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Specialty: Drugs & Pharmacology
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Total 194 results found since Jan 2013.
Pharmacological management of fibromyalgia: a Bayesian network meta-analysis
Expert Rev Clin Pharmacol. 2022 Feb 23:1-10. doi: 10.1080/17512433.2022.2044792. Online ahead of print.ABSTRACTINTRODUCTION: The identification of the most effective therapy for patients with fibromyalgia (FM) remains controversial. Thus, we conducted a Bayesian network meta-analysis to compare several drugs employed as pharmacological management for FM.AREAS COVERED: The following databases were accessed in October 2021: PubMed, Google Scholar, Embase, and Scopus. All the randomized clinical trials (RCTs) that compare two or more pharmacological management for fibromyalgia were accessed. Only studies involving a minimum o...
Source: Pharmacological Reviews - February 21, 2022 Category: Drugs & Pharmacology Authors: Filippo Migliorini Nicola Maffulli J örg Eschweiler Matthias Knobe Markus Tingart Giorgia Colarossi Source Type: research
Evidence Needed for Efficacy of Antidepressant Medications Among Patients With Rheumatoid Arthritis
Ann Pharmacother. 2022 Jan 7:10600280211062271. doi: 10.1177/10600280211062271. Online ahead of print.ABSTRACTPatients with rheumatoid arthritis (RA) experience pain from inflammation, joint destruction, and neuropathy. Antidepressants may play a role among patients with RA and depression, fibromyalgia, or neuropathy to achieve desired outcomes. This commentary evaluated evidence for medications individually and identified important variables for future research. While we await the results of well-designed studies, a trial of duloxetine or milnacipran may be considered for patients with remnant pain and RA remission. Resea...
Source: The Annals of Pharmacotherapy - January 8, 2022 Category: Drugs & Pharmacology Authors: Armando Silva Almod óvar Dung Nguyen Milap C Nahata Source Type: research
Cannabis-Based Medicines and Medical Cannabis in the Treatment of Nociplastic Pain
AbstractNociplastic pain is defined as pain due to sensitization of the nervous system, without a sufficient underlying anatomical abnormality to explain the severity of pain. Nociplastic pain may be manifest in various organ systems, is often perceived as being more widespread rather than localized and is commonly associated with central nervous system symptoms of fatigue, difficulties with cognition and sleep, and other somatic symptoms; all features that contribute to considerable suffering. Exemplified by fibromyalgia, nociplastic conditions also include chronic visceral pain, chronic headaches and facial pain, and chr...
Source: Drugs - November 20, 2021 Category: Drugs & Pharmacology Source Type: research
Spinal CCK contributes to somatic hyperalgesia induced by orofacial inflammation combined with stress in adult female rats
Eur J Pharmacol. 2021 Nov 5:174619. doi: 10.1016/j.ejphar.2021.174619. Online ahead of print.ABSTRACTIn some chronic primary pain conditions such as temporomandibular disorder (TMD) and fibromyalgia syndrome (FMS), mild or chronic stress enhances pain. TMD and FMS often occur together, but the underlying mechanisms are unclear. The purpose of this study was to investigate the role of cholecystokinin (CCK) in the spinal cord in somatic hyperalgesia induced by orofacial inflammation combined with stress. Somatic hyperalgesia was detected by the thermal withdrawal latency and mechanical withdrawal threshold. The expression of...
Source: European Journal of Pharmacology - November 8, 2021 Category: Drugs & Pharmacology Authors: Lu-Lu Duan Xin-Yi Qiu Si-Qi Wei Han-Yu Su Fu-Rong Bai Richard J Traub Qin Zhou Dong-Yuan Cao Source Type: research
Suicidality and other severe psychiatric events with duloxetine: Re-analysis of safety data from a placebo-controlled trial for juvenile fibromyalgia
CONCLUSIONS: Antidepressants may put adolescents at risk of suicidality and other severe psychiatric disorders even when the treatment indication is not depression or anxiety.PMID:34397423 | DOI:10.3233/JRS-200033
Source: International Journal of Risk and Safety in Medicine - August 16, 2021 Category: Drugs & Pharmacology Authors: Michael P Hengartner Martin Pl öderl Source Type: research
