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Nutrition: Calcium
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Triptans and vascular comorbidity in persons over fifty: Findings from a nationwide insurance database - A cohort study
CONCLUSION: In persons over 50 years of age, a prescription of triptans is common. Vascular comorbidity is comparable in users and nonusers of triptans showing that triptans are prescribed despite vascular comorbidity and suggesting that triptan use does not increase vascular risk in patients with migraine over the age of 50 years. Nevertheless, regular evaluation for contraindications against triptans and for vascular risk factors is recommended in this age group.PMID:35593784 | DOI:10.1111/head.14304
Source: Headache - May 20, 2022 Category: Neurology Authors: Karin Zebenholzer Walter Gall Andreas Gleiss Antun R Pavelic Christian W öber Source Type: research
Vascular age based on coronary calcium burden and carotid intima media thickness (a comparative study)
CONCLUSION: Calcium score is as helpful as CIMT for vascular age estimation.PMID:35874297 | PMC:PMC9301091
Source: Molecular Medicine - July 25, 2022 Category: Molecular Biology Authors: Maryam Moradi Mahnaz Fosouli Jalil Khataei Source Type: research
Tanshinone IIa attenuates vascular calcification through inhibition of NF- κB and β-catenin signaling pathways
This study aims to investigate whether Tanshinone IIa can inhibit vascular calcification using high phosphate-induced vascular smooth muscle cell and aortic ring calcification model, and high dose vitamin D3 (vD3)-induced mouse models of vascular calcification. Alizarin red staining and calcium quantitative assay showed that Tanshinone IIa significantly inhibited high phosphate-induced vascular smooth muscle cell and aortic ring calcification. qPCR and Western blot showed that Tanshinone IIa attenuated the osteogenic transition of vascular smooth muscle cells. In addition, Tanshinone IIa also significantly inhibited high d...
Source: Atherosclerosis - January 3, 2023 Category: Cardiology Authors: Hui Zhong Dai-Ying Li Su-Ying Wang Jie-Yi Chen Jia-Xin Chen Xiao Tan Yue-Heng Wang Yu-Chen Xie Dong-Xing Zhu Source Type: research
Transcription factor 21 accelerates vascular calcification in mice by activating the IL-6/STAT3 signaling pathway and the interplay between VSMCs and ECs
In this study we investigated the role of TCF21 in vascular calcification and the underlying mechanisms. In carotid artery atherosclerotic plaques collected from 6 patients, we found that TCF21 expression was upregulated in calcific areas. We further demonstrated TCF21 expression was increased in an in vitro vascular smooth muscle cell (VSMC) osteogenesis model. TCF21 overexpression promoted osteogenic differentiation of VSMC, whereas TCF21 knockdown in VSMC attenuated the calcification. Similar results were observed in ex vivo mouse thoracic aorta rings. Previous reports showed that TCF21 bound to myocardin (MYOCD) to inh...
Source: Acta Pharmacologica Sinica - March 30, 2023 Category: Drugs & Pharmacology Authors: Xiao-Kang Zhao Meng-Meng Zhu Sheng-Nan Wang Ting-Ting Zhang Xiao-Ning Wei Cheng-Yi Wang Juan Zheng Wen-Ya Zhu Mei-Xiu Jiang Suo-Wen Xu Xiao-Xiao Yang Ya-Jun Duan Bu-Chun Zhang Ji-Hong Han Qing R Miao Hao Hu Yuan-Li Chen Source Type: research
Mitochondrial Contributions to Vascular Endothelial Dysfunction, Arterial Stiffness and Cardiovascular Diseases
Am J Physiol Heart Circ Physiol. 2021 Apr 9. doi: 10.1152/ajpheart.00917.2020. Online ahead of print.ABSTRACTCardiovascular diseases (CVD) affect 1 in 3 adults and remain the leading causes of death in America. Advancing age is the major risk factor for CVD. Recent plateaus in CVD-related mortality rates in high income countries after decades of decline highlight a critical need to identify novel therapeutic targets and strategies to mitigate and manage the risk of CVD development and progression. Vascular dysfunction, characterized by endothelial dysfunction and large elastic artery stiffening, is independently associated...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 9, 2021 Category: Physiology Authors: Danielle L Kirkman Austin T Robinson Matthew J Rossman Douglas R Seals David G Edwards Source Type: research
