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Specialty: Drugs & Pharmacology
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Total 194 results found since Jan 2013.
Microglia polarization in nociplastic pain: mechanisms and perspectives
AbstractNociplastic pain is the third classification of pain as described by the International Association for the Study of Pain (IASP), in addition to the neuropathic and nociceptive pain classes. The main pathophysiological mechanism for developing nociplastic pain is central sensitization (CS) in which pain amplification and hypersensitivity occur. Fibromyalgia is the prototypical nociplastic pain disorder, characterized by allodynia and hyperalgesia. Much scientific data suggest that classical activation of microglia in the spinal cord mediates neuroinflammation which plays an essential role in developing CS. In this r...
Source: Inflammopharmacology - April 17, 2023 Category: Drugs & Pharmacology Source Type: research
Drug discovery and development for fibromyalgia using practical biomarkers throughout the process from relevant animal models to patients
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Source: Expert Opinion on Drug Discovery - April 14, 2023 Category: Drugs & Pharmacology Authors: Yukinori Nagakura Hidetoshi Tozaki-Saitoh Hiroshi Takeda Source Type: research
Spinal dopaminergic D < sub > 1 < /sub > -and D < sub > 2 < /sub > -like receptors have a sex-dependent effect in an experimental model of fibromyalgia
Eur J Pharmacol. 2023 Mar 30:175696. doi: 10.1016/j.ejphar.2023.175696. Online ahead of print.ABSTRACTThere is evidence about the importance of sex in pain. The purpose of this study was to investigate the effect of sex in the antiallodynic activity of spinal dopamine D1-and D2-like receptors in a model of fibromyalgia-type pain in rats. Reserpine induced the same extent of tactile allodynia in female and male rats. Intrathecal injection of SCH- 23390 (3-30 nmol, D1-like receptor antagonist), pramipexole (0.15-15 nmol) or quinpirole (1-10 nmol D2-like receptor agonists) increased withdrawal threshold in reserpine-treated f...
Source: European Journal of Pharmacology - April 1, 2023 Category: Drugs & Pharmacology Authors: Yarim Elideth De la Luz-Cuellar Ulises Coffeen Francisco Mercado Vinicio Granados-Soto Source Type: research
Could the fibromyalgia syndrome be triggered or enhanced by COVID-19?
AbstractFibromyalgia (FM) is a complex disease with an uncertain aetiology and intricate pathophysiology. Although its genesis is not fully explained, potential environmental factors, such as viral infections might trigger FM or worsen patients' clinical outcomes. The SARS-CoV-2 virus may affect central and peripheral nervous systems, leading to musculoskeletal, neurological, and psychological disturbances. These symptoms might persist at least 12 months beyond the recovery, often referred to as post-COVID syndrome, which resembles FM syndrome. In this sense, we argued the potential consequences of COVID-19 exclusively o...
Source: Inflammopharmacology - February 27, 2023 Category: Drugs & Pharmacology Source Type: research
Consider cannabinoids as an individual therapeutic trial in nociplastic pain
AbstractNociplastic pain, which is characterized by widespread chronic pain and a range of central nervous system and other somatic symptoms, is associated with significant emotional distress and disability. Fibromyalgia is the prototypical example of a nociplastic condition. Traditional treatments for chronic pain, especially nociplastic pain, provide mostly modest relief. Medical cannabis and cannabis-based medicines can potentially address this therapeutic gap. Although evidence supporting their use in nociplastic pain is insufficient to endorse general use, they can be regarded as an individual therapeutic trial if est...
Source: Drugs and Therapy Perspectives - November 22, 2022 Category: Drugs & Pharmacology Source Type: research
Fibromyalgia treated with oxygen-ozone auto-haemotherapy (O2-O3-AHT): a case study on 200 patients with a modified 10-PI-NRS evaluation
CONCLUSIONS: Oxygen-ozone autohemotherapy represents a formidable therapeutic approach for FM, deserving further studies to be made in order to fully elucidate ozone effect of this pathology.PMID:36394747 | DOI:10.26355/eurrev_202211_30150
Source: Pharmacological Reviews - November 17, 2022 Category: Drugs & Pharmacology Authors: U Tirelli M Franzini L Valdenassi S Pandolfi R Taibi S Chirumbolo Source Type: research
