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Nutrition: Calcium

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Epidermal Growth Factor Receptor Inhibition Prevents Vascular Calcifying Extracellular Vesicle Biogenesis
Am J Physiol Heart Circ Physiol. 2023 Feb 24. doi: 10.1152/ajpheart.00280.2022. Online ahead of print.ABSTRACTChronic kidney disease (CKD) increases the risk of cardiovascular disease, including vascular calcification, leading to higher mortality. Release of calcifying extracellular vesicles (EVs) by vascular smooth muscle cells (VSMCs) promotes ectopic mineralization of vessel walls. Caveolin-1 (CAV1), a structural protein in the plasma membrane, plays a major role in calcifying EV biogenesis in VSMCs. Epidermal growth factor receptor (EGFR) co-localizes with and influences the intracellular trafficking of CAV1. The goal ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 24, 2023 Category: Physiology Authors: Amirala Bakhshian Nik Hooi Hooi Ng Sophie K Ashbrook Patrick Sun Francesco Iacoviello Paul R Shearing Sergio Bertazzo Deniel Mero Bohdan B Khomtchouk Joshua D Hutcheson Source Type: research

FHL5 Controls Vascular Disease-Associated Gene Programs in Smooth Muscle Cells
CONCLUSIONS: Taken together, these studies provide mechanistic insights into the pleiotropic genetic associations of UFL1-FHL5. We show that FHL5 mediates vascular disease risk through transcriptional regulation of downstream vascular remodeling gene programs. These transacting mechanisms may explain a portion of the heritable risk for complex vascular diseases.PMID:37017084 | DOI:10.1161/CIRCRESAHA.122.321692
Source: Cell Research - April 5, 2023 Category: Cytology Authors: Doris Wong Ga ëlle Auguste Christian L Lino Cardenas Adam W Turner Yixuan Chen Yipei Song Lijiang Ma R Noah Perry Redouane Aherrahrou Maniselvan Kuppusamy Chaojie Yang Jose Verdezoto Mosquera Collin J Dube Mohammad Daud Khan Meredith Palmore Jaspreet K K Source Type: research

Analysis of the prevalence and influencing factors of hyperuricemia in children and adolescents aged 6-17 years in northeastern Sichuan Province
CONCLUSION: The prevalence of hyperuricemia was higher in children and adolescents aged 6-17 years in northeastern Sichuan Province, with a higher prevalence in boys than in girls, and the prevalence increased with age.PMID:37236266 | DOI:10.1016/j.jped.2023.05.001
Source: Jornal de Pediatria - May 26, 2023 Category: Pediatrics Authors: Xuemei Guo Ningting Xiao Xueming Jing Zhennan Zhu Heping Zhang Source Type: research

Roles of Vascular Smooth Muscle Cells in Atherosclerotic Calcification
J Lipid Atheroscler. 2023 May;12(2):106-118. doi: 10.12997/jla.2023.12.2.106. Epub 2023 May 3.ABSTRACTThe accumulation of calcium in atherosclerotic plaques is a prominent feature of advanced atherosclerosis, and it has a strong positive correlation with the total burden of atherosclerosis. Atherosclerotic calcification usually appears first at the necrotic core, indicating that cell death and inflammatory processes are involved in calcification. During atherosclerotic inflammation, various cell types, such as vascular smooth muscle cells, nascent resident pericytes, circulating stem cells, or adventitial cells, have been ...
Source: Atherosclerosis - June 2, 2023 Category: Cardiology Authors: Sang-Ho Woo Dae-Yong Kim Jae-Hoon Choi Source Type: research

Cutaneous vascular calcifications in patients with chronic kidney disease and calcific uremic arteriolopathy: a cross-sectional study
DISCUSSION: Despite a high burden of systemic vascular calcification, cutaneous calcium deposits in non-lesional tissue could not be demonstrated histopathologically in patients with chronic kidney disease (with or without current or previous calcific uremic arteriolopathy). Further studies to determine whether these findings are representative or attributed to other factors are warranted.PMID:37466817 | DOI:10.1007/s40620-023-01707-8
Source: Journal of Nephrology - July 19, 2023 Category: Urology & Nephrology Authors: Anne Kristine R øndbjerg Mette Gyldenl øve Dorrit Krustrup Marianne Rix Ilse Vejborg Lars Lonn Niklas Rye J ørgensen Andreas Pasch Lone Skov Ditte Hansen Source Type: research

Endothelial-Dependent and Independent Vascular Relaxation Effect of Tetrahydropalmatine on Rat Aorta
This study was supported by the Science and Technology Commission of Shanghai (16ZR1437600), Shanghai Hospital Development Center (SHDC12015313), Shanghai University of Traditional Chinese Medicine (A1-U1720501030101), National Natural Science Foundation of China (81603549, 81673726, and 81760860), and National Health Commission of Shanghai [GWIV-28 and ZY-(2018-2020)-FWTX-8001]. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementar...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research