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Nutrition: Calcium
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Calciprotein Particles: Balancing Mineral Homeostasis and Vascular Pathology
Arterioscler Thromb Vasc Biol. 2021 Mar 11:ATVBAHA120315697. doi: 10.1161/ATVBAHA.120.315697. Online ahead of print.ABSTRACTHypercalcemia and hyperphosphatemia associate with an elevated risk of cardiovascular events, yet the pathophysiological basis of this association is unclear. Disturbed mineral homeostasis and the associated hypercalcemia and hyperphosphatemia may result in the formation of circulating calciprotein particles (CPPs) that aggregate the excessive calcium and phosphate ions. If not counteracted, the initially formed harmless amorphous spherical complexes (primary CPPs) may mature into damaging crystalline...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 11, 2021 Category: Cardiology Authors: Anton G Kutikhin Lian Feenstra Alexander E Kostyunin Arseniy E Yuzhalin Jan-Luuk Hillebrands Guido Krenning Source Type: research
Ligustrazine activate the PPAR- γ pathway and play a protective role in vascular calcification
CONCLUSION: Ligustrazine activates the PPAR-γ pathway and plays a protective role in vascular calcification.PMID:34670463 | DOI:10.1177/17085381211051477
Source: Vascular - October 21, 2021 Category: Surgery Authors: Hui Li Min Yang Source Type: research
Arginase-1 Deletion in Erythrocytes Promotes Vascular Calcification via Enhanced GSNOR (S-Nitrosoglutathione Reductase) Expression and NO Signaling in Smooth Muscle Cells
CONCLUSIONS: Our findings support an important role of erythrocyte ARG1 for NO bioavailability and L-arginine metabolism in VSMCs, which controls atherosclerotic lesion composition and calcification.PMID:36252109 | DOI:10.1161/ATVBAHA.122.318338
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 17, 2022 Category: Cardiology Authors: Rajinikanth Gogiraju Luisa Renner Magdalena L Bochenek Konstantinos Zifkos Michael Molitor Sven Danckwardt Philip Wenzel Thomas M ünzel Stavros Konstantinides Katrin Sch äfer Source Type: research
