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Nutrition: Calcium

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Total 42604 results found since Jan 2013.

Aberrant Splicing Induced by Dysregulated Rbfox2 Produces Enhanced Function of CaV1.2 Calcium Channel and Vascular Myogenic Tone in HypertensionNovelty and Significance Vascular Myogenic Tone
Calcium influx from activated voltage-gated calcium channel CaV1.2 in vascular smooth muscle cells is indispensable for maintaining myogenic tone and blood pressure. The function of CaV1.2 channel can be optimized by alternative splicing, one of post-transcriptional modification mechanisms. The splicing factor Rbfox2 is known to regulate the CaV1.2 pre-mRNA alternative splicing events during neuronal development. However, Rbfox2’s roles in modulating the key function of vascular CaV1.2 channel and in the pathogenesis of hypertension remain elusive. Here, we report that the proportion of CaV1.2 channels with alternative e...
Source: Hypertension - November 8, 2017 Category: Cardiology Authors: Yingying Zhou, Jia Fan, Huayuan Zhu, Li Ji, Wenyong Fan, Isha Kapoor, Yue Wang, Yuan Wang, Guoqing Zhu, Juejin Wang Tags: Ion Channels/Membrane Transport, Vascular Biology, Hypertension Original Articles Source Type: research

Regulation of the pulmonary vascular tone by p66shc and cyclophilin D
Mitochondria regulate intracellular calcium homeostasis and thereby may affect pulmonary vascular functions, in particular the response of the pulmonary vasculature to hypoxia. We investigated whether the proteins p66shc and cyclophilin D (CypD), which regulate release of mitochondrial reactive oxygen species and apoptosis, may influence pulmonary vascular functions. Mice deficient for p66shc (p66shc–/-), CypD (CypD–/-), or both proteins (p66shc/CypD–/-) exhibited a lower pulmonary vascular resistance compared to wildtype (WT) mice determined in vivo by hemodynamic measurements and in isolated lungs. Syst...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Gierhardt, M., Pak, O., Sydykov, A., Quanz, K., Esfandiary, A., Wilhelm, J., Ghofrani, H. A., Schermuly, R. T., Seeger, W., Grimminger, F., Herden, C., Schulz, R., Weissmann, N., Sommer, N. Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Chronic Kidney Disease Circulating Calciprotein Particles and Extracellular Vesicles Promote Vascular Calcification: A Role for GRP (Gla-Rich Protein).
CONCLUSIONS: Uremic CPPs and EVs are important players in the mechanisms of widespread calcification in CKD. We propose a major role for cGRP as inhibitory factor to prevent calcification at systemic and tissue levels. PMID: 29301790 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 4, 2018 Category: Cardiology Authors: Viegas CSB, Santos L, Macedo AL, Matos AA, Silva AP, Neves PL, Staes A, Gevaert K, Morais R, Vermeer C, Schurgers L, Simes DC Tags: Arterioscler Thromb Vasc Biol Source Type: research

Toxic Metals and Subclinical Atherosclerosis in Carotid, Femoral, and Coronary Vascular Territories: The Aragon Workers Health Study
CONCLUSIONS: Our results support arsenic and cadmium and identify titanium and potentially antimony as atherosclerosis risk factors. Exposure reduction and mitigation interventions of these metals may decrease cardiovascular risk in individuals without clinical disease.PMID:34879710 | DOI:10.1161/ATVBAHA.121.316358
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 9, 2021 Category: Cardiology Authors: Maria Grau-Perez Maria J Caballero-Mateos Arce Domingo-Relloso Ana Navas-Acien Jose L Gomez-Ariza Tamara Garcia-Barrera Montse Leon-Latre Zoraida Soriano-Gil Estibaliz Jarauta Ana Cenarro Belen Moreno-Franco Martin Laclaustra Fernando Civeira Jose A Casas Source Type: research

Lercanidipine and labedipinedilol-A attenuate lipopolysaccharide/interferon-γ-induced inflammation in rat vascular smooth muscle cells through inhibition of HMGB1 release and MMP-2, 9 activities
Conclusion: Lercanidipine and labedipinedilol-A can exert their anti-inflammatory effects through suppression of NO, ROS and TNF-α through down-regulation of iNOS, MMP-2/MMP-9, and HMGB1, with inhibition of signaling transduction of MAPKs, Akt/IkB-α and NF-κB pathways. These findings implicate a valuable role of new generation dihydropyridine CCBs lercanidipine and labedipinedilol-A for the treatment of inflammatory vascular diseases.Highlights: ► Lercanidipine and labedipinedilol-A decreased NO, ROS and TNF-α release. ► Lercanidipine and labedipinedilol-A diminished the levels of iNOS, MMP-2/MMP-9, and HMGB1. ► ...
Source: Atherosclerosis - January 7, 2013 Category: Cardiology Authors: Jwu-Lai Yeh, Jong-Hau Hsu, Jyh-Chong Liang, Ing-Jun Chen, Shu-Fen Liou Tags: Vascular Biology, Hemostasis, Oxidative Stress Source Type: research

Influence of Aortic Valve Calcium on Outcome in Patients Undergoing Peripheral Vascular Surgery
Aortic valve calcium is common in vascular surgical patients. Aortic stenosis is associated with negative postoperative and long-term outcomes. An increased propensity for left ventricular dysfunction and silent coronary artery disease places vascular surgery patients at an increased risk for adverse cardiac events after surgery. The Revised Cardiac Risk Index (RCRI) is commonly used for preoperative risk stratification. The RCRI awards 1 point for each of the following characteristics: high-risk surgery, coronary heart disease, history of congestive heart failure, history of cerebrovascular disease, insulin therapy for d...
Source: Journal of Vascular Surgery - May 29, 2013 Category: Surgery Authors: T.M. Valentijn, S.E. Hoeks, E.J. Bakker Tags: Abstracts Source Type: research

Role of Local Versus Systemic Vitamin D Receptors in Vascular Calcification.
CONCLUSIONS: Calcitriol promotes vascular calcification through a systemic action rather than through a direct vascular action. PMID: 24202304 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 7, 2013 Category: Cardiology Authors: Lomashvili K, Wang X, O'Neill WC Tags: Arterioscler Thromb Vasc Biol Source Type: research

L-Type Calcium Channel Inhibitor Diltiazem Prevents Aneurysm Formation by Blood Pressure-Independent Anti-Inflammatory Effects Vascular Inflammation
Formation of abdominal aortic aneurysms is a progressive inflammatory process that involves infiltration and differentiation of monocytes in the vessel wall, proliferation and migration of smooth muscle cells, and eventually the degradation of the internal elastic lamina, which leads to outward vascular remodeling and distension of the vessel. Because calcium channel blockers exert multiple beneficial effects on the vascular system, we investigated the effect of the benzothiazepine-type calcium channel blocker diltiazem on aneurysm formation in a mouse model. Angiotensin II infusion induced massive suprarenal aortic aneury...
Source: Hypertension - November 13, 2013 Category: Cardiology Authors: Mieth, A., Revermann, M., Babelova, A., Weigert, A., Schermuly, R. T., Brandes, R. P. Tags: Vascular Inflammation Source Type: research

Lower dairy products and calcium intake is associated with adverse retinal vascular changes in older adults
Conclusions: A significant association was observed between lower intake of dairy products or calcium and adverse retinal vascular signs. We cannot discount the possibility of confounding from unmeasured risk factors; hence, further studies are warranted to confirm these findings.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 13, 2014 Category: Nutrition Authors: B. Gopinath, V.M. Flood, J.J. Wang, G. Burlutsky, P. Mitchell Tags: Electrolyte intake, blood pressure and vascular changes Source Type: research

Ca2/Calmodulin-Dependent Protein Kinase- II in Vasoactive Peptide-Induced Responses and Vascular Biology.
Abstract Vasoactive peptides such as angiotensin II and endothelin-1 as well as growth factors regulate vascular homeostasis through signaling pathways that are triggered in both normal and disease states. These vasoactive peptides and growth factors also increase the cellular levels of calcium which, through calcium binding effector systems initiates the downstream signaling and physiological responses in target cells. A multifunctional calcium-calmodulin-dependent protein kinase II (CaMKII) has emerged as an important transducer of vasoactive peptide-induced responses in vascular smooth muscle cells (VSMC). The ...
Source: Current Vascular Pharmacology - February 26, 2014 Category: Drugs & Pharmacology Authors: Simo Cheyou ER, Bouallegue A, Srivastava AK Tags: Curr Vasc Pharmacol Source Type: research