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Total 42604 results found since Jan 2013.

Vitamin D Receptor From VSMCs Regulates Vascular Calcification During CKD: A Potential Role for miR-145a
CONCLUSIONS: Our study provides evidence proving that inhibition of local VDR signaling in VSMCs could prevent VC in CKD and indicates a possible role for miR-145a in this process.PMID:37381989 | DOI:10.1161/ATVBAHA.122.318834
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 29, 2023 Category: Cardiology Authors: Maite Caus Cristina Alonso-Montes Jose Luis Fernandez-Martin Manuel Marti-Antonio Milica Bozic Jose M Valdivielso Source Type: research

Chronic deficit in nitric oxide elicits oxidative stress and augments T-type calcium-channel contribution to vascular tone of rodent arteries and arterioles
Conclusion We conclude that nitric oxide deficit produces a significant increase in the contribution of Cav3.1 and Cav3.2 T-type calcium channels to vascular tone, by regulating the bioavailability of reactive oxygen species produced by NADPH oxidase. Our data provide evidence for a novel causal link between nitric oxide deficit, oxidative stress, and T-type calcium channel function.
Source: Cardiovascular Research - May 17, 2013 Category: Cardiology Authors: Howitt, L., Kuo, I. Y., Ellis, A., Chaston, D. J., Shin, H.-S., Hansen, P. B., Hill, C. E. Tags: Vascular biology Source Type: research

Effects of obesity on vascular potassium channels.
In conclusion, obesity and metabolic syndrome alter expression, function and sensitivity of vascular K channel subtypes causing smooth muscle dysfunction and probably endothelial dysfunction which makes these patients particularly prone to premature cardiovascular disease. Modulation of K channel activity by use of openers of e.g. KCa and KATP channels may also be attractive to counteract vascular dysfunction observed in obesity. PMID: 24846233 [PubMed - in process]
Source: Current Vascular Pharmacology - May 24, 2014 Category: Drugs & Pharmacology Authors: Climent B, Simonsen U, Rivera L Tags: Curr Vasc Pharmacol Source Type: research

Activation of Nrf2 by dimethyl fumarate improves vascular calcification.
In conclusion, our data support that DMF stimulates Nrf2 activity to attenuate hyperphosphatamia in vitro or Vitamin D3-induced in vivo vascular calcification, which would be a beneficial effect on vascular diseases induced by oxidative stress such as vascular calcification. PMID: 25135648 [PubMed - as supplied by publisher]
Source: Vascular Pharmacology - August 15, 2014 Category: Drugs & Pharmacology Authors: Ha CM, Park S, Choi YK, Jeong JY, Oh CJ, Bae KH, Lee SJ, Kim JH, Park KG, Jun DY, Lee IK Tags: Vascul Pharmacol Source Type: research

Microsomal Prostaglandin E Synthase-1-Derived PGE2 Inhibits Vascular Smooth Muscle Cell Calcification.
CONCLUSIONS: Our data revealed the pivotal role of COX-2-mPGES-1-PGE2 axis in vascular calcification. The selective inhibition of COX-2 or mPGES-1 may increase the risk of calcification and subsequent adverse cardiovascular events during chronic renal failure. PMID: 26543101 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 5, 2015 Category: Cardiology Authors: Gao C, Fu Y, Li Y, Zhang X, Zhang L, Yu F, Xu SS, Xu Q, Zhu Y, Guan Y, Wang X, Kong W Tags: Arterioscler Thromb Vasc Biol Source Type: research

Abstract MP06: Mitochondrial Dynamics and Vascular Effects: Role of OPA1 in Hypertension Session Title: Vascular Biology/Remodeling and Dysfunction
Conclusions: Thus mitochondria alteration due to OPA1 down-regulation did not affect baseline blood pressure and vascular tone but induced an excessive elevation in blood pressure in hypertension. These results suggest for the first time that OPA1 may play an important role in protection of the vasculature in pathological conditions such as hypertension.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Nguyen, P. M. C., Grenier, C., Lelievre, E., Grimaud, L., Vessieres, E., Sarzi, E., Bonneau, D., Reynier, P., Fassot, C., Lenaers, G., Henrion, D., Loufrani, L. Tags: Session Title: Vascular Biology/Remodeling and Dysfunction Source Type: research

Rab11a Mediates Vascular Endothelial-Cadherin Recycling and Controls Endothelial Barrier Function.
CONCLUSIONS: Rab11a/family-interacting protein2-mediated VE-cadherin recycling is required for formation of adherens junctions and restoration of VE barrier integrity and hence a potential target for clinical intervention in inflammatory disease. PMID: 26663395 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 10, 2015 Category: Cardiology Authors: Yan Z, Wang ZG, Segev N, Hu S, Minshall RD, Dull RO, Zhang M, Malik AB, Hu G Tags: Arterioscler Thromb Vasc Biol Source Type: research

Aldosterone-Induced Vascular Remodeling and Endothelial Dysfunction Require Functional Angiotensin Type 1a Receptors Vascular Remodeling
We investigated the role of angiotensin type 1a receptors (AGTR1a) in vascular injury induced by aldosterone activation of mineralocorticoid receptors in Agtr1a–/– and wild-type (WT) mice infused with aldosterone for 14 days while receiving 1% NaCl in drinking water. Aldosterone increased systolic blood pressure (BP) by 30 mm Hg in WT mice and 50 mm Hg in Agtr1a–/– mice. Aldosterone induced aortic and small artery remodeling, impaired endothelium-dependent relaxation in WT mice, and enhanced fibronectin and collagen deposition and vascular inflammation. None of these vascular effects were observed i...
Source: Hypertension - April 12, 2016 Category: Cardiology Authors: Briet, M., Barhoumi, T., Mian, M. O. R., Coelho, S. C., Ouerd, S., Rautureau, Y., Coffman, T. M., Paradis, P., Schiffrin, E. L. Tags: Basic Science Research, Vascular Biology, Hypertension Vascular Remodeling Source Type: research

Augmentation of phosphate-induced osteo-/chondrogenic transformation of vascular smooth muscle cells by homoarginine
Conclusion Homoarginine augments osteo-/chondrogenic transformation of VSMCs and vascular calcification, effects involving impaired NO formation from homoarginine.
Source: Cardiovascular Research - May 18, 2016 Category: Cardiology Authors: Alesutan, I., Feger, M., Tuffaha, R., Castor, T., Musculus, K., Buehling, S. S., Heine, C. L., Kuro-O, M., Pieske, B., Schmidt, K., Tomaschitz, A., Maerz, W., Pilz, S., Meinitzer, A., Voelkl, J., Lang, F. Tags: Vascular Biology Source Type: research

H2O2 generated from mitochondrial electron transport chain in thoracic perivascular adipose tissue is crucial for modulation of vascular smooth muscle contraction.
Abstract The perivascular adipose tissue (PVAT) releases a variety of factors that affect vascular function. PVAT in the thoracic aorta shares characteristics with the brown adipose tissue, including a large amount of mitochondria. PVAT-derived factors influence both endothelial and smooth muscle function via several signaling mechanisms including the release/generation of reactive nitrogen and oxygen species. Considering the importance of reactive oxygen species (ROS) on vascular function and that mitochondria are an important source of ROS, we hypothesized that mitochondria-derived ROS in the PVAT modulates vasc...
Source: Vascular Pharmacology - May 28, 2016 Category: Drugs & Pharmacology Authors: Costa RM, Filgueira FP, Tostes RC, Carvalho MH, Akamine EH, Lobato NS Tags: Vascul Pharmacol Source Type: research

The association of mineral metabolism with vascular access patency.
CONCLUSIONS: This study suggests a relationship between vitamin D3 usage and better vascular access patency, independent of the effect of vitamin D on PTH. Though this relationship needs more rigorous investigation prior to clinical application, the known differences in the pro- and anti-inflammatory effects of various vitamin D metabolites provide a potential mechanism for these clinical observations. PMID: 27470251 [PubMed - as supplied by publisher]
Source: The Journal of Vascular Access - July 31, 2016 Category: Surgery Tags: J Vasc Access Source Type: research