Filtered By:
Nutrition: Calcium

This page shows you your search results in order of relevance. This is page number 8.

Order by Relevance | Date

Total 42604 results found since Jan 2013.

Endothelial G{alpha}q/11 is required for VEGF-induced vascular permeability and angiogenesis
Conclusion Gαq/11 critically contributes to VEGF-A-dependent permeability control and angiogenic behaviour in vitro and in vivo.
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Sivaraj, K. K., Li, R., Albarran-Juarez, J., Wang, S., Tischner, D., Grimm, M., Swiercz, J. M., Offermanns, S., Wettschureck, N. Tags: Vascular biology Source Type: research

Endoplasmic Reticulum Stress-Mediated Apoptosis Contributing to High Glucose-Induced Vascular Smooth Muscle Cell Calcification
We examined the effects of high glucose on the ER stress response of VSMCs. High glucose treatment drastically increased the ER stress response in VSMCs. The high glucose-induced osteoblastic differentiation of VSMCs was significantly attenuated by pretreatment with 500 μM of 4-PBA (an ER stress inhibitor) prior to the exposure to high glucose, as evidenced by decreases in the expression of Runx2 and activity of alkaline phosphatase, as well as calcium nodules. These results suggest that high glucose induces the ER stress response and apoptosis, leading to high glucose-elicited VC.J Vasc Res 2015;52:291-298
Source: Journal of Vascular Research - February 19, 2016 Category: Research Source Type: research

Inhibition of endoplasmic reticulum stress protected DOCA-salt hypertension-induced vascular dysfunction.
Abstract Hypertension has complex vascular pathogenesis and therefore the molecular etiology remains poorly elucidated. Endoplasmic reticulum stress (ERS), which is a condition of the unfolded/misfolded protein accumulation in the endoplasmic reticulum, has been defined as a potential target for cardiovascular disease. In the present study, the effects of ERS inhibition on hypertension-induced alterations in the vessels were investigated. In male Wistar albino rats, hypertension was induced through unilateral nephrectomy, deoxycorticosterone-acetate (DOCA) injection (20 mg/kg, twice a week) and 1% NaCl with 0.2%...
Source: Vascular Pharmacology - November 17, 2018 Category: Drugs & Pharmacology Authors: Han S, Bal NB, Sadi G, Usanmaz SE, Tuglu MM, Uludag MO, Demirel-Yilmaz E Tags: Vascul Pharmacol Source Type: research

Differential Control of Calcium Homeostasis and Vascular Reactivity by Ca2+/Calmodulin-Dependent Kinase II Calcium Channels and Vasoconstriction
The multifunctional Ca2+/calmodulin-dependent kinase II (CaMKII) is activated by vasoconstrictors in vascular smooth muscle cells (VSMC), but its impact on vasoconstriction remains unknown. We hypothesized that CaMKII inhibition in VSMC decreases vasoconstriction. Using novel transgenic mice that express the inhibitor peptide CaMKIIN in smooth muscle (TG SM-CaMKIIN), we investigated the effect of CaMKII inhibition on L-type Ca2+ channel current (ICa), cytoplasmic and sarcoplasmic reticulum Ca2+, and vasoconstriction in mesenteric arteries. In mesenteric VSMC, CaMKII inhibition significantly reduced action potential duratio...
Source: Hypertension - July 17, 2013 Category: Cardiology Authors: Prasad, A. M., Nuno, D. W., Koval, O. M., Ketsawatsomkron, P., Li, W., Li, H., Shen, F. Y., Joiner, M.-l. A., Kutschke, W., Weiss, R. M., Sigmund, C. D., Anderson, M. E., Lamping, K. G., Grumbach, I. M. Tags: ACE/Angiotension receptors, Calcium cycling/excitation-contraction coupling, Hypertension - basic studies, Ion channels/membrane transport, Other Vascular biology Calcium Channels and Vasoconstriction Source Type: research

Protective Effects of Ginaton on Vascular Endothelial Cells Injured by Angiotensin II and Hypoxia In Vitro
This study suggested that Ginaton could effectively protect VECs against injury, and lower dose would be used clinically rather than the higher dose for obtaining better results.
Source: Vascular and Endovascular Surgery - July 18, 2013 Category: Surgery Authors: Han, L., Li, M. Tags: Basic Research Article Source Type: research

Protection of Vascular Endothelial Cells Injured by Angiotensin II and Hypoxia In Vitro by Ginkgo biloba (Ginaton)
This study suggested that Ginaton could effectively protect VECs against injury, and the dose used clinically would rather be low than too high for getting better results.
Source: Vascular and Endovascular Surgery - September 19, 2013 Category: Surgery Authors: Han, L., Li, M. Tags: Basic Research Articles Source Type: research

Opposing changes in thoracic and abdominal aortic biomechanical properties in rodent models of vascular calcification and hypertension
This study investigated the effects of hypertension on regional aortic biomechanical and structural properties in three rat models of vascular calcification: the hypertensive Lewis polycystic kidney (LPK; n = 13) model of chronic kidney disease, spontaneously hypertensive rats (SHRs; n = 12), and calcification in normotensive Lewis rats induced by vitamin D3 and nicotine (VDN; n = 8). Lewis and Wistar-Kyoto rats were controls. Thoracic and abdominal aortic stiffness parameters were assessed by tensile testing. In models where aortic stiffness differences compared with controls existed in both thoracic and abdominal segment...
Source: AJP: Heart and Circulatory Physiology - July 15, 2014 Category: Cardiology Authors: Ameer, O. Z., Salman, I. M., Avolio, A. P., Phillips, J. K., Butlin, M. Tags: VASCULAR BIOLOGY AND MICROCIRCULATION Source Type: research

Activation of Endothelial Transient Receptor Potential C3 Channel Is Required for Small Conductance Calcium-Activated Potassium Channel Activation and Sustained Endothelial Hyperpolarization and Vasodilation of Cerebral Artery Vascular Medicine
Conclusions We propose that TRPC3 dynamically regulates SKCa channel activation through receptor-dependent trafficking to the plasma membrane, where it provides the source of Ca2+ influx for sustained SKCa channel activation, EC hyperpolarization, and endothelium-dependent hyperpolarization–mediated vasodilation.
Source: JAHA:Journal of the American Heart Association - August 20, 2014 Category: Cardiology Authors: Kochukov, M. Y., Balasubramanian, A., Abramowitz, J., Birnbaumer, L., Marrelli, S. P. Tags: Vascular Medicine Source Type: research

Investigation of relation between visceral and subcutaneous abdominal fat volumes and calcified aortic plaques via multislice computed tomography.
CONCLUSIONS: We have demonstrated a significant correlation between visceral fat volume and abdominal aorta atherosclerosis, while there was absence of significant correlation between subcutaneous fat volume and abdominal atherosclerosis. PMID: 25245049 [PubMed - as supplied by publisher]
Source: Vascular - September 22, 2014 Category: Surgery Authors: Efe D, Aygün F, Acar T, Yildiz M, Gemici K Tags: Vascular Source Type: research

Collectivization of Vascular Smooth Muscle Cells via TGF-β-Cadherin-11-Dependent Adhesive Switching.
CONCLUSIONS: SMCs can self-organize, structurally and functionally, via transforming growth factor-β-p38-dependent adhesive switching and a novel adherens junction architecture comprised of hybrid nanotracks of cadherin-11 and N-cadherin. The findings define a mechanism for the assembly of SMCs into networks, a process that may be relevant to the stability and function of blood vessels. PMID: 25767275 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 12, 2015 Category: Cardiology Authors: Balint B, Yin H, Chakrabarti S, Chu MW, Sims SM, Pickering JG Tags: Arterioscler Thromb Vasc Biol Source Type: research

One-year results of the ANCHOR trial of EndoAnchors for the prevention and treatment of aortic neck complications after endovascular aneurysm repair.
CONCLUSION: Despite a high frequency of hostile neck anatomy, proximal neck complications were relatively infrequent after EndoAnchor use. PMID: 26069087 [PubMed - as supplied by publisher]
Source: Vascular - June 10, 2015 Category: Surgery Authors: Jordan WD, Mehta M, Ouriel K, Arko FR, Varnagy D, Joye J, Moore WM, de Vries JP Tags: Vascular Source Type: research

Calcium/Calmodulin-Dependent Kinase II Inhibition in Smooth Muscle Reduces Angiotensin II-Induced Hypertension by Controlling Aortic Remodeling and Baroreceptor Function Vascular Medicine
Conclusions CaMKII in VSMCs regulates blood pressure under Ang II hypertension by controlling structural gene expression, wall stiffness, and baroreceptor activity.
Source: JAHA:Journal of the American Heart Association - June 15, 2015 Category: Cardiology Authors: Prasad, A. M., Morgan, D. A., Nuno, D. W., Ketsawatsomkron, P., Bair, T. B., Venema, A. N., Dibbern, M. E., Kutschke, W. J., Weiss, R. M., Lamping, K. G., Chapleau, M. W., Sigmund, C. D., Rahmouni, K., Grumbach, I. M. Tags: Vascular Medicine Source Type: research

Abstract MP05: Knockdown of Gamma-adducin Expression Impairs the Myogenic Response of the Cerebral and Renal Arterioles Session Title: Vascular Biology/Remodeling and Dysfunction
We recently identified a region on chromosome 1 containing 15 genes that rescues the impaired myogenic response in the afferent arteriole (Af-art) and the development of renal injury in Fawn Hood Hypertensive (FHH) rats. We also found an inactivating K572Q mutation in the gamma-Adducin (Add3) gene in FHH rats in this region that may play a causal role. To test this hypothesis, the present study examed the effect of knockdown of the expression of Add3 with DsiRNA on the myogenic response of renal and cerebral arterioles. A newly designed 27-mer Add3 DsiRNA blocked the expression of the Add3 protein in 293 cells and reduced ...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Fan, F., Pabbidi, M. R., Ge, Y., Roman, R. J. Tags: Session Title: Vascular Biology/Remodeling and Dysfunction Source Type: research

Abstract P198: Differential Regulation of Endothelial Nitric Oxide Synthase Phosphorylation by Protease-Activated Receptors in Adult Human Endothelial Cells Session Title: Receptors and Signal Transduction/Vascular Biology and Stiffness
In this study, we demonstrate a differential regulation of the eNOS/NO pathway by the PARs using primary adult human coronary artery endothelial cells (HCAEC). Thrombin and the PAR-1 activating peptide, TFLLR, which are known to phosphorylate eNOS-Thr-495 in bovine and human umbilical vein endothelial cells, phosphorylated eNOS-Ser-1177 in HCAECs, and increased NO production. The PAR-1 responses were blocked using SCH-79797, a PAR-1 inhibitor, and L-NAME was used to inhibit NO production. A PAR-2 specific ligand, SLIGRL, which has been shown to phosphorylate eNOS-Ser-1177 in bovine and human umbilical vein endothelial cell...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Tillery, L. C., Motley-Johnson, E. D. Tags: Session Title: Receptors and Signal Transduction/Vascular Biology and Stiffness Source Type: research

Coronary Computed Tomography (CT) Angiography as a Predictor of Cardiac and Noncardiac Vascular Events in Asymptomatic Type 2 Diabetics: A 7-Year Population-Based Cohort Study Imaging
Conclusions Computed tomography angiography provides additional prognostic information in asymptomatic type 2 diabetics not obtainable from clinical risk assessment and coronary artery calcium alone.
Source: JAHA:Journal of the American Heart Association - June 12, 2016 Category: Cardiology Authors: Halon, D. A., Azencot, M., Rubinshtein, R., Zafrir, B., Flugelman, M. Y., Lewis, B. S. Tags: Diabetes, Type 2, Primary Prevention, Computerized Tomography (CT), Coronary Artery Disease, Vascular Disease Imaging Source Type: research