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Fight Aging! Newsletter, January 13th 2020
In this study, we investigated the link between AF and senescence markers through the assessment of protein expression in the tissue lysates of human appendages from patients in AF, including paroxysmal (PAF) or permanent AF (PmAF), and in sinus rhythm (SR). The major findings of the study indicated that the progression of AF is strongly related to the human atrial senescence burden as determined by p53 and p16 expression. The stepwise increase of senescence (p53, p16), prothrombotic (TF), and proremodeling (MMP-9) markers observed in the right atrial appendages of patients in SR, PAF, and PmAF points toward multiple inter...
Source: Fight Aging! - January 12, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, June 1st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - May 31, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, October 18th 2021
In this study, we therefore analysed the influence of lithium treatment on lifespan and parameters of health during ageing in mice.
To determine the concentration of lithium suitable to be administered in a longitudinal ageing study, we first tested the effects of lithium chloride (LiCl) in doses from 0.01 to 2.79 g LiCl per kg chow. C57Bl/6J mice fed with 1.05-2.79 g/kg LiCL in the diet showed lithium plasma levels between 0.4 and 0.8 mM/l. While plasma levels to 0.4 and 0.8 mM/l are well tolerated by human patients, at doses above 1.44 g LiCl/kg, we observed an obvious dose-dependent polydipsia combined with a dis...
Source: Fight Aging! - October 17, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, April 4th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 3, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, May 2nd 2022
In this study, we tested the therapeutic potential of VHHASC and a newly generated VHH against murine ASC (VHHmASC) to target ASC specks in vitro and in vivo. We show that pre-incubation of extracellular ASC specks with VHHASC abrogated their inflammatory functions in vitro. Recombinant VHHASC rapidly disassembled pre-formed ASC specks and thus inhibited their ability to seed the nucleation of soluble ASC. Notably, VHHASC required prior cytosolic access to prevent inflammasome activation within cells, but it was effective against extracellular ASC specks released following caspase-1-dependent loss of membrane integrity, an...
Source: Fight Aging! - May 1, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
DYRK1B Inhibition Destroys Senescent Endothelial Cells
The endothelium lines the interior of blood vessels, and endothelial dysfunction is a feature of aging. Inflammation and changed cell behavior in the endothelium contributions to the formation of atherosclerotic lesions, as well being disruptive of normal management of blood flow by constriction and dilation. A rising burden of cellular senescence in the endothelium is thought to contribute to this age-related dysfunction of the tissue, and thus senolytic treatments to selectively destroy these errant cells are under consideration as a means of treatment. Given the sizable funding devoted to this part of the field in recen...
Source: Fight Aging! - June 23, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Landscape of WASH-relevant Training for Humanitarian Emergencies
In this study the terms “certificates” and “certification” are used as defined elsewhere7. The professionalisation of the humanitarian sector is currently being discussed6. Relevant professional qualifications for WASH professionals are varied (e.g. engineers, social sciences, environmental or public health related disciplines), thus the professionalisation of humanitarian WASH workers may be a challenge. Moreover, many of such professionals are frequently certified through other professional organisations usually at a national level. On the other hand, minimum standards in humanitarian WASH interventions do exist9...
Source: PLOS Currents Disasters - May 11, 2015 Category: Global & Universal Authors: Caetano Source Type: research
BDNF Actions in the Cardiovascular System: Roles in Development, Adulthood and Response to Injury
This study also identified the cardiac myocyte as a significant local source of BDNF, as cardiac myocyte-specific deletion of BDNF induced a similar cardiomyopathy phenotype. While these results do not exclude a role for other neurotrophins, particularly in injury states, they point to the requirement for continued, local synthesis of BDNF to maintain optimal cardiac function. A major, unresolved question relates to how the truncated TrkB isoform (TrkBT1) transduces the inotropic effects of BDNF, which will require additional study.
A concurrent study evaluated the potential impact of the BDNF-mediated activation of the k...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research
Oligonucleotide Microarrays Identified Potential Regulatory Genes Related to Early Outward Arterial Remodeling Induced by Tissue Plasminogen Activator
This study was supported by National Institutes of Health grant HL-62836 to BB, by NHLBI funds for exchanges of scientists under the auspices of the United States–Russia Joint Agreement in Cardiopulmonary Research, by NATO LST. CLG.979209, by Grants of the Russian Science Foundation (No. 14-24-00086 in part of gene expression profiling induced by tPA; No. 19-75-30007 in part of vessel and tissue remodeling processes).
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of inter...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research
Fight Aging! Newsletter, January 27th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Welcome the New RePORT and RePORTER Tools!
Ten years ago, NIH launched the RePORT (Research Portfolio Online Reporting Tools) website to serve as a one-stop shop for reports, data, and analyses of NIH research activities. Well, drum roll please, a new and modernized RePORT site as well as a faster and easier to use NIH RePORTER have now arrived.
The updated RePORT site strives to meet the needs of today’s users based on feedback received over the years. It is easier, simpler, and quicker to access the same information you have come to rely upon. Right from the homepage, for instance, you can jump into data with interactive charts that connect out to NIH Data Bo...
Source: NIH Extramural Nexus - October 13, 2020 Category: Research Authors: Mike Lauer Tags: blog Open Mike ExPORTER Funding data NIH Data Book RePORT RePORTER Source Type: funding
The effects of radiofrequency electromagnetic fields exposure on tinnitus, migraine and non-specific symptoms in the general and working population: A protocol for a systematic review on human observational studies
Environ Int. 2021 Sep 6;157:106852. doi: 10.1016/j.envint.2021.106852. Online ahead of print.ABSTRACTBACKGROUND: Applications emitting radiofrequency electromagnetic fields (RF-EMF; 100 kHz to 300 GHz) are widely used for communication (e.g. mobile phones), in medicine (diathermy) and in industry (RF heaters). Concern has been raised that RF-EMF exposure affects health related quality of life, because a part of the population reports to experience a variety of symptoms related to low exposure levels below regulatory limits.OBJECTIVES: To systematically review the effects of longer-term or repeated local and whole human bod...
Source: Environment International - September 9, 2021 Category: Environmental Health Authors: Martin R öösli Stefan Dongus Hamed Jalilian Maria Feychting John Eyers Ekpereonne Esu Chioma Moses Oringanje Martin Meremikwu Xavier Bosch-Capblanch Source Type: research
RNA-seq research landscape in Africa: systematic review reveals disparities and opportunities
Eur J Med Res. 2023 Jul 22;28(1):244. doi: 10.1186/s40001-023-01206-3.ABSTRACTRNA sequencing has emerged as the standard method for transcriptome profiling of several human diseases. We performed a systematic review detailing the state of RNA-seq analyses in Africa from its inception till February 2022. Our goal was to provide an update on the state of RNA-seq analyses in Africa, including research gaps, funding information, participants information, authorship and collaborations. Following the PRISMA guidelines, we performed an exhaustive literature search for RNA-seq studies conducted in Africa, using PubMed, Scopus and ...
Source: Biomed Res - July 21, 2023 Category: Research Authors: Albert Doughan Wisdom Adingo Samson Pandam Salifu Source Type: research
Mipomersen Approved (Bonus Antisense Roundup Included)
So Isis and their partner Sanofi have received FDA approval for mipomersen (branded as Kynamro). Late last year, the European Medicines Agency turned them down, which has people wondering about the drug's future, but here they are, albeit with a warning on the label about liver toxicity.
Mipomersen is designed to lower the Apo-B lipoprotein in people with the most severe (homozygous) form of familial hypercholesterolemia. That's a small patient population, but they're definitely in need of help. The really significant thing about this approval, in my mind, is that it's a pure antisense therapy, and it comes about twenty y...
Source: In the Pipeline - January 31, 2013 Category: Chemists Tags: Clinical Trials Source Type: blogs
