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Total 11357 results found since Jan 2013.
Estrogen-dependent regulation of human uterine natural killer cells promotes vascular remodelling via secretion of CCL2
This study demonstrates a critical role for E2 in regulating cellular cross-talk within the endometrium during early pregnancy. We provide the first evidence that E2 directly regulates the function of human uNK cells by altering uNK cell migration and the secretion of uNK-derived angiogenic factors. We describe a novel mechanism of estrogen-dependent secretion of CCL2 which critically mediates uNK-dependent endometrial angiogenesis. Dysregulation of uNK cell function has been implicated in the aetiology of early implantation disorders and disorders of pregnancy. These novel findings provide unique insight into the regulati...
Source: Human Reproduction - May 19, 2015 Category: Reproduction Medicine Authors: Gibson, D. A., Greaves, E., Critchley, H. O. D., Saunders, P. T. K. Tags: Early pregnancy Source Type: research
Yuri Milner: Why I Funded the Largest Search for Alien Intelligence Ever
On July 20, a consortium of scientists funded by billionaire investor Yuri Milner announced a $100 million project to answer one of the biggest questions in the universe: Is there intelligent life beyond our solar system? Milner, 53, a former scientist who was CEO of Russia’s largest Internet portal Mail.ru before making prescient investments in Facebook, Twitter and Alibaba, has focused his philanthropic efforts on science. The endowment—dubbed Breakthrough Listen—will fund telescope time in North America and Australia as well as data processing to look for radio signals in distant solar systems. Milner ...
Source: TIME.com: Top Science and Health Stories - July 20, 2015 Category: Consumer Health News Authors: Matt Vella Tags: Uncategorized Ann Druyan Billionaires Breakthrough Listen Extraterrestrial Life Frank Drake Martin Rees philanthropy SETI Stephen Hawking The Royal Society Yuri Milner Source Type: news
Search for Alien Life Ignites Battle over Giant Telescope
Private funding for the Arecibo Observatory—the largest single-dish radio telescope in the world—may be a poison pill
-- Read more on ScientificAmerican.com
Source: Scientific American - Official RSS Feed - July 29, 2015 Category: Science Tags: More Science History of Science Physics Society & Policy Space Astrophysics Cosmology Extraterrestrial Life Galaxies Space Exploration Communications ENGINEERING Source Type: research
Vascular endothelial growth factor (VEGF) regulation by hypoxia inducible factor-1 alpha (HIF1A) starts and peaks during endometrial breakdown, not repair, in a mouse menstrual-like model
This study is not a clinical trial.
Source: Human Reproduction - August 19, 2015 Category: Reproduction Medicine Authors: Chen, X., Liu, J., He, B., Li, Y., Liu, S., Wu, B., Wang, S., Zhang, S., Xu, X., Wang, J. Tags: Reproductive biology Source Type: research
Correction
In the February 2015 issue of the Journal of Vascular Surgery, the article by McNally et al (McNally MM, Scali ST, Feezor RJ, Neal D, Huber TS, Beck AW. Three-dimensional fusion computed tomography decreases radiation exposure, procedure time, and contrast use during fenestrated endovascular aortic repair. J Vasc Surg 2015;61:309-16) should have contained the following funding statement:
Source: Journal of Vascular Surgery - August 22, 2015 Category: Surgery Tags: Correction Source Type: research
Silk Road Medical raises $57 million
Silk Road Medical today said it reeled in a $57 million equity-and-debt round from a group of new and existing backers.
Sunnyvale, Calif.-based Silk Road, which makes the Enroute transcarotid artery stent and neuroprotection system, said CRG led the debt round and participated in the equity portion, joined by prior investors Warburg Pincus and The Vertical Group.
“The strength of this financing is a testament to the large opportunity we have to solve unmet clinical needs and lead the next endovascular revolution with TCAR,” CEO Erica Rogers said in prepared remarks. “Our proprietary advances in tempo...
Source: Mass Device - October 20, 2015 Category: Medical Equipment Authors: Brad Perriello Tags: Funding Roundup Stents Vascular Silk Road Medical Inc. Stroke Source Type: news
UPDATE: Embolization coil maker Blockade Medical pulls in $2.2m
UPDATED Oct. 27, 2015, with comment from Blockade Medical.
Blockade Medical pulled in $2.2 million and is looking for another $5.8 million in a new round of equity financing, according to an SEC filing published today.
The round was joined by new investors TitanMed Capital and GP Healthcare Capital, as well as returning investors and other venture capital and private equity funds in the healthcare sector, Blockade Medical said.
Funds from the round will support commercialization efforts for the Barricade coil system, as well as the development of novel neurovascular devices to treat aneurysms, stroke and other conditions,...
Source: Mass Device - October 27, 2015 Category: Medical Equipment Authors: Fink Densford Tags: Business/Financial News Vascular Blockade Medical Source Type: news
Prostaglandin E2 and vascular endothelial growth factor A mediate angiogenesis of human ovarian follicular endothelial cells
STUDY QUESTION
Which receptors for prostaglandin E2 (PGE2) and vascular endothelial growth factor A (VEGFA) mediate angiogenesis in the human follicle around the time of ovulation?
SUMMARY ANSWER
PGE2 and VEGFA act via multiple PGE2 receptors (PTGERs) and VEGF receptors (VEGFRs) to play complementary roles in follicular angiogenesis.
WHAT IS KNOWN ALREADY
Production of PGE2 and VEGFA by the follicle are prerequisites for ovulation. PGE2 is an emerging regulator of angiogenesis and has not been examined in the context of the human ovulatory follicle. VEGFA is an established regulator of follicular angiogenesis.
STUDY DES...
Source: Human Reproduction - January 18, 2016 Category: Reproduction Medicine Authors: Trau, H. A., Brännström, M., Curry, T. E., Duffy, D. M. Tags: Reproductive biology Source Type: research
Mechanistic Basis of Diffuse White Matter Disease in Vascular Contributions to Cognitive Impairment and Dementia (VCID) (R01)
Funding Opportunity RFA-NS-16-021 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to support hypothesis-testing research to elucidate cellular and molecular mechanisms that underlie diffuse white matter disease of vascular origin including multifocal, small, and silent brain infarcts that may contribute to cognitive impairment and dementia.
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 3, 2016 Category: Research Source Type: funding
David Vivero, Amino– Yes, We Need Another Doctor Search Company!
By MATTHEW HOLT
Those of you dismayed at the dearth of recent interviews of notable health tech startups on THCB will be glad to hear I have several in the can and will be putting them up starting with Amino today. And the rest of you can move along….
David Vivero made his money at a company matching renters to apartments that ended up part of Zillow. That was too easy, so now he’s decided to match people up with the right doctor. Amino came out of stealth late last year with about $20m in funding and it has acquired large data sets (including being one of the few with official access to all CMS physici...
Source: The Health Care Blog - February 6, 2016 Category: Consumer Health News Authors: Matthew Holt Tags: Health 2.0 Matthew Holt THCB Amino David Vivero doctor search Source Type: blogs
Mortality of people with chronic fatigue syndrome: a retrospective cohort study in England and Wales from the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLaM BRC) Clinical Record Interactive Search (CRIS) Register
Publication date: Available online 10 February 2016 Source:The Lancet Author(s): Emmert Roberts, Simon Wessely, Trudie Chalder, Chin-Kuo Chang, Matthew Hotopf Background Mortality associated with chronic fatigue syndrome is uncertain. We investigated mortality in individuals diagnosed with chronic fatigue syndrome in secondary and tertiary care using data from the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLaM BRC) Clinical Record Interactive Search (CRIS) register. Methods We calculated standardised mortality ratios (SMRs) for all-cause, suicide-specific, and cancer-specific mortal...
Source: The Lancet - February 10, 2016 Category: Journals (General) Source Type: research
Velano Vascular Raises $3.5 Million To Support Commercialization Needle-Free Blood Draw Device
Velano Vascular, a medical technology company transforming and enhancing the care experience for hospitalized patients and their practitioners, announced today that the company has raised an additional$3.5 millionin funding. Velano will use the proceeds from this financing, an extension of a$5 millionSeries A financing completed inJanuary 2015, to support the development and commercialization of the company's inpatient blood-draw technology in adult and pediatric populations.
Source: Medical Design Online News - February 8, 2016 Category: Medical Equipment Source Type: news
Small Vessel Vascular Contributions to Cognitive Impairment and Dementia (VCID) Biomarkers Consortium: Coordinating Center (U24)
Funding Opportunity RFA-NS-16-019 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to establish the Coordinating Center for the new Small Vessel Vascular Contributions to Cognitive Impairment and Dementia (VCID) Biomarkers Consortium. This FOA together with its companion FOA ("Small Vessel VCID Biomarkers Development Projects"; RFA-NS-16-020) establish the Small Vessel VCID Biomarkers Consortium. The Coordinating Center will consist of: (i) an Administrative Core responsible for organizing, coordinating and administratively driving Consortium activities; and (ii)...
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 26, 2016 Category: Research Source Type: funding
