Filtered By:
Management: Funding

This page shows you your search results in order of relevance. This is page number 19.

Order by Relevance | Date

Total 11357 results found since Jan 2013.

Take a Look at the Science Research Supported by Federal Funders
Frequent readers of the blog and the Extramural Nexus know that RePORT is your first stop on the way to finding information about NIH funded research, as well as data on trends in NIH funding and the biomedical workforce. But did you know NIH is collaborating with other agencies to create Federal RePORTER, a single web portal that allows you to search federal-funded science projects across multiple agencies? While the site is still in alpha testing, we’ve recently added a new partner agency’s data, so I thought it would be a great time to introduce you to this resource. The project is part of the STAR METRICS® program...
Source: NIH Extramural Nexus: Rock Talk Blog - September 23, 2014 Category: Research Authors: Sally Rockey Tags: Rock Talk Funding data RePORT STAR METRICS Source Type: blogs

Senolytic Drugs to Kill Off Senescent Cells and Thereby Slow the Progression of Degenerative Aging
As we age, an increasing number of cells fall into a senescent state in which they cease dividing and begin to secrete all sorts of compounds that both harm surrounding tissue structure and raise the odds of nearby cells also becoming senescent. This seems to be a tool of embryonic development that now also acts to suppress cancer risk by removing the ability to divide from those cells most likely to become cancerous. Unfortunately it harms tissue function in doing so, and worse, only actually suppresses cancer risk when there are comparatively few senescent cells. Given a lot of these cells their activities cause chronic ...
Source: Fight Aging! - March 9, 2015 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Who Is Worst Off? Developing a Severity-scoring Model of Complex Emergency Affected Countries in Order to Ensure Needs Based Funding
This study has several limitations. It is based on the assumption that needs and level of severity are interchangeable. A small group of experts, who were also the authors, selected the indicators and developed the model. However, the experts, who all have experience with CE, needs assessments, and academia, have explained in detail the process of selection for the indicators and priorities. The main challenge for this model has been how to balance pragmatism with robust scientific methods. It was important to develop a model that could be used easily, rather than a complex model that may have strong theoretical validity...
Source: PLOS Currents Disasters - November 3, 2015 Category: Global & Universal Authors: Anneli Eriksson Source Type: research

Scores of Labs Should be Gearing Up to Work on Glucosepane Cross-Link Breakers, But Are They?
As we age skin and blood vessels lose their elasticity. People care too much about the skin and too little about the blood vessels, but that is always the way of it. Appearance first and substance later, if at all. Yet you can live inside an aged skin; beyond the raised risk of skin cancer its damaged state arguably only makes life less pleasant, and the present state of medical science can ensure that the numerous age-related dermatological dysfunctions can be kept to a state of minor inconvenience. Loss of blood vessel elasticity, on the other hand, will steadily destroy your health and then kill you. Arterial stiffening...
Source: Fight Aging! - December 8, 2015 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, September 5th 2016
This study is a good example of the degree to which the choice to remain active in later life makes a difference. That implies a range of other choices over the decades in order to raise the odds that you can in fact choose to remain active when older, such as avoiding weight gain. Moderate physical activity is associated with a greater than 50% reduction in cardiovascular death in over-65s. The 12 year study in nearly 2500 adults aged 65 to 74 years found that moderate physical activity reduced the risk of an acute cardiovascular event by more than 30%. High levels of physical activity led to greater risk reducti...
Source: Fight Aging! - September 4, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

London Info International 2017 announces three core conference themes and call for speakers
London Info International 2017 announces three core conference themes: Planning for uncertainty Networks, personalisation and the market of one and Impact, ownership and rights Paul Blake and Vincent Cassidy, co-chairs of the London Info International Conference have announced the conference themes for this year’s event. The conference will pose the questions: What happens next? What will the information landscape look like in 5 or 10 years’ time? Who will be the stakeholders? What can we do today that will prepare us for tomorrow? Most of all, the event is a celebration of everything that actively enables the inform...
Source: News from STM - March 22, 2017 Category: Databases & Libraries Authors: STM Publishing News Tags: European Featured Source Type: news

Getting to Know Federal Funders and their Research Interests
Working with NIH applicants and awardees as an extramural program division director, I often shared the NIH RePORTER resource as a tool for exploring the research topics NIH supports.  Learning what projects we support, using a robust database of historical and newly-funded projects (updated weekly), provides researchers valuable insight as they consider developing their own research programs and applications for funding. Another valuable tool which you might be familiar with is Federal RePORTER, which expands the RePORTER concept to support searching over 800,000 projects across 17 Federal research agencies, with trans-a...
Source: NIH Extramural Nexus - June 6, 2017 Category: Research Authors: Mike Lauer Tags: blog Open Mike Federal Reporter General New Resources Source Type: funding

Fight Aging! Newsletter, November 20th 2017
This study cohort is a healthy subset of the EpiPath cohort, excluding all participants with acute or chronic diseases. With a mediation analysis we examined whether CMV titers may account for immunosenescence observed in ELA. In this study, we have shown that ELA is associated with higher levels of T cell senescence in healthy participants. Not only did we find a higher number of senescent cells (CD57+), these cells also expressed higher levels of CD57, a cell surface marker for senescence, and were more cytotoxic in ELA compared to controls. Control participants with high CMV titers showed a higher number of senes...
Source: Fight Aging! - November 19, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, February 5th 2018
In this study, we tested the hypothesis that Gbp1 plays a role in regulating immunometabolism and senescence of macrophages. We found that Gbp1 was mainly expressed in macrophages, but not adipocytes in response to IFNγ/LPS stimulation; Gbp1 expression was significantly decreased in inguinal white adipose tissue (iWAT) of high-fat diet (HFD)-fed and aged mice. We also observed that downregulation of Gbp1 in macrophages resulted in M1 polarization and impairment of mitochondrial respiratory function possibly via disrupting mitophagy activity. Moreover, macrophages with downregulated Gbp1 displayed dampened glycolysis and e...
Source: Fight Aging! - February 4, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Atypon ’ s Artificial Intelligence R & D Fuels Four More BioASQ Awards in Semantic Technologies
For the fifth year in a row, Atypon has placed in the widely respected International BioASQ Awards competition. Atypon’s ongoing research and development (R&D) into artificial intelligence technologies led to four awards for four different semantic technology categories in the 2017 BioASQ Challenge. BioASQ organizes international contests in biomedical semantic indexing and question answering (QA) to help advance technologies that make it faster and easier for researchers to find the most relevant and actionable information from within the vast corpus of published biomedical research. Atypon’s R&D in machine le...
Source: News from STM - February 21, 2018 Category: Databases & Libraries Authors: STM Publishing News Tags: Digital Featured Source Type: news

A Selection of Recent Research in the Alzheimer ' s Field
Today I'll point out a few recent examples of research into Alzheimer's disease; they are representative of present shifts in emphasis taking place in the field. There is a great deal of reexamination of existing mechanisms, alongside a search for new mechanisms. This is prompted by the continued failure to obtain meaningful progress towards patient improvement via clearance of amyloid, which some are interpreting as a need to look elsewhere for a viable basis for therapy. I believe it probably has more to do with the condition arising from multiple processes that have similarly sized contributions to cognitive decline: am...
Source: Fight Aging! - June 8, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Effect of the Sequential Inoculation of Non-Saccharomyces/Saccharomyces on the Anthocyans and Stilbenes Composition of Tempranillo Wines
This study has been undertaken with a grant from the Instituto Nacional de Investigaciones Agrarias (INIA), Spain (Project RTA2013-0053-C03-03). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We would like to thank Victor Llop for his collaboration in laboratory analysis and Ian Thomas for revising the English of the text. References Altschul, S. F., Gish, W., Miller, W., Myers, E. W., and Lipman, D. J. (1990). Basic local alignment search tool....
Source: Frontiers in Microbiology - April 8, 2019 Category: Microbiology Source Type: research

Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple Sclerosis
We report many of them for the first time. For the already described citrullinated proteins MBP, GFAP, and vimentin, we could identify additional citrullinated sites. The number of modified proteins in MS white matter was higher than control tissue. Citrullinated peptides are considered neoepitopes that may trigger autoreactivity. We used newly identified epitopes and previously reported immunodominant myelin peptides in their citrullinated and non-citrullinated form to address the recognition of CSF-infiltrating CD4+ T cells from 22 MS patients by measuring proliferation and IFN-γ secretion. We did not detect ...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Living at the Extremes: Extremophiles and the Limits of Life in a Planetary Context
Nancy Merino1,2,3, Heidi S. Aronson4, Diana P. Bojanova1, Jayme Feyhl-Buska1, Michael L. Wong5,6, Shu Zhang7 and Donato Giovannelli2,8,9,10* 1Department of Earth Sciences, University of Southern California, Los Angeles, CA, United States 2Earth-Life Science Institute, Tokyo Institute of Technology, Tokyo, Japan 3Biosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Lab, Livermore, CA, United States 4Department of Biology, University of Southern California, Los Angeles, CA, United States 5Department of Astronomy – Astrobiology Program, University of Was...
Source: Frontiers in Microbiology - April 14, 2019 Category: Microbiology Source Type: research

Distinct Tumor Microenvironment at Tumor Edge as a Result of Astrocyte Activation Is Associated With Therapeutic Resistance for Brain Tumor
This study demonstrated that the vessels at the tumor edge are heterogeneous. The transient hypoxia at the tumor edge as the result of the appearance of immature NG2-CD31+ vessels is likely one reason for the radiochemoresistance of brain tumor. Although the heterogeneity of tumor oxygenation in space and time is well-recognized, this study is the first to report two spatially and functionally distinct types of tumor hypoxia in brain tumors, namely peripheral and central hypoxia. As cancer cells frequently proliferate faster than parenchyma, such as endothelia, tumor progression is frequently accompanied with the deve...
Source: Frontiers in Oncology - April 25, 2019 Category: Cancer & Oncology Source Type: research