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The Sharing Experimental Animal Resources, Coordinating Holdings (SEARCH) Framework: Encouraging Reduction, Replacement, and Refinement in Animal Research
by Bethny Morrissey, Karen Blyth, Phil Carter, Claude Chelala, Louise Jones, Ingunn Holen, Valerie Speirs
While significant medical breakthroughs have been achieved through using animal models, our experience shows that often there is surplus material remaining that is frequently never revisited but could be put to good use by other scientists. Recognising that most scientists are willing to share thi s material on a collaborative basis, it makes economic, ethical, and academic sense to explore the option to utilise this precious resource before generating new/additional animal models and associated samples. To bring toge...
Source: PLoS Biology: Archived Table of Contents - January 11, 2017 Category: Biology Authors: Bethny Morrissey Source Type: research
Corindus closes $45m offering, sees shares slide on Q4, FY2016 earnings miss
Corindus Vascular Robotics (NYSE:CVRS) this week announced the closing of a $45 million offering and 4th quarter and fiscal year 2016 earnings which just missed expectations on Wall Street.
In the offering, Waltham, Mass.-based Corindus floated an aggregate of 68.1 million shares of common stock at 66¢ per share, with proceeds intended to support general corporate purposes as well as commercialization of its next-gen CorPath GRX system.
As part of the funding round, Dr. Louis Cannon of the Cardiac & Vascular Research Center of Northern Michigan was appointed to the company’s board of directors.
“Corindus ...
Source: Mass Device - March 16, 2017 Category: Medical Equipment Authors: Fink Densford Tags: Business/Financial News MassDevice Earnings Roundup Corindus Vascular Robotics Source Type: news
Search strategies for finding systematic reviews.
This study makes a very important point about the influence of funding sources and conflicts of interests on the methodological quality of systematic reviews. However, I have some concerns about the search strategy used to find systematic reviews for this analysis. This article is protected by copyright. All rights reserved.
PMID: 28295197 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - March 12, 2017 Category: Dermatology Authors: Grindlay D Tags: Br J Dermatol Source Type: research
Search strategies for finding systematic reviews: reply from authors
This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - March 1, 2017 Category: Dermatology Authors: F. G ómez‐García, J. Ruano, M. Aguilar‐Luque, J. Gay‐Mimbrera, B. Maestre‐Lopez, J. L. Sanz‐Cabanillas, P. J. Carmona‐Fernández, M. González‐Padilla, A. Vélez García‐Nieto, B. Isla‐Tejera Tags: Reply Source Type: research
Corindus registers for $60m mixed shelf offering
Corindus Vascular Robotics (NYSE:CVRS) this week registered for an upcoming mixed shelf offering worth up to $60 million.
The company said that net proceeds from the round are currently slated to support further commercialization of its coronary robotic-assisted intervention programs as well as expanding the capabilities of its CorPath system, according to an SEC filing.
The Waltham, Mass.-based company has not yet released any more details about the offering.
Last month, Corindus Vascular Robotics announced the closing of a $45 million offering and 4th quarter and fiscal year 2016 earnings which just missed expectations ...
Source: Mass Device - April 18, 2017 Category: Medical Equipment Authors: Fink Densford Tags: Business/Financial News Robotics Corindus Vascular Robotics Source Type: news
Humacyte lands $14m to expand uses for human acellular vessel
Humacyte said today that it landed a $14.1 million award from the California Institute for Regenerative Medicine to support a clinical trial comparing its human acellular vessel, Humacyl, to arteriovenous fistulas – the traditional way to create vascular access in patients who need hemodialysis.
The Research Triangle Park, N.C.-based company said it plans to evaluate Humacyl as a conduit for hemodialysis in a group of patients with end-stage renal disease who need renal replacement therapy.
“This significant and incremental investment from CIRM further validates the potential of our bioengineered human acellula...
Source: Mass Device - September 29, 2017 Category: Medical Devices Authors: Sarah Faulkner Tags: Clinical Trials Funding Roundup Regenerative Medicine Vascular Humacyte Inc. Source Type: news
Placental Nano-vesicles Target to Specific Organs and Modulate Vascular Tone In Vivo
AbstractSTUDY QUESTIONHow do nano-vesicles extruded from normal first trimester human placentae affect maternal vascular function?SUMMARY ANSWERPlacental nano-vesicles affect the ability of systemic mesenteric arteries to undergo endothelium- and nitric oxide- (NO-) dependent vasodilationin vivo in pregnant mice.WHAT IS KNOWN ALREADYDramatic cardiovascular adaptations occur during human pregnancy, including a substantial decrease in total peripheral resistance in the first trimester. The human placenta constantly extrudes extracellular vesicles that can enter the maternal circulation and these vesicles may play an importan...
Source: Human Reproduction - October 13, 2017 Category: Reproduction Medicine Source Type: research
Access Vascular raises $2m
Access Vascular has raised $1.9 million in a new round of equity financing, according to an SEC filing posted this week.
Money in the round came from seven unnamed sources, with the first sale recorded on May 4, according to the filing.
The company is looking for an additional $2.1 million before it plans to close the round, with a hopeful end goal of $4 million, according to the SEC filing. The Bedford, Mass.-based company has not yet stated how it plans to spend funds in the round.
In February, Access Vascular said that its HydroPICC catheter won 510(k) clearance from the FDA.
The peripherally-inserted central catheter ...
Source: Mass Device - May 17, 2018 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Funding Roundup accessvascular Source Type: news
A Distinct Population of Smooth Muscle Cells is Associated with Vascular Disease
Researchers have identified a marker for a small population of smooth muscle cells in blood vessel walls that show up in larger numbers in cases of vascular disease, such as atherosclerosis. These cells may be dysfunctional in the sense that they (a) appear to be involved in inflammatory signaling and (b) lose the normal behavior of smooth muscle tissue. My first thought on reading the abstract of the paper was that this may be a senescent population, as inflammation and disruption of tissue function are quite characteristic of the bad behavior of senescent cells. On closer reading that sounds less likely, however. These m...
Source: Fight Aging! - November 8, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Vascular E-Selectin Acts As a Gatekeeper Inducing Commitment and Loss of Self-Renewal in HSC Transmigrating through the Marrow Vasculature
Hematopoietic stem cells (HSC) reside in specific peri-vascular niches in the bone marrow (BM). We have shown interactions with the inflammatory vascular adhesion molecule E-(endothelial)-selectin awakens HSC (Nat Med 2012). We now report that BM vascular cell-surface E-selectin expression is strongly upregulated during HSC mobilization regimens raising the question of a role for endothelial E-selectin in HSC transplant outcome.G-CSF was administered to cohorts of E gene-deleted or wildtype C57BL/6 mice together with E-selectin antagonist Uproleselan (Upro, GMI-1271). We found absence (Sele-/- mice) or therapeutic blockade...
Source: Blood - November 21, 2018 Category: Hematology Authors: Winkler, I. G., Barbier, V., Lowe, J., Tay, J., Magnani, J. L., Marlton, P., Mills, A. K., Perkins, A., Fiveash, C. E., Erbani, J. M., Levesque, J.-P. Tags: 711. Cell Collection and Processing: Poster III Source Type: research
‘Search For & Refuse All Deliveries. ’ Amid Trade War, Trump Urges USPS Crackdown on Fentanyl Trafficking From China
With tensions over trade with China escalating, President Donald Trump said on Friday that he is “ordering” the U.S. postal service and express shipping companies to “SEARCH FOR & REFUSE all deliveries of fentanyl,” a deadly synthetic opioid. American officials have long blamed China for the influx of fentanyl and related drugs reaching U.S. borders — sent directly and trafficked via other countries — while federal efforts to limit (if not stop outright) their import have long been underway.
….your companies HOME and making your products in the USA. I will be responding to C...
Source: TIME: Health - August 24, 2019 Category: Consumer Health News Authors: Sanya Mansoor Tags: Uncategorized China Drugs White House Source Type: news
Limited Competition for the Closeout of the SEARCH for Diabetes in Youth Cohort Study (R01 Clinical Trial Not Allowed)
Funding Opportunity RFA-DK-19-507 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to complete the SEARCH for Diabetes in Youth Cohort Study. SEARCH has recruited a cohort of youth with diabetes who have been followed longitudinally. The purpose of this FOA is to complete data analyses and disseminate scientific findings regarding the evolution of diabetes-related complications, including mortality, and processes of care and quality of life.
Source: NIH Funding Opportunities (Notices, PA, RFA) - November 8, 2019 Category: Research Source Type: funding
Venous Thromboembolism Research Priorities: A Scientific Statement From the American Heart Association and the International Society on Thrombosis and Haemostasis.
rsing; Council on Clinical Cardiology; Council on Epidemiology and Prevention; and the International Society on Thrombosis and Haemostasis
Abstract
Venous thromboembolism is a major cause of morbidity and mortality. The impact of the US Surgeon General's The Surgeon General's Call to Action to Prevent Deep Vein Thrombosis and Pulmonary Embolism in 2008 has been lower than expected given the public health impact of this disease. This scientific statement highlights future research priorities in venous thromboembolism, developed by experts and a crowdsourcing survey across 16 scientific organizations. At the fundame...
Source: Circulation - August 10, 2020 Category: Cardiology Authors: Cushman M, Barnes GD, Creager MA, Diaz JA, Henke PK, Machlus KR, Nieman MT, Wolberg AS, American Heart Association Council on Peripheral Vascular Disease; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Stroke N Tags: Circulation Source Type: research
Vascular endothelial growth factor and angiopoietin production by primate follicles during culture is a function of growth rate, gonadotrophin exposure and oxygen milieu
This study reports VEGF-A, ANGPT-1 and -2 production by in vitro-developed individual primate (macaque) follicles, that is limited to the interval from the secondary to small antral stage. After VEGF and ANGPT-1 assays, the limited remaining samples did not allow assessment of the independent effects of gonadotrophin and O2 on the ANGPT-2 production by cultured follicles. Findings await translation to human follicles.
WIDER IMPLICATION OF THE FINDINGS
The above findings provide novel information on the process of primate follicle maturation. We hypothesize that a symbiotic relationship between elevated concentrations of A...
Source: Human Reproduction - November 15, 2013 Category: Reproduction Medicine Authors: Fisher, T. E., Molskness, T. A., Villeda, A., Zelinski, M. B., Stouffer, R. L., Xu, J. Tags: Reproductive biology Source Type: research
