Filtered By:
Nutrition: Calcium
This page shows you your search results in order of relevance. This is page number 6.
Order by Relevance | Date
Total 42604 results found since Jan 2013.
Interference With Peroxisome Proliferator-Activated Receptor-{gamma} in Vascular Smooth Muscle Causes Baroreflex Impairment and Autonomic Dysfunction Nervous System
In conclusion, S-P467L mice exhibit baroreflex dysfunction because of a defect in the afferent limb of the baroreflex arc caused by impaired vascular function, altered vascular structure, or compromised neurovascular coupling. These findings implicate vascular smooth muscle peroxisome proliferator activated receptor- as a critical determinant of neurovascular signaling.
Source: Hypertension - August 13, 2014 Category: Cardiology Authors: Borges, G. R., Morgan, D. A., Ketsawatsomkron, P., Mickle, A. D., Thompson, A. P., Cassell, M. D., Mohapatra, D. P., Rahmouni, K., Sigmund, C. D. Tags: Animal models of human disease, Functional genomics, Peripheral vascular disease, Endothelium/vascular type/nitric oxide Nervous System Source Type: research
Gallic acid inhibits vascular calcification through the blockade of BMP2-Smad1/5/8 signaling pathway.
Abstract
Vascular calcification is associated with increased risk of morbidity and mortality in patients with cardiovascular diseases, chronic kidney diseases, and diabetes. Gallic acid, a natural compound found in gallnut and green tea, is known to be antifungal, antioxidant, and anticancer. Here we investigated the effect of gallic acid on vascular smooth muscle cell (VSMC) calcification and the underlying mechanism. Gallic acid inhibited inorganic phosphate-induced osteoblast differentiation markers as well as calcification phenotypes (as determined by calcium deposition, Alizarin Red, and Von Kossa staining). ...
Source: Vascular Pharmacology - November 1, 2014 Category: Drugs & Pharmacology Authors: Kee HJ, Cho SN, Kim GR, Choi SY, Ryu Y, Kim IK, Hong YJ, Park HW, Ahn Y, Cho JG, Park JC, Jeong MH Tags: Vascul Pharmacol Source Type: research
Role of In Vivo Vascular Redox in Resistance Arteries Vascular Redox
Vascular thiol redox state has been shown to modulate vasodilator functions in large conductance Ca2+-activated K+ channels and other related channels. However, the role of vascular redox in small resistance arteries is unknown. To determine how in vivo modulation of thiol redox state affects small resistance arteries relaxation, we generated a transgenic mouse strain that overexpresses thioredoxin, a small redox protein (Trx-Tg), and another strain that is thioredoxin-deficient (dnTrx-Tg). The redox state of the mesenteric arteries (MAs) in Trx-Tg mice is found to be predominantly in reduced state; in contrast, MAs from d...
Source: Hypertension - December 10, 2014 Category: Cardiology Authors: Hilgers, R. H. P., Das, K. C. Tags: Other hypertension, Genetically altered mice, Hypertension - basic studies, Endothelium/vascular type/nitric oxide Vascular Redox Source Type: research
Regulation of thrombosis and vascular function by protein methionine oxidation
Redox biology is fundamental to both normal cellular homeostasis and pathological states associated with excessive oxidative stress. Reactive oxygen species function not only as signaling molecules but also as redox regulators of protein function. In the vascular system, redox reactions help regulate key physiologic responses such as cell adhesion, vasoconstriction, platelet aggregation, angiogenesis, inflammatory gene expression, and apoptosis. During pathologic states, altered redox balance can cause vascular cell dysfunction and affect the equilibrium between procoagulant and anticoagulant systems, contributing to throm...
Source: Blood - June 18, 2015 Category: Hematology Authors: Gu, S. X., Stevens, J. W., Lentz, S. R. Tags: Thrombosis and Hemostasis, Vascular Biology, Review Articles Source Type: research
Apocynin reduces blood pressure and restores the proper function of vascular endothelium in SHR.
This study has evaluated how the vascular endothelium of hypertensive rats chronically treated with apocynin affects acetylcholine (ACh), sodium nitroprusside (SNP), and phenylephrine (PE) action on the NO signal transduction pathway in endothelial (EC) and vascular smooth muscle cells. Treatment with apocynin significantly reduced the mean arterial pressure in spontaneously hypertensive rats (SHR). In addition, apocynin improved the impaired ACh hypotensive effect on SHR. Although systemic oxidative stress was high in SHR, SHR treated with apocynin and normotensive rats presented similar systemic oxidative stress levels. ...
Source: Vascular Pharmacology - June 24, 2016 Category: Drugs & Pharmacology Authors: Perassa LA, Graton ME, Potje SR, Troiano JA, Lima MS, Vale GT, Pereira AA, Nakamune AC, Sumida DH, Tirapelli CR, Bendhack LM, Antoniali C Tags: Vascul Pharmacol Source Type: research
Vitamin K2 can suppress the expression of Toll-like receptor 2 (TLR2) and TLR4, and inhibit calcification of aortic intima in ApoE(-/-) mice as well as smooth muscle cells.
Conclusion VitK2 can inhibit intimal calcification of aortic artery induced by high-fat diet in ApoE(-/-) mice and A7r5 SMCs calcification induced by β-sodium glycerophosphate, and meanwhile can reduce the expression of TLR2 and TLR4. These results suggested that the effects of VitK2 on vascular calcification may be associated with the expression of TLR2 and TLR4.
PMID: 28587577 [PubMed - as supplied by publisher]
Source: Vascular - January 1, 2017 Category: Surgery Authors: Wang Z, Wang Z, Zhu J, Long X, Yan J Tags: Vascular Source Type: research
Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II-mediated blood pressure control.
Abstract
G-Protein coupled receptors (GPCRs) activate intracellular signalling pathways by coupling to heterotrimeric G-proteins that control many physiological processes including blood pressure homeostasis. The Regulator of G-Protein Signalling-1 (RGS1) controls the magnitude and duration of downstream GPCR signalling by acting as a GTPase-activating protein for specific Gα-proteins. RGS1 has contrasting roles in haematopoietic and non-haematopoietic cells. Rgs1-/-ApoE-/- mice are protected from Angiotensin II (Ang II)-induced aortic aneurysm rupture. Conversely, Ang II treatment increases systolic blood pressu...
Source: Vascular Pharmacology - April 11, 2018 Category: Drugs & Pharmacology Authors: Patel J, Chuaiphichai S, Douglas G, Gorvin CM, Channon KM Tags: Vascul Pharmacol Source Type: research
Cagent Vascular closes $12m Series B
Cagent Vascular said today it closed a $11.9 million Series B round of financing to help support expand manufacturing and a limited launch of the company’s Serranator Alto angioplasty device.
The round was led by two strategic investors and joined by Balestier Investments, Ben Franklin Technology Partners, Synergy Ventures and other private investors, the Wayne, Penn.-based company said.
Cagent Vascular’s Serranator is an angioplasty device that uses serrated metal strips on a semi-complaint balloon to create multiple longitudinal lines of micro-serrations within the luminal surface to aid in arterial expansio...
Source: Mass Device - July 13, 2018 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Vascular Cagent Vascular Source Type: news
miR-34a Promotes Vascular Smooth Muscle Cell Calcification by Downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase).
CONCLUSIONS: miR-34a promotes VC via vascular SMC mineralization by inhibiting cell proliferation and induci senescence through direct Axl and SIRT1 downregulation, respectively. This miRNA could be a good therapeutic target for the treatment of VC.
PMID: 30026277 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 19, 2018 Category: Cardiology Authors: Badi I, Mancinelli L, Polizzotto A, Ferri D, Zeni F, Burba I, Milano G, Brambilla F, Saccu C, Bianchi ME, Pompilio G, Capogrossi MC, Raucci A Tags: Arterioscler Thromb Vasc Biol Source Type: research
Transrenal Ureteral Occlusion for Palliation of Refractory Urine Leaks Using Vascular Plugs and Liquid Ethylene Vinyl Alcohol
ConclusionsTransrenal anterograde ureteral occlusion using EVOH between vascular plugs could be considered a relatively safe and potentially valuable treatment option for refractory ureteral fistulae.
Source: Journal of Vascular and Interventional Radiology - September 16, 2019 Category: Radiology Source Type: research
Nanoparticles to Spot Vascular Calcification in Atherosclerosis
Atherosclerosis affects most of us by a certain age, and it is the underlying cause of most cardiovascular diseases. The condition results in arteries being coated with plaques and fatty deposits, as well as being chronically inflamed. While vascular...
Source: Medgadget - December 16, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Cardiac Surgery Cardiology Nanomedicine Neurology Neurosurgery Vascular Surgery Source Type: blogs
Disparate Effect of Antioxidant Supplements on the Basal Tone and Vascular Remodeling of the Aorta in Hypertensive Rats
Conclusions: Tempol decreased calcium-dependent basal aortic tone and improved vascular homeostasis in L-NAME rats. Vit-C did not lead to a similar effect, suggesting that alterations in the superoxide dismutase pathway may play a role in the basal aortic tone.J Vasc Res
Source: Journal of Vascular Research - June 18, 2020 Category: Research Source Type: research
Statin Effects on Vascular Calcification: Microarchitectural Changes in Aortic Calcium Deposits in Aged Hyperlipidemic Mice.
CONCLUSIONS: These results suggest that pravastatin treatment alters the microarchitecture of aortic calcium deposits with potential effects on plaque stability.
PMID: 33472400 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 21, 2021 Category: Cardiology Authors: Xian JZ, Lu M, Fong F, Qiao R, Patel NR, Abeydeera D, Iriana S, Demer LL, Tintut Y Tags: Arterioscler Thromb Vasc Biol Source Type: research
Hyperglycemia-Induced Secretion of Endothelial Heparanase Stimulates a Vascular Endothelial Growth Factor Autocrine Network in Cardiomyocytes That Promotes Recruitment of Lipoprotein Lipase.
CONCLUSIONS: Our data suggest that the heparanase-lipoprotein lipase-VEGF axis amplifies fatty acid delivery, a rapid and adaptive mechanism that is geared to overcome the loss of glucose consumption by the diabetic heart. If prolonged, the resultant lipotoxicity could lead to cardiovascular disease in humans.
PMID: 24115032 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 10, 2013 Category: Cardiology Authors: Zhang D, Wan A, Chiu AP, Wang Y, Wang F, Neumaier K, Lal N, Bround MJ, Johnson JD, Vlodavsky I, Rodrigues B Tags: Arterioscler Thromb Vasc Biol Source Type: research
The ethanol extract of zingiber zerumbet rhizomes mitigates vascular lesions in the diabetic retina.
In conclusion, restoring the balance between stimulators and inhibitors of angiogenesis may be associated with the protective effect of EEZZR on DR. In addition, EEZZR can ameliorate retinal inflammation via transrepression of NF-κB and inhibition of ERK1/2 signaling pathway.
PMID: 26319672 [PubMed - as supplied by publisher]
Source: Vascular Pharmacology - August 28, 2015 Category: Drugs & Pharmacology Authors: Hong TY, Tzeng TF, Liou SS, Liu IM Tags: Vascul Pharmacol Source Type: research
