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Cross ‐talk Between Enzymes Matrix‐metalloproteinsese 2 and 9 and Regulatory T‐cell Immunity in the Global Burden of Atherosclerosis
This article is protected by copyright. All rights reserved.
Source: Scandinavian Journal of Immunology - May 1, 2017 Category: Allergy & Immunology Authors: Andrica Lekic, Zdrinko Brekalo, Ante Kvesic, Miljenko Kovacevic, Zdenka Baricev ‐Novakovic, Ivana Sutic, Aleksandar Bulog, Ingrid Sutic, Valentino Pavisic, Ines Mrakovcic‐Sutić Tags: Regular Manuscript Source Type: research

Survival analysis using primary care electronic health record data.
CONCLUSION: Survival analysis applied to primary care electronic medical data is a research approach that has been frequently used in recent times. The utility of this approach was demonstrated by the ability to produce research with large numbers of subjects, across a wide range of conditions and with the potential of a high impact. Importantly, primary care data were thus available to inform primary care practice. PMID: 28537200 [PubMed - as supplied by publisher]
Source: Health Information Management Journal - May 26, 2017 Category: Health Management Tags: HIM J Source Type: research

Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis
Abstract Changes in immune and inflammatory responses may play a crucial role in the development and progression of atherosclerosis, as an autoimmune, chronic and progressive inflammatory disease. Immunological activity and vascular inflammation during atherosclerosis can be modulated by autoimmune responses against self‐antigens, according to changeable risk factors (cholesterol, oxidized low‐density lipoprotein (ox‐LDL) in the vascular wall, fatty acids, etc.), and accompanied by accumulation of leucocytes and proinflammatory cytokines, which stimulate the transcription of matrix metalloproteinases (MMPs), whose co...
Source: Scandinavian Journal of Immunology - June 15, 2017 Category: Allergy & Immunology Authors: A. Lekic, Z. Brekalo, A. Kvesic, M. Kovacevic, Z. Baricev ‐Novakovic, I. Sutic, A. Bulog, I. Sutic, V. Pavisic, I. Mrakovcic‐Sutic Tags: Human Immunology Source Type: research

Telephone consultations for general practice: a systematic review
ConclusionThere is a lack of high level evidence for telephone consultations in a GP setting; however, current evidence suggests that telephone consultations as an alternative to face-to-face general practice consultations offers an appropriate option in certain settings.Systematic review registrationPROSPEROCRD42015025225
Source: Systematic Reviews - July 3, 2017 Category: International Medicine & Public Health Source Type: research

Trazodone for Insomnia: A Systematic Review
Conclusion. A review of the literature suggests that there are adequate data supporting the efficacy and general safety of the low-dose use of trazodone for the treatment of insomnia. keywords: insomnia, hypnotics, treatment, trazodone, sedative Keywords: insomnia, hypnotics, treatment, trazodone, sedative Innov Clin Neurosci. 2017;14(9–10):24–34 Introduction Insomnia is characterized by difficulty falling asleep, difficulty staying asleep, or waking too early1 and is associated with significant impairments in daytime activities, which might occur despite adequate opportunities for sleep.2–6 Primary insomnia is an or...
Source: Innovations in Clinical Neuroscience - July 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review hypnotics insomnia sedative trazodone treatment Source Type: research

The distribution of COPD in UK general practice using the 2017 GOLD classification
Conclusion The proportion of people with COPD under treatment in the high-risk groups C and D falls from 48.0% (2013) to 29.6% (2017).The GOLD 2017 ABCD tool results in greater homogeneity as the risk stratification is based on exacerbation history alone. This revision of the COPD grading system is commendably clear, avoiding the need for sub-classification of patients. It will therefore be useful for practising clinicians in patient management.1. Haughney et al Eur Respir J 2014; 43: 993-1002.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Haughney, J., Lee, A., Pertsovskaya, I., McKnight, E., McGarvey, L. Tags: General Practice and Primary Care Source Type: research

Effectiveness of community-based self-management interventions among primary care COPD patients: a systematic review
DiscussionSelf-management interventions for COPD in primary care show promise in reducing patient anxiety, but no effect on HRQoL. The heterogeneity of outcome measures precluded synthesis of the full evidence.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Jolly, K., Sidhu, M., Bates, E., Majothi, S., Sitch, A., Bayliss, S., Kim, S., Jordan, R. Tags: General Practice and Primary Care Source Type: research

Prevalence of treatment-resistant hypertension after considering pseudo-resistance and morbidity: a cross-sectional study in Irish primary care.
CONCLUSION: Reviewing individual patient records results in a lower estimate of prevalence of TRH than has been previously reported. Further consideration for individual patients of pseudo-resistance additionally lowers these estimates, and may be all that is required for management in the vast majority of cases. PMID: 29739776 [PubMed - as supplied by publisher]
Source: The British Journal of General Practice - May 8, 2018 Category: Primary Care Authors: Hayes P, Casey M, Glynn LG, Molloy GJ, Durand H, O'Brien E, Dolan E, Newell J, Murphy AW Tags: Br J Gen Pract Source Type: research

Systematic Review and Meta-analysis of Short- versus Long-Acting Granulocyte Colony-Stimulating Factors for Reduction of Chemotherapy-Induced Febrile Neutropenia
ConclusionsOverall, the weight of evidence from RCTs indicates little difference in efficacy between the short- and long-acting G-CSFs if dosed according to recommended guidelines. There is some evidence for greater efficacy for long-acting G-CSFs in non-RCTs, which may be a result of under-dosing of short-acting G-CSFs in general practice in real-world usage.FundingHospira Inc, which was acquired by Pfizer Inc in September 2015, and Pfizer Inc.
Source: Advances in Therapy - October 8, 2018 Category: Drugs & Pharmacology Source Type: research

Sound therapy (using amplification devices and/or sound generators) for tinnitus.
CONCLUSIONS: There is no evidence to support the superiority of sound therapy for tinnitus over waiting list control, placebo or education/information with no device. There is insufficient evidence to support the superiority or inferiority of any of the sound therapy options (hearing aid, sound generator or combination hearing aid) over each other. The quality of evidence for the reported outcomes, assessed using GRADE, was low. Using a combination device, hearing aid or sound generator might result in little or no difference in tinnitus symptom severity.Future research into the effectiveness of sound therapy in patients w...
Source: Cochrane Database of Systematic Reviews - December 27, 2018 Category: General Medicine Authors: Sereda M, Xia J, El Refaie A, Hall DA, Hoare DJ Tags: Cochrane Database Syst Rev Source Type: research

Impact of GP gatekeeping on quality of care, and health outcomes, use, and expenditure: a systematic review.
CONCLUSION: Gatekeeping was associated with lower healthcare use and expenditure, and better quality of care, but with lower patient satisfaction. Survival rate of patients with cancer in gatekeeping schemes was significantly lower than those in direct access, although primary care gatekeeping was not otherwise associated with delayed patient referral. The long-term outcomes of gatekeeping arrangements should be carefully studied before devising new gatekeeping policies. PMID: 30910875 [PubMed - as supplied by publisher]
Source: The British Journal of General Practice - March 24, 2019 Category: Primary Care Authors: Sripa P, Hayhoe B, Garg P, Majeed A, Greenfield G Tags: Br J Gen Pract Source Type: research

Bereavement practices employed by hospitals and medical practitioners toward attending funeral of patients: A systematic review
Conclusion: Several bereavement practices are provided by hospitals and MPs. Funeral attendance is an uncommon bereavement practice. MPs’ attitudes toward attending a patient's funeral are understudied in many specialties. Patient factors that influence MPs’ participation in bereavement practices are poorly understood.
Source: Medicine - September 1, 2019 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Withdrawal of inhaled corticosteroids in COPD patients with mild or moderate airflow limitation: who is suitable for a trial of withdrawal?
Conclusion: The determinants of suitability for HD-ICS prescription in primary care records are inconsistently recorded, difficult to identify and challenging to apply.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Harries, T., Gilworth, G., Thomas, M., Corrigan, C., Murphy, P., Hart, N., Hamilton, L., White, P. Tags: General practice and primary care Source Type: research

Chronic respiratory diseases (CRDs) in low- and middle-income countries (LMICs): A scoping review of survey methodologies
Conclusion: Descriptions for CRDs vary in operational study definitions and instruments. Future surveys should optimise and standardise their methodology in order to provide robust estimates of disease burden.Method: NIHR RESPIRE Global Health Research Unit and is written on behalf of the RESPIRE collaborators
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Hanafi, n. s., Agarwal, D., Chippagiri, S., Brakema, E. A., Pinnock, H., Khoo, E.-M., Sheikh, A., Liew, S.-M., Ng, C.-W., Isaac, R., Chinna, K., Wong, L.-P., Hussein, N., Abu Bakar, A. I., Pang, Y.-K., Juvekar, S. Tags: General practice and primary care Source Type: research

Which patients miss appointments with general practice and why? A systematic review
CONCLUSIONS: Findings from this review have potential implications for targeted interventions to address missed appointments in primary care. This is the first step for clinicians being able to target interventions to reduce the rate of missed appointments.PMID:33606660 | DOI:10.3399/BJGP.2020.1017
Source: The British Journal of General Practice - February 19, 2021 Category: Primary Care Authors: Joanne Parsons Carol Bryce Helen Atherton Source Type: research