgia
Several studies have reported a high prevalence of fibromyalgia in patients with migraines,1 but there is little research on the prevalence of migraines in patients with fibromyalgia, despite clinical observation suggesting that migraines are a common complaint. Given the high degree of comorbidity between fibromyalgia and migraines, assessment of headache in patients with fibromyalgia is important. A total of 3,717 patients in the Mayo Clinic Fibromyalgia Registry who had previously agreed to be contacted regarding fibromyalgia research were sent an electronic survey consisting of medical history and demographic questions...
Source: The Journal of Pain - March 27, 2015 Category: Materials Science Authors: B. Vij, M. Whipple, S. Tepper, A. Mohabbat, M. Stillman, A. Vincent Source Type: research
Altered Psychophysiological Responses to the View of Others' Pain and Anger Faces in Fibromyalgia Patients
Abstract: Facial expression provides information for an accurate estimation of others' pain. Nevertheless, little is known about psychophysiological responses to pain faces in chronic pain. Event-related potentials and brain oscillations, corrugator activity, and heart rate were recorded in 20 fibromyalgia patients and 20 pain-free controls when viewing pain, anger, happy, and neutral faces. Pain and anger faces elicited greater unpleasantness and arousal than happy and neutral faces, and pain faces evoked greater corrugator response than the rest of faces in all participants. Fibromyalgia patients displayed greater cardia...
Source: The Journal of Pain - April 29, 2013 Category: Materials Science Authors: Ana M. González-Roldán, Miguel A. Muñoz, Ignacio Cifre, Carolina Sitges, Pedro Montoya Tags: Original Reports Source Type: research
(221) Associations between post-traumatic stress disorder symptoms and mental health in fibromyalgia
Research suggests that many patients who suffer from post-traumatic stress disorder (PTSD) frequently also have fibromyalgia and vice versa. Patients with PTSD with concurrent fibromyalgia reported more pain, greater tenderness, lower quality of life, greater functional impairment, and more psychological distress as compared to patients with PTSD without concurrent fibromyalgia. However, it is unknown how PTSD may contribute to the mental health impairment in fibromyalgia. The purpose of this study was to evaluate symptoms of PTSD in patients with fibromyalgia and determine if PTSD symptoms could mediate differences in men...
Source: The Journal of Pain - March 31, 2016 Category: Materials Science Authors: M. Whipple, L. Toussaint, K. Fleming, S. Nanda, A. Mohabbat, A. Vincent Source Type: research
(395) Patient-reported outcomes of disease impact and change experienced with pregabalin treatment in patients with fibromyalgia and moderate or severe baseline pain
Fibromyalgia is generally associated with widespread chronic pain. In this analysis, we used patient-reported outcomes (Patient Global Impression of Change [PGIC], Fibromyalgia Impact Questionnaire [FIQ]) to evaluate management of fibromyalgia with pregabalin. Data were pooled from five randomized, placebo-controlled clinical trials of pregabalin (8-15 weeks at 300 mg/day, 450 mg/day, or flexible dosing [300-450 mg/day]) in patients with fibromyalgia. Patients were subgrouped by moderate (mean baseline pain scores ≥4-
Source: The Journal of Pain - March 27, 2015 Category: Materials Science Authors: A. Clair, B. Emir Source Type: research
Longitudinal stability of fibromyalgia symptom clusters
Using self-report questionnaires of key fibromyalgia symptoms domains (fatigue, sleep disturbance, pain, function, stiffness, dyscognition, depression, and anxiety) we previously identified four unique symptom clusters. The purpose of this study was to examine the stability of fibromyalgia symptom clusters between baseline and two years follow-up. Female patients with a diagnosis of fibromyalgia completed a baseline Brief Pain Inventory, the 30-item Profile of Mood States, the Medical Outcomes Sleep Scale, the Multidimensional Fatigue Inventory, the Multiple Ability Self-Report Questionnaire, the Fibromyalgia Impact Questi...
Source: The Journal of Pain - February 14, 2018 Category: Materials Science Authors: T. Hoskin, A. Vincent, M. Whipple, S. Nanda Source Type: research
(147) Relation of Fibromyalgia Severity and the Exercise-Induced Pain Response, Prognostic or Inconsequential?
This study investigated the relation of fibromyalgia severity on the acute pain response following isometric and dynamic muscle contractions. Thirty-four participants with fibromyalgia (52.5 ±11.9yr.; BMI:31.1±6.1; 32 women) completed a quiet rest and two randomized exercise sessions (isometric or dynamic) of the elbow flexors matched for intensity, duration, and duty-cycle. The quiet rest session included assessment of fibromyalgia severity (Fibromyalgia Symptom Scale [FS]), conditio ned pain modulation (CPM), and mechanical temporal summation (TS).
Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: G. Berardi, C. Eble, M. Hoeger Bement Tags: Treatment Approaches (Psychological & Rehabilitative) (with CE) Source Type: research
Large treatment effect with extended home-based transcranial direct current stimulation over dorsolateral prefrontal cortex in fibromyalgia: A Proof of Concept Sham-Randomized Clinical Study
Fibromyalgia encompasses symptoms of central sensitization syndrome (CSS)26 such as increased levels of emotional distress, sleep disorders, depressed mood, catastrophizing thinking, cognitive deficits, and memory impairment58 However, according to systematic reviews, the pharmacologic treatments have a limited role in a substantial number of fibromyalgia patients.22,23 A new option with growing evidence for fibromyalgia treatment is the transcranial direct current stimulation (tDCS). Its effect is likely sensible to the neuroplastic state, as demonstrated in recent studies in the fibromyalgia serum brain-derived neurotrop...
Source: The Journal of Pain - July 25, 2019 Category: Materials Science Authors: Aline P Brietzke, Maxciel Zortea, Fabiana Carvalho, Paulo R S Sanches, Jr Danton P Silva, Iraci Lucena da Silva Torres, Felipe Fregni, Wolnei Caumo Tags: Original Reports Source Type: research
Spa therapy for the treatment of fibromyalgia: an open, randomized multicenter trial
Fibromyalgia is a common chronic pain pathology with an incidence of 4.3 per 1000 person-years. An open, randomized clinical trial of patients with fibromyalgia comparing an immediate vs. delayed 18-day spa therapy in five spa therapy care facilities in France enrolled 220 patients. Randomization was in blocks of four, stratified by center, severity of fibromyalgia and previous spa therapy. Patients continued usual treatment. The main endpoint was the number of patients achieving minimal clinically important difference (MCID) at 6 months, defined as 14% change in their baseline fibromyalgia impact questionnaire (FIQ) score.
Source: The Journal of Pain - March 3, 2021 Category: Materials Science Authors: Caroline Maindet, Aurore Maire, C éline Vermorel, Claire Cracowski, Carole Rolland, Romain Forestier, Alexa Comte, Christian-François Roques, Eric Serra, Jean Luc Bosson Tags: Original Reports Source Type: research
Variable Voxel-based Morphometry Observations of Gray Matter Differences in Fibromyalgia: Individual Differences or Methodological Inconsistency?
Fibromyalgia is a prevalent chronic pain condition characterized by widespread pain and sensory hypersensitivity. While much remains to be learned about the neurobiological underpinnings of this condition, alterations to the central nervous system appear to be heavily implicated in fibromyalgia's pathophysiology. Previous research examining brain structural abnormalities among fibromyalgia patients has yielded inconsistent findings. Thus, we followed previous voxel-based morphometry methods in magnetic resonance imaging to examine brain gray matter differences in females (n=17) with fibromyalgia and female healthy controls (n=17).
Source: The Journal of Pain - May 1, 2022 Category: Materials Science Authors: Anne Baker, Meghna Nanda, Su Hyoun Park, Katherine T. Martucci Tags: 166 Source Type: research
Focal Modulation of the Primary Motor Cortex in Fibromyalgia Using 4×1-Ring High-Definition Transcranial Direct Current Stimulation (HD-tDCS): Immediate and Delayed Analgesic Effects of Cathodal and Anodal Stimulation
Abstract: Fibromyalgia is a prevalent chronic pain syndrome characterized by altered pain and sensory processing in the central nervous system, which is often refractory to multiple therapeutic approaches. Given previous evidence supporting analgesic properties of noninvasive brain stimulation techniques in this condition, this study examined the effects of a novel, more focal method of transcranial direct current stimulation (tDCS), using the 4×1-ring configuration of high-definition (HD)-tDCS, on overall perceived pain in fibromyalgia patients. In this patient- and assessor-blind, sham-controlled, crossover trial, 18 pa...
Source: The Journal of Pain - February 18, 2013 Category: Materials Science Authors: Mauricio F. Villamar, Pakorn Wivatvongvana, Jayanton Patumanond, Marom Bikson, Dennis Q. Truong, Abhishek Datta, Felipe Fregni Tags: Original Reports Source Type: research
Changes in Pain Coping, Catastrophizing, and Coping Efficacy After Cognitive-Behavioral Therapy in Children and Adolescents With Juvenile Fibromyalgia
Abstract: A recent randomized multisite clinical trial found that cognitive-behavioral therapy (CBT) was significantly more effective than fibromyalgia education (FE) in reducing functional disability in adolescents with juvenile fibromyalgia (JFM). The primary objective of this study was to examine the psychological processes of CBT effectiveness by evaluating changes in pain coping, catastrophizing, and coping efficacy and to test these changes as mediators of continued improvements in functional disability and depressive symptoms at 6-month follow-up. One hundred adolescents (11–18 years old) with JFM completed the cl...
Source: The Journal of Pain - March 28, 2013 Category: Materials Science Authors: Susmita Kashikar-Zuck, Soumitri Sil, Anne M. Lynch-Jordan, Tracy V. Ting, James Peugh, Kenneth N. Schikler, Philip J. Hashkes, Lesley M. Arnold, Murray Passo, Margaret M. Richards-Mauze, Scott W. Powers, Daniel J. Lovell Tags: Original Reports Source Type: research
Central Pain Sensitization, COMT Val158Met Polymorphism, and Emotional Factors in Fibromyalgia
Abstract: Neurobiological evidence points to altered central nervous system processing of nociceptive stimuli in fibromyalgia. Enzymes like catechol-O-methyl-transferase (COMT) are involved in the elimination of catecholamines playing a possible role in central sensitization and pain. We used quantitative sensory testing to evidence central sensitization in fibromyalgia patients and test whether COMTVal158Met polymorphism, associated with a reduction in enzyme activity, plays a role in sensitized patients. Pain evaluation and quantitative sensory testing were performed including the spinal nociceptive flexion reflex, a phy...
Source: The Journal of Pain - December 16, 2013 Category: Materials Science Authors: Jules Desmeules, Jocelyne Chabert, Michela Rebsamen, Elisabetta Rapiti, Valerie Piguet, Marie Besson, Pierre Dayer, Christine Cedraschi Tags: Original Reports Source Type: research
(479) Higher physical activity is associated with lower pain in women with fibromyalgia
Fibromyalgia is characterized by enhanced central excitability and pain inhibition, resulting in impaired physical function and diminished quality of life. Regular physical activity is associated with reduced central excitability and enhanced endogenous inhibition of pain. However, many women with fibromyalgia do not participate in regular physical activity. The purpose of this investigation was to determine differences in physiological and psychological pain outcomes in sedentary (SED), moderately active (MOD), and vigorously active (VIG) women with fibromyalgia.
Source: The Journal of Pain - March 27, 2015 Category: Materials Science Authors: E. Merriwether, B. Rakel, D. Dailey, L. Alemo Munters, L. Darghosian, C. Vance, L. Crofford, K. Sluka Source Type: research
(470) Effect of environmental enrichment, associate or not to physical activity, on nociceptive and motor functions in an animal model of Fibromyalgia
This study proposes the investigation of environmental enrichment (EE), a technique based on physical, sensory and cognitive stimulation, and physical activity (PA) as strategies for fibromyalgia prevention.
Source: The Journal of Pain - March 27, 2015 Category: Materials Science Authors: L. Lima, S. Dourado, T. Souza, D. Carvalho, F. Oliveira, J. DeSantana Source Type: research
