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Research for Cytomegalovirus Mutations Associated With Resistance to Antivirals in Kidney Transplant Receptors
Cell Transplant. 2023 Jan-Dec;32:9636897231195245. doi: 10.1177/09636897231195245.ABSTRACTCytomegalovirus (CMV) mutations associated with antiviral resistance have become a major problem related to high mortality in kidney transplant patients. The aim of the study was to investigate mutations in the CMV genes UL97 and UL54 associated with antiviral resistance. A retrospective observational cohort study was carried out at Hospital Ophir Loyola (HOL), a reference in Kidney Transplantation. A total of 81 patients who underwent kidney transplantation were followed up between 2016 and 2018 were monitored for CMV viral load by p...
Source: Cell Transplantation - September 19, 2023 Category: Cytology Authors: Carla de Castro Sant' Anna Silvia Regina da Cruz Migone Carlos Alberto Machado da Rocha Fernando Augusto Rodrigues Mello J únior Aline Damasceno Seabra Tha ís Brilhante Pontes Jo ão Marildo Rodrigues Salom é Aparecida Soares Viviane de Paiva Rego Joan Source Type: research
AHL score for predicting mortality risk in patients with pulmonary tuberculosis
Chest. 2023 Sep 17:S0012-3692(23)05434-X. doi: 10.1016/j.chest.2023.09.008. Online ahead of print.ABSTRACTBACKGROUND: A clinically applicable mortality-risk prediction system for pulmonary tuberculosis may improve treatment outcomes, but no easy-to-calculate and accurate score has yet been reported. We aimed to construct a simple and objective disease-severity score for patients with pulmonary tuberculosis.RESEARCH QUESTION: Does a clinical score consisting of simple objective factors predict the mortality risk of patients with pulmonary tuberculosis?STUDY DESIGN AND METHODS: The dataset from our previous prospective study...
Source: Chest - September 19, 2023 Category: Respiratory Medicine Authors: Takeshi Osawa Masato Watanabe Kozo Morimoto Takashi Yoshiyama Shuichi Matsuda Keiji Fujiwara Koji Furuuchi Masafumi Shimoda Masashi Ito Tatsuya Kodama Fumiko Uesugi Masao Okumura Yoshiaki Tanaka Yuka Sasaki Hideo Ogata Hajime Goto Shoji Kudoh Ken Ohta Source Type: research
Quality Contract for the Prevention of Postoperative Delirium
Anasthesiol Intensivmed Notfallmed Schmerzther. 2023 Sep;58(9):525-539. doi: 10.1055/a-2065-3806. Epub 2023 Sep 19.ABSTRACTDelirium is one of the most common postoperative complications. Delayed initiation of treatment leads to an increased mortality rate within the first 90 days and to an increased need for post-hospital care. Similarly, neurocognitive disorders (NCDs) occur in a quarter of affected patients over the long-term. The use of evidence-based guideline recommendations can reduce incidence rates of delirium, shorten delirium duration, and prevent complications. Implementing delirium management according to evide...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - September 19, 2023 Category: Intensive Care Authors: Fatima Y ürek Ursula Marschall Ursula Gaedigk Sinah Kr üger Moritz H öft Claudia Spies Source Type: research
Non-pharmacological Management of Postoperative Delirium
Anasthesiol Intensivmed Notfallmed Schmerzther. 2023 Sep;58(9):494-512. doi: 10.1055/a-2065-3764. Epub 2023 Sep 19.ABSTRACTPostoperative delirium is common especially in the elderly and is associated with high rates of morbidity and mortality. Non-pharmacological multicomponent interventions are effective in reducing the incidence and to a degree the duration of postoperative delirium and are recommended in international guidelines on postoperative delirium as first line intervention for management of delirium. Non-pharmacological management of postoperative delirium consists of strategies for risk stratification, risk red...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - September 19, 2023 Category: Intensive Care Authors: Elisa Weidner Laura Hancke Peter Nydahl Claudia Spies Alawi L ütz Source Type: research
Research for Cytomegalovirus Mutations Associated With Resistance to Antivirals in Kidney Transplant Receptors
Cell Transplant. 2023 Jan-Dec;32:9636897231195245. doi: 10.1177/09636897231195245.ABSTRACTCytomegalovirus (CMV) mutations associated with antiviral resistance have become a major problem related to high mortality in kidney transplant patients. The aim of the study was to investigate mutations in the CMV genes UL97 and UL54 associated with antiviral resistance. A retrospective observational cohort study was carried out at Hospital Ophir Loyola (HOL), a reference in Kidney Transplantation. A total of 81 patients who underwent kidney transplantation were followed up between 2016 and 2018 were monitored for CMV viral load by p...
Source: Cell Transplantation - September 19, 2023 Category: Cytology Authors: Carla de Castro Sant' Anna Silvia Regina da Cruz Migone Carlos Alberto Machado da Rocha Fernando Augusto Rodrigues Mello J únior Aline Damasceno Seabra Tha ís Brilhante Pontes Jo ão Marildo Rodrigues Salom é Aparecida Soares Viviane de Paiva Rego Joan Source Type: research
Moral resilience in registered nurses: Cultural adaption and validation study
This study aimed to translate the Rushton Moral Resilience Scale (RMRS) into Chinese and evaluate the psychometric properties of the Chinese version of RMRS (Chi-RMRS).RESEARCH DESIGN: A methodological and descriptive research design.PARTICIPANTS AND RESEARCH CONTEXT: A convenience sample of 411 Chinese professional nurses was recruited through an online survey platform between February and March 2023.ETHICAL CONSIDERATIONS: This study was approved by the Research Ethics Committees of the University and hospitals involved.RESULTS: The RMRS was translated and culturally adapted into a Chinese version. Neither floor nor ceil...
Source: Nursing Ethics - September 19, 2023 Category: Nursing Authors: Xu Tian Qiaoling He Xiaoling Liu Xiuni Gan Mar ía F Jiménez Herrera Source Type: research
Physician and administrator experience of preparing to implement Ontario's intensive care unit Triage Emergency Standard of Care during the COVID-19 pandemic: a qualitative study
CMAJ Open. 2023 Sep 19;11(5):E838-E846. doi: 10.9778/cmajo.20220168. Print 2023 Sep-Oct.ABSTRACTBACKGROUND: As the COVID-19 pandemic created a surge in demand for critical care resources, the province of Ontario, Canada, released the Adult Critical Care Clinical Emergency Standard of Care for Major Surge (Emergency Standard of Care [ESoC]), a triage framework to guide the allocation of critical care resources in the expectation that intensive care units would be overwhelmed. Our aim was to understand physicians' and administrators' experiences and perceptions of planning to implement the ESoC, and to identify ways to impro...
Source: cmaj - September 19, 2023 Category: General Medicine Authors: Brandon A Heidinger Ariane Downar Andrea Frolic James Downar Sarina R Isenberg Source Type: research
Ensuring Fairness in Medical Education Assessment
This study takes a first step in centering the margins as we as medical educators grow our understanding of the dynamics of promoting fairness in assessment. Future studies should explore feedback with intentional inclusion and involvement of diverse students, teachers, and researchers at every stage of the research process from conceptualization through dissemination and application of the new learning. We thank our participants for their time and candor discussing this sensitive topic and the Group on Educational Affairs for funding our work. Thank you for your time and attention and the focus that you’ll put on th...
Source: Academic Medicine Blog - September 18, 2023 Category: Universities & Medical Training Authors: amrounds Tags: AM Podcast AM Podcast Transcript Academic Medicine podcast assessment equity Macy Foundation medical education Source Type: blogs
Optimal hospital discharge time after CIED implantation: A retrospective study from a reference electrotherapy center
Kardiol Pol. 2023 Sep 18. doi: 10.33963/v.kp.97210. Online ahead of print.NO ABSTRACTPMID:37718580 | DOI:10.33963/v.kp.97210
Source: Kardiologia Polska - September 18, 2023 Category: Cardiology Authors: Grzegorz S ławiński Piotr Zieleniewicz Miko łaj Młyński Szymon Budrejko Tomasz Kr ólak Ludmi ła Daniłowicz-Szymanowicz Maciej Kempa Source Type: research
ASO Visual Abstract: COVID-19 Pandemic Did Not Influence the Number of Oncologic and Emergency Surgeries-A Retrospective Cohort Study from a Tertiary Hospital in Austria
Ann Surg Oncol. 2023 Sep 18. doi: 10.1245/s10434-023-14330-5. Online ahead of print.NO ABSTRACTPMID:37721692 | DOI:10.1245/s10434-023-14330-5
Source: Ann Oncol - September 18, 2023 Category: Cancer & Oncology Authors: Lukas Gasteiger Gabriel Putzer Elisabeth Hoerner Michael Joannidis Timo Mayerhoefer Tobias Hell Ottokar Stundner Judith Martini Source Type: research
Genotyping of the rs1800440 Polymorphism in CYP1B1 Gene and the rs9258883 Polymorphism in HLA-B Gene in a Spanish Cohort of 223 Patients with Frontal Fibrosing Alopecia
Acta Derm Venereol. 2023 Sep 18;103:adv9604. doi: 10.2340/actadv.v103.9604.ABSTRACTThe pathogenesis of frontal fibrosing alopecia has been linked to specific genetic variants. CYP1B1 codes for a component of the cytochrome p450 machinery that is involved in the metabolism of xenobiotic oestrogens. The study of the prevalence of polymorphisms in this gene may help to understand their role in the development of frontal fibrosing alopecia. The aim of this study is to describe the frequency of genetic variations in the alleles HLA-B*07:02 and CYP1B1 in patients with frontal fibrosing alopecia. A cross-sectional study was desig...
Source: Acta Dermato-Venereologica - September 18, 2023 Category: Dermatology Authors: David Saceda-Corralo Daniel Ortega-Quijano Gloria Mu ñoz-Martín Óscar M Moreno-Arrones Cristina Pindado-Ortega Tuntas Rayinda Ana Meli án-Olivera Carlos Azc árraga-Llobet Patricia Burgos-Blasco Mar ía Elena Castañeda-Bermúdez Francisco J Del Casti Source Type: research
Optimal hospital discharge time after CIED implantation: A retrospective study from a reference electrotherapy center
Kardiol Pol. 2023 Sep 18. doi: 10.33963/v.kp.97210. Online ahead of print.NO ABSTRACTPMID:37718580 | DOI:10.33963/v.kp.97210
Source: Polish Heart Journal - September 18, 2023 Category: Cardiology Authors: Grzegorz S ławiński Piotr Zieleniewicz Miko łaj Młyński Szymon Budrejko Tomasz Kr ólak Ludmi ła Daniłowicz-Szymanowicz Maciej Kempa Source Type: research
Bacillus Calmette-Gu érin vaccination for protection against recurrent herpes labialis: a nested randomised controlled trial
EClinicalMedicine. 2023 Sep 11;64:102203. doi: 10.1016/j.eclinm.2023.102203. eCollection 2023 Oct.ABSTRACTBACKGROUND: Recurrences of herpes simplex virus (HSV) in the orofacial region (herpes labialis or cold sores) impact quality-of-life. We aimed to study whether the bacille Calmette-Guérin (BCG) vaccine can attenuate cold sore recurrences through off-target immunomodulatory effects.METHODS: In this nested randomised controlled trial within the multicentre, phase 3 BRACE trial, 6828 healthcare workers were randomised in 36 sites in Australia, the Netherlands, Spain, the United Kingdom and Brazil, to receive BCG-Denmark ...
Source: Herpes - September 18, 2023 Category: Infectious Diseases Authors: Laure F Pittet Cecilia L Moore Ellie McDonald Simone Barry Marc Bonten John Campbell Julio Croda Margareth Dalcolmo Andrew Davidson Mark W Douglas Kaya Gardiner Amanda Gwee Bruno Jardim Marcus V G Lacerda Michaela Lucas David J Lynn Laurens Manning Robert Source Type: research
Emergency department visits and hospital admissions for suicidal ideation, self-poisoning and self-harm among adolescents in Canada during the COVID-19 pandemic
CMAJ. 2023 Sep 18;195(36):E1221-E1230. doi: 10.1503/cmaj.220507.ABSTRACTBACKGROUND: The COVID-19 pandemic had profound effects on the mental wellbeing of adolescents. We sought to evaluate pandemic-related changes in health care use for suicidal ideation, self-poisoning and self-harm.METHODS: We obtained data from the Canadian Institute for Health Information on emergency department visits and hospital admissions from April 2015 to March 2022 among adolescents aged 10-18 years in Canada. We calculated the quarterly percentage of emergency department visits and hospital admissions for a composite outcome comprising suicidal...
Source: cmaj - September 18, 2023 Category: General Medicine Authors: Naveen Poonai Stephen B Freedman Amanda S Newton Scott Sawyer Nathalie Gaucher Samina Ali Bruce Wright Michael R Miller Ahmed Mater Eleanor Fitzpatrick Mona Jabbour Roger Zemek Mohamed Eltorki Quynh Doan Pediatric Emergency Research Canada (PERC) Network Source Type: research
